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저탄소 Cr-Mo 강의 플라즈마 침탄식 표면탄소농도의 영향에 관한 연구
이경섭,신동명,박경봉 대한금속재료학회(대한금속학회) 2000 대한금속·재료학회지 Vol.38 No.2
It was investigated the influence of process variables, such as time, temperature, pressure and current density on the hardness, microstructure and surface carbon content during plasma carburizing of a low carbon Cr-Mo steel(0.176C, 0.119Si, 1.014Cr, 0.387Mo). As the process variables increased, the effective case depth in plasma carburized steel increased up to 50% in comparison to that of gas carburizing. With increasing time, cementite formed along the austenite grain boundaries at carburized surface and thickened. Also the surface carbon content increased initially, then its rate slowed down. Owing to the enhanced carbon adsorption rate on the surface during plasma carburizing, the supersaturation of austenite with respect to carbon occurred faster than in conventional gas carburizing process. The effective case depth increased with the surface carbon content. It is considered that the formation of carburized layer of low carbon Cr-Mo steel during plasma carburizing depends on the surface carbon content so that the use of plasma would not influence the diffusion rate of carbon in steel.
Inhibition of S6K1 enhances dichloroacetate-induced cell death
Hong, Sung-Eun,Shin, Keong-Sub,Lee, Yun-Han,Seo, Sung-Kum,Yun, Sun-Mi,Choe, Tae-Boo,Kim, Hyun-Ah,Kim, Eun-Kyu,Noh, Woo Chul,Kim, Jong-Il,Hwang, Chang-Sun,Lee, Jin Kyung,Hwang, Sang-Gu,Jin, Hyeon-Ok,Pa Springer-Verlag 2015 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY Vol.141 No.7
인체적용시험을 통한 홍삼기반 'SSR'이 인체 피로도 감소 및 혈액성분 변화에 미치는 영향분석
신경섭,이홍기,박선미,Shin, Keong Sub,Lee, Hong Gi,Park, Sun Mi 한국식품영양학회 2021 韓國食品營養學會誌 Vol.34 No.2
The main purpose of this study was to examine the correlation between the consumption of red ginseng-based 'SSR' for 30 days and the reduction in human fatigue, blood component changes, and immune cell activity in 35 human subjects. 'SSR' is composed of zinc oxide, folic acid, and D-α-tocopherol with red ginseng as the main component. According to the protocol criteria of the study, 35 subjects who understood the purpose of the study and signed an informed consent form were selected. The fatigue survey was conducted through a questionnaire, and after taking 'SSR', a decreased tendency of physical, mental, and neurosensory fatigue was observed. In hematological analysis, no significant changes were observed in the levels of WBC, RBC, and hemoglobin; however, AST (SGOT) and ALT (SGPT) levels were statistically significantly decreased. In immunological analysis, it was observed that the proliferative effect of T cells (CD3+CD4+) was greater than that of NK cells (CD16+CD56+). The collected data were subjected to t-test analysis using the SPSS 25.0 statistical program. The result from this study proposes that 'SSR' can be used as a functional food material as it reduces human fatigue and enhances immune function.
An Seungwon,Nedumaran Balachandar,Koh Hong,Joo Dong Jin,Lee Hyungjo,Park Chul-Seung,Harris Robert A.,Shin Keong Sub,Djalilian Ali R.,Kim Yong Deuk 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Melatonin is involved in the regulation of various biological functions. Here, we explored a novel molecular mechanism by which the melatonin-induced sestrin2 (SESN2)-small heterodimer partner (SHP) signaling pathway protects against fasting- and diabetes-mediated hepatic glucose metabolism. Various key gene expression analyses were performed and multiple metabolic changes were assessed in liver specimens and primary hepatocytes of mice and human participants. The expression of the hepatic cereblon (CRBN) and b-cell translocation gene 2 (BTG2) genes was significantly increased in fasting mice, diabetic mice, and patients with diabetes. Overexpression of Crbn and Btg2 increased hepatic gluconeogenesis by enhancing cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CREBH), whereas this phenomenon was prominently ablated in Crbn null mice and Btg2-silenced mice. Interestingly, melatonin-induced SESN2 and SHP markedly reduced hepatic glucose metabolism in diabetic mice and primary hepatocytes, and this protective effect of melatonin was strikingly reversed by silencing Sesn2 and Shp. Finally, the melatonin-induced SESN2-SHP signaling pathway inhibited CRBN- and BTG2-mediated hepatic gluconeogenic gene transcription via the competition of BTG2 and the interaction of CREBH. Mitigation of the CRBN-BTG2-CREBH axis by the melatonin-SESN2-SHP signaling network may provide a novel therapeutic strategy to treat metabolic dysfunction due to diabetes.