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The Observations of Surface Diffusion in Tungsten and Rhenium in FIM
Orr, K. K.,Tsong, T. T. 한국부식학회 1981 Corrosion Science and Technology Vol.10 No.3
FIM을 사용하여 tungsten 표면에서의 ion 상태로 된 tungsten 그리고 rhenium 원자들의 확산현상 반응에 대해서 고찰했다. Using a field ion microscope (FIM) the inter-atomic interaction between tungsten and tungsten, and tungsten and rhenium was investigated.
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
Orr, Nick,Dudbridge, Frank,Dryden, Nicola,Maguire, Sarah,Novo, Daniela,Perrakis, Eleni,Johnson, Nichola,Ghoussaini, Maya,Hopper, John L.,Southey, Melissa C.,Apicella, Carmel,Stone, Jennifer,Schmidt, M IRL Press 2015 Human molecular genetics Vol.24 No.10
<P>We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 600 controls of European ancestry ascertained from 52 studies and a further 5795 cases and 6624 controls of Asian ancestry from nine studies. Single nucleotide polymorphism (SNP) rs676256 was most strongly associated with risk in Europeans (odds ratios [OR] = 0.90 [0.88–0.92]; <I>P</I>-value = 1.58 × 10<SUP>−25</SUP>). This SNP is one of a cluster of highly correlated variants, including rs865686, that spans ∼14.5 kb. We identified two additional independent association signals demarcated by SNPs rs10816625 (OR = 1.12 [1.08–1.17]; <I>P</I>-value = 7.89 × 10<SUP>−09</SUP>) and rs13294895 (OR = 1.09 [1.06–1.12]; <I>P</I>-value = 2.97 × 10<SUP>−11</SUP>). SNP rs10816625, but not rs13294895, was also associated with risk of breast cancer in Asian individuals (OR = 1.12 [1.06–1.18]; <I>P</I>-value = 2.77 × 10<SUP>−05</SUP>). Functional genomic annotation using data derived from breast cancer cell-line models indicates that these SNPs localise to putative enhancer elements that bind known drivers of hormone-dependent breast cancer, including ER-α, FOXA1 and GATA-3. <I>In vitro</I> analyses indicate that rs10816625 and rs13294895 have allele-specific effects on enhancer activity and suggest chromatin interactions with the <I>KLF4</I> gene locus. These results demonstrate the power of dense genotyping in large studies to identify independent susceptibility variants. Analysis of associations using subjects with different ancestry, combined with bioinformatic and genomic characterisation, can provide strong evidence for the likely causative alleles and their functional basis.</P>
연구논문초록(’81-’90) : Corrosion of Oxygen and Sulfur Systems in Al , Zn , In
Orr, K. K. 한국부식학회 1991 Corrosion Science and Technology Vol.20 No.1
Phase relationships of Al₂O₃-Al₂S₃ were investigated between300C and 1200C. The solid solutions of Al₂(O, S)₃ wem found to be water soluble. As an exploratory work the Al₂S₃ -ZnS system was studied resulting in the fact that ZnAl₂S₄ spinel and wurtzite forms. Furthermore subsolidus phase relations in ZnAl₂S₄-ZnI₂S₄ were studied.
Corrosion of Oxygen and Sulfur Systems in Al ,Zn , In
Orr, K. K. 한국부식학회 1981 Corrosion Science and Technology Vol.10 No.3
Al₂O₃-Al₂S₃의 相 관계를 300℃에서부터 1200℃ 사이에서 조사했으며 Al₂O₃의 유황 고용체 (Al₂(O, S)₃)가 물에 녹는 현상을 발견했다. Al₂S₃-ZnS의 상관계를 초기적인 단계에서 실험했으며 ZnAl₂S₄의 intermediate 相툴을 합성했으며 이것은 spinel과 Wurtzite의 결정 구조를 가졌다. ZnAl₂S₄와 ZnI₂S₄의 相관계를 조사했다. Phase relationships of Al₂O₃-Al₂S₃ were investigated between 300℃ and 1200℃. The solid solutions of Al₂ (O,S)₃ were found to be water soluble. As an exploratory work the Al₂S₃-ZnS system was studied resulting in the fact that ZnAl₂S₄ is spinel and wurtzite forms. Furthermore subsolidus phase relations in ZnAl₂S₄-ZnI₂S₄ were studied.
오소정(So Jung orr),김영태(Young Tae Kim),임동선(Dong Sun Yim) 한국언어치료학회 2011 言語治療硏究 Vol.20 No.4
This study aimed to take a closer look at accuracy and response time of vocabulary tasks between children from multicultural families and non-multicultural families. Thirty multi-cultural children and CA matched non-multicultural children, who have normal intelligence, attended to computerized receptive and expressive vocabulary test including three word classes (noun, verb, adjective). Significant differences were observed in overall accuracy of expressive vocabulary tasks, but not in receptive tasks. Compared to non-multicultural children, children from multi-cultural families performed significantly poorer in noun items both receptive and expressive tasks. Verb accuracy, however, was significantly lower only in expressive tasks. None of the analyses of response latency reached significant differences between the two groups. Results are discussed in terms of performance differences between overall tasks and separate word class items, and the roles of perceptual-motor skills and language experience for processing speed observed in response time. Despite partly deteriorated accuracy, multicultural children have comparable processing speed, and this implies that they differ from the language-impaired population.
Johnson, Nichola,Dudbridge, Frank,Orr, Nick,Gibson, Lorna,Jones, Michael E,Schoemaker, Minouk J,Folkerd, Elizabeth J,Haynes, Ben P,Hopper, John L,Southey, Melissa C,Dite, Gillian S,Apicella, Carmel,Sc BioMed Central 2014 Breast cancer research Vol.16 No.3
<P><B>Introduction</B></P><P>We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the <I>CYP3A</I> locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.</P><P><B>Methods</B></P><P>We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.</P><P><B>Results</B></P><P>We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; <I>P</I> = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; <I>P</I> = 0.004), respectively (<I>P</I><SUB>trend</SUB> = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (<I>P</I><SUB>trend</SUB> = 0.005) but not cases (<I>P</I><SUB>trend</SUB> = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (<I>P</I><SUB>het</SUB> = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (OR<SUB>het</SUB> = 0.84, 95% CI 0.75, 0.94; OR<SUB>hom</SUB> = 0.81, 95% CI 0.51, 1.30; <I>P</I><SUB>trend</SUB> = 0.002) but not for those who had their menarche age ≤11 years (OR<SUB>het</SUB> = 1.06, 95% CI 0.95, 1.19, OR<SUB>hom</SUB> = 1.07, 95% CI 0.67, 1.72; <I>P</I><SUB>trend</SUB> = 0.29).</P><P><B>Conclusions</B></P><P>To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.</P>