Assessing the Blood Supply Status of the Focal Ground-Glass Opacity in Lungs Using Spectral Computed Tomography

Guanfu Liu,Mengying Li,Guosheng Li,Zhiyong Li,Ailian Liu,Renwang Pu,Huizhi Cao,Yijun Liu 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.1

Objective: To exploit material decomposition analysis in dual-energy spectral computed tomography (CT) to assess the blood supply status of the ground-glass opacity (GGO) in lungs. Materials and Methods: This retrospective study included 48 patients with lung adenocarcinoma, who underwent a contrast-enhanced dual-energy spectral CT scan before treatment (53 GGOs in total). The iodine concentration (IC) and water content (WC) of the GGO, the contralateral and ipsilateral normal lung tissues were measured in the arterial phase (AP) and their differences were analyzed. IC, normalized IC (NIC), and WC values were compared between the pure ground-glass opacity (pGGO) and the mixed ground-glass opacity (mGGO), and between the group of preinvasive lesions and the minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA) groups. Results: The values of pGGO (IC = 20.9 ± 6.2 mg/mL and WC = 345.1 ± 87.1 mg/mL) and mGGO (IC = 23.8 ± 8.3 mg/mL and WC = 606.8 ± 124.5 mg/mL) in the AP were significantly higher than those of the contralateral normal lung tissues (IC = 15.0 ± 4.9 mg/mL and WC = 156.4 ± 36.8 mg/mL; IC = 16.2 ± 5.7 mg/mL and WC = 169.4 ± 41.0 mg/mL) and ipsilateral normal lung tissues (IC = 15.1 ± 6.2 mg/mL and WC = 156.3 ± 38.8 mg/mL; IC = 15.9 ± 6.0 mg/mL and WC = 174.7 ± 39.2 mg/mL; all p < 0.001). After normalizing the data according to the values of the artery, pGGO (NIC = 0.1 and WC = 345.1 ± 87.1 mg/mL) and mGGO (NIC = 0.2 and WC = 606.8 ± 124.5 mg/mL) were statistically different (p = 0.049 and p < 0.001, respectively), but not for the IC value (p = 0.161). The WC values of the group with preinvasive lesions and MIA (345.4 ± 96.1 mg/mL) and IA (550.1 ± 158.2 mg/mL) were statistically different (p < 0.001). Conclusion: Using dual-energy spectral CT and material decomposition analysis, the IC in GGO can be quantitatively measured which can be an indicator of the blood supply status in the GGO.

Isolation of a New Flavonone Glycoside from Eria marginata

Sun, Qionghui,Liu, Yijun,Jiang, Jinhe,Huang, Guoli,Liu, Bo,Liu, Ying,Zhan, Rui,Chen, Yegao Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.8

Isolation of a New Flavonone Glycoside from Eria marginata

Qionghui Sun,Yijun Liu,Jinhe Jiang,Guoli Huang,Bo Liu,Ying Liu,Rui Zhan,Yegao Chen 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.8

Mining Sequential Trees in a Tree Sequence Database

Yijun Bei,Zhen Lin,Qiyao Wang,Erteng Liu 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.3

Joint wireless and computational resource allocation for ultra-dense mobile-edge computing networks

( Junyi Liu ),( Hongbing Huang ),( Yijun Zhong ),( Jiale He ),( Tiancong Huang ),( Qian Xiao ),( Weiheng Jiang ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.7

In this paper, we study the joint radio and computational resource allocation in the ultra-dense mobile-edge computing networks. In which, the scenario which including both computation offloading and communication service is discussed. That is, some mobile users ask for computation offloading, while the others ask for communication with the minimum communication rate requirements. We formulate the problem as a joint channel assignment, power control and computational resource allocation to minimize the offloading cost of computing offloading, with the precondition that the transmission rate of communication nodes are satisfied. Since the formulated problem is a mixed-integer nonlinear programming (MINLP), which is NP-hard. By leveraging the particular mathematical structure of the problem, i.e., the computational resource allocation variable is independent with other variables in the objective function and constraints, and then the original problem is decomposed into a computational resource allocation subproblem and a joint channel assignment and power allocation subproblem. Since the former is a convex programming, the KKT (Karush-Kuhn-Tucker) conditions can be used to find the closed optimal solution. For the latter, which is still NP-hard, is further decomposed into two subproblems, i.e., the power allocation and the channel assignment, to optimize alternatively. Finally, two heuristic algorithms are proposed, i.e., the Co-channel Equal Power allocation algorithm (CEP) and the Enhanced CEP (ECEP) algorithm to obtain the suboptimal solutions. Numerical results are presented at last to verify the performance of the proposed algorithms.

A Model Stacking Algorithm for Indoor Positioning System using WiFi Fingerprinting

JinQuan Wang,YiJun Wang,GuangWen Liu,GuiFen Chen 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.4

With the development of IoT and artificial intelligence, location-based services are getting more and more attention. For solving the current problem that indoor positioning error is large and generalization is poor, this paper proposes a Model Stacking Algorithm for Indoor Positioning System using WiFi fingerprinting. Firstly, we adopt a model stacking method based on Bayesian optimization to predict the location of indoor targets to improve indoor localization accuracy and model generalization. Secondly, Taking the predicted position based on model stacking as the observation value of particle filter, collaborative particle filter localization based on model stacking algorithm is realized. The experimental results show that the algorithm can control the position error within 2m, which is superior to KNN, GBDT, Xgboost, LightGBM, RF. The location accuracy of the fusion particle filter algorithm is improved by 31%, and the predicted trajectory is close to the real trajectory. The algorithm can also adapt to the application scenarios with fewer wireless access points.

Exosome-mediated lnc-ABCA12-3 promotes proliferation and glycolysis but inhibits apoptosis by regulating the toll-like receptor 4/nuclear factor kappa-B signaling pathway in esophageal squamous cell carcinoma

Junliang Ma,Yijun Luo,Yingjie Liu,Cheng Chen,Anping Chen,Lubiao Liang,Wenxiang Wang,Yongxiang Song 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.1

Esophageal squamous cell carcinoma (ESCC) is a kind of malignant tumor with high incidence and mortality in the digestive system. The aim of this study is to explore the function of lnc-ABCA12-3 in the development of ESCC and its unique mechanisms. RT-PCR was applied to detect gene transcription levels in tissues or cell lines like TE-1, EC9706, and HEEC cells. Western blot was conducted to identify protein expression levels of mitochondrial apoptosis and toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling pathway. CCK-8 and EdU assays were carried out to measure cell proliferation, and cell apoptosis was examined by flow cytometry. ELISA was used for checking the changes in glycolysis-related indicators. Lnc-ABCA12-3 was highly expressed in ESCC tissues and cells, which preferred it to be a candidate target. The TE-1 and EC9706 cells proliferation and glycolysis were obviously inhibited with the downregulation of lnc-ABCA12-3, while apoptosis was promoted. TLR4 activator could largely reverse the apoptosis acceleration and relieved the proliferation and glycolysis suppression caused by lnc-ABCA12-3 downregulation. Moreover, the effect of lnc-ABCA12-3 on ESCC cells was actualized by activating the TLR4/NF-κB signaling pathway under the mediation of exosome. Taken together, the lnc-ABCA12-3 could promote the proliferation and glycolysis of ESCC, while repressing its apoptosis probably by regulating the TLR4/NF-κB signaling pathway under the mediation of exosome.

The JFNK method for the PWR's transient simulation considering neutronics, thermal hydraulics and mechanics

He, Qingming,Zhang, Yijun,Liu, Zhouyu,Cao, Liangzhi,Wu, Hongchun Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.2

A new task of using the Jacobian-Free-Newton-Krylov (JFNK) method for the PWR core transient simulations involving neutronics, thermal hydraulics and mechanics is conducted. For the transient scenario of PWR, normally the Picard iteration of the coupled coarse-mesh nodal equations and parallel channel TH equations is performed to get the transient solution. In order to solve the coupled equations faster and more stable, the Newton Krylov (NK) method based on the explicit matrix was studied. However, the NK method is hard to be extended to the cases with more physics phenomenon coupled, thus the JFNK based iteration scheme is developed for the nodal method and parallel-channel TH method. The local gap conductance is sensitive to the gap width and will influence the temperature distribution in the fuel rod significantly. To further consider the local gap conductance during the transient scenario, a 1D mechanics model is coupled into the JFNK scheme to account for the fuel thermal expansion effect. To improve the efficiency, the physics-based precondition and scaling technique are developed for the JFNK iteration. Numerical tests show good convergence behavior of the iterations and demonstrate the influence of the fuel thermal expansion effect during the rod ejection problems.

Monolayer Molybdenum Disulfide Transistors with Single-Atom-Thick Gates

Zhu, Yibo,Li, Yijun,Arefe, Ghidewon,Burke, Robert A.,Tan, Cheng,Hao, Yufeng,Liu, Xiaochi,Liu, Xue,Yoo, Won Jong,Dubey, Madan,Lin, Qiao,Hone, James C. American Chemical Society 2018 NANO LETTERS Vol.18 No.6

<P>Two-dimensional transition-metal dichalcogenides (TMDs) are unique candidates for the development of next-generation electronic devices. However, the large contact resistance between metal and the monolayer TMDs have significantly limited the devices’ performance. Also, the integration of ultrathin high-<I>k</I> dielectric layers with TMDs remains difficult due to the lack of dangling bonds on the surface of TMDs. We present monolayer molybdenum disulfide field-effect transistors with bottom local gates consisting of monolayer graphene. The atomic-level thickness and surface roughness of graphene facilitate the growth of high-quality ultrathin HfO<SUB>2</SUB> and suppress gate leakage. Strong displacement fields above 8 V/nm can be applied using a single graphene gate to electrostatically dope the MoS<SUB>2</SUB>, which reduces the contact resistances between Ni and monolayer MoS<SUB>2</SUB> to 2.3 kΩ·μm at low gate voltages. The devices exhibit excellent switching characteristics including a near-ideal subthreshold slope of 64 millivolts per decade, low threshold voltage (∼0.5 V), high channel conductance (>100 μS/μm), and low hysteresis. Scaled devices with 50 and 14 nm channels as well as ultrathin (5 nm) gate dielectrics show effective immunity to short-channel effects. The device fabricated on flexible polymeric substrate also exhibits high performance and has a fully transparent channel region that is desirable in optical-related studies and practical applications.</P> [FIG OMISSION]</BR>

Black and Green Tea Supplements Ameliorate Male Infertility in a Murine Model of Obesity

Chunyang Han,Cuiyan Liu,Jiangsu Geng,Yun Tang,Yunsheng Li,Yijun Wang,Zhongwen Xie 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.12

Obesity, a chronic metabolic disorder, can affect male reproductive function. As a functional beverage, tea has many biological activities and potential in the treatment of obesity. However, its effects on male reproductive damage induced by obesity are not yet clear. In this study, a murine model of obesity was established by feeding with high-fat diet (HF). A total of 24 male mice were divided into four groups: normal diet (control), HF, HF supplemented with 5% green tea powder (HF+G), and HF supplemented with 5% black tea powder (HF+B). The results showed that the HF + B significantly reduced the mouse body weight gain and testicular coefficient and lowered the serum insulin and leptin levels compared with the HF group. The sperm malformation rate of mice in the HF group had a significant increase when compared with the control group, the HF + B group had a significant decrease compared with the HF group, and no difference from the control group. The HF + G and HF + B significantly increased testosterone levels in serum compared with the HF group. The testosterone production-related gene cytochrome P450 family 11 subfamily a member (CYP11A1) and cytochrome p450 family 17 subfamily a member 1 (CYP17A1) expressions in testis were significantly increased in the HF + G group compared with HF group. In addition, the HF + G and HF + B abolished the effects of HF on superoxide dismutase (SOD), malondialdehyde, and glutathione levels in testis and antioxidant-related gene expressions of XRCC1 and SOD1. Overall, our findings have provided evidence that black and green tea has a positive effect on reducing reproductive damage in a male murine model of obesity, and that black tea is more effective than green tea.