정신분열증 환자군에서 낮병원 치료가 경각심과 정신운동기능에 미치는 영향에 대한 예비 연구

오태성,김도훈,오병훈,현명호,유계준 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

Objectives : The aim of study is to compare the neuropsychological function changes between day hospital schizophrenic patients and out patient schizophrenic patients and to examine the effect of day hospital program on the cognitive function of schizophrenics. Methods : Neuropsychological test was done two times at discharge and 2 months later in 11 day hospital schizophrenic patients and 10 out patient schizophrenic patients by DSM-Ⅳ criteria. Vigilance, motor performance series are used as a computerized neuropsychological batteries. Results : Day hospital patients have significantly increased performance in some of motor performance series test items, but sustained attention have no tendency for increasing in day hospital patients. Conclusion : This results are preliminary. But this study suggest that psychomotor function of schizophrenics can be changed following day hospital treatment. And also we suggest that further day hospital treatment program expecially including congnitive rehabilitation needed.

糖, 아미노酸 및 無機窒素化合物이 人蔘褐變促進에 미치는 影響

都在浩,金相達,吳勳一,洪淳根 한국응용생명화학회 1982 Applied Biological Chemistry (Appl Biol Chem) Vol.25 No.3

紅蔘褐變의 適合한 促進方法을 究明하기 위하여 人蔘에 糖, amino酸 및 無機窒素化合物을 處理한 結果 糖類中에서는 maltose와 glucose가 가장 强한 褐變促進作用을 나타내었다. amino酸은 basic amino acid인 lysine, histidine, arginine이 가장 크게 促進했으며 糖과 amino酸 混合處理에서는 glucose와 glutamic acid 退合處理區가 가장 크게 促進되었다. Glucose 濃度別 處理時의 褐變促進效果는 glucose濃度가 增加함에 따라 褐變이 促進되었으며 無機窒素化合物中에서는 urea>(NH₄)₂)HCO₃>COONH₄등의 順으로 褐變이 促進되었다. In order to find out pertinent methods for the acceleration of browing during ginseng processing, various treatments were made or fresh ginseng (Panax Ginseng C.A. Meyer) with sugars, amino acids and inorganic nitrogenous compounds and the extent of browning was measured. Among sugars tested, maltose resulted in the greatest acceleration of browning followed in decreasing order by glucose and lactose, whereas pentoses, fructose, sucrose and raffinose had negligible effect. A marked browning occurred in ginseng treated with basic amino acids, while the extent of browning was not greatly increased when ginseng was treated with aliphatic amino acids, hydroxy amino acids, or acidic amino acids used in the experiment. Among treatments with sugar-amino acid mixture, a mixture of glucose with glutamic acid gave the greatest acceleration. The brown color intensity gradually increased with an increase in glucose concentration for up to 0.5M. inorganic nitrogenous compounds enhanced the browning in general, and the effect varied greatly with the different compounds.

pH, 有機酸, 아스코르빈酸 및 紫外線照射가 人蔘褐變促進에 미치는 影響

金相達,都在浩,吳勳一 한국응용생명화학회 1982 Applied Biological Chemistry (Appl Biol Chem) Vol.25 No.4

pH, 有機酸, ascorbic acid 및 紫外線照射가 紅蔘褐色化反應促進에 미치는 影響을 調査하였다. 紅蔘의 褐色化反應은 弱 alkali性 範圍에서 褐變이 促進되는 傾向을 보였으며 citric acid, succinic acid, tartaric acid等의 有機酸 添加도 紅蔘의 褐變反應을 促進하였다. Fumalic acid의 單獨添加는 紅蔘의 褐色化反應을 促進하였으나 glucose, glutamic acid , glucose+glutamic acid의 混合處理는 褐變을 低下시켰다. 0.1M 以上의 ascorbic acid 處理는 紅蔘褐色化反應에 아주 큰 促進效果가 있었으며 同時에 良質紅蔘의 特有한 色相인 紅色度도 크게 增大되었다. 紫外線照射는 紅蔘乾燥 初期에는 褐變을 상당히 促進하였으나 그 以後에는 褐色度가 滅少되었다. Effects of pH, organic acides and UV irradiation on the browning of ginseng were investigated. Browning of ginseng tended to increase slightly in the alkaline pH range, whereas no discernible pH effect was observed in the pH ranges of 3.0-5.0 and 10.0-12.5. The treatment of fresh ginseng with organic acid such as citric acid, succinic acid, and tartaric acid greatly enhanced the browning reaction of ginseng but all treatments of mixture of glucose, glutamic acid, and glucose+glutamic acid with fumaric acid decreased the browning reaction except the treatment of fumaric acid only. The addition of ascorbic acid in concentration of greater than 0.1 M markedly accelerated the browning reaction and concurrently increased the red color, a characteristic color of quality red ginseng. Irradiation of ultraviolet light while drying red ginseng increased the brown color intensity in the first 5 day·s and thereafter decreased the brown color intensity.

파킨슨씨병 환자에 있어서 자가부신수질 이식술

정상섭,박상근,오성훈,김선호,윤도흠,박정수,양우익,최인준,안영수,김경환,박창일,김진수,이현철 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6

Recent experimental studies and clinical cases have suggested that grafting tissue from the adrenal medulla into the brain may alleviate the symptoms of Parkinson's disease. Autologous adrenal medullary grafts into the striatum was performed stereotactically in two patients with Parkinson's disease. Both patients were bedridden preoperatively, but 4 months after the surgery both became ambulatory and one was even capable of returning to his job. Even though the number of cases was small⑵ and the follow-up period was short, this study shows that adrenal medullary transplantation into the striatum may have some beneficial effects in patient with Parkinson's disease. Further experimental and clinical trials are necessary to see whether this procedure will be a recommendable surgical treatment for patients suffering from Parkinson's disease.

Effect of Home-based Self-administered Transcranial Direct Stimulation in Patients with Mild to Moderate Major Depressive Disorder: A Single-arm, Multicentral Trial

Jihoon Oh(Jihoon Oh),Sekye Jeon(Sekye Jeon),Tae Hyon Ha(Tae Hyon Ha),Woojae Myung(Woojae Myung),Seung-Hwan Lee(Seung-Hwan Lee),Young-Hoon Ko(Young-Hoon Ko),Do Hoon Kim(Do Hoon Kim),Hwa-Young Lee(Hwa-Y 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: Although the effects and safety of transcranial direct current stimulation (tDCS) treatment in depressive patients are largely investigated, whether the self-administration of tDCS treatment at patient’s home is comparable to clinic-based treatment is still unknown. Methods: In this single-arm, multi-center clinical trial, 61 patients with mild to moderate major depressive disorder were enrolled. tDCS treatment was delivered at the patient’s home once a day, 5 to 7 times a week for 6 weeks, and each session lasted for 30 minutes. The primary outcome was a total Beck-Depression Inventory-II score, and no concurrent antidepressants were used. Results: The remission rates in both Full-Analysis (FA) (n = 61) and Per-Protocol (PP) (n = 43) groups were statistically significant (FA: 57.4% [0.44−0.70], PP: 62.8% [0.47−0.77]; percent [95% confidence interval]). The degree of depression- related symptoms was also significantly improved in 2, 4, and 6 weeks after the treatment when compared with baseline. There was no significant association between treatment compliance and remission rate in both FA and PP groups. Conclusion: These results suggest that acute treatment of patient-administered tDCS might be effective in improving the subjective feeling of depressive symptoms in mild to moderate major depressive disorder patients.

[Free Paper] Sensitivity of FNAC and Applicability of intraoperative frozen section on preoperative atypical FNAC result in follicular variant of papillary thyroid carcinoma

Do Hoon Koo,Kyu Eun Lee,June Young Choi,Kyu Hyung Kim,Dong Sik Bae,Eun Mee Oh,Eun Young Kim,Seung Keun Oh,Yeo-Kyu Youn 대한외과학회 2011 대한외과학회 학술대회 초록집 Vol.2011 No.11

Learning One-to-Many Mapping With Locally Linear Maps Based on Manifold Structure

Do-Kwan Oh,Sang-Hoon Oh,Soo-Young Lee IEEE 2011 IEEE signal processing letters Vol.18 No.9

<P>This letter proposes a new method to realize a nonlinear mapping of one-to-many correspondences. Assuming that a small number of training pairs are given with their actual correspondences, each tangent space is locally constructed on a submanifold around each labeled sample. Moreover, the linear transformation between paired tangent spaces is derived by solving an optimization problem, which is designed to bring locally linear maps into closer proximity in each class. Finally, a global nonlinear mapping is realized by combining these locally linear maps. In simulations of an S-curve to Swiss-roll, a lip to speech, and room impulse response to position of microphone mappings, the proposed method shows the remarkable mapping ability.</P>

Assessment of Capsular Insertion Type and of Capsular Elongation in Patients with Anterior Shoulder Instability and It’s Correlation with Surgical Outcome

Do Hoon Kim,Do Yeon Kim,Hye Yeon Choi,Ji Soon Park,Ye Hyun Lee,Joo Han Oh 대한견주관절의학회 2016 대한견주관절학회지 Vol.19 No.3

Background: The study aimed to determine the type of capsular insertion and the extent of capsular elongation in anterior shoulder instability by quantitatively evaluating their computed tomography arthrographic (CTA) findings, and to investigate the correlation of these parameters with surgical outcomes. Methods: We retrospectively reviewed 71 patients who underwent CTA and arthroscopic capsulolabral reconstruction for anterior shoulder instability between April 2004 and August 2008. The control group comprised 72 patients diagnosed as isolated type II superior labrum anterior to posterior (SLAP) lesion during the period. Among the 143 patients, 71 were examined with follow-up CTA at an average 13.8 months after surgery. It was measured the capsular length and cross-sectional area at two distinct capsular regions: the 4 and 5 o’clock position of the capsule. Results: With regards to the incidence of the type of anterior capsular insertion, type I was more common in the control group, whereas type III more common than in the instability group. Anterior capsular length and cross-sectional area were significantly greater in the instability group than in the control group. Among patients of the instability group, the number of dislocations and the presence of anterior labroligamentous periosteal sleeve avulsion lesion were significantly associated with anterior capsular redundancy. Postoperatively, recurrence was found in 3 patients (4.2%) and their postoperative capsular length and cross-sectional area were greater than those of patients without recurrence. Conclusions: Capsular insertion type and capsular redundancy derived through CTA may serve as important parameters for the management of anterior shoulder instability.

노인의 여가기능이 우울척도에 미치는 영향

김도훈(Do Hoon Kim),오병훈(Byoung Hoon Oh),이후경(Hoo Kyeong Lee),유계준(Kae Joon Yoo) 대한노인정신의학회 1997 노인정신의학 Vol.1 No.1

본 연구에서는 사회-문화적 환경이 다른 곳에서 성장한 노인집단 간의 우울경향성과 여가기능의 차이를 살펴보고, 여가기능이 노인의 우울 경향성에 미치는 영향을 알아보고자 하였다. 서울소재 양로원에 거주하고 있는 국내 거주노인 55명과 강원도 소재 양로원에 거주하고 있는 사할린 교포 귀국노인 35명 등 총 90명의 노인을 연구대상으로 하였으며, 여가기능을 측정하기 위해서 Witt와 Eliss(1987)가 고안한 Leisure Diagnostic Battery(LDB)를 실시하였고 우울경향성을 측정하기 위해서 Yesavage(1983)의 Geriatric Depression Scale(GDS)을 면담을 통한 설문지 조사방법으로 실시하였다. 연구결과, 사할린 교포 귀국 노인들이 국내 노인들에 비해서 우울 경향성이 높았다. 그리고 여가기능이 많은 국내 노인들이 여가기능이 적은 사할린 교포 귀국 노인들에 비해서 우울 경향성이 낮을 것이라는 가설은 지지되었다. 즉, 여가기능이 높은 국내 집단이 다른 집단과는 달리 우울 경향성이 가장 낮았으며 집단간 차이도 유의미하였다. 본 연구를 통해서 노인들의(특히 양로원 거주노인) 정신건강 증진을 위해서 여가기능의 향상 및 만족도를 높여주기 위한 교육 및 프로그램의 개발과 적용의 필요성을 제시할 수 있었다. The purpose of this study is to compare the difference of the tendency for depression and leisure functioning between two elderly groups in differnt socio-cultural environment. Also, this study investigated whether the difference of lesiure functioning affected the tendency for depression. The participants are 55 elderly residing in the nursing home in Seoul and 35 Sahalin returning Koreans in KangWon-Do. Leisure Diagnostic Battery (LDB) developed by Witt and Eliss (1987) was used to measure leisure functioning of the elderly and Yesavage (1983)'s Geriatric Depression Scale (GDS measured the tendency of depression. The LDB and GDS were gathered through interviewing. The result of this study reports that the tendency of depreesion in Sahalin returning Koreans was higher than the elderly in Seoul. And the result supports the hypothesis that the elderly in Seoul who have maintained higher leisure functioning showed lower depression level than the Sahalin elderly who had poor leisure functioning. In other words, there were significance between these two groups. This study suggests that education and the leisure program shoud developed and applied for the higher leisure functioning and satisfaction of the elderly (especially elderly in nursing home).

A Case of Dural Ectasia with Low Back Pain and Sciatica Treated with Integrative Korean Medical Treatment

Kwon, Oh-Hoon,Kim, Sang-Gyun,Park, Ju-Hun,Yoo, Dong-Hwi,Choi, Ki-Hoon,Choi, Ki-Won,Ha, Do-Hyung,Cho, Hyun-Woo Korean AcupunctureMoxibustion Medicine Society 2019 Korean Journal of Acupuncture Vol.36 No.3

Dural ectasia is defined as ballooning or expansion of the dural sac surrounding the spinal cord. This report describes a rare case of low back pain and sciatica, suspected as being dural ectasia. The patient was hospitalized for 45 days, and underwent integrative Korean medical treatment, including pharmacopuncture, acupuncture, herbal medicine, Chuna therapy, cupping therapy, and physiotherapy. The effect of the treatment was evaluated using the numerical rating scale, Oswestry disability index, European quality of life 5 dimensions, and subjective symptoms. After inpatient treatment, the pain the patient experienced was significantly reduced and the evaluation indices improved. This case report suggested that integrative Korean medical treatment could be an effective therapeutic choice for low back pain and sciatica, with dural ectasia. Further clinical studies are needed to support this observation.