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Thermoset polyester droplet-based microfluidic devices for high frequency generation
Kim, Jin-young,deMello, Andrew J.,Chang, Soo-Ik,Hong, Jongin,O'Hare, Danny Royal Society of Chemistry 2011 Lab on a chip Vol.11 No.23
<P>The vast majority of droplet-based microfluidic devices are made from polydimethylsiloxane (PDMS). Unfortunately PDMS is not suitable for high frequency droplet generation at high operating pressure due to its low shear modulus. In this paper, we report the fabrication and testing of microfluidic devices using thermoset polyester (TPE). The optical characteristics of the fabricated devices were assessed and substrate resistance to pressure also investigated. TPE devices bonded using an O<SUB>2</SUB> plasma treated PET substrate at 76 °C were shown to function efficiently at pressures up to 18 MPa. TPE material retains many of the attractive features of PDMS such as ease of fabrication but significantly, has superior mechanical properties. The improved resistance of TPE to high pressures enabled investigation of high frequency droplet generation as a function of a wide range of flow-rates with three different oils as continuous phase.</P> <P>Graphic Abstract</P><P>Droplet-based microfluidic devices to withstand high pressure have been successfully fabricated using thermoset polyester (TPE) materials for high frequency generation of droplets. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1lc20603f'> </P>
Disrupted network cross talk, hippocampal dysfunction and hallucinations in schizophrenia
Hare, Stephanie M.,Law, Alicia S.,Ford, Judith M.,Mathalon, Daniel H.,Ahmadi, Aral,Damaraju, Eswar,Bustillo, Juan,Belger, Aysenil,Lee, Hyo Jong,Mueller, Bryon A.,Lim, Kelvin O.,Brown, Gregory G.,Preda Elsevier 2018 Schizophrenia Research Vol.199 No.-
<P><B>Abstract</B></P> <P>Hallucinations characterize schizophrenia, with approximately 59% of patients reporting auditory hallucinations and 27% reporting visual hallucinations. Prior neuroimaging studies suggest that hallucinations are linked to disrupted communication across distributed (sensory, salience-monitoring and subcortical) networks. Yet, our understanding of the neurophysiological mechanisms that underlie auditory and visual hallucinations in schizophrenia remains limited.</P> <P>This study integrates two resting-state functional magnetic resonance imaging (fMRI) analysis methods – amplitudes of low-frequency fluctuations (ALFF) and functional network connectivity (FNC) – to explore the hypotheses that (1) abnormal FNC between salience and sensory (visual/auditory) networks underlies hallucinations in schizophrenia, and (2) disrupted hippocampal oscillations (as measured by hippocampal ALFF) beget changes in FNC linked to hallucinations. Our first hypothesis was supported by the finding that schizophrenia patients reporting hallucinations have higher FNC between the salience network and an associative auditory network relative to healthy controls. Hippocampal ALFF was negatively associated with FNC between primary auditory cortex and the salience network in healthy subjects, but was positively associated with FNC between these networks in patients reporting hallucinations. These findings provide <I>indirect</I> support favoring our second hypothesis. We suggest future studies integrate fMRI with electroencephalogram (EEG) and/or magnetoencephalogram (MEG) methods to <I>directly probe</I> the temporal relation between altered hippocampal <I>oscillations</I> and changes in cross-network functional communication.</P>
( Raphael Trouillon ),( Danny O`hare ),( Soo Ik Chang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.11
Nitric oxide (NO) is a critical biological mediator involved in numerous diseases. However, the short lifetime of this molecule in biological conditions can make its study in situ complicated. Here, we review some recent results on the role of NO in angiogenesis, obtained using a biocompatible microelectrode array. This simple system allowed for the quick and easy quantification of NO released from cells grown directly on the surface of the sensor. We have used this technology to demonstrate that angiogenin induces NO release, and to partially elucidate its intracellular transduction pathway. [BMB reports 2011; 44(11): 699-704]
Ok, Kang Min,O'Hare, Dermot,Smith, Ronald I,Chowdhury, Mohammed,Fikremariam, Hanna American Institute of Physics 2010 Review of scientific instruments Vol.81 No.12
<P>The design and testing of a new large volume Inconel pressure cell for the in situ study of supercritical hydrothermal syntheses using time-resolved neutron diffraction is introduced for the first time. The commissioning of this new cell is demonstrated by the measurement of the time-of-flight neutron diffraction pattern for TiO(2) (Anatase) in supercritical D(2)O on the POLARIS diffractometer at the United Kingdom's pulsed spallation neutron source, ISIS, Rutherford Appleton Laboratory. The sample can be studied over a wide range of temperatures (25-450 °C) and pressures (1-355 bar). This novel apparatus will now enable us to study the kinetics and mechanisms of chemical syntheses under extreme environments such as supercritical water, and in particular to study the crystallization of a variety of technologically important inorganic materials.</P>
Monolithic nano-porous polymer in microfluidic channels for lab-chip liquid chromatography
Kim Jin-young,O’Hare Danny 나노기술연구협의회 2018 Nano Convergence Vol.5 No.19
In this paper, a nano-porous polymer has been integrated into the microfluidics device as on-chip monolithic liquid chromatography column for separation of chemical and biological samples. Monolithic nano-porous polymer (MNP) was formed and firmly grafted on the surface of the microfluidic channel. Neurotransmitters, 5-hydroxyindole-3-acetic acid (5-HIAA) and 5-hydroxytryptamine (serotonin, 5-HT), were successfully separated with the developed on-chip MNP column.
Angiogenin induces nitric oxide release independently from its RNase activity
Trouillon, Raphaë,l,Kang, Dong-Ku,Chang, Soo-Ik,O'Hare, Danny Royal Society of Chemistry 2011 Chemical communications Vol.47 No.12
<P>Nitric oxide (NO), a biological mediator involved in vascular physiology, was sensed electrochemically using a microelectrode array. Angiogenin was shown to trigger nitric oxide synthase (NOS) activity in human umbilical vein endothelial cells and embryonic stem cell derived endothelial cells independently from its RNase activity.</P> <P>Graphic Abstract</P><P>Angiogenin induced NO release was sensed electrochemically using a microelectrode array. This phenomenon is independent from angiogenin RNase activity. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc04527f'> </P>