Hydrogel Nanospike Patch as a Flexible Anti-Pathogenic Scaffold for Regulating Stem Cell Behavior

Park, Sunho,Park, Hyun-Ha,Sun, Kahyun,Gwon, Yonghyun,Seong, Minho,Kim, Sujin,Park, Tae-Eun,Hyun, Hoon,Choung, Yun-Hoon,Kim, Jangho,Jeong, Hoon Eui American Chemical Society 2019 ACS NANO Vol.13 No.10

<P>Vertically aligned nanomaterials, such as nanowires and nanoneedles, hold strong potential as efficient platforms onto which living cells or tissues can be interfaced for use in advanced biomedical applications. However, their rigid mechanical properties and complex fabrication processes hinder their integration onto flexible, tissue-adaptable, and large-area patch-type scaffolds, limiting their practical applications. In this study, we present a highly flexible patch that possesses a spiky hydrogel nanostructure array as a transplantable platform for enhancing the growth and differentiation of stem cells and efficiently suppressing biofilm formation. <I>In vitro</I> studies show that the hydrogel nanospike patch imposes a strong physical stimulus to the membranes of stem cells and enhances their osteogenic, chondrogenic, and adipogenic differentiation and the secretion of crucial soluble factors without altering cell viability. At the same time, the array exhibits effective bactericidal properties against Gram-positive and Gram-negative bacteria. <I>In vivo</I> studies further demonstrate that the flexible hydrogel patch with its spiky vertical nanostructures significantly promotes the regeneration of damaged cranial bone tissues while suppressing pathogenic bacterial infections in mouse models.</P> [FIG OMISSION]</BR>

공공임대주택과 민간임대주택의 주거 만족도 영향요인 및 차이 분석

박선호(Park, Sunho),김남정(Kim, Namjung),박환용(Park, Hwanyong) 한국주거환경학회 2021 주거환경(한국주거환경학회논문집) Vol.19 No.4

본 연구는 민간임대주택을 비교 대상으로 하여 공공임대주택의 주거 만족도 영향요인을 분석하고, 공공임대주택의 만족도를 높이기 위한 정책적 시사점을 도출하는데 연구의 목적을 갖고 있다. 연구의 공간적 범위는 전국이며, 공공임대주택과 민간임대주택의 주거 만족도 자료는 정부가 가장 최근에 실시한 2019년 ‘주거실태조사’의 결과를 활용하였다. 본 연구는 로지스틱 회귀모형을 활용하여 다음과 같은 분석결과를 도출하였다. 첫째, 공공임대주택과 민간임대주택에 있어서 전반적인 주택 만족도의 영향요인은 ‘안전·위생상태’요인, ‘방수·난방상태’요인, ‘소음상태’요인이 공통적으로 영향을 미치는 것으로 분석되었다. 먼저, 공공임대주택의 경우는 ‘방수·난방’요인이 1단위(1단계) 증가(상승)하면 전반적인 주택 만족도가 높아질 확률이 4.549배 증가하고, ‘안전·위생상태’요인은 전반적인 주택 만족도 수준을 높일 확률이 3.697배, ‘소음상태’요인은 2.191배인 것으로 나타났다. 다음으로 민간임대주택은 ‘방수·난방상태’요인의 수준이 1단위(1단계) 증가(상승)하면 전반적인 주택 만족도가 높아질 확률이 3.871배 증가하고, ‘안전·위생상태’요인은 전반적인 주택 만족도를 높일 확률이 3.587배, ‘소음상태’요인은 1.943배 증가하는 것으로 나타났다. 주택유형의 경우는 비아파트에서 아파트로 주택유형이 변화되면 전반적인 주택 만족도 수준이 불만족에서 만족 수준으로 개선될 확률이 1.328배 증가하고, 월소득은 소득이 증가할수록 만족도 수준도 증가하는 경향을 갖는 것으로 나타났다. 이 외에도 환기의 상태 수준이 ‘불량’에서 ‘양호’로 개선되면 전반적인 주택 만족도가 높아질 확률이 2.094배가 증가하고, 채광의 경우는 1.460배가 증가하는 것으로 분석되었다. 둘째, 전반적인 주거환경 만족도에 미치는 영향요인은 공공임대주택과 민간임대주택에서 공통적으로 ‘외부시설 접근환경’요인, ‘거주 환경성’요인, ‘주차·보행환경’요인 모두 영향을 미치는 것으로 분석되었다. 또한, 요인 구성에는 포함되지 않았으나 공원·녹지 접근성, 교육시설 이용성, 방범, 이웃관계에 대한 만족도가 영향을 미치는 것으로 분석되었다. 먼저, 공공임대주택의 경우는 ‘외부시설 접근환경’요인의 만족도 수준이 1단위(1단계) 증가(상승)하면 전반적인 주거환경 만족도 수준이 높아질 확률이 6.334배 증가하는 것으로 분석되었다. ‘거주 환경성’요인은 2.747배, ‘주차·보행환경’요인은 2.007배가 증가하는 것으로 나타났다. 월소득의 경우는 Exp(B)의 값이 0.998배로서 만족도 수준 변화에 미치는 확률은 매우 적지만 월소득이 높아질수록 전반적인 주거환경 만족도 수준이 낮아지며, 반대로 소득이 낮아질수록 만족도 수준이 높아지는 경향을 갖고 있는 것으로 나타났다. 지역1의 경우는 비수도권보다 수도권에 거주할 경우에 전반적인 주거환경 만족도가 높아질 확률이 1.684배로 나타났다. 다음으로 민간임대주택은 ‘외부시설 접근환경’요인의 만족도 수준이 1단위(1단계) 증가(상승)하면 전반적인 주거환경 만족도가 높아질 확률이 3.492배 증가하는 것으로 분석되었다. ‘거주 환경성’요인의 만족도 수준이 1단위 증가하면 전반적인 주거환경 만족도가 2.020배 증가하고, ‘주차·보행환경’요인은 1.906배 증가하는 것으로 나타났다. 지역1에 있어서 도에서 광역시·특별시로 거주지가 이전되면 전반적인 주거환경 만족도 수준이 개선될 확률이 1.229배 증가하고, 주택 노후도의 경우는 1.486배 증가하는 것으로 나타났다. 이러한 분석결과를 놓고 볼 때, 공공임대주택을 공급함에 있어서 방수, 균열, 난방·단열 등 ‘방수·난방상태’와 관련된 건축물의 물리적 환경의 질적 향상에 노력을 기울여야 할 필요가 있다. 건축물의 상태가 개선될 때 전반적인 주택 만족도가 높아질 확률이 가장 크기 때문이다. 또한, 공공임대주택의 건설·공급 입지와 단지내 위치에 대한 계획적 배려가 요구된다. 의료시설·상업시설·공공기관·문화시설·대중교통 접근성을 개선될 때 전반적인 주거환경 만족도가 높아질 확률이 가장 큰 것으로 분석되었기 때문이다. 이 같은 맥락에서 수요가 많은 도심 내에서 공공참여형 또는 공공주도형 정비사업 등을 통해 공공임대주택을 확보하고 기존 공공임대주택의 리모델링이나 재건축을 통해 양질의 임대주택 수요에 부응해 나갈 필요가 있다고 하겠다. There is growing demand for more emphasis to be placed on the quality of public rental housing rather than only expanding its supply. The Korean government plans to extend eligibility for public rental housing for middle income households. Quality of public housing is more likely to be enhanced when we accurately understand factors affecting residents’ level of satisfaction. This study examines the factors affecting residents’ satisfaction with public rental housing compared with private rental housing. We analyzed the micro data obtained from the 2019 Korean Housing Survey conducted by the Korean Ministry of Land, Infrastructure and Transport. Overall housing facility satisfaction levels with public and private rental housing are commonly affected by “water-proofing and heating” followed by, in order of importance, “security and sanitation” and “noise.” Apart from this, satisfaction with private rental housing is influenced by “income,” “types of building,” “ventilation,” and “sun lighting.” In addition, residential environment satisfaction levels with public and private rental housing are commonly affected by “accessibility of neighborhood facilities,” “environmental aspects for residents,” and “car-park and pedestrian-friendliness,” in order of importance. Other common variables explaining residents’ overall satisfaction with the residential environment are parks, green areas, and educational facilities. Although these factors are common determinants of satisfaction for both types of housing, in terms of how strongly each factor influences satisfaction, there is a significant difference between public and private rental housing.

해상 물류 효율성을 위한 선박의 전자적 처리 수단과의 항만 정보 연계 방안 연구

박순호(Park Sunho),박원재(Park Wonjae),박새롬(Park Saerom) 한국통신학회 2014 한국통신학회 학술대회논문집 Vol.2014 No.6

Engineering nanowrinkled microfibers composed of eggshell membrane and graphene

Park, Sunho,Choi, Kyoung Soon,Kim, Woochan,Lee, Dohyeon,Kim, Daun,Kim, Myung-Sun,Kim, Kyunghoon,Kim, Jangho Elsevier 2018 Materials letters Vol.229 No.-

<P><B>Abstract</B></P> <P>We present a facile method for designing and manipulating eggshell membrane-based nanowrinkled microfibers (EMNMs) using graphene and a spin-coating technique. Graphene is simply spin-coated on the eggshell membrane to form multiscale structures of nanowrinkled microfibers. We demonstrate that the EMNMs combine the unique properties of the raw eggshell membrane and graphene, such as micro- and nanoscale hierarchical morphologies, specific crystalline structures, and surface wettability. We also show that the properties of the EMNMs can be controlled by adjusting the concentration of graphene.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nanowrinkled microfibers composed of eggshell membrane and graphene are fabricated. </LI> <LI> The properties of the prepared nanowrinkled microfibers are investigated. </LI> <LI> The microfiber properties can be controlled by adjusting the graphene concentration. </LI> </UL> </P>

Flexible Anti-Pathogenic Patch Composed of Vertically Aligned Nanospike Arrays for Regulating Stem Cell Behavior

Sunho Park,Hyun-Ha Park,Woochan Kim,Yonghyun Gwon,Hoon Eui Jeong,Jangho Kim 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11

Aligned nanotopography including nanopattern, nanoneedle, and nanowire hold strong potential to regulate stem cell behaviors. In this study, we present a highly flexible hydrogel nanospike array as a precisely defined, vertically aligned polymeric platform for enhancing the differentiation of stem cells and efficiently suppressing biofilm. This vertical nanostructure not only imposes a strong physical stimulus to the cells but also leads to a three-dimensional spherical morphology of the cells, which remarkably promotes their osteogenic differentiation and secretion of growth factors. At the same time, it shows efficient biofilm resistance. This multifunctional flexible hydrogel platform with its vertical nanoarchitectures can be used as transplantable stem cell scaffold or biomedical implant with enhanced stem cell and anti-pathogenic functions.

Bio-instructive Nanospike Patch as a Multifunctional Platform for Agricultural and Biomedical Applications

( Sunho Park ),( Hyun-ha Park ),( Yonghyun Gwon ),( Sujin Kim ),( Daun Kim ),( Hoon Eui Jeong ),( Jangho Kim ) 한국농업기계학회 2019 한국농업기계학회 학술발표논문집 Vol.24 No.2

Nanoengineering offers great opportunities for advanced applications in agricultural and biological fields. Here, we proposed a bio-instructive nanospike patch with the precisely controlled sizes using a sophisticated nanoengineering (e.g., capillary force lithography). To investigate the effect of a developed nanospike, the various types of cells including the mammalian cells and bacterial were cultured. Interestingly, the nanospike can both promote the behaviors including proliferation, differentiation, and cytokine excretion of the mammalian cells and prevent the bacterial biofilm formation by the designed feature sized of the nanospike. More specifically, the mammalian cells with relatively large size were received the proper structural stimulation from the nanopske, while the bacterial membrane were damaged by the structure of the nanospike. Our finding reveal the importance of the nanoscale sizes of the spikes to regulate the behaviors of cells, and the proposed nanospike could be used as new bio-instructive platforms such as food packaging and cell therapy platforms in agricultural and biological fields.

Treatment of Macular Edema Secondary to Branch Retinal Vein Occlusion

Sunho Park,Kyung Seek Choi 대한검안학회 2015 Annals of optometry and contact lens Vol.14 No.2

Purpose: To compare the effect and complications of treatments for macular edema secondary to branch retinal vein occlusion. Methods: Literature review using the Korean medical database and the Korean Ophthalmological Society database, Korean Journal of Ophthalmology was performed. To compare the effect, studies used consisted of patients with macular edema secondary to branch retinal vein occlusion, according to visual acuity (VA) outcomes, central macular thickness (CMT) at 1, 3, and 6 months. Results: In the three studies comparing Intravitreal Triamcinolone Acetonide (IVTA) injection with intravitreal bevacizumab (IVB) injection, IVB injection demonstrated greater improvement in CMT at 1 month. In the three studies comparing IVTA or IVB single injection with laser photocoagulation or subtenon triamcinolone acetonide (STTA) combination therapy, combination therapy demonstrated greater improvement in VA and CMT at 3 and 6 months. Conclusions: The functional and anatomical improvements are achieved by IVTA injection, IVB injection, and combination therapy for macular edema secondary to branch retinal vein occlusion. The effect of IVB and IVTA injection is nearly similar and combination therapy is more prominent than monotherapy with longer duration.

Investigation on the wall function implementation for the prediction of ship resistance

Park, Sunho,Park, Se Wan,Rhee, Shin Hyung,Lee, Sang Bong,Choi, Jung-Eun,Kang, Seon Hyung The Society of Naval Architects of Korea 2013 International Journal of Naval Architecture and Oc Vol.5 No.1

A computational fluid dynamics (CFD) code, dubbed SNUFOAM, was developed to predict the performance of ship resistance using a CFD tool kit with open source libraries. SNUFOAM is based on a pressure-based cell-centered finite volume method and includes a turbulence model with wall functions. The mesh sensitivity, such as the skewness and aspect ratio, was evaluated for the convergence. Two wall functions were tested to solve the turbulent flow around a ship, and the one without the assumption of the equilibrium state between turbulent production and dissipation in the log law layer was selected. The turbulent flow around a ship simulated using SNUFOAM was compared to that by a commercial CFD code, FLUENT. SNUFOAM showed the nearly same results as FLUENT and proved to be an alternative to commercial CFD codes for the prediction of ship resistance performance.

Environmentally Friendly Nanoparticles for Enhanced Plant Growth and Pesticide Performance

( Sunho Park ),( Yonghyungwon ),( Woochankim ),( Janghokim ) 한국농업기계학회 2022 한국농업기계학회 학술발표논문집 Vol.27 No.2

It is an important challenge to control and improve plant growth and pesticide performance in agriculture, and nanomaterials as novel strategy have been used to achieve these challenges. However, it is usually recognized that nanomaterials including carbon- and metal-based nanomaterials might influence toxicity in plant growth and does cause environmental pollution. In this study, we propose environmentally friendly nanoparticles (NPs) as versatile tool to improve plant growth and pesticide performance. Based on unique properties of NPs (e.g., very tiny size, surface charge, and loading capacity), it can be easily attached to plant leaves regardless of surface properties, and the agrochemical materials with NPs can maintain their effect on the surface of plant leaves for longer. In addition, NPs does not prevent the adsorption of nutrients on the root surfaces, and it can promote the plant growth. In addition, agrichemical materials-loaded NPs can induce the insecticidal and weed-killing effects by maintaining pesticide performance in vitro and in vivo. These findings demonstrate the potential of NPs in the real agricultural fields, and the proposed NPs might be used for future sustainable agriculture.

Environmentally Friendly Nanoparticles for Enhanced Plant Growth and Pesticide Performance

( Sunho Park ),( Yonghyungwon ),( Woochankim ),( Janghokim ) 한국농업기계학회 2022 한국농업기계학회 학술발표논문집 Vol.27 No.2

It is an important challenge to control and improve plant growth and pesticide performance in agriculture, and nanomaterials as novel strategy have been used to achieve these challenges. However, it is usually recognized that nanomaterials including carbon- and metal-based nanomaterials might influence toxicity in plant growth and does cause environmental pollution. In this study, we propose environmentally friendly nanoparticles (NPs) as versatile tool to improve plant growth and pesticide performance. Based on unique properties of NPs (e.g., very tiny size, surface charge, and loading capacity), it can be easily attached to plant leaves regardless of surface properties, and the agrochemical materials with NPs can maintain their effect on the surface of plant leaves for longer. In addition, NPs does not prevent the adsorption of nutrients on the root surfaces, and it can promote the plant growth. In addition, agrichemical materials-loaded NPs can induce the insecticidal and weed-killing effects by maintaining pesticide performance in vitro and in vivo. These findings demonstrate the potential of NPs in the real agricultural fields, and the proposed NPs might be used for future sustainable agriculture.