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Sugiyama, Minetaka,Baek, Seong Yeol,Takashima, Shohei,Miyashita, Natsumi,Ishida, Kei,Mun, Jiyoung,Yeo, Soo-Hwan Elsevier 2018 Journal of bioscience and bioengineering Vol.126 No.6
<P>The yeast <I>Pichia kudriavzevii</I> N77-4 was isolated from the Korean traditional fermentation starter <I>nuruk</I>. In this study, fermentation performance and stress resistance ability of N77-4 was analyzed. N77-4 displayed superior thermotolerance (up to 44°C) in addition to enhanced acetic acid resistance compared to <I>Saccharomyces cerevisiae</I>. Moreover, N77-4 produced 7.4 g/L of ethanol with an overall production yield of 0.37 g/g glucose in 20 g/L glucose medium. However, in 250 g/L glucose medium the growth of N77-4 slowed down when the concentration of ethanol reached 14 g/L or more and ethanol production yield also decreased to 0.30 g/g glucose. An ethanol sensitivity test indicated that N77-4 was sensitive to the presence of 1% ethanol, which was not the case for <I>S. cerevisiae</I>. Furthermore, N77-4 displayed a severe growth defect in the presence of 6% ethanol. Because inositol biosynthesis is critical for ethanol resistance, expression levels of the <I>PkINO1</I> encoding a key enzyme for inositol biosynthesis was analyzed under ethanol stress conditions. We found that ethanol stress clearly repressed <I>PkINO1</I> expression in a dose-dependent manner and overexpression of <I>PkINO1</I> improved the growth of N77-4 by 19% in the presence of 6% ethanol. Furthermore, inositol supplementation also enhanced the growth by 13% under 6% ethanol condition. These findings indicate that preventing downregulation in <I>PkINO1</I> expression caused by ethanol stress improves ethanol resistance and enhances the utility of <I>P. kudriavzevii</I> N77-4 in brewing and fermentation biotechnology.</P>
The Nutrition Assessment and Care for the Elderly in Japan
Sugiyama, Michiko,Nishimura, Akio,Koyama, Hideo Korean Society of Community Nutrition 2000 Journal of community nutrition Vol.2 No.1
In Japan, a new nursing insurance system was enforced in April 2000, where premiums were paid according to the level of necessary care. Our project, Nutrition Care and Management(NCM) for the elderly was started in 1995, funded by the Ministry of Health and Welfare of Japan. The NCM project was to provide appropriate nutrition care for the elderly and to see that it effectively functions as part of the health care services. There were 4 stages to the project : the first stage was to find out the PEM status among the elderly patients in hospital and home-care settings in Japan. The 2nd stage was to develop and evaluate nutritional assessment methods, anthropometry, resting energy expenditure measuring methods using of portable indirect calorimeter, and the convenient protein energy intake assessment methods, etc. for the elderly patients with PEM risk. The 3rd stage was to examine the effectiveness of the nutrition care plan induced of protein energy supplement and team care in improving nutrition among the elderly patients. The last stage was to develop the NCM set for the elderly patient based on the past three years of scientific evidence. it is expected that the NCM system for the elderly will provide adequate nutritional care management, improve the elderly care environment and create effective resource management.
THE VLBI MONITORING PROJECT FOR 6.7 GHz METHANOL MASERS USING THE JVN/EAVN
SUGIYAMA, KOICHIRO,FUJISAWA, KENTA,HACHISUKA, KAZUYA,YONEKURA, YOSHINORI,MOTOGI, KAZUHITO,SAWADA-SATOH, SATOKO,MATSUMOTO, NAOKO,SAITO, YU,HIRANO, DAIKI,HAYASHI, KYONOSUKE,SHEN, ZHIQIANG,HONMA, MAREKI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
We have initiated a Very Long Baseline Interferometer (VLBI) monitoring project of 36 methanol maser sources at 6.7 GHz using the Japanese VLBI Network (JVN) and East-Asian VLBI Network (EAVN), starting in August 2010. The purpose of this project is to systematically reveal 3-dimensional (3-D) kine-matics of rotating disks around forming high-mass protostars. As an initial result, we present proper mo- tion detections for two methanol maser sources showing an elliptical spatial morphology, G 002.53+00.19 and G 006.79-00.25, which could be the best candidates associated with the disk. The detected proper motions indicate a simple rotation in G 002.53+00.19 and rotation with expansion in G 006.79-00.25, respectively, on the basis of disk model fits with rotating and expanding components. The expanding motions might be caused by the magnetic-centrifugal wind on the disk.
Influence of Isoflavone Intake and Equol-producing Intestinal Flora on Prostate Cancer Risk
Sugiyama, Yukiko,Masumori, Naoya,Fukuta, Fumimasa,Yoneta, Akihiro,Hida, Tokimasa,Yamashita, Toshiharu,Minatoya, Machiko,Nagata, Yoshie,Mori, Mitsuru,Tsuji, Hirokazu,Akaza, Hideyuki,Tsukamoto, Taiji Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: The age-adjusted incidence rate of prostate cancer (PCa) has been reported to be lower among Asians than Western populations. A traditional Japanese meal, high in soybean products or isoflavones, may be associated with a decreased risk of PCa. Equol, which is converted from daidzein by human intestinal flora, is biologically more active than any other isoflavone aglycone. Materials and Methods: We reviewed not only recent epidemiological studies on association of isoflavones with PCa risk, but also recent research on human intestinal bacteria responsible for converting daidzein into equol. Studies were systematically searched from the database published within the last 5 years of from 2008-2012. Results: Five out of 6 articles showed significant association of isoflavones with a decreased risk of PCa, and two of them consistently showed that equol-producers carry a significantly reduced risk of PCa. Furthermore, 5 human intestinal bacteria that can convert daidzein into equol were identified in the last 5 years. Conclusions: If equol can reduce risk of PCa, a possible strategy for reducing the risk of PCa may be to increase the proportion of equol-producers by changing the intestinal flora to carrying an equol-producing bacterium with dietary alteration or probiotic technology.
Sugiyama, Yukiko,Nagata, Yoshie,Fukuta, Fumimasa,Takayanagi, Akio,Masumori, Naoya,Tsukamoto, Taiji,Akasaka, Hiroshi,Ohnishi, Hirofumi,Saito, Shigeyuki,Miura, Tetsuji,Moriyama, Kaoru,Tsuji, Hirokazu,Ak Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: Isoflavones, which are included in soybeans, have been suggested to protect against prostate cancer. Equol, one of isoflavones, is an intestinally derived bacterial metabolite of daidzein. A newly identified equol-producing bacterium, Slackia sp. strain NATTS, with a high equol-producing activity was isolated from human feces in Japanese adults. Counts of Slackia sp. strain NATTS in intestinal flora have not been assessed with regard to prostate cancer risk. In this study, we investigated the association of serum isoflavones and counts of Slackia sp. strain NATTS with prostate cancer risk in a case-control study. Materials and Methods: Concentrations of isoflavones and counts of Slackia sp. strain NATTS in feces were measured from 44 patients with prostate cancer and 28 hospital controls. The risk of prostate cancer was evaluated in terms of odds ratios (ORs) and 95% confidence intervals (CIs) by the logistic regression analysis. Results: The detection proportions of Slackia sp. strain NATTS in cases and controls were 34.1% and 25.0%, respectively. Counts of Slackia sp. strain NATTS were significantly correlated with serum concentrations of equol both in cases and controls (Spearman correlation coefficients, $r_s$=0.639 and $r_s$=0.572, p<0.01, respectively). Serum concentrations of genistein, daidzein, glycitein, and equol were not significantly associated with risk of prostate cancer. Conclusions: This study found that counts of Slackia sp. strain NATTS correlated with serum concentrations of equol both in prostate cancer cases and controls, but serum isoflavone concentrations were not associated with risk of prostate cancer in our patients.
Prediction of Wear Depth Distribution by Slurry on a Pump Impeller
Sugiyama, Kenichi,Nagasaka, Hiroshi,Enomoto, Takeshi,Hattori, Shuji Korean Society for Fluid machinery 2009 International journal of fluid machinery and syste Vol.2 No.1
Slurry wear with sand particles in rivers is a serious problem for pump operation. Therefore, a technique to predict wear volume loss is required for selecting wear resistant materials and determining specifications for the maintenance period. This paper reports a method for predicting the wear depth distribution on the blade of an impeller. Slurry wear tests of an aluminum pump impeller were conducted. Prediction results of wear depth distribution approximately correspond with the results of slurry wear tests. This technique is useful for industrial application.
Slenderness ratio of telescopic cylinder-columns
Sugiyama, Yoshihiko,Ohtomo, Takamitsu Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.12 No.3
The present paper deals with the effective slenderness ratio of telescopic cylinders as a long column having different cross sections. Firstly, the slenderness ratio defined in the current standard for the telescopic cylinders is discussed to point out some difficulties which arise when the ratio is applied to the column having different cross sections. Secondly, a new effective slenderness ratio is proposed for columns having different cross sections by introducing a partial effective slenderness ratio. Finally, the proposed slenderness ratio is applied, for extending and development of discussion, to a two-staged column having piece-wise constant cross sections and a cylindrical column having linearly varying diameters.