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Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19
<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>
( Sung Woo Moon ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Moo Suk Park ),( Young Sam Kim ),( Joon Chang ),( Se Kyu Kim ),( Hyo Chae Paik ),( Jun Won Cheong ),( Song Yee Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening complication after solid organ transplantation. HLH has been reported as problem related with kidney and liver transplant, and there are limited reports of HLH after lung transplantation. Case: A 60-year-old man with idiopathic pulmonary fibrosis underwent bilateral lung transplantation. After lung transplantation, acute rejection was suspected and high dose steroid therapy was done. Since postoperative day(POD) 25, thrombocytopenia( platelet 112*1000/uL) and leukopenia(2530/uL)) were presented. The patient complained of intermittent symptom of low-grade fever, chest discomfort and dyspnea. Echocardiography showed stress induced cardiomyopathy and results of peripheral blood smear was nonspeci. c. Pneumonia was developed and patient was treated with antibiotics. Hyperbilirubinemia(total bilirubin 2.1 mg/dL) started to present at POD 50. Results of abdomen sonography was nonspeci. C except for mild splenomegaly (11.4cm). By POD 80, bilirubin was getting higher(total bilirubin 33.3mg/dL, direct bilirubin 25.7mg/dL, gamma glutamyl transpeptidase 260IU/L) and leukopenia and thrombocytopenia was getting aggravated (white blood cell 2080/uL and platelet 57* 1000/uL). The . brinogen was mildly elevated (4210m/dL), triglyceride was normal (127 mg/dL), the ferritin was elevated (4518 ng/mL) and soluble interleukin-2 receptor was elevated (8730U/ml). However, the finding of peripheral blood smear was still nonspeci. c. The cause of pancytopenia, low grade fever and hyperbilirubinemia was unclear, and we conducted bone marrow biopsy on POD 82. The finding showed that histiocytes were frequently seen with occasional hemophagocytes. Taken together, cytopenia, bone marrow hemophagocytes, elevated soluble interleukin-2 receptor and elevated ferritin were positive among laboratory tests listed in diagnostic criteria of HLH. We managed with etoposide and high dose steroid, but patient deteriorated and died on POD 87. Summary: HLH is a significant diagnostic and therapeutic challenge in lung transplantation and is potentially lethal complication. Therefore, clinicians should consider HLH as possible diagnosis in clinical context.
( Sung Woo Moon ),( Ji Ye Jung ),( Young Ae Kang ),( Moo Suk Park ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Hyo Chae Park ),( Chang Young Lee ),( Song Yee Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Primary graft dysfunction (PGD) is a severe type of acute lung injury after lung transplantation and is reported to be associated with early morbidity and mortality.We were to investigate donor, recipient, and perioperative risk factors and outcome of PGD. Methods: We performed a retrospective study using data collected in one tertiary care hospital in South Korea. The patients who underwent lung transplantation between January 2010 and March 2014 were enrolled. The primary outcome was grade 3 PGD (PaO2/ fiO2 < 200 and presence of diffuse infi ltrates on chest radiograph of allograft at 48 or 72 hours after transplant) and PGD grade was defi ned according to International Society for Heart and Lung Transplantation criteria. Results: A total of 61 patients were enrolled and 16 subjects (26.2%) developed grade 3 PGD. In univariate study, higher body mass index (BMI) in recipients, any history of recipient smoking, extracorporeal membrane oxygenation usage before transplantation in recipients, and ischemic time during operation were associated with PGD. Primary recipient diagnosis, transplant type, mean pulmonary artery pressure, donor-smoking history were not related with PGD. In multivariate model, independent risk factors for PGD were BMI in recipients (Odds ratio [OR], 1.290; P=0.048) and total ischemic time during operation (OR, 1.013; P=0.009). PGD was signifi cantly associated with higher re-operation rate (OR, 3.500; P=0.042), longer days of ventilator apply (median 6 days vs.14.5 days; P=0.044), longer intensive care unit stay (median 9 days vs. 17 days; P=0.041) and higher rate of renal replacement therapy (OR, 7.708; P=0.002) after transplantation. Conclusions: We identifi ed risk factors and outcome of grade 3 PGD after lung transplantation. Our fi ndings can be used to develop predictive models for PGD that may allow for modifi cation of risk factors.
Chae, Kyu-Ho,Kang, Jin-Koo,Kim, Su-Kyung,Chough, Sung-Hyo Korean Society of Photoscience 2000 Journal of Photosciences Vol.7 No.2
The copolymmers of N, N-dimethylaminoethyl methacrylate(DAEM) and N-arylmethacrylamide (AMA) were prepared, and their photochemical properties as a negative photoresist were studied by the measurements of insoluble fraction, and by UV and IR absorption spectral changes. These copolymers are soluble in DMF, actone, methanol, of acidic buffer solutions. Solubility of these copolymer films in the vuffer solutions increased with the amount of DAEM units in the copolymer and decreased with the pH value. The insoluble fraction of the copolymer films in the buffer solution of pH 4 of in methanol increased with irradiation time and the amount of AMA units in the copolymer. UV and IR spectral changes indicated that not only photo-crosslinking but also the photo-Fries rearrangement took place upon irradiation with a 254nm UV light.
( Kyu Sik Jung ),( Beom Kyung Kim ),( Seung Up Kim ),( Young Eun Chon ),( Kyung Hyun Cheon ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Chae Yoon Chon ),( Young Nyun Park ),( Kwang Hyub Ha 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Controlled attenuation parameter (CAP) is a noninvasive method that measures hepatic steatosis using a process based on transient elastography. However, factors affecting its accuracy have not been described yet. We aimed to identify predictors of discordance between liver biopsy (LB) and CAP when assessing hepatic steatosis. Methods: A total of 129 patients with chronic liver disease who underwent LB and CAP were prospectively enrolled. Histological steatosis was categorized as S0 (<5%), S1 (5-33%), S2 (34-66%), or S3 (>66% of hepatocytes). Discordance was defined as a discordance of at least two stages between LB and CAP. Reference cutoff CAP values to determine discordance were calculated from our cohort (250 dB/m for ≥S1, 299 dB/m for ≥S2, and 327 dB/m for=S3). Results: The median age of the patients (84 men and 45 women) was 52 years. The etiologies of chronic liver disease (CLD) included nonalcoholic fatty liver disease (n=60, 46.5%), chronic hepatitis B (n=45, 34.9%), chronic hepatitis C (n=12, 9.3%) and others (n=12, 9.3%). Histological steatosis repartition was as follows: S0 32.6% (n=42), S1 44.2% (n=57), S2 19.4% (n=25), and S3 3.9% (n=5). Overall discordances were identified in 11 (8.1%) patients. When the histological steatosis grade and necroinflammatory activity were entered into multivariate analysis along with BMI and IQR/M CAP, S3 showed independent higher rates of discordance, as compared to S0-2 (hazard ratio [HR] 14.117 P=0.020). Similarly, when CAP was entered into multivariate analysis instead of histological parameters, along with alanine aminotransferase, BMI and IQR/M CAP, only CAP was independently associated with discordance (HR, 1.016, P=0.041). Conclusions: Our data suggest that patients with a higher CAP (or higher steatosis grade) are at greater risk of discordance between LB and CAP when assessing hepatic steatosis. Further studies should investigate how to enhance the accuracy of CAP interpretation, especially in patients with higher CAP values.