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Sung Min Nam,Sun Shin Yi,Ki-Yeon Yoo,Ok Kyu Park,Bingchun Yan,Wook Song,Moo-Ho Won,Yeo Sung Yoon,Je Kyung Seong 한국실험동물학회 2011 Laboratory Animal Research Vol.27 No.3
Cyclooxygenase-2 (COX-2) is believed to be a multifunctional neural modulator that affects synaptic plasticity in the hippocampus. In the present study, we investigated the differential effects of treadmill exercise on COX-2 immunoreactivity in the dentate gyrus in early and chronic diabetic stages in Zucker diabetic fatty (ZDF) rats and lean control (ZLC) rats. To this end, ZLC and ZDF rats at 6 or 23 weeks of age were put on a treadmill with or without running for 1 h/day for 5 consecutive days at 16-22 m/min for 5 weeks or 12-16 m/min for 7 weeks, respectively. Treadmill exercise in prediabetic and chronic diabetic rats significantly reduced blood glucose levels. In particular, exercise in the prediabetic rat blocked the onset of diabetes. COX-2 immunoreactivity was mainly detected in the granule cell layer of the dentate gyrus and stratum pyramidale of the CA3 region in all groups. COX-2 immunoreactivity was significantly increased in these regions of ZLC and ZDF rats after treadmill exercise in the early diabetic stage. However, COX-2 immunoreactivity was not changed in these regions in ZDF rats after treadmill exercise in the chronic stage. These results suggest that treadmill exercise in diabetic animals in the chronic stage has limited ability to cause plasticity in the dentate gyrus.
4.2 PW, 20 fs Ti:sapphire laser at 0.1 Hz
Sung, Jae Hee,Lee, Hwang Woon,Yoo, Je Yoon,Yoon, Jin Woo,Lee, Chang Won,Yang, Jeong Moon,Son, Yeon Joo,Jang, Yong Ha,Lee, Seong Ku,Nam, Chang Hee OPTICAL SOCIETY OF AMERICA 2017 Optics letters Vol.42 No.11
<P>We demonstrated the generation of 4.2 PW laser pulses at 0.1 Hz from a chirped-pulse amplification Ti:sapphire laser. The cross-polarized wave generation and the optical parametric chirped-pulse amplification stages were installed for the prevention of the gain narrowing and for the compensation of the spectral narrowing in the amplifiers, obtaining the spectral width of amplified laser pulses of 84 nm (FWHM), and enhancing the temporal contrast. The amplified laser pulses of 112 J after the final booster amplifier were compressed to the pulses with 83 J at 19.4 fs with a shot-to-shot energy stability of 1.5% (RMS). This 4.2 PW laser will be a workhorse for exploring high field science. (C) 2017 Optical Society of America</P>
( Sang Jun Suh ),( Young Kul Jung ),( Sun Young Yim ),( Ji Hye Je ),( Yang Jae Yoo ),( Hae Rim Kim ),( Sung Hee Kang ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Soon Ho 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Among the patients with hematologic malignancy, hepatitis occurs after recovering from neutropenic fever. Clinical course is decided according to appropriate treatment to causative pathogen. Various organisms can cause acute hepatitis in immunecompromised host, early inspection to the causative pathogen is essential. We investigated which pathogen cause acute hepatitis after recovering from neutropenic fever in patients with hematologic malignancy. Methods: From January 2011 to april 2014, we included the patients with acute hepatitis (elevated Aspartate transaminase and/or total bilirubin above 2 times upper limit of normal range) within two weeks after recoverinig from neutropenic fever. We excluded the patients with acute hepatitis within two weeks after infused by chemoagent or hepatotoxic drugs. Results: Neutropenic fever was occurred in 173 patients, and 43 patients were appropriate to acute hepatitis of above criteria. Male gender was 28 patients, mean age was 51 years. Causative pathogen was identifi ed in 22 patients. The pathogen was aspergillus 5, infl uenza 4, O.tsutsugamushi 2, varicella zoster virus 1, hepatitis E virus 1 pateint, and other 9 patients were bacterial infection. Among 43 patients, 13 patients occurred septic shock and 11 patients were died. Among survived 2 patients, 1 patient was diagnosed as pulmonary aspergillosis and recovered after therapy with voriconazole, other 1 patients was recovered after therapy with broad-spectrum antibiotics under diagnosis of unknown origin pathegen. Conclusions: Acute hepatitis occur in about 25% after recovering from neutropenic fever, and mortality rate was 25% in the patients with acute hepatitis. Early investigation is essential to such patients, and test for aspergillus and infl uenza would be essential.
Catalytic degradation of phenols by recyclable CVD graphene films
Yoo, Je Min,Park, Baekwon,Kim, Sang Jin,Choi, Yong Seok,Park, Sungmin,Jeong, Eun Hye,Lee, Hyukjin,Hong, Byung Hee The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.13
<P>Ferrous ion-based catalysts have been widely employed to oxidatively destruct the major industrial pollutants such as phenolic compounds through advanced oxidation processes (AOPs). These agents, however, inevitably show several drawbacks including the need for pH adjustment and further purification steps to remove residual salts. Here we report the use of a chemical vapour deposition (CVD) graphene film as a novel metal-free catalyst for the AOP-based degradation of phenols in aqueous solution, which does not require additional steps for salt removal nor external energy to activate the process. We have also verified that the catalytic activity is strongly dependent on the surface area of the graphene film and the degradation efficiency can be markedly improved by exploiting an array of multiple graphene films. Finally, the recyclability of the graphene film has been validated by performing repetitive degradation tests to ensure its practical use.</P>