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      • 원발성진행성 실어증

        한설희 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.2

        원발성진행성실어증은 수년간에 걸쳐 대뇌고위 기능중 언어영역만 고립적으로 침범되어 서서히 진행하는데 임상적으로 치매와 구별되어야 하는 비교적 드문 증후군이다. 저자는 최근에 62세 여자환자가 약 4년간에 걸쳐 서서히 진행한 언어장애를 주소로 본원 치매크리닉을 방문하여 신경심리검사, 뇌파검사, 뇌핵자기공면영상, 단일광자방출단층촬영술 등에서 전형적인 원발성진행성실어증으로 확인된 우리 나라 최초의 예를 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. A 62-year-old right-handed woman presented with a progressive deterioration in her ability to name common object used in everyday life. Her initial language disturbance, word-finding difficulty, got worsened gradually over the next 4 years, She was able to point to the correct object when the word is provided by the examiner despite being unable to name it spontaneously. Her memory, attention, visuospatial skills and comportment were all intact. She is doing well in her daily living activities including taking care of herself, shopping and paying bills. MRI showed left perisylvian atrophy and dilated left frontal horn. SPECT study revealed decreased perfusion in left temporal lobe. Her clinical presentation together with the characteristic structural and functional neuroimaging findings were typical of 'primary progressive aphasia'.

      • KCI등재

        김관 평론과 '민족음악'론

        신설령 민족음악학회 2004 음악과 민족 Vol.28 No.-

        Since there were few musical critics in 1930s, Kim Guan proposed the reexamination of "the national music." During this era, there were no support or exchanging of views from his fellow musical critics toward his proposal. Many believed that because of the closely monitored Japanese imperialism, they were intimidated to express their points of views and support for Kim's, "the national music." Besides of being suppressed, many found that Kim's opinion were very ahead of time or very futuristic and therefore, it didn't get the importance of its issues. After the independence from Japan, there were bursts of discussions about his proposal as like the darn water exploded. Many people including the musical critics were able to express their views towards the proposal. They could sing for joy during the independence. In 1980s, the systematic written exposition or argument about Korean music could point out and discussed the problems of the western music influences. However, during the occupation of the Japanese, there was one musical critic who gave his valuable opinion on "the national music" --- Kim Guan. Even though there was no freedom, there was advancement and it led the Korean music where it is today.

      • KCI등재

        부검으로 확진된 알쯔하이머병 1예 : An Autopsy Report

        한설희,이건국,양기화,장순환 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

        While the clinical diagnostic accuracy of probable Alzheimer′s disease (AD) is 87-96% with a diagnostic sensitivity/specificity of 0 81-0 87, the unequivocal diagnosis of AD rests on histopathological evidence at brain autopsy and/or biopsy We report here a 92-year-old woman whose clinical presentation suggested a far advanced Alzheimer′s disease Formal neuropsychological evaluations were not applicable due to severe cognitive impairments With a relatively good general physical condition she could walk with aid during her last days no focal neurological signs were noted on a detailed examination Brain MRI revealed a diffuse cortical atrophy with a marked reduction in the hippocampal volume The brain obtained weighted 780g The cerebral hemispheres examined after fixation disclosed moderately severe atrophy in prefrontal and temporal lobes on coronal section, the hippocampus was likewise severely atrophied the lateral ventricles were moderately dilated On microscope examination, there were numerous senile plaques and neurofibrillary tangles in the neocortices. hippocampus and amyglada, compatible with advanced Alzheimer′s disease In summary we report the first Korean autopsy-proven case with advanced Alzheimer′s disease.

      • KCI등재

        경도인지장애 : 알쯔하이머병의 초기단계인가? Is it an Early Stage of Alzheimer's Disease?

        한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

        Aging causes deterioration of various aspects of memory performance in norma adults In recent years. a great deal of interest has been generated around the concept of a boundary or transitional state between normal aging and dementia or, more specifically, Alzheimer's disease (AD). This condition has received a number of descriptions including incipient dementia. questionable dementia. age-associated cognitive decline, isolated memory impairment and mild cognitive impairment (MCI) Commonly accepted guidelines for MCI have been established-memory complaint, preferably corroborated by an informant. objective memory impairment for age and education. normal general cognition, preserved activities of daily living, and not demented The precise definitions need to be explicated. but these will probably simply be a refinement of a concept. rather than a major re-definition Importantly, clinical and neurobiological evidence suggests that patients with MCI are at an increased risk for developing AD. Current research efforts are geared with MCI are at an increased risk for developing AD. Current research efforts are geared towards intervention strategies aimed at preventing the development of AD among persons with MCI.

      • 초고속 HMC 주축계의 열특성 해석

        김석일,김기상,김기태,나승표 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

        This paper presents the thermal characteristics analysis of a high-speed HMC spindle system with angular contact ball bearings, built-in motor, oil-jet lubrication method, oil jacket cooling method, and so on. The spindle system is composed of the main spindle and sub-spindle which are mechanically connected by a flexible coupling. The spindles are supported by two front and rear bearings, and the built-in motor is located between the front and rear bearings of the sub-spindle. The thermal analysis model of spindle system is constructed by the finite element method, and the thermal characteristics in the design stage are estimated based on temperature distribution and heat flow under the various testing conditions related to material of bearing ball, spindle speed and coolant temperature.

      • 백서 뇌에서의 Nitric Oxide Synthase를 함유한 신경세포의 분포에 관한 연구 : 해마 구조를 중심으로 An NADPH-diaphorase Histochemical Study

        한설희 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.1

        뇌에 존재하는 어떤 종류의 신경세포는 nicotinamide adenin dinucleotide phosphate-diaphorase (NADPH-d) 활성을 함유하고 있어 조직화학 기법에 의해 특이성을 가지며 강하게 염색된다. NADPH-d에 염색되는 신경 세포들은 다양한 종류의 신경 독성과 퇴행성 신경변성에 대하여 강한 저항성을 나타내는 것으로 알려져 있다. 또한 NADPH-d는 formaldehyde에 저항성을 나타내는 조직화학적 특성을 가지고 있으며 이는 nitric oxide synthase (NOS) 성질과 동일하다. 따라서 NADPH-d는 formaldehyde로 고정된 신경조직에서 NOS의 활성을 가진 신뢰성 높은 조직화학지표로 생각된다. 본 연구에서는 백서 뇌조직 중 해마에서의 NOS표현을 알아보기 위해 NADPH-d 조직화학 기법을 사용하였다. Certain neurons in the brain are specifically and intensely stained by a histochemical method which demonstrates nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity. These NADPH-d positive neurons are known to exhibit high resistance to various neurotoxins and to neurodegeneration. NADPH-d is a formaldehyde-resistant histochemical activity which has been shown to be exerted by nitric oxide synthase (NOS). Thus NADPH-d serve as a reliable histochemical marker for NOS in formaldehyde-fixed sections of neural tissue, the present study uses NADPH-diaphorase histochemistry to see the expression of NOS in the rat hippocampus.

      • Henigway의 主人公들에 關한 考察

        鄭卨秀 忠州大學校 1976 한국교통대학교 논문집 Vol.8 No.1

        When we read Hemingway's works, we can find that Hemingway offers three Patterns of his heroes in his works. One is the pattern of Nick Adams, another is the pattern of Jake Barnes, a third is the pattern of Frederic Henry. Hemingway's heroes have 'moral code' which Hemingway made in his works in order to express his literary ideas. Nick Adams does not have moral code, but Nick experiences, Violence, evil and death which man has in this world. Jake has moral code receiving and enduring his conditions given him. Henry has moral code conquering his conditions. Hemingway's heroes must conduct acoording to these codes. If heroes and charaters in his works do not observe them, he regard as a coward. Hemingway exoressed all his literary ideas through his heroes. And we can guess Hemingway's heroes are Hemingway himself because all the contents of his works agree with his practical life.

      • 美國大學의 特異性 : 近大美國 文學을 中心으로

        鄭卨秀 忠州大學校 1968 한국교통대학교 논문집 Vol.2 No.-

        Every literature of Europe began before the time of printing. This was a period of folklore, legends, and ballads. Such a collection of simple songs and stories represents the "childhood" of a literature, in which it is starting to grow up and develop. But American literature had no such childhood. American literature was begun by the colonists who came from England to settle the New Condinent. We can divide Ameracan literature as the following : 1. The Period of the American Colonies ; The writings of this period dealt with religion, morals, and church teachings by Puritanism and Frontier Mind. 2. The Period of the American Revolution ; Because of Independence War, American literature did not develop in this period. 3. Romanticism ; The romantic writers dealt with admiration of nature, individual dignity freedom, right and to sing the rustic life. The active writers of this Period were Irving, Cooper, Emerson, Thoreau and Poe. 4. Realism ; American realism was led by Mark Twain who wrote「The Adventure of Tom Sawyer」,「The Adventure of Huckleberry Finn」etc. with American humour and style. From this period American literature, completely, escaped from the literature of another counntry. 5. Naturalism ; American realism was grown up by naturalists. Naturalists wrote the exposing novels to American society of this period. In this treatise, I described only about the peculiarity of modern American literature. I think what we know of the peculiarity of a period is very important. By understanding the literature of another country, we must know the peculiarity of that peroid well. As a result we can understand their literature deeply.

      • KCI등재

        치매의 행동심리증상의 개관 : An Overview

        한설희 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1

        Behavioral and psychological symptoms of dementia (BPSD) are among the most distressing manifestations of dementia and results in considerable social and economic burden. They are highly prevalent in Alzheimer's disease (AD) and other progressive degenerative dementias. BPSD are one of main reasons for premature institutionalization and are major causes of significant loss of quality-of-life for the patient and his/her family and caregivers. Recent investigations indicate that BPSD are not an epiphenomenona of cognitive impairment, but could be attributed to specific biological brain dysfunction. This brief review provides an overview of recent advances in the field of BPSD research.

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