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( Kil Hyo Park ),( Soon Ha Kwon ),( Yong Sub Lee ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang Woo Cha ),( Young Seok Kim ),( Young Deok Cho ),( Hong Soo Kim ),( 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2
Background/Aims: The predictive role of contrast-enhanced ultrasonography (CEUS) before performing transarterial chemoembolization (TACE) has not been determined. We assessed the possible predictive factors of CEUS for the response to TACE. Methods: Seventeen patients with 18 hepatocellular carcinoma (HCC) underwent TACE. All of the tumors were studied with CEUS before TACE using a second-generation ultrasound contrast agent (SonoVue®, Bracco, Milan, Italy). The tumor response to TACE was classified with a score between 1 and 4 according to the remaining enhancing-tumor percentage based on modified response evaluation criteria in solid tumors (mRECIST): 1, enhancing tumor <25%; 2, 25%≤enhancing tumor<50%; 3, 50%≤enhancing tumor<75%; and 4, enhancing tumor≥75%). A score of 1 was defined as a “good response” to TACE. The predictive factors for the response to TACE were evaluated during CEUS based on the maximum tumor diameter, initial arterial enhancing time, arterial enhancing duration, intensity of arterial enhancement, presence of a hypoenhanced pattern, and the feeding artery to the tumor. Results: The median tumor size was 3.1 cm. The distribution of tumor response scores after TACE in all tumors was as follows: 1, n=11; 2, n=4; 3, n=2; and 4, n=1. Fifteen tumors showed feeding arteries. The presence of a feeding artery and the tumor size (≤5 cm) were the predictive factors for a good response ( P=0.043 and P=0.047, respectively).Conclusions: The presence of a feeding artery and a tumor size of less than 5 cm were the predictive factors for a good response of HCC to TACE on CEUS. (Clin Mol Hepatol 2015;21:158-164)
Ha Seong Kim,Kil-Byung Lim,Jiyong Kim,Joongmo Kang,Hojin Lee,Sang Wan Lee,유지현 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.1
Objective To investigate the epidemiologic and demographic characteristics of patients with spinal cord injury (SCI) who were admitted to a department of rehabilitation of a university hospital. Methods This was a descriptive cross-sectional study. Medical records including sex, age at injury, type of disability, traumatic or non-traumatic etiology and presence of ossification of posterior longitudinal ligament (OPLL) of patients with SCI who were admitted to the department of rehabilitation between 2012 and 2018 were reviewed. Results Of the 221 cases of SCI, 161 were traumatic and 60 were non-traumatic. The mean age at injury was 52.8 years. People aged 40–49 years showed highest proportion among overall SCI patients (19.0%). The proportion of male patients was higher in traumatic SCI at 4.96:1 than in non-traumatic SCI at 1.30:1. The most common cause of traumatic SCI was falling off (37.3%), followed by motor vehicle crash (35.4%) and tripping over (19.3%). Meanwhile, the most common cause of non-traumatic SCI was neoplasm (35.0%). Tripping over was the leading cause of traumatic SCI in patients aged ≥60 years (42.6%). A high proportion of traumatic SCI patients were found to have underlying OPLL (26.1%), particularly those who were injured by tripping over (64.5%). Conclusion The mean age of SCI patients was higher than that of previous studies. Falls was the single most common cause of traumatic SCI, and tripping over was the most common cause of injury in the elderly patients. OPLL was prevalent in patients who were injured from tripping over.
Ha Ya Sung,Jong Jin Kim,Myoung Kil Youn 한국유통과학회 2014 한국유통과학회 학술대회 논문집 Vol.2014 No.-
Purpose - This study investigated effects of five consumption values of family restaurants, that is to say, functional value, economic value, social value, creative value and emotional value, upon consumers' satisfaction and brand reliability, and effects of satisfactionsupon brand reliability, and effects of satisfaction and brand reliability upon consumers' behavioral intention to help develop family restaurant industry. Research design, data, and methodology - Frequency analysis was done. The interviewees had demographic characteristics of gender: 156men (54.4%) and 131 women (45.6%). The interviewees lived lives at the places: 136 persons (47.4%) at Gyeonggi and Metropolitan area, 57 persons (27.0%) at Gangbuk, Seoul, 38 persons (13.2%) at other areas at Seoul, 34 persons (11.8%) at Gangnam, Seoul, 18 persons (6.3%)at Incheon and 4 persons (1.4%) at other regions. Results - Values of the use of family restaurants, for instance, functional value, economic value, social value, emotional value and rarity valuehad influence upon satisfaction and brand reliability, had influence upon satisfaction as well as brand reliability. Conclusions - This study investigated consumption values of which consumers thought much, effects of consumption values upon satisfaction and brand reliability, effects of consumer's satisfactionupon brand reliability, and consumer's satisfaction and brand reliability upon behavioral intention, and to verify effects having influence upon local and foreign family restaurant.
KMT-2017-BLG-0165Lb: A Super-Neptune-mass Planet Orbiting a Sun-like Host Star
Kil Jung, Youn,Gould, Andrew,Zang, Weicheng,Hwang, Kyu-Ha,Ryu, Yoon-Hyun,Han, Cheongho,Yee, Jennifer C.,Albrow, Michael D.,Chung, Sun-Ju,Shin, In-Gu,Shvartzvald, Yossi,Zhu, Wei,Cha, Sang-Mok,Kim, Dong American Astronomical Society 2019 The Astronomical journal Vol.157 No.2
Hypotension in patients administered indigo carmine containing impurities -A case report-
Sung Hoon Kim,Eun Ha Suk,So Hyun Kil,함경돈,황재현 대한마취통증의학회 2011 Korean Journal of Anesthesiology Vol.61 No.5
Indigo carmine has been used for eight decades with few adverse effects. Several of our patients, however,experienced severe hypotensive episodes after indigo carmine administration within a period of one month. Analysis of the raw materials used to formulate the preparation of indigo carmine we used showed that they contained impurities. Following recall of these impure materials, none of our patients experienced further hypotensive episodes
Ha, Ji-Hyang,Shin, Jae-Sun,Yoon, Mi-Kyung,Lee, Min-Sung,He, Fahu,Bae, Kwang-Hee,Yoon, Ho Sup,Lee, Chong-Kil,Park, Sung Goo,Muto, Yutaka,Chi, Seung-Wook American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.10
<P>Molecular interactions between the tumor suppressor p53 and the anti-apoptotic Bcl-2 family proteins play an important role in the transcription-independent apoptosis of p53. The p53 transactivation domain (p53TAD) contains two conserved Φ<I>XX</I>ΦΦ motifs (Φ indicates a bulky hydrophobic residue and <I>X</I> is any other residue) referred to as p53TAD1 (residues 15–29) and p53TAD2 (residues 39–57). We previously showed that p53TAD1 can act as a binding motif for anti-apoptotic Bcl-2 family proteins. In this study, we have identified p53TAD2 as a binding motif for anti-apoptotic Bcl-2 family proteins by using NMR spectroscopy, and we calculated the structures of Bcl-X<SUB>L</SUB>/Bcl-2 in complex with the p53TAD2 peptide. NMR chemical shift perturbation data showed that p53TAD2 peptide binds to diverse members of the anti-apoptotic Bcl-2 family independently of p53TAD1, and the binding between p53TAD2 and p53TAD1 to Bcl-X<SUB>L</SUB> is competitive. Refined structural models of the Bcl-X<SUB>L</SUB>·p53TAD2 and Bcl-2·p53TAD2 complexes showed that the binding sites occupied by p53TAD2 in Bcl-X<SUB>L</SUB> and Bcl-2 overlap well with those occupied by pro-apoptotic BH3 peptides. Taken together with the mutagenesis, isothermal titration calorimetry, and paramagnetic relaxation enhancement data, our structural comparisons provided the structural basis of p53TAD2-mediated interaction with the anti-apoptotic proteins, revealing that Bcl-X<SUB>L</SUB>/Bcl-2, MDM2, and cAMP-response element-binding protein-binding protein/p300 share highly similar modes of binding to the dual p53TAD motifs, p53TAD1 and p53TAD2. In conclusion, our results suggest that the dual-site interaction of p53TAD is a highly conserved mechanism underlying target protein binding in the transcription-dependent and transcription-independent apoptotic pathways of p53.</P>
Ha, Hyo-Jeong,Kil, Eun-Hye,Kwon, Yo Han,Kim, Je Young,Lee, Chang Kee,Lee, Sang-Young The Royal Society of Chemistry 2012 ENERGY AND ENVIRONMENTAL SCIENCE Vol.5 No.4
<P>A facile approach to fabricate a highly bendable plastic crystal composite electrolyte (PCCE) for use in shape conformable all-solid-state lithium-ion batteries is demonstrated. This strategy is based on integration of a semi-interpenetrating polymer network (semi-IPN) matrix with a plastic crystal electrolyte (PCE, 1 M lithium bis-trifluoromethanesulfonimide in succinonitrile). In comparison to conventional carbonate-based electrolytes, salient benefits of the PCE are the thermal stability and nonflammability, which show promising potential as a safer electrolyte. The semi-IPN matrix in the PCCE is composed of a UV (ultraviolet)-crosslinked ethoxylated trimethylolpropane triacrylate polymer network and polyvinylidene fluoride-<I>co</I>-hexafluoropropylene (as a linear polymer). Solid electrolyte properties of the PCCE are investigated in terms of plastic crystal behavior, mechanical bendability, and ionic transport. Owing to the presence of the anomalous semi-IPN matrix, the PCCE exhibits unprecedented improvement in bendability, along with affording high ionic conductivity. Based on this understanding of the PCCE characteristics, feasibility of applying the PCCE to solid electrolytes for lithium-ion batteries is explored. The facile ionic transport of the PCCE, in conjunction with suppressed growth of cell impedance during cycling, plays a crucial role in providing excellence in cell performance. These advantageous features of the PCCE are further discussed with an in-depth consideration of the semi-IPN matrix architecture and its specific interaction with the PCE.</P> <P>Graphic Abstract</P><P>A highly bendable plastic crystal composite electrolyte for use in shape-conformable all-solid-state lithium-ion batteries is fabricated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2ee03025j'> </P>
Kil, Eun‐,Hye,Choi, Keun‐,Ho,Ha, Hyo‐,Jeong,Xu, Sheng,Rogers, John A.,Kim, Mi Ri,Lee, Young‐,Gi,Kim, Kwang Man,Cho, Kuk Young,Lee, Sang‐,Young WILEY‐VCH Verlag 2013 ADVANCED MATERIALS Vol.25 No.10
<P><B>A class of imprintable, bendable, and shape‐conformable polymer electrolyte</B> with excellent electrochemical performance in a lithium battery system is reported. The material consists of a UV‐cured polymer matrix, high‐boiling point liquid electrolyte, and Al<SUB>2</SUB>O<SUB>3</SUB> nanoparticles, formulated for use in lithium‐ion batteries with 3D‐structured electrodes or flexible characteristics. The unique structural design and well‐tuned rheological characteristics of the UV‐curable electrolyte mixture, in combination with direct UV‐assisted nanoimprint lithography, allow the successful fabrication of polymer electrolytes in geometries not accessible with conventional materials.</P>