원행을묘정리의궤 중 조리면에서 본 죽상 . 미음상 및 현륭원에서의 상차림고

김상보,이성우,한복진 한국식생활문화학회 1989 韓國食生活文化學會誌 Vol.4 No.4

To analyze dialy meal of royal meal, studied Jook Soora Sang (Rice Gruel), Mieum Sang (Thin Gruel) and Bankwa Sang, Soora Sang in Hyun Neung Won were on record Wonheng Ulmyo Jungri Euigwae (1795). Historic book "Jungri Euigwae" described the king's visit to his father's royal tomb "Hyun Neung Won", during the domain of Cheung Jo, the 22nd king of Choson Dynasty. The results obtained from this study are as follows. Rice Gruel (Jook Soora Sang), taken before breakfast, was arranged the same as the Soora Sang. The table for thin gruel (Mieum) was arranged in three kinds of sets; one for thin gruel, the others for stewed meat (Goem) and sugared fruit (Jeong Kwa). The diet seems to have been quit scientific and restorative. Bankwa Sang and Soora Sang in Hyun Neung Won was arranged the same as the other Bankwa Sang and Soora Sang. Therefore setting the table of royal meal had a rule.

戱曲 「山돼지」 硏究

김성진(Kim Sung-jin) 중앙어문학회 2000 語文論集 Vol.28 No.-

This dissertation deals with Kim Woo-jin's 「Wild Boar」. Kim Woo-jin became indulged in his art during his University education. What's more, he tried to express the theatre art through a sharp insight of the times and created an optimistic atmosphere for Koreans under Japanese rule. His father, Kim Sung-kyu, was a president of the 'Mokpo Literary Association' and enjoyed writing poems. He also had such a special affection for literature that he contributed lots of money to support the 'Mokpo Literary Association'. And the world of death in Kim Woo-jin's works does not mean a real death. The world suggests the death of Korea traditional and conservative customs and reflects the difficult reality to break the traditional customs. His leaving home to lead a spiritual life carried on the very important meaning. 〈Noon〉 deals with the consciousness of class and nation, and 〈Lee Young-yeo〉 criticizes the defect of masculine centered society through Lee Yong-yeo. According to 「The Disgust of Poet Dooduckee」 and 「Shipwreck」 represent Kim Woo-jin's self conscious drama and the words of disgust and wreck symbolizes Kim Woo-jin's self desire for a new world. 「Wild Boar」 represents the free society for all people and the social awareness for reform. Kim Woo-jin includes the 'Dong Hak movement' in his drama and suggests a uncompromising willingness of social revolution established by young intellectuals and himself who showed only conscious conflict within the predestined yoke of the individual. In the play he changed his dramatic techniques which brought him closer to his readers and audiences but he emphasized intellectuals' awakening in much of his work. In other way, Kim Woo-jin developed a new contemporary drama movement in Korea for the nation which might have expressed real life under Japanese colonial rule. Kim Woo-jin was the representative of Korean drama in the 1920's who lived as a poet and critic as well as a experimental playwriter. Kim Woo-jin was one of the most excellent dramatists and the forerunner of Korean modern literature who led the new theatre movement, developed Korean drama from the early literature stages of the 1920's, and established himself as a leader in Korea literature.

Differential Manifestation of Ocular Phenotypes in TALEN-mediated p19arf Knockout FVB/N and C57BL/6J mouse lines

Jin‑Sung Park,Joo‑Il Kim,Hyun‑Jin Lim,Soo‑Kyung Ryu,Euna Kwon,Kang‑Min Han,Ki‑Taek Nam,Han‑Woong Lee,Byeong‑Cheol Kang 한국유전학회 2020 Genes & Genomics Vol.42 No.9

Background p19arf, primarily known as a tumor suppressor, has also been reported to play an essential role in normal development of mouse eyes. Consistently, lack of p19arf has been associated with ocular defects, but the mixed background of the knockout (KO) mouse strain used raised a concern on the accuracy of the phenotypes observed in association with the targeted gene due to genetic heterogeneity. Object We carried out a study to investigate into the efect of genetic background on the manifestation of p19arf KO associated phenotypes. Methods We characterized the phenotypes of novel p19arf KO mouse lines generated in FVB/N and C57BL/6J using a transcription activator-like efector nuclease (TALEN) system in comparison to the reported phenotypes of three other p19arf-defcient mouse lines generated using homologous recombination. Results Ninety-fve percent of FVB/N-p19arf KO mice showed ocular opacity from week 4 after birth which worsened rapidly until week 6, while such abnormality was absent in C57BL/6J-p19arf KO mice up to the age of 26 weeks. Histopathological analysis revealed retrolental masses and dysplasia in the retinal layer in FVB/N-p19arf KO mice from week 4. Besides these, both strains developed normally from birth to week 26 without increased tumorigenesis except for a subcutaneous tumor found in a C57BL/6J-p19arf KO mouse. Conclusion Our fndings demonstrated surprisingly variable manifestation of p19arf-linked phenotypes between FVB/N and C57BL/6J mice, and furthermore between our mouse lines and the established lines, indicating a critical impact of genetic background on functional study of genes using gene targeting strategies in mice.

Analysis of Short-Term Prestress Losses in Post-tensioned Structures Using Smart Strands

Sang?Hyun Kim,Sung Yong Park,Sung Tae Kim,Se?Jin Jeon 한국콘크리트학회 2022 International Journal of Concrete Structures and M Vol.16 No.1

Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes

Sung‑Soo Kim,Sang In Lee,Hyun‑Seok Jin,Sangjung Park 한국유전학회 2020 Genes & Genomics Vol.42 No.10

Background Vitamin D (Vit. D) is used extensively during tuberculosis treatment. Low levels of serum Vit. D increase the risk of active tuberculosis development. Altered expression of the proteins involved in Vit. D metabolism impairs cathelicidin production, thereby increasing the host susceptibility to tuberculosis. Objective We are trying to investigate whether single nucleotide polymorphisms (SNPs) in LRP2, CUBN, and VDR genes could afect tuberculosis development. Methods We included participants of the Korean Association Resource (KARE), part of the Korean Genome and Epidemiology Study (KoGES), and used their recorded data. A total of 8840 people (4182 men and 4658 women) were eligible subjects. The 5-kb regions from the ends of transcripts of GC, LRP2, CUBN, and VDR genes were amplifed to select 13, 47, 70, and 15 SNPs, respectively. For association analysis and statistical analysis, PLINK version 1.07 and PASW Statistics version 18.0 were used. Results Signifcant correlation was observed in 11, 2, and 1 SNPs in LRP2, CUBN, and VDR genes. The efect of rs6747692 of LRP2 on transcription factor binding was confrmed using RegulomeDB. We confrmed that rs2239182 of VDR is located in the genomic eQTL region and can afect transcription factor binding and gene expression. Conclusions Genetic polymorphisms in genes encoding proteins involved in Vit. D metabolism infuence immune system components. Therefore, such polymorphisms may infuence the susceptibility to Mycobacterium tuberculosis invasion and alter the defense mechanisms against Mycobacterium tuberculosis infection. The correlation between genetic variation and tuberculosis development can provide new guidelines for the management of tuberculosis.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

한국인의 우울증 진단기준의 특성

장성만,손지훈,이준영,최지환,조성진,전홍진,함봉진,이동현,조맹제 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

목적 국내의 여러 역학 조사에 따르면 한국인은 서구에 비하여 우울증의 유병률이 낮은 것으로 보고되고 있다. 낮은 유병률에 대하여 서구에서 정의하는 우울증의 진단 기준이 한국인의 문화에 맞지 않다는 진단 기준의 오류를 제시하거나, 실제로 유병률이 낮다는 설명을 시도하기도 하였다. 본 연구는 DSM-IV에서 제시하는 우울증의 진단 기준에 대하여 한국인의 반응 특성을 알아보고자 한다. 방법 2001년 KECA 연구에 응답한 만 18세 이상 65세 미만의 6,275명을 대상으로 하였다. 한국어판 CIDI (K-CIDI)를 통해 정신장애의 이환을 진단하였으며, K-CIDI 내의 우울장애 진단 기준만을 추출하여 분석하였다. 분석은 문항반응이론(Item Response Theory)을 적용하였다. 결과 한국인에서 DSM-IV의 주요우울장애 진단 기준의 오류는 없었으나, 진단 기준의 역치는 높았다. 한국인이 호소하는 우울증상으로서 "피로감"과 "집중력 저하", "수면 변화"는 진단되는 우울증의 초기부터 잘 나타나는 증상 들이며, "정선운동변화", "죽음/자살사고", "무가치함/죄책감"은 보다 심한 우울증에서 잘 나타나는 증상들이었다. 결론 DSM-IV가 제시하는 주요우울장애 진단 기준은 한국인의 우울증을 평가하는 데 있어 타당하기는 하나, 진단 기준의 역치가 높다. 우울증의 중증도에 따라 호소하는 증상들이 달랐다. Baekgrounds : Many Korean epidemiologic studies reported lower prevalence rates of depression than those of Western countries. For the low prevalence, it is explained that there's something wrong in the direct application of diagnostic criteria of depression to Korean culture, i.e. categorical fallacy, or it may be truly low-prevalent. We will analyze diagnostic criteria for depression detined by Western. Methods : Six thousand and two hundred seventy-five cummunity dwelling subjects, aged 18-64 years were interviewed by using Korean version of Composite International Diagnostic Interview (K-CIDI). Diagnostic criteria for depression defined by DSM-IV were analyzed using the item response theory. Rcsults : We could not find any fallacies of diagnostic critcria tbr depression defined by DSM-IV when assessing depre-ssion among Koreans. Fatigue, concentration difficultics, and sleep disturbance appeared more fequently in mild depression, while psychomotor change, death/suicide, and worthlessness/guilt did not appear until severe depression. Cunclusion : The diagnostic criteria for depression defined by DSM-IV arc appropriate for the Koreans. There are different responding levels, i.e. threshold, of depressive criteria according to severities of depression. Koreans with depression are more likely to complain of appetite change, but less of worthless or guilty feelings than Western people.

論文(론문) : 大腸正格證(대장정격증)과 장누수증후군(Leaky Gut Syndrome)과의 관계 考察(고찰)

이진철 ( Jin Cheoul Lee ),박상균 ( Sang Kyun Park ),방정균 ( Jung Kyun Bang ) 대한한의학원전학회(구 대한원전의사학회) 2013 대한한의학원전학회지 Vol.26 No.4

A Study on the Relationship between Dae-Jang-Jung-Gyeok(大腸正格) and Leaky Gut Syndrome Lee Jin-Cheoul1·Park Sang-Kyun2·Bang Jung-kyun3 *1Dept. of Medical History, College of Korean Medicine, Kyunghee University 2Dept. of Meridian, College of Korean Medicine, Sangji University 3Dept. of Korean Medical Classics and History, College of Korean Medicine, Sangji University Objective: If the penetration ratio of the intestinal mucosa is increased, the toxic or unhealthy materials - which should not be absorbed into our bodies - will be come into our bodies. They cause a sort of anti-toxic response or confusion of the immune system, and ultimately bring various types of diseases. This syndrome is related "Poison in Excrement" or "Internal Damage(內傷發□)" and Leaky Gut Syndrome, so I will study on the relationship between them. Method: Study on the relationship between Dae-Jang-Jung-gyeok and Leaky Gut Syndrome. Result: Korean doctors in ancient times called this syndrome "Poison in Excrement" or "Internal Damage(內傷發□)" and treated it with "Dae-Jang-Jung-Gyeok(大腸正格)". Leaky Gut Syndrome is a sort of clinical lesion, which allows foreign and harmful toxins in and results in a disorder of the immune system due to the leaking intestinal mucosa. Conclusion: Based upon the analyses, Dae-Jang-Jung-Gyeok and Leaky Gut Syndrome are closely related. Therefore diseases caused by the Leaky Gut Syndrome might be expected to be cured by Dae-Jang-Jung-Gyeok. Particularly the use of treatments for self-immune diseases and allergic diseases such as atopyic dermatitis and articular rheumatism should be expected to reveal a new path of treatment for other disorders such as Leaky Gut Syndrome. Key Words: Poison in Excrement, Internal Damage(內傷發□), Dae-Jang-Jung-Gyeok(大腸正格), Leaky Gut Syndrome

Piezoelectric Materials: All‐Solution‐Processed Flexible Thin Film Piezoelectric Nanogenerator (Adv. Mater. 45/2012)

Chung, Sung Yun,Kim, Sunyoung,Lee, Ju‐,Hyuck,Kim, Kyongjun,Kim, Sang‐,Woo,Kang, Chong‐,Yun,Yoon, Seok‐,Jin,Kim, Youn Sang WILEY‐VCH Verlag 2012 ADVANCED MATERIALS Vol.24 No.45

<P>An all‐solution‐processed flexible piezoelectric nanogenerator, composed of polycrystalline ZnO thin film and functional polymer layers such as P3HT/PCBM and PEDOT:PSS, generates energy through a mechanical rolling and muscle stretching system. On page 6022, Youn Sang Kim, Sang‐Woo Kim, and co‐workers show that this all‐solution‐processed nanogenerator is feasible as a piezoelectric patchable device and is promising for use in future energy harvesters such as wearable human patches and mobile electronics. </P>

홍민어 Sciaenops ocellatus에서의 바이러스성 신경괴사증 viral nervous necrosis

김진도,김석렬,정성주,김영진,정태성,최태진,박성우,오명주 한국어병학회 2001 한국어병학회지 Vol.14 No.2

1999년 10월에서 11월 사이에 남해안 일대의 홍민어 종묘 생산장에서 20~30열령의 치어가 척추만곡 및 이상유영을 하며 대량 폐사하였다. 병어는 특이 외부 증상이 없었고, 높은 누적폐사량이 바이러스 질병으로 의심되어, 조직학적 및 분자생물학적인 검사를 행하여 폐사원인을 확인하였다. 폐사개체의 조직을 H-E 염색하여 관찰한 결과 뇌와 안구의 신경세포에서 공포와 괴사가 관찰되었고, 전자현미경 관찰에서는 안구와 뇌에서 바이러스 입자가 관찰되었다. RT-PCR 결과에서는 ≒426 bp의 DNA 단편을 확인할 수 있었다. 이러한 결과로 홍민어에서 발생한 대량폐사는 바이러스성 신경괴사증(VNN)으로 진단되었다. Mass mortalities occurred among red drum lavae, 20 to 30 days old, culturing at hatcheries on southern costal area. No specific external signs were observed except abnormal swimming and spinal deformity. It was, however, suspected as a viral etiology due to high mass mortalities so that histopathological and molecular biological study was performed to evaluate the agent. Both vacuoles and necrosis were observed on nerve cells of brain and eye by H-E staining, and viral particles were observed on electronmicroscopic examination. On the other hand, DNA fragment, approximately 426 bps, was amplified with RT-PCR. The above results were able to diagnosis the etiological agent of mass moralities in red drum larvae as VNN(viral nervous necrosis)virus.