Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

Possibility of Empowerment in The Surrendered by Chang-rae Lee

Seul Ki Lee Ewha Institute of English and American Studies 2022 Journal of English and American studies Vol.20 No.1

This paper supports the interpretation that the main characters in Chang-rae Lee’s The Surrendered find liberation in being surrendered. As a novel written by a recognized Korean-American writer about The Korean War, The Surrendered received many reviews concentrating on the author’s writing style and artistry. These early critics stated that the novel’s varying temporal and geographical shifts and the fact that the novel revolves around three different characters make the novel unnecessarily complex. In addition, the scholarly works that do analyze the novel concentrate on the trauma, disability, and post-traumatic stress disorder resulting from the violence. Although prior research touched upon the characters and the symbolism within the setting, I would like to do a more in depth analysis. I use the concept of “abjection” to analyze the symbolism of the three main characters: June, Hector, and Sylvia. All three characters have distinct individuals while also representing others who have survived the social situations they faced. Therefore, it is meaningful to analyze three characters and how they use their status as abjects to find a form of liberation and empowerment.

The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection

Choi, Seul-Ki,Mun, Gil-Im,Choi, Eun,Kim, Seo-Young,Kwon, Youngjoo,Na, Younghwa,Lee, Yun-Sil American Society of Pharmacognosy 2017 Journal of natural products Vol.80 No.8

<P>Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.</P>

초등학교 고학년 학생의 장애아동에 대한 인식 조사

김보람,김호영,손유라,오진주,윤슬기,이효정,장문영 대한감각통합치료학회 2011 대한감각통합치료학회지 Vol.9 No.1

목적 : 초등학교 고학년 학생의 장애아동에 대한 인식을 알아보는 것이다. 연구방법 : 연구 대상은 김해시에 소재한 통합교육을 실시하지 않는 초등학교의 4, 5, 6학년의 비장애 아동이었다. 연구 기간은 2008년 10월 2일부터 10월 17일까지였으며, 설문지를 사용하였다. 설문지의 하위 영역은 사귐, 활 동, 학업 영역의 세 부분으로 각 10문항으로 이루어져 있으며 SPSS 12.0을 사용하여 분석하였다. 결과 : 장애아동에 대한 인식조사 결과 첫째, 성별에 따른 인식은 남학생보다 여학생의 평균 점수가 높았으나 통계 적으로 유의미한 차이는 없었다. 둘째, 학년에 따른 인식은 4학년의 평균 점수가 가장 높았고 6학년이 가장 낮았으 며 통계적으로 유의미한 차이가 있었다(F=3.546, p<0.05). 셋째, 장애인 접촉 유무에 따른 인식은 접촉 경험이 없 는 학생이 있는 학생보다 평균점수가 높았으나 통계적으로 유의미한 차이는 없었다. 결론 : 비장애학생의 장애아동에 대한 인식은 학년에 따라 차이가 있었다. 본 연구는 작업치료사들에게 장애아동에 대한 또래집단의 인식에 대한 정보를 제공함으로써 학교환경에 대한 이해를 도울 수 있을 것이다. Objective : The purpose of this study was to investigate attitude of grade-schoolers toward children with disabilities. Methods : The subjects of this study were grade-schoolers who have not received an inclusive education in Gim-hae. The study was surveyed from October second to 17th in 2008. The survey was categorized into three parts; comradeship, activity, and study. Each part of the survey consists of 10 questions. Data were analyzed by SPSS (version 12.0). Results : The results were as follows; First, the attitude of girls toward disabled students was non-significant compared to boys. Second, the order of attitude degree in grade of students was 4, 6, and 5. The attitude toward children with disabilities showed statistically significant difference according to grade(F=3.546, p<0.05). Third, the attitude of students who have experience of contact with people with disabilities was non-significant compared to non-experienced students. Conclusion : In conclusion, therefore peer groups in lower class levels showed more positive attitude toward the children with disabilities. The result will be useful information for understanding disabled children and making positive attitude. Also it is expected that occupational therapists help disabled children to participate in school life successfully using these information.

ALEP (acute localized exanthematous pustulosis): a rare variant of AGEP (acute generalized exanthematous pustulosis)

( Seul Ki Lim ),( Myung Im ),( Young Lee ),( Jeung Hoon Lee ),( Young Joon Seo ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Acute localized exanthematous pustulosis (ALEP) is a variant of acute generalized exanthematous pustulosis (AGEP). The epidemiology of ALEP is not established. In worldwide, only 21 cases have been reported in the literature. The most common localized site is face and most of cases were induced by systemically administered drugs. A 47-year-old male visited our clinic for an acute outbreak of pustule with underlying erythematous base affecting face and neck. He had itching and burning sensation on this lesions. There was no history of taking medicine. However after working in greenhouse, the clinical symptoms have been worsened. This history suggested that agricultural pesticides might be the cause. On histopathological study, it showed subcorneal pustule with perivascular lymphocyte and neutrophil infiltration. The pustular lesions were resolved in 5 days by methylprednisolone treatment. Here, we report the ALEP patient who has localized pustule on face and neck. Though it is rare variant of AGEP, it should be regarded in noninfectious multiple pustular lesions.

A case of linear lupus panniculitis

( Seul Ki Lim ),( Myung Im ),( Young Lee ),( Jeung Hoon Lee ),( Young Joon Seo ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Linear lupus panniculitis(LLP) is a variant of lupus erythematosus panniculitis(LEP) which is characterized by localized subcutaneous nodules. LLP can mimic scleroderma or lichen striatus because of linear shape that follows Blaschko’s line. As well as hitopathological findings of LEP, LLP shows lobular panniculitis with lymphocyte infiltrations. However, it has fewer associations with systemic lupus erythematosus than LEP. A 20-year-old female visited our clinic for linear brownish patch on her right arm and leg. 7 years ago, subcutaneous brownish nodules appeared at the first time. Until last year, the lesions had been no changes. However 3 months ago, the lesions were getting larger and spreading. She felt little tenderness on these sites. On histopathological study, it showed lymphocyte infiltration in deep dermis and subcutaneous tissue. After taking a cyclosporine for 2 months, the lesions on her right arm have been improved, but the lesions on her leg have had little changes. Here, we report the LLP patient who had misdiagnosed as lichen striatus. Clinicians should consider LLP when meet the patients with linear tender nodule on Blaschko’s line.

P070 : Genkwadaphnin inhibits the growth of squamous cell carcinoma (SCC) cells

( Seul Ki Lim ),( Zheng Jun Li ),( Kyung Cheol Sohn ),( Myung Im ),( Young Lee ),( Chang Deok Kim ),( Young Joon Seo ),( Jae Wha Kim ),( Jeung Hoon Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Genkwadaphnin was isolated from the flower buds of Daphne genkwa, showing cytotoxicity against several cancer cell lines. Objectives: To investigate the effect of Genkwadaphnin on SCC cells. Methods: SCC12 cells were treated with Genkwadaphnin and effects were evaluated. Results: Genkwadaphnin treatment resulted in apoptosis of SCC12 cells in the dose- and time-dependent manner, evidenced by cleavage of procaspase-3 and PARP. Genkwadaphnin induced phosphorylations of JNK and p38 MAPK. When JNK and p38 MAPK were knockdowned by recombinant adenovirus expressing microRNA (miR), Genkwadaphnin-induced apoptosis was significantly inhibited. Pretreatment of SCC12 cells with the ROS scavenger N-acteylcysteine (NAC) inhibited Genkwadaphnin-induced apoptosis significantly. Conclusion: These results suggest that Genkwadaphnin has an anti-cancer potential against SCC cells.

Clear cell papulosis: one of the hypopigmentation disorders in early childhood

( Seul Ki Lim ),( Hae Eul Lee ),( Myung Im ),( Young Joon Seo ),( Jeung Hoon Lee ),( Young Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Clear cell papulosis (CCP) is a rare condition in early childhood with hypopigmented macules or palpable papules on pubic region, lower abdomen, and anterior trunk. A 2-year-old girl visited our clinic for asymptomatic hypopigmented macules and flat topped papules on the inguinal area, suprapubic area and anterior trunk. The patient had no history of trauma or inflammation. Histopathological examination showed the clear cells which were round and oval shape with abundant pale cytoplasm. These cells were mostly located in basal layers and occasionally in spinous layers. Fontana-Masson stain showed decreased pigmentation compared with adjacent normal skin. The patient was diagnosed as CCP with clinical manifestation and characteristic histologic findings. CCP often can be confused with tinea versicolor, anectoderma, idiopathic guttate hypomelanosis or chicken pox scars. Though it is a rare disease entity, CCP should be kept in mind as one of the differential diagnoses of localized hypopigmented macules on trunk in early childhood.

Inhibitory Effect of Ore Minerals on the Allergic Inflammation in Mouse

( Seul Ki Park ),( Chang Won Lee ),( Mi Young Lee ) 한국응용생명화학회 2008 Applied Biological Chemistry (Appl Biol Chem) Vol.51 No.4

Critical Success Factors for Project Management Information System in Construction

Lee, Seul-Ki,Yu, Jung-Ho Korea Institute of Construction Engineering and Ma 2011 Journal of construction engineering and project ma Vol.1 No.1

With a focus on different aspects of PMIS in construction projects, various sets of critical success factors (CSFs) have been suggested in the literature such as IS Success Model by various researchers. It is crucial to explore the relative importance and groupings of these factors. This paper aims to identify CSFs associated with Project Management Information System (PMIS) in construction projects, and explore their ranking and underlying relationship. CSFs for PMIS identified through a literature review, and consolidated by interviews and pilot studies with professionals in construction industry. A questionnaire instrument was sent out to experienced users (Construction Manager and Constructor) in Korea, and 253 completed questionnaires were retrieved. To increase the generalizability of the results, the respondents were spread across construction site. Using factor analysis and considering the high importance of the factor, CSFs were grouped into three dimensions. All these three groupings and their relationship were included in a framework for successful PMIS in construction projects. These findings help to clarify what the high prioritized factors are, and could also be used as an assessment tool to evaluate the performance of PMIS and thus help to identify areas for improvement.