폴록사머를 이용한 디클로페낙 고형 좌제의 개발

용철순,오유경,김정애,김용일,박상만,양준호,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

To develop a poloxamer-based solid suppository with poloxamer mixtures, the melting points of various formulations composed of P 124 and P 188 were investigated. To investigate the effect of poloxamer to the dissolution and dissolution mechanism of diclofenac sodium from the suppository the dissolution of diclofenac sodium delivered by the poloxamer-based suppository was performed. Furthermore, to investigate the mucoadhesive property of the poloxamer-based solid suppository, the identification test in the rectum was carried out after its rectal administration in rats. The poloxamer mixtures composed of P 124 and P 188 were homogeneous. Very small amounts of P 188 affected the melting points of poloxamer mixtures. In particular, the poloxamer mixture [P 124/P 188 (97/3%)] with the melting point of about 32℃ was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, very small amounts of P 188 in the poloxamer-based suppository hardly affected the dissolution rates of diclofenac sodium from the suppository. Dissolution mechanism analysis showed the dissolution of diclofenac sodium was proportional to the time. At 4 h after administration, the blue color of poloxamer-based suppository [diclofenac sodium/poloxamer mixture (2.5/97.5%)] with the P 124/P 188 ratio of (97/3%) and blue lake in the rectum was faded. However, the position of suppository in the rectum did not significantly change with time. Thus, it retained in the rectum for at least 4 h. Our results indicated that the poloxamer-based solid suppository with P 124 and P 188 would be a candidate of rectal dosage from for diclofenac sodium.

수근관 증후군에서의 무증상성 척골신경병증

문준식,이성수,이지용,한범기,권준범,양현덕,이성익 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

천안시 아파트 수요추정 모형구축에 관한 연구

양승원,한용대,박근준 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

This study attempted to address certain elements that are measurable in order forecast the growth demand for apartments in Cheon-An area. A good forecasting method needs to include both regional condition and historical trend-based data. Accordingly, this study was conducted to analyze elements of demands for apartments and develop the model of forecasting demands for apartments by using them. The main conclusions drawn from the analysis of elements related with demands for apartment in Cheon-An area are that the expectation of apartment supplies can be estimated from the model forecasting demands of apartments.

완전 기저 동맥 중복과 동반된 모야모야병(Moyamoya disease) 1예

권준범,양현덕,한범기,이지용,문준식,이성수 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

肝吸蟲 感染家兎에 있어서 感染强度, 經過 및 治療에 따른 ELISA抗體價의 變動에 관한 實驗的 硏究

梁元容,李駿商,林漢鍾 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3

Human clonorchiasis is one of the most common trmatode diseases and of very important pubic health problems in Korea. In the present study, the changing patterns of specific IgG antibody was demonstrated by the enzyme-linked immunosorbent assay(ELISA) in the sera rabbits infected with clonorchis sinensis. The O.D> (optical density) values of the ELISA in the sera were merwured according to intensity and course of infections and tendency of decrease after chemotherapy. The ELISA was performed with veronal buffered saline antigen of clonorchis, peroxidase conjugated antirabbit IgG and ortho- phenylendiamine as a substrate by micro method. In the 3 groups of rabbits infected with 50(A group), 500(B group) or 100×5(C group) metacercariae, the sera were prepared biweekly up to 18th week before chemotherapy, and biweekly up to 24th week after chemotherapy. The results were as follows: 1. O.D. values increased gradually with lapse of time before treatment. The O.D. values indicated firstly 1.000 or more in 8 weeks after infection in A group and 4 weeks after infection in both B and C groups. The O.D. values reached plateau at 10 weeks after infection in A group and 8 weeks after infection in both B and C groups. Regression equations between the O.D. values of the ELISA and period(week) after infection among 2 groups were as fllows, y=0.09x+0.319 in A group y=0.08x+ 0.826 in B group and y=0.08x+0.807 in C group. 2. The O.D. values in A group which had been treated decreased gradually and became preinfection level at 24 weeks after chemotherapy. On the contrary the O.D. values in A group which has not been treated showde plateau. The O.D. values in both B and C groups which had been cured decreased gradually and became preinfection level at 24 weeks after chemotherapy.

닭의 장풀의 수경재배시 적정 pH 및 질소량 분석

양용준,김영식 덕성여자대학교 식물자원연구소 1993 植物資源硏究誌 Vol.1 No.-

본 연구는 닭의장풀의 생육에 미치는 배양액내 NH_4NO_3 농도와 여러 pH값의 효과를 구명함으로써 수경재배시 적합한 배양액내 적정 pH와 질소농도를 밝히는데 목적이 있으며 그 결과는 다음과 같다. 1. 생육중 배양액 pH는 생육전반기 및 배양액 교환초기(2일간)에는 상승하다가 생육후반기 및 배양액 교환 후 (3-5일간)에는 급격히 감소하였다. 2. 재배기간이 경과함에 따라 초장이 신장되고 엽수가 증가하였는데 이러한 경향은 배양액중 처리 질소농도가 높을수록 뚜렷하였다. 3. 생체중과 건물중은 생육중 크게 증가하였으나 pH값(1-6)과 NH_4NO_3 농도에 의해 영향은 인정되지 않았다. 4. Relative growth rate(RGR)는 1M일 때가 6M 보다 약간 높았으며 생육전반기가 후반기보다 높았다 5. NO_3 농도는 매주 처리후 시간이 경과할수록 감소되었는데, 6M의 pH 7에서 잔류량이 가장 높고 1M의 pH 5에서 가장 낮았다. This study was conducted to investigate the effect of NH_4NO_3 concentrations and different solution pHs on growth of Commelina communis and remaining NO_3 contents in nutrient solution. The objects of this research was to reveal the optimum pH value and nitrogen concentration in hydroponic medium. The results were summarized as follows: 1) The solution pH value tended to increase until 2 days after each medium exchange weekly and the first 2 weeks after planting, after then decreased largely. 2) Growth in plant height and development in number of leaves accelerated with adding the hydroponically cultured period and increasing the nitrogen concentration. 3) Fresh and dryweight were markedly influenced by pH values(1 or 6) and NH_4NO_3 concentrations in nutrient solution. 4) Relative growth rate(RGR) showed the highest value at 1M NH_4NO_3 concentrations in nutrient solution, and the RGR between the initial and the 3rd week was more higher than that between the 3rd and 6th week. 5) NO_3 concentration decreased slowly after the change of nutrient solution weekly. The remaining contents were highest at 6M NH_4NO_3 concentrations and pH 7 in nutrient solution.

다극형 스파크 �b과 다중평행판 축전기형 전송회로를 사용한 질소레이저의 동작특성

장철용,박영수,양준목,이치원 충남대학교 기초과학연구소 1994 忠南科學硏究誌 Vol.21 No.1

We have studied on the operational characteristics of a nitrogen laser which was coupled with a multiplex parallel capacitor type Blumlein transmission line circuit and a multiplex sparkgap. This spark gap consisted of 8 pairs of electrode and was 50 ㎝ in length, as long as the laser tube. According to increasing the number of electrodes in the spark gaps up to the 6 pairs, the output power and stability of the laser was increased. It was to be improved that the multiplex spark gap was operated as a good peformance to the nitrogen laser system. The optimum operational condition of the nitrogen laser at 20㎐ of repetition rate could be obtained with the nitrogen gas pressure of 80 torr, E/P value of 325.0 v/㎝ torr at the electrodes spacing 5.0 ㎜ and of 90 torr, E/P value of 311.1 v/㎝ torr at the electrodes spacing 6.0 ㎜ respectively.

사춘기전 Ⅰ,Ⅱ급 부정교합 아동의 기도 면적, 혀의 위치와 안면 형태에 관한 연구

황용인,이규홍,이기준,김상철,조형준,천세환,박양호 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.2

본 연구는 사춘기 성장 이전의 I, II급 부정교합을 갖는 아동 환자들의 측모 두부 규격 방사선사진을 이용하여 두개 안면 형태를 조사하고 이들과 혀의 위치 및 면적, 기도의 면적과의 관계를 조사하여 비인두 기도 및 혀의 형태가 악골 및 부정 교합의 형태에 미치는 영향을 알아보았다. 9 - 11세의 교정환자 76명을 대상으로 측모 두부 규격 방사선사진상 ANB difference를 기준으로 대조군(I급 부정교합군: 0 ≤ ANB difference < 4.0)과 실험군(II급 부정교합군: ANB difference ≥ 4.0)으로 분류하였다. 혀 면적, 혀와 구개 사이의 면적, 비인두 기도 면적과 두개안면형태 항목을 측정하고 비교하여 다음과 같은 결과를 얻었다. 혀 면적, 혀와 구개 사이의 면적, 비인두 기도 면적은 II급 부정교합군과 I급 부정교합군 간에 유의한 차이를 보이지 않았다. Hyperdivergent안면 형태일수록 비인두 기도 면적이 좁았다. 안모의 전후방 수직 길이가 길수록 혀의 면적이 넓었고, 전안면 고경이 길수록 혀는 하방위치 하였다. 비인두기도 면적이 좁을수록 혀의 면적도 좁아졌다. 이상의 연구 결과 혀의 면적과 위치, 비인두 기도의 면적은 I급, II급 부정교합 간에 차이를 보이지 않으며 hyperdivergent 안면 형태 및 안모의 전후방 수직 길이와 관련이 있는 것으로 사료된다. Objective: This study examined the craniofacial morphology of young patients in their prepubertal stage showing class I, II malocclusion, by analyzing lateral cephalograms, and analyzed its relationship with tongue position, tongue space, and airway space in order to ascertain the effects of nasopharyngeal airway and tongue morphology on the form of the malocclusion. Methods: Seventy-six patients aging from 9 to 11 were divided into two groups depending on the ANB difference on the lateral cephalogram: Experimental grouP (CI II malocclusion group) showing 0 ≤ ANB difference < 4.0; Control group (CI I malocclusion group) showing 0 ≤ ANB difference < 4.0. The tongue space, space between palate and tongue, nasopharyngeal airway space and craniofacial morphology were compared between the two groups. Results: Tongue space, Palate-tongue space, nasopharyngeal airway space showed no significant differences between class I and class II malocclusion groups. Hyperdivergent faces were associated with smaller nasopharyngeal airway space. Longer anterior facial height and posterior facial height were associated with larger tongue space, and greater anterior facial height were associated with lower tongue position, Smaller nasopharyngeal airway space showed smaller tongue space. Conclusions: Tongue space and nasopharyngeal airway space showed no significant differences between class I malocclusion group and class II malocclusion group. Only anterior facial height and posterior facial height had an influence on tongue space and nasopharyngeal airway space.

지리정보체계를 이용한 송배전 지하시설물관리시스템 구축

장용구,강인준,김상석,양승태 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.2

현재 국내에서 관리하고 있는 지하시설물들은 몇몇의 문제점을 가지고 있다. 특히, 한국전력공사의 경우 현장에서 구축되는 지리정보 및 속성정보의 신속한 갱신이 되지 않아 보다 정밀하고 안정된 한국전력 선로관리가 어려운 실정이다. 또한, 토목공사 현장에서 관리감독을 수행하고 있는 한국전력 관계자들은 지리정보체계에 대한 지식과 정보는 부족하지만, 현장에 부합되는 지리정보 및 속성정보를 파악하고 있다. 따라서 보다 효율적인 한국전력의 선로관리를 위해서는 이들의 업무분석내용을 충분히 참조해야 하는데 기존의 한국전력 선로관리시스템의 정보는 그러하지 못한 문제점을 가지고 있다. 본 연구에서는 한국전력공사에서 시설물공사를 통하여 구축된 송·배전 지하시설물에 관한 지리정보 및 속성 정보를 이용하여 실무자에게 보다 쉽고 안전하게 유지 관리할 수 있도록 사용자 중심의 송·배전 지하시설물관리시스템을 구축하였다. Now, there are some problems to manage underground facilities in domestic. Specially, in the case of KEPCO (Korea Electric Power Corporation). it is so difficult to manage electronic line more stably and detailedly because the geographic information and attribute information being built is not easy to be updated in the field. KEPCO officials who are accompanying management and supervision in earthwork do not have sufficient knowledge and information about GIS but they grasp the information of geography and property which coincide with the field. Therefore they have to refer their business analysis contents sufficiently for more efficient lines management in the KEPCO, but it is problem that the existing information of electronic lines management system is not. In this study, we constructed power transmission and power distribution underground facility management system for the user to manage and maintain underground facilities more easily and safely using the information of geography and property about power transmission and power distribution underground facility which have been built by KEPCO.

용융염산화 반응기에서 기체체류량 및 기-액 흐름특성

조용준,양희철,은희철,유재형,김준형 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.5

용융염산화는 혼성폐기물과 유해폐기물을 효과적으로 산화 및 분해할 수 있는 소각대체기술중 하나이다. 본 연구에서는 직경이 0.079 m이고 높이가 0.653 m인 용융염산화 반응기에서 기체체류량 및 기-액 흐름특성에 대한 연구를 수행하였다. 액상으로 용융탄산나트륨을 기상으로 건조된 공기를 사용하였으며 기체유속(0.05-0.22 m/s)과 용융염온도(870-970℃) 변화가 기체체류량 및 기-액 흐름특성에 미치는 영향을 규명하였다. 기체체류량은 용융염 온도가 상승함에 따라 증가하였는데, 이는 용융염 온도의 증가로 인해 용융된 탄산나트륨의 점도와 표면장력이 감소하였기 때문이다. 실험에서 얻어진 기체체류량 데이터를 drift-flux 모델에 적용하여 용융염반응기 내의 흐름특성을 규명할 수 있었으며, 이를 통해 흐름영역에 따른 기체체류량을 정확하게 예측할 수 있었다. Molten salt oxidation is one of the most promising alternatives to incineration that can be used to efficiently destroy the organic components of mixed wastes and hazardous wastes. In this study, the gas holdup and gas-liquid flow characteristics are investigated in the molten salt oxidation reactor (0.076 m D×0.653 m H.). Effects of input air velocity (0.05-0.22m/s ) and molten salt temperature (870-970℃) on the gas holdup and flow characteristics have been studied. Molten carbonate as the liquid phase and air as the gas phase have been used in this study. The gas holdup increases with increasing molten salt temperature due to the decrease of viscosity and surface tension of molten carbonate. The experimentally obtained gas holdups in the molten salt reactor have been well described and characterized by means of drift-flux model. The gas holdups with variation of the flow regime have been well predicted.