Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis

Seunghee Jun(Seunghee Jun),Hyunjin Park(Hyunjin Park),Ui-Jeong Kim(Ui-Jeong Kim),Eun Jeong Choi(Eun Jeong Choi),Hye Ah Lee(Hye Ah Lee),Bomi Park(Bomi Park),Soon Young Lee(Soon Young Lee),Sun Ha Jee(Su 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis. METHODS: Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis. RESULTS: Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males. CONCLUSIONS: Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.

Remote Impedance-based Loose Bolt Inspection Using a Radio-Frequency Active Sensing Node

Seunghee Park,Chung-Bang Yun,Daniel J. Inman 한국비파괴검사학회 2007 한국비파괴검사학회지 Vol.27 No.3

Identical twin with discordant classification of pituitary adenoma, and different GNAS gene sequence

( Seunghee Han ),( Hye-sun Park ),( Ji-yeon Lee ),( Sehee Park ),( Cheol Ryong Ku ),( Dong Yeob Shin ),( Young Suk Jo ),( Sun Ho Kim ),( Eun Jig Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

The majority of pituitary adenomas are sporadic tumors with recognized genetic mutations seldom being found. And familial pituitary tumors account for about 5%, carrying germline mutations in predisposition genes, including MEN1, PRKAR1A, and AIP. But, about 85% of familial pituitary adenoma kindred have unknown genetic cause. Meanwhile, the concordant occurrence of pituitary adenoma in identical twins is extremely rare. This case which report different subtypes of pituitary adenoma occurred in identical twins could contribute to elucidate the tumorogenesis of pituitary adenoma. A 26-year-old woman visited hospital with amenorrhea for 1.5 years. Her initial serum prolactin level was 141.0 ng/mL. Sella magnetic resonance imaging (MRI) showed a 0.6 cm sized right pituitary adenoma. After transsphenoidal surgery, serum prolactin level normalized and her menstruation returned regularly. Her twin sister had acromegalic features, such as enlarged face, hands and feet. Basal serum insulin-like growth factor (IGF-1) levelwas 770.9 ng/mL. Sella MRI showed a 1.5 cm sized left pituitary adenoma.. Serum growth hormone (GH) level was not suppressed by 75g oral glucose tolerance test (OGTT). After tumor removal, serum GH level was suppressed by OGTT. Their pathologic results consisted with prolactinoma andgrowth hormone secreting tumor, respectively. In evaluating family history, their father’s brother had pituitary adenoma. Short tandem repeat (STR)analysis results consisted with identical twins. Because of their family history and early onset of pituitary adenoma, genetic test was done for determining familial pituitary adenoma. And, genetic alterations in sporadic pituitary tumor also evaluated, because different subtypes of pituitary tumor was occurred in identical twins. We found GNAS gene mutation only in acromegaly patient. But the primary oncogenic potential of GNAS mutations remains a matter of debate. Thus, a better understanding of the causative genes and the pathogenic mechanisms of pituitary tumorogenesis is needed to improve the diagnosis and management of pituitary tumor patients.

A study on development of car seat thermal comfort evaluation system

( Seunghee Hong ),( Daee Kim ),( Young Seo ),( Baekhee Lee ),( Hyunkyu Park ),( Yeongsik Kim ),( Se Jin Park ) 한국감성과학회 2017 한국감성과학회 국제학술대회(ICES) Vol.2017 No.-

In the automobile industry, the technical characteristic of each component has been exploding improved. The technology level is capable of benchmarking from many manufacturers and it is possible to maintain a similar level, so recently, the sensitivity aspect given to users has emerged as an important part. Among them, the seat is in contact with the passenger's body during boarding, and it has a very close relationship to judging the comfort or discomfort. In this research, we tried to develop a seat thermal comfort evaluation method to evaluate the influence of the characteristic on the real environment and the human sensibility, based on the physical properties of the seat cover. In addition, by using the qualitative data (subjective assessment questionnaire) and quantitative evaluations (temperature / humidity, physiological signal; EEG, ECG, GSR), the validity of the evaluation method was verified. As a result, it was observed that the variation of the temperature and humidity of the seat cushion with the change of the seasons had a very significant effect on the comfort of the seat. In addition, it proved that the seat thermal comfort evaluation system satisfying the sensitivity from the physical property is valid.

Health monitoring of steel structures using impedance of thickness modes at PZT patches

Park, Seunghee,Yun, Chung-Bang,Roh, Yongrae,Lee, Jong-Jae Techno-Press 2005 Smart Structures and Systems, An International Jou Vol.1 No.4

This paper presents the results of a feasibility study on an impedance-based damage detection technique using thickness modes of piezoelectric (PZT) patches for steel structures. It is newly proposed to analyze the changes of the impedances of the thickness modes (frequency range > 1 MHz) at the PZT based on its resonant frequency shifts rather than those of the lateral modes (frequency range > 20 kHz) at the PZT based on its root mean square (RMS) deviations, since the former gives more significant variations in the resonant frequency shifts of the signals for identifying localities of small damages under the same measurement condition. In this paper, firstly, a numerical analysis was performed to understand the basics of the NDE technique using the impedance using an idealized 1-D electro-mechanical model consisting of a steel plate and a PZT patch. Then, experimental studies were carried out on two kinds of structural members of steel. Comparisons have been made between the results of crack detections using the thickness and lateral modes of the PZT patches.

Atmospheric deposition of anthropogenic inorganic nitrogen in airborne particles and precipitation in the East Sea in the northwestern Pacific Ocean

Park, Geun-Ha,Lee, Seon-Eun,Kim, Young-il,Kim, Dongseon,Lee, Kitack,Kang, Jeongwon,Kim, Yeo-Hun,Kim, Haryun,Park, Seunghee,Kim, Tae-Wook Elsevier 2019 Science of the Total Environment Vol.681 No.-

<P><B>Abstract</B></P> <P>The atmospheric deposition of anthropogenic nitrogen is an increasingly important new source of nitrogen to the ocean. Coastal areas east of the Korean Peninsula are suitable for the investigation of the effects of atmospheric anthropogenic nitrogen on the ocean nutrient system because of the low riverine discharge rates and the prevailing influence of the East Asian outflow. Thus, we measured the concentrations of nitrate (NO<SUB>3</SUB> <SUP>−</SUP>) and ammonium (NH<SUB>4</SUB> <SUP>+</SUP>) in airborne particles and in precipitation from March 2014 to February 2016 at a coastal site (37.08°N, 129.41°E) on the east coast of Korea. The dry deposition of NO<SUB>3</SUB> <SUP>−</SUP> (27–30 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>) was far greater than that of NH<SUB>4</SUB> <SUP>+</SUP> (6–8 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>). The greater rate of dry NO<SUB>3</SUB> <SUP>−</SUP> deposition was associated with air masses traveling over northeastern China and central Korea. In contrast, the rates of wet deposition of NO<SUB>3</SUB> <SUP>−</SUP> (17–24 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>) and NH<SUB>4</SUB> <SUP>+</SUP> (14–27 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>) were comparable and were probably associated with in-cloud scavenging of these ions. The results indicate that the total deposition of NO<SUB>3</SUB> <SUP>−</SUP> and NH<SUB>4</SUB> <SUP>+</SUP> combined could contribute to ~2.4% and ~1.9% of the primary production in the coastal areas east of the Korean Peninsula and in the East Asian marginal seas, respectively, which would be a lower bound because the dry deposition of reactive nitrogen gas was not included. Our study shows that the atmospheric input of anthropogenic NO<SUB>3</SUB> <SUP>−</SUP> and NH<SUB>4</SUB> <SUP>+</SUP> may substantially increase phytoplankton biomass in the coastal waters of the East Sea near the Korean Peninsula.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Atmospheric Nitrogen Deposition (AND) was 64–89 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP> in the East Sea. </LI> <LI> AND was enhanced in air masses traveling over northeastern China and central Korea. </LI> <LI> AND could contribute to ~1.9% of the primary production of East Asian seas. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

PZT-based active damage detection techniques for steel bridge components

Park, Seunghee,Yun, Chung-Bang,Roh, Yongrae,Lee, Jong-Jae Institute of Physics Publishing 2006 Smart materials & structures Vol.15 No.4

<P>This paper presents the results of experimental studies on piezoelectric lead-zirconate–titanate (PZT)-based active damage detection techniques for nondestructive evaluations (NDE) of steel bridge components. PZT patches offer special features suitable for real-time <I>in?situ</I> health monitoring systems for large and complex steel structures, because they are small, light, cheap, and useful as <I>built-in</I> sensor systems. Both impedance and Lamb wave methods are considered for damage detection of lab-size steel bridge members. Several damage-sensitive features are extracted: root mean square deviations (RMSD) in the impedances and wavelet coefficients (WC) of Lamb waves, and the times of flight (TOF) of Lamb waves. Advanced signal processing and pattern recognition techniques such as continuous wavelet transform (CWT) and support vector machine (SVM) are used in the current system. Firstly, PZT patches were used in conjunction with the impedance and Lamb waves to detect the presence and growth of artificial cracks on a 1/8 scale model for a vertical truss member of Seongsu Bridge, Seoul, Korea, which collapsed in 1994. The RMSD in the impedances and WC of Lamb waves were found to be good damage indicators. Secondly, two PZT patches were used to detect damage on a bolt-jointed steel plate, which was simulated by removing bolts. The correlation of the Lamb wave transmission data with the damage classified by in and out of the wave path was investigated by using the TOF and WC obtained from the Lamb wave signals. The SVM was implemented to enhance the damage identification capability of the current system. The results from the experiments showed the validity of the proposed methods. </P>

Occupational Characteristics of Semiconductor Workers with Cancer and Rare Diseases Registered with a Workers' Compensation Program in Korea

Park, Dong-Uk,Choi, Sangjun,Lee, Seunghee,Koh, Dong-Hee,Kim, Hyoung-Ryoul,Lee, Kyong-Hui,Park, Jihoon Occupational Safety and Health Research Institute 2019 Safety and health at work Vol.10 No.3

Background: The aim of this study was to describe the types of diseases that developed in semiconductor workers who have registered with the Korea Workers' Compensation and Welfare Service (KWCWS) and to identify potential common occupational characteristics by the type of claimed disease. Methods: A total of 55 semiconductor workers with cancer or rare diseases who claimed to the KWCWS were compared based on their work characteristics and types of claimed diseases. Leukemia, non-Hodgkin lymphoma, and aplastic anemia were grouped into lymphohematopoietic (LHP) disorder. Results: Leukemia (n = 14) and breast cancer (n = 10) were the most common complaints, followed by brain cancer (n = 6), aplastic anemia (n = 6), and non-Hodgkin lymphoma (n = 4). LHP disorders (n = 24) accounted for 43%. Sixty percent (n = 33) of registered workers (n = 55) were found to have been employed before 2000. Seventy-six percent (n = 42) of registered workers and 79% (n = 19) among the registered workers with LHP (n = 24) were found to be diagnosed at a relatively young age, ${\leq}40years$. A total of 18 workers among the registered semiconductor workers were finally determined to deserve compensation for occupational disease by either the KWCWS (n = 10) or the administrative court (n = 8). Eleven fabrication workers who were compensated responded as having handled wafers smaller than eight inches in size. Eight among the 18 workers compensated (44 %) were found to have ever worked at etching operations. Conclusion: The distribution of cancer and rare diseases among registered semiconductor workers was closely related to the manufacturing era before 2005, ${\leq}8$ inches of wafer size handled, exposure to clean rooms of fabrication and chip assembly operations, and etching operations.

Quantification of a Mixture of Insoluble Submicrometer Particles and Dissolved Solids in Water using Membrane Filtration and Aerosolization Method

Park, Ji Yeon,Lim, Sungil,Han, Seunghee,Park, Kihong Elsevier 2011 AEROSOL SCIENCE AND TECHNOLOGY Vol.45 No.8

<P> Microfiltration (MF) and ultrafiltration (UF) membrane filtration and separation of insoluble particles and dissolved solid in water, aerosolization, and subsequent sizing and counting of airborne particles were used to determine the number concentration of insoluble particles (#/ml) and mass concentration of dissolved solids (ppm) in water. By using a variety of solutions and their mixtures, we determined the penetration of insoluble particles and dissolved solids via the MF and UF membranes, as well as established a relationship between particle quantity in water and air. Both sub-500 nm insoluble particles and most dissolved solids passed through the MF membrane, while only dissolved solids passed through the UF membrane, enabling separation of waterborne insoluble particles and dissolved solids. Accordingly, we estimated the submicrometer particle number concentration and dissolved species mass concentrations via the proposed technique with 15% and 16% accuracy, respectively. Further, we examined the effects of mixing insoluble particles and dissolved solids with aerosolized particles by using a mixture of silica particles (insoluble particles) and artificial seawater (25,000 ppm) containing various dissolved ions. Afterward, we applied the proposed technique to quantify insoluble particles and dissolved solids in seawater. Concentrations of insoluble particles in MF membrane-filtrated seawater sampled from the cities of Pohang, Taean and Yeosu in Korea were 1.16 × 10<SUP>12</SUP>, 5.45 × 10<SUP>11</SUP>, and 4.82 × 10<SUP>11</SUP> #/ml, respectively; mass concentrations of dissolved solids were 24362, 23358, and 24640 ppm, respectively, concurring closely with values measured by the Total Dissolved Solids (TDS) meter. Our quantification technique will be useful in monitoring both insoluble submicrometer particles and dissolved solids to examine water quality and primary marine aerosol formation in seawater more effectively. </P>

Development of a Next-Generation Overloaded Vehicle Enforcement System integrating built-in tire sensors with vision sensors

Seunghee Park,Tae-Heon Kim,Chang-Guen Lee,Jong-Jae Lee,Seongho Kim 한국콘텐츠학회 2010 ICCC International Digital Design Invitation Exhib Vol.2010 No.12