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[P498] Acquired dermal melanocytosis confined to the hand
( Ji-young Jun ),( Hyun Jeong Byun ),( Se Jin Oh ),( Seunghwan Oh ),( Ji-hye Park ),( Jong-hee Lee ),( Dong-yoon Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Acquired dermal melanocytosis (ADM) classically occurs on the face of Asian women. However, extrafacial ADM is uncommon, especially those that are on the extremities. To our knowledge, there are only six cases of ADM confined to the hands. We present a 40-year-old Korean woman who has brown to blue pigmentation on left hand. The pigmentation was prominent on and around palmar creases and on the knuckle joints of the dorsum of a hand. She was both-handed, and denied any history of preceding trauma, inflammation, or occupational exposure to chemicals. Histopathological examination revealed scattered spindle-shaped cells with melanin granules and melanophages in the upper to middle dermis. We review the published work for ADM on the hands and suggest that ADM confined to hands may be a new entity.
Complications after intralesional steroid injection for cosmetic purposes: 5 cases
( Ji Young Jun ),( Se Jin Oh ),( Seunghwan Oh ),( Joon Ho Shim ),( Ji Hye Park ),( Jong Hee Lee ),( Dong Yoon Lee ),( Joo Heung Lee ),( Jun Mo Yang ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Variable intralesional injections are widely used in dermatologic clinics since 1960. Triamcinolone acetonide is the most common steroid used for intralesional injections. Its common complication is skin atrophy. Skin atrophy occurs when it is injected into deep dermis or subcutis and when it is injected in high doses or in high concentrations. We present five patients who had facial injections for cosmetic reasons in local clinic. Exact ingredients were unknown but it turned out to be some mixtures including triamcinolone acetonide. Patients got serious skin defect on their face at presentation. After several trials of treatment over considerable period, skin lesion showed improvement but some scars remained. Clinicians should use intralesional injections more cautiously especially when using in cosmetic procedures.
A case of eruptive vellus hair cysts successfully treated by topical tretinoin ointment
( Ji Young Jun ),( Se Jin Oh ),( Seunghwan Oh ),( Joon Ho Shim ),( Ji Hye Park ),( Jong Hee Lee ),( Dong Yoon Lee ),( Joo Heung Lee ),( Jun Mo Yang ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Eruptive vellus hair cysts(EVHCs) are benign dermal cysts that develop as a consequence of occlusion of the infundibulum of vellus hairs. The primary cause of occlusion is unknown. There are no standard treatments to date, but surgical removal, laser therapy, and various topical treatments have been reported. To our knowledge, there are 4 English literatures that treated EVHCs with retinoic acid with variable outcomes. Herein, we present a 4 year-old male. Papules appeared on his chest 1 year ago and spread continuously. Biopsy was done and it was diagnosed as EVHCs. Topical tretinoin 0.01% cream was applied on the lesion for 6 months and lesions markedly improved. Our case shows tretinoin is an effective and safe treatment modality of EVHCs.
A case of plasmacytoma associated with aggravation of multiple myeloma
( Ji Young Jun ),( Seunghwan Oh ),( Joonho Shim ),( Jun Hwan Kim ),( Jong Hee Lee ),( Dong Yoon Lee ),( Joo Heung Lee ),( Jun Mo Yang ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Skin involvement is relatively rare in plasma cell myeloma. It comprises only 2% of multiple myeloma. The features of skin involvement can be divided into four categories; paraneoplastic processes, skin manifestations of associated hematologic abnormalities, cutaneous complications of the proteins the malignant plasma cells produce and direct involvement of the skin by malignant plasma cells, in other words, plasmacytomas. Herein, wepresent a 58 year-old male patient who was diagnosed with multiple myeloma. During the course of disease, some subcutaneous nodules appeared along with disease progression. Skin biopsy was done and secondary cutaneous plasmacytoma was diagnosed. It is known that secondary cutaneous plasmacytoma is usually associated with a very poor prognosis and our case also presented cutaneous plasmacytoma with disease progression. When apatient with multiple myeloma presents with skin nodule, skin biopsy and further evaluation may reveal underlying disease progression.
Multiple cutaneous plexiform schwannoma as a diagnostic clue in a neurofibromatosis type 2 child.
( Ji Young Jun ),( Seunghwan Oh ),( Joonho Shim ),( Jun Hwan Kim ),( Jong Hee Lee ),( Dong Yoon Lee ),( Joo Heung Lee ),( Jun Mo Yang ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Plexiform schwannomas (PS) comprise of 4.3% of all schwannomas and 15% of cutaneous schwannomas. Cutaneous PS usually occurs solitary but rarely multiple, of which are known to be associated with neurofibromatosis type 2 (NF2). In contrast to NF1, there are no characteristic cutaneous abnormalities in NF2. Vestibular schwannoma is most characteristic and diagnostic clinical manifestation of NF2, presenting as tinnitus, dizziness or imbalance as first symptom. These manifestations usually do not present early in childhood, delaying diagnosis. Therefore, only 18% of NF2 patients are diagnosed in childhood, and of them, only 8% presents skin tumor. Herein, we present a 10 year-old boy who had multiple cutaneous plexiform schwannomas. His father was diagnosed as NF2. On brain MRI, he had multiple small nodules around left cavernous sinus which were likely to be neurofibromas, and multiple cystic lesions in the left frontal lobe and basal ganglia which were likely to be meningoangiomatosis. By definition, he satisfied the diagnostic criteria of NF2. There are 13 cases of PS in NF2 patient in literature, and this case is 14th case. Since the strongest single predictor of the risk of mortality in NF2 is the age at diagnosis, it is important not to miss the diagnostic clues. When a child presents with multiple cutaneous plexiform schwannoma, it might be a diagnostic clue for underlying NF2.
A case of Jadassohn-Lewandowsky syndrome (type 1 pachyonychia congenita)
( Ji Young Jun ),( Se Jin Oh ),( Seunghwan Oh ),( Joon Ho Shim ),( Ji Hye Park ),( Jong Hee Lee ),( Dong Yoon Lee ),( Joo Heung Lee ),( Jun Mo Yang ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Pachyonychia congenita(PC) is in a spectrum of dominantly inherited disorders associated with focal palmo-plantar keratosis. Clinical features and severity are greatly variable among patients. Common features of PC are painful focal palmo-plantar keratosis and hypertrophic dystrophy of the distal nails. Type 1 PC (Jadassohn-Lewandowsky) shows follicular keratosis, oral leukokeratosis, and hoarseness. Type 2 PC (Jackson- Lawler) shows multiple pilosebaceous cysts, teeth present at birth and hair changes. We present a patient with severe thick nails, plantar keratoderma, oral leukokeratosis, and follicular hyperkeratosis to share typical features of type 1 PC.
[P247] Congenital curved nail of the fourth toe
( Ji-young Jun ),( Hyun Jeong Byun ),( Se Jin Oh ),( Seunghwan Oh ),( Ji-hye Park ),( Jong-hee Lee ),( Dong-yoon Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
A five-year-old Korean boy with bilateral fourth toenail deformity since birth visited our clinic. None of his family members had curved toenails. Radiologic examination revealed aplastic middle phalangeal bones of fourth toe bilaterally. Congenital curved nail of the fourth toe is a rare nail deformity. It is known to be inherited in an autosomal recessive fashion. Hypoplasia of ungual phalanx of fourth toe is often associated, but no general complication was reported. To our knowledge, there are only 5 reports with 14 cases in English literatures. Two of them were Korean patients but none of them had bony deformity. This case was first Korean case of congenital curved nail of the fourth toe with bony deformity.
Common ABCB1 SNP, C3435T could affect systemic exposure of dapagliflozin in healthy subject
Jun Gi Hwang,Sae Im Jeong,Yu Kyong Kim,Yujin Lee,Sang Chun Ji,SeungHwan Lee,Min Kyu Park 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.4
P-glycoprotein (P-gp) is a transporter that plays an excretory role in epithelial cells. It is encoded by ABCB1, and single nucleotide polymorphisms (SNPs) in this gene can affect systemic drug exposure. Dapagliflozin and sitagliptin, used in type 2 diabetes treatment, are P-gp substrates. Here, we aimed to investigate whether ABCB1 polymorphisms affect dapagliflozin and sitagliptin pharmacokinetics (PK) in healthy Korean subjects. The study population consisted of 100 healthy Korean subjects (94 men and 6 women) who participated in four different clinical trials and received dapagliflozin and sitagliptin doses of 10 and 100 mg, respectively. We determined ABCB1 genotypes for the C3435T, C1236T, and G2677T/A SNPs. The relationship between the genotypes and dapagliflozin PKs was examined. Dapagliflozin and sitagliptin PK parameters were not statistically significantly affected by ABCB1 SNP genotypes. However, homozygous 3435TT subjects showed higher dapagliflozin PK parameters than CT and CC subjects. In subjects with the 3435TT and those with 3435CC and 3435CT genotypes, mean C max , AUC inf , and AUC 0-1 values of dapagliflozin were 223.06 ng/ mL and 194.81 ng /mL (p = 0.2767), 673.58 ng*h/mL and 573.96 ng*h/mL (p = 0.0492), and 128.53 ng*h/mL and 104.61 ng*h/mL (p = 0.2678), respectively. In summary, dapagliflozin and sitagliptin PK parameters were not significantly different between individuals with C1236T and C2677T/A ABCB1 genetic polymorphisms. Dapagliflozin exhibited higher systemic exposure in 3435TT subjects than in CC/CT subjects.