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      • KCI등재

        NOVEL TEST SCENARIO GENERATION TECHNOLOGY FOR PERFORMANCE EVALUATION OF AUTOMATED VEHICLE

        Shuang Li,Wei Li,Penghui Li,Ping Ma,Ming Yang 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.5

        As one of the critical technologies for performance evaluation of automated vehicles, the test scenario generation has been widespread concerned. In this paper, we propose a novel test scenario generation technology based on optimized Latin Hypercube Sampling (OLHS) and Test Matrix method (TM), named HIS-MPSO, which is efficient to generate the test scenario that consider the complexity, coverage, and potential relationships of factors. Based on naturalistic driving data, numerous carfollowing scenarios are generated by HIS-MPSO. Then, an adaptive cruise control system (ACC) are evaluated in terms of the tracking errors, comfort, and safety using the generated scenarios. Results show that compared with other existing OLHS algorithms, the HIS-MPSO can better restore the relationships among test factors existed in realistic traffic scenarios.

      • KCI등재

        Survival of Cancer Patients in Northeast China: Analysis of Sampled Cancers from Population-Based Cancer Registries

        Yanxia Li,Liya Yu,Jun Na,Shuang Li,Li Liu,Huijuan Mu,Xuanjuan Bi,Xiaoxia An,Xun Li,Wen Dong,Guowei Pan 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4

        Purpose The cancer survival was characterized by following up sampled subgroups of cancer cases from three population-based cancer registries in Northeast China. Materials and Methods Survival analysis was used to analyze 6,871 patients, who had one of the 21 most common cancers based on sampling from the population-based cancer registries of three cities in Liaoning Province. All patients were diagnosed between 2000 and 2002 and were followed up to the end of 2007 by active and passive methods. The 5-year age standardized relative survival rates (ASRS) were estimated for all cancers combined and each of the 21 individual cancers. Results The survival status was traced for 80.8% of 8,506 sampled cancer cases. The 5-year ASRS for all 21 cancers combined was 41.5% (95% confidence interval, 40.3 to 42.7), the highest ASRS was observed for thyroid cancer (85.2%), breast cancer (78.9%), uterine corpus cancer (75.9%), and urinary bladder cancer (70.2%); the lowest 5-year ASRS was noted in pancreatic cancer (8.8%), liver cancer (11.0%), esophageal cancer (18.8), and lung cancer (19.6%). The cancer survival rates in Liaoning cities were similar to those of urban areas in mainland China, but significantly lower than those in Hong Kong, Korea, and Japan. Conclusion The strikingly poor cancer survival rates in three cities of Liaoning Province and in other places in China highlight the need for urgent investment in cancer prevention, early detection, and standardized and centralized treatment.

      • Association between a p73 Gene Polymorphism and Genetic Susceptibility to Non-small Cell Lung Cancer in the South of China

        Wang, Shuang-Shuang,Guo, Hai-Yan,Dong, Lin-Li,Zhu, Xiang-Qian,Ma, Liang,Li, Wen,Tang, Jian-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

        Background: This study aimed to identify any association between the p73 gene G4C14-to-A4T14 polymorphism and risk of non-small cell lung cancer (NSCLC) in the south of China. Materials and Methods: We genotyped the p73 gene polymorphism of peripheral blood DNA from 168 patients with NSCLC and 195 normal controls using HRM (high resolution melting) and PCR-CTPP (polymerase chain reaction with confronting two-pair primers). Results: The results of genotyping by HRM and PCR-CTPP were consistent with direct sequencing, the p73 genotype distribution in 168 lung cancer patients being as follows: GC/GC 101 cases (60.1%), GC/AT 59 cases (35.1%), AT/AT 8 cases (4.8%). The carriers of AT/AT genotype had a significantly reduced risk of NSCLC (OR=0.370; 95%CI: 0.170-0.806; p=0.010) as compared with non-carriers. However, we found no relations between p73 genotypes and histological type (p=0.798, $x^2=0.452$), tumor stage (p=0.806, $x^2=0.806$), or lymph node metastasis (p=0.578, $x^2=1.098$). Conclusions: Our findings suggest that the p73 G4C14-to-A4T14 polymorphism may be a modifier of NSCLC susceptibility in the Chinese population.

      • KCI등재후보

        The Impact of Public Pension on Chinese Household Consumption

        Ya-Hao LI(Ya-Hao LI),Fan YANG(Fan YANG),Shuang ZHANG(Shuang ZHANG) 한국웰빙융합학회 2024 웰빙융합연구 Vol.7 No.1

        Purpose: The improvement of the social security system can greatly affect residents' future uncertainty, and it is important to study the relationship between public pensions and household consumption. Research design, data and methodology: Using the 2018 China Household Panel Survey (CFPS) data, the instrumental variable method is used to analyze the impact of pension insurance on urban residents' consumption. Results: The results of the study show that there are differences in the impact of three different pension insurance systems on household consumption. The pension insurance for public sector significantly boosts household consumption, and having a pension insurance for public sector can increase household consumption by 7.7%. The pension insurance for enterprise employee will reduce household consumption, but this is only significant for urban households. The pension insurance for urban and rural residents has a negative impact on household consumption. For the 16- to 39-year-old group, having a pension insurance for urban and rural residents will reduce household consumption by 5.7%. At the same time, household income, assets, scale, and education level will positively stimulate household consumption. Conclusions: The study reveals varying impacts among different pension types, highlighting the need for optimizing social security schemes to incentivize higher consumption rates.

      • KCI등재

        Protocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1

        Yu Deng,Wanjun Guo,Guancheng Li,Shuang Li,Hong Li,Xinyan Li,Bei Niu,Mingzhu Song,Yamei Zhang,Zhijian Xu,Fulun Li 한국유방암학회 2020 Journal of breast cancer Vol.23 No.1

        Purpose: C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that is overexpressed in many cancers. CtBP1 transcriptionally represses a broad array of tumor suppressors, which promotes cancer cell proliferation, migration, invasion, and resistance to apoptosis. Recent studies have demonstrated that CtBP1 is a potential target for cancer therapy. This study was designed to screen for compounds that potentially target CtBP1. Methods: Using a structure-based virtual screening for CtBP1 inhibitors, we found protocatechuic aldehyde (PA), a natural compound found in the root of a traditional Chinese herb, Salvia miltiorrhiza, that directly binds to CtBP1. Microscale thermophoresis assay was performed to determine whether PA and CtBP1 directly bind to each other. Further, clustered regularly interspaced short palindromic repeats associated Cas9 nuclease-mediated CtBP1 knockout in breast cancer cells was used to validate the CtBP1 targeting specificity of PA. Results: Functional studies showed that PA repressed the proliferation and migration of breast cancer cells. Furthermore, PA elevated the expression of the downstream targets of CtBP1, p21 and E-cadherin, and decreased CtBP1 binding affinity for the promoter regions of p21 and E-cadherin in breast cancer cells. However, PA did not affect the expression of p21 and E-cadherin in the CtBP1 knockout breast cancer cells. In addition, the CtBP1 knockout breast cancer cells showed resistance to PA-induced repression of proliferation and migration. Conclusion: Our findings demonstrated that PA directly bound to CtBP1 and inhibited the growth and migration of breast cancer cells through CtBP1 inhibition. Structural modifications of PA are further required to enhance its binding affinity and selectivity for CtBP1.

      • KCI등재

        A Light-weighted Data Collection Method for DNS Simulation on the Cyber Range

        ( Shuang Li ),( Shasha Du ),( Wenfeng Huang ),( Siyu Liang ),( Jinxi Deng ),( Le Wang ),( Huiwu Huang ),( Xinhai Liao ),( Shen Su ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.8

        The method of DNS data collection is one of the most important parts of DNS simulation. DNS data contains a lot of information. When it comes to analyzing the DNS security issues by simulation on the cyber range with customized features, we only need some of them, such as IP address, domain name information, etc. Therefore, the data we need are supposed to be light-weighted and easy to manipulate. Many researchers have designed different schemes to obtain their datasets, such as LDplayer and Thales system. However, existing solutions consume excessive computational resources, which are not necessary for DNS security simulation. In this paper, we propose a light-weighted active data collection method to prepare the datasets for DNS simulation on cyber range. We evaluate the performance of the method and prove that it can collect DNS data in a short time and store the collected data at a lower storage cost. In addition, we give two examples to illustrate how our method can be used in a variety of applications.

      • Design and Practice of Teacher Training Supported by a Web 2.0 Community

        Shuang Li,Li Chen,Hongtao Sun APEC국제교육협력원 2010 Asia-Pacific Cybereducation Journal Vol.6 No.2

        Web 2.0 communities are providing new opportunities for teachers’ professional development by supporting more flexible sharing, communicating, and collaborating among teachers at a distance. Meanwhile, literature concerning teachers’ professional development increasingly places value on communities of practice and web-based learning communities. This paper presents a case study on the design of teacher training supported by a Web 2.0 community. The training program discussed in the paper is characterized by employing peer-coaching to facilitate teachers’ learning in a Web 2.0 community, and is a part of a project funded by the Ford Foundation. The paper gives a brief introduction to the training program, and reports some important findings and reflections on design and practice for in-service teacher training. It includes the theoretical framework design, a training model as well as activity design, and the implementation and evaluation of the training program and useful experiences. Initially, taking account school teachers’ needs at the K12 level for curriculum reform and quality education, theory, knowledge and practice competences for learner-centered instruction were examined by using peer-coaching methods supported by online communities. The suggested training program was delivered in two Chinese districts in August 2009: Tianhe district of Guangzhou, and Wuhou district of Chengdu. More than 120 participants, including subject teachers, school principals and local teaching researchers, took part in the f2f training, online activities and the further practice activities. Even still on-going, the comprehensive investigation and evaluation of the training program explains that the initial results and observations collected during the process of training are very positive. With cause for optimism as to the prospect of achieving the training program’s goals, the study has demonstrated that a task-driven approach and peer-coaching supported by a web 2.0 community are effective methods for in-service teacher training, and that peer-coaching can be greatly extended by out-of-school activities.

      • KCI등재

        Analysis of Analog and Digital MRC in Massive MU-MIMO Systems over Correlated Channels

        Shuang Li,Peter J. Smith,Pawel A. Dmochowski,Jingwei Yin 한국통신학회 2021 Journal of communications and networks Vol.23 No.6

        While digital multi-user (MU) maximal ratio combining(MRC) is well understood, relatively few analytical resultsexist for analog MU-MRC. For example, it has recently beenshown that MU system performance is highly dependent onthe correlation model used, but the scope is limited to digitalprocessing. Thus, in this paper we compare the performance ofanalog and digital MRC, focusing on the effects of correlation.Webegin by deriving the expected signal and interference powers,demonstrating that the signal-to-interference ratio decreases withcorrelation when users have the same correlation matrices, whileit increases when their correlation matrices are different. Thesefinite system results are then extended by deriving asymptoticsignal-to-interference-and-noise ratio expressions for both analogand digital MRC for the benchmark scenarios of uncorrelatedand perfectly correlated Rayleigh channels. Here, we once againdemonstrate that the performance is critically dependent on thecorrelation scenario

      • The Research of Constrained Optimization Method Based on BP Neural Network and Its Application

        Shuang-jing Li,Fu-lin Wang 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.10

        This essay proposes a method of BP neural network constrained optimization based on previous studies. The optimization method based on the BP neural network, takes the minimum output of a neural network as an example, gives the general mathematical models, derives and gives the partial derivatives of BP network's output to input, and uses the Sigmoid Function as the transmission function in the article. On the previous studies basis, the basic ideas, algorithms and related models are given, based on the constrained optimization issues of BP neural network. We can adjust the input values of BP neural network to obtain the minimum or maximum output value by using this method. This optimization method links the optimization and fitting of BP networks together and expands the application of the BP neural network. At last, in this essay, the optimization method is applied in an example.

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