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Lee, Taeksu,Son, Hye Young,Choi, Yuna,Shin, Youngmin,Oh, Seungjae,Kim, Jinyoung,Huh, Yong-Min,Haam, Seungjoo The Royal Society of Chemistry 2017 Journal of Materials Chemistry B Vol.5 No.7
<P>We report minimal amount of hyaluronic acid (HA) conjugated magnetic nanocrystals (mHMs) for targeted imaging of CD44 abundant breast cancer cells <I>via</I> MRI. These mHMs lead to less induced cancer migration and drug resistance, which is distinct from conventional approaches using nanoplatforms (imaging or therapeutic systems) that are completely covered with HA. To synthesize mHMs, magnetic nanocrystals (MNCs), as MRI contrast agents, were encapsulated mostly with polysorbate 80 (P80, non-reactive to HA) and partially with aminated P80 (reactive to HA). This system enabled conjugation of an immensely diminished amount of HA onto MNCs. While these nanoparticles maintained good CD44 targeted imaging efficacy, they also showed no cytotoxicity and colloidal stability. We varied the HA ratios on an equal amount of MNCs and identified that when more HA was attached on nanoparticles, there was more facilitated cancer migration and drug resistant potentials. We chose the lowest amount of HA conjugated mHMs (mHM1) and demonstrated that mHM1 selectively diagnosed tumor regions <I>in vivo</I>. We believe that the technique described herein can be applied to various applications using HA to detect CD44 abundant cancer cell lines and offer a basis to understand the interaction between the cellular response and surface modification of nanoparticles.</P>
Metal Beam Extraction Experiment of a SC-ECRIS at the RAON Accelerator
Yonghwan Kim,Jeongil Heo,Taeksu Shin,Hironobu Ishiyama 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.7
We designed and fabricated a sputtering source with a simple structure to extract metal beam for the RAON heavy ion accelerator. As a test material, Bi with a mass number of 209 was selected, and a beam extraction experiment was conducted. A Bi25+ beam with a current of 3 euA was extracted during the preliminary beam extraction experiment. We confirmed that impurity control and a high-power comparative experiment are necessary for future experiments.
Jeongil Heo,Yonghwan Kim,Taeksu Shin 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.7
We designed and manufactured a 28-GHz electron cyclotron resonance ion source (ECRIS) to obtain a steady heavy-ion beam. The ECRIS consists of various equipment for beam extraction and transmission, such as superconducting magnet, electro static quadrupole (ESQ), pair solenoid magnet, dipole magnet and etc. For the support frame of ECRIS, it is necessary to use a material with high strength must be used for stable support, and it should be easy to assemble for installation. In addition, dielectric breakdown should not occur at a high voltage applied when the beam is extracted. The manufactured frame is currently made of steel pipe, which has excellent in strength and dielectric characteristic. However assembly and installation is not convenient due to weight, corrosion, welding, etc. In order to overcome this problem, we redesigned a new frame using an aluminum profile. the advantages of the aluminum profile are easy acquisition, low cost, high strength, and easy assembly and installation. However, dielectric breakdown may occur at the edge of the aluminum profile. Therefore, a high-voltage electricfield analysis is required to design the support frame of the ECRIS. This paper, reports on the design of a high voltage support frame through an electricfield analysis using a finite element method (FEM) and a breakdown experiment.
기호실행을 이용한 C 언어 단위테스트 케이스 자동 생성기의 구현
서윤주 ( Yunju Seo ),김택수 ( Taeksu Kim ),이춘우 ( Chunwoo Lee ),김기문 ( Kimun Kim ),박복남 ( Boknam Park ),신철오 ( Chuloh Shin ),우치수 ( Chisu Wu ) 한국정보처리학회 2007 한국정보처리학회 학술대회논문집 Vol.14 No.2
본 연구에서는 소프트웨어의 구현 코드로부터 테스트 케이스 자동에 관해 연구하며 도구를 구현한다. 이를 통해 개발자가 직접 테스트 케이스를 작성하는 데 소요되는 비용을 절감하고, 소프트웨어의 요구사항 명세가 잘 작성되어 있지 않거나 실제 구현과 차이가 있는 경우에도 영향을 받지 않고 테스트 케이스를 생성 가능하도록 한다.
Construction of a Time-Of-Flight System for Beams Charge-Bred by using the Electron Beam Ion Source
Hao-Lin Liu,Hyock-Jun Son,Young-Ho Park,Taeksu Shin,Jongwon Kim 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.7
A time-of-flight (TOF) system adopting single reflection has been constructed to identify the charge states of ions charge-bed by using the electron beam ion source (EBIS). The reflection allows for time focusing of the system in a compact manner. The EBIS under construction will enhance the charge states of rare isotopes produced by isotope separation on line (ISOL) so as to utilize the superconducting post linear accelerator efficiently. The TOF system consists of an ion-gate, reflection electrodes and multi-channel plates (MCP) detector. The maximum voltage on ions is 20 kV, and the beam optics design was performed using SIMION. In the front end of the TOF an ion gate is located to produce a single 5- to 10-ns pulse operating at a maximum voltage of ±1 kV. The circuit of the fast switching system, which converts -1 kV to 1 kV in a few ns, was simulated for an equivalent circuit of the gate by using LTspice. The TOF system is being fabricated and will be connected to a Cs ion source for initial beam tests with Cs1+ mixed with background ions.
Commissioning preparation of RAON rare isotope accelerator facility
정연세,Hong Seung-Woo,장현만,Ki Tae-Kyung,Kim Hyoung-Jin,Kim Young Jin,권면,Lee Jinho,Tshoo Kyoungho,Shin Taeksu 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.6
RAON (Rare isotope Accelerator complex for ON-line experiments), started by the Rare Isotope Science Project (RISP) in Dec 2011, is the fagship rare isotope accelerator facility in Korea to promote the fundamental science of rare isotopes and the application. The construction of facility buildings and installation of the low-energy superconducting linac (SCL3) including injector system, ISOL (Isotope Separation On-Line) for the rare isotope production, a recoil spectrometer KoBRA, and MR-TOF for the mass measurement system were fnished in 2021. Expecting the completion of the frst phase of the RAON construction project in 2022, the beam commissioning experiments of low-energy superconducting linac (SCL3) and the ISOL system are underway. The status and overview of the RAON accelerator facility are reported in this paper.