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Song, Young-Sun,Choi, Chun-Yeon,Suh, Hongsuk,Song, Yeong-Ok The Korean Society of Food Science and Nutrition 2004 Preventive Nutrition and Food Science Vol.9 No.3
Previous studies have shown that kimchi and kimchi-derived 3-(4'-hydroxyl-3', 5'-dimethoxyphenyl) propionic acid have anti-oxidative and hypolipidemic effects in rats and rabbits. This study was designed to investigate whether chemically synthesized 3-(4'-hydroxyl-3', 5' -dimethoxyphenyl) propionic acid (HDMPPA) may ameliorate oxidative stress through the regulation of nuclear factor KB (NFkB) activation in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage cells. Treatment of RAW 264.7 cells with 400 uM of HDMPPA significantly reduced LPS-stimulated nitric oxide (NO) production. Treatments with HDMPPA at 100 uM to 400 uM concentrations significantly elevated glutathione (GSH) level. However, cell viability and thiobarbituric acid-reactive substances (TBARS) concentrations were not affected by the concentrations of HDMPPA used. The specific DNA binding activities of NFKB, a transcription factor which is sensitive to oxidative stress, were not down-regulated by HDMPPA treatments. These results suggest that HDMPPA may have weak anti-oxidative activity against LPS challenge by scavenging NO and stimulating GSH production.
( Yeong Bok Song ),( Boh Kyung Kim ),( Mi Jin Choi ),( Yeong Ok Song ),( Eun Ju Cho ) 부산대학교 김치연구소 2012 김치의 과학과 기술 Vol.15 No.-
The protective effects of L-arabinose and sugar beet (SBP) on high glucose-induced oxidative stress were investigated using LLC-PK cells. Under the high glucose-induced cellular oxdative model, the treatment of 45 mM of glucose led to the decrease in cell viability and increase in lipod peroxidation_However. L-arabinose and SBP significantly inhibited the high glucose-induced cytotoxicity and lipid per-oxidation. In addition, the formation of nitric oxide(NO) was increased by the treatment of 45mM glu-cose. while the treatment of L-arabinose or SBP inhibited signigicantly the NO formation compared with high glucose-treated control. The superoxide anion production of groups treated whth L-arabinose or SBP was significantly lower than that of the control treated with high glucose. Futhermore. L-arabinose and SBP elevated the glucose uptake. resulting in lower glucose concentration compared with non-treated control. High glucose levels induced the overexpressions of bax. inducible NO synthase and cyclooxygen-ase-2. but L-arabinose or SBP treatrnent down-regulated the expressions of these genes. Arabinose and SBP also inhibited the expression of nuclear factor-kappa B induced by 45mM glucose in LLC-PK cells. In particular, arabinose exhibited stronger inhibitory activities on high glucose-induced oxdative stress than SBP did. These findings indicate that L-arabinose and SBP are promising antioxidative agents with protective activities against hyperglycemia.