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RISS 인기검색어
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- 저자 : Muhammad IRFAN (검색결과 154 건)
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REVIEW : Open Access ; Peste des petits ruminants in Pakistan; past, present and future perspectives
( Muhammad Abubakar ),( Muhammad Irfan ),( Shumaila Manzoor ) 한국동물자원과학회(구 한국축산학회) 2015 한국축산학회지 Vol.57 No.32
Peste des petits ruminants (PPR) is considered to be one of the main constraints to enhancing the productivity of goats and sheep in regions where it is present and becoming endemic. PPR was recognized in Pakistan in early 1990s but got importance during the Participatory Disease Surveillance (PDS) of Rinderpest Eradication Campaign. Lot of research work has been initiated during last decade towards disease epidemiology, risk factor recognition, laboratory diagnosis, vaccination and demonstration of control strategies. Although there are ongoing projects working towards the progressive control of the disease in country yet there is need to have a national level control program for PPR. Also there is need to have comprehensive social economic surveys, disease hot spot recognition and identification of role of other species in disease transmission. With combined efforts of local and national authorities and political will, there is high likelihood that this devastating disease can be controlled and eventually eradicated in near future.
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Morphology of Iron and Agglomeration Behaviour During Reduction of Iron Oxide Fines
Muhammad Irfan Ahadian Barustan,Sung‑Mo Jung 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4
The morphology of iron and agglomeration behaviour in the reduction progress of iron oxide fi nes were investigated interms of isothermal reduction at 800 °C in an atmosphere of CO and H 2 . Agglomeration index was employed to evaluate theagglomeration behaviour during reduction. Sticking and agglomeration occurred regardless of the iron oxides and reducingatmosphere. Reduction by CO showed a higher tendency for sticking due to the formation of iron whiskers. The addition ofCaO and MgO to Fe 2 O 3 in sintering process could improve the reduction, and also decrease the sticking by forming calcio/magnesio-wustite on the surface. Iron whiskers were still formed with the addition of CaO and MgO, and the shape of whiskerswere diff erent from that of pure Fe 2 O 3 . Uniform coating layer on the surface of particles might be one of the importantfactors aff ecting the decrease in sticking between particles.
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Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases
Irfan, Muhammad,Kim, Minki,Rhee, Man Hee The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.1
Cardiovascular diseases prevail among modern societies and underdeveloped countries, and a high mortality rate has also been reported by the World Health Organization affecting millions of people worldwide. Hyperactive platelets are the major culprits in thrombotic disorders. A group of drugs is available to deal with such platelet-related disorders; however, sometimes, side effects and complications caused by these drugs outweigh their benefits. Ginseng and its nutraceuticals have been reported to reduce the impact of thrombotic conditions and improve cardiovascular health by antiplatelet mechanisms. This review provides (1) a comprehensive insight into the available pharmacological options from ginseng and ginsenosides (saponin and nonsaponin fractions) for platelet-originated cardiovascular disorders; (2) a discussion on the impact of specific functional groups on the modulation of platelet functions and how structural modifications among ginsenosides affect platelet activation, which may further provide a basis for drug design, optimization, and the development of ginsenoside scaffolds as pharmacological antiplatelet agents; (3) an insight into the synergistic effects of ginsenosides on platelet functions; and (4) a perspective on future research and the development of ginseng and ginsenosides as super nutraceuticals.
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Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases
Muhammad Irfan,김민기,Man Hee Rhee 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.1
Cardiovascular diseases prevail among modern societies and underdeveloped countries, and a highmortality rate has also been reported by the World Health Organization affecting millions of peopleworldwide. Hyperactive platelets are the major culprits in thrombotic disorders. A group of drugs isavailable to deal with such platelet-related disorders; however, sometimes, side effects and complicationscaused by these drugs outweigh their benefits. Ginseng and its nutraceuticals have been reported toreduce the impact of thrombotic conditions and improve cardiovascular health by antiplatelet mechanisms. This review provides (1) a comprehensive insight into the available pharmacological options fromginseng and ginsenosides (saponin and nonsaponin fractions) for platelet-originated cardiovasculardisorders; (2) a discussion on the impact of specific functional groups on the modulation of plateletfunctions and how structural modifications among ginsenosides affect platelet activation, which mayfurther provide a basis for drug design, optimization, and the development of ginsenoside scaffolds aspharmacological antiplatelet agents; (3) an insight into the synergistic effects of ginsenosides on plateletfunctions; and (4) a perspective on future research and the development of ginseng and ginsenosides assuper nutraceuticals.
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Antiplatelet Effects of Garlic and Chitosan
Muhammad Irfan,Minki Kim,Hyuk-Woo Kwon,Man Hee Rhee,Hyun-Kyoung Kim 대한의생명과학회 2018 Biomedical Science Letters Vol.24 No.3
The incidence of cardiovascular diseases (CVDs) is increasing rapidly in developed countries, with CVDs now representing the leading cause of morbidity and mortality. Natural products and ethnomedicines have been shown to reduce the risk of CVDs. Garlic is a medicinal plant used throughout the world for its anti-inflammatory, antioxidant, and antiplatelet activities. Chitosan is a natural polysaccharide obtained from chitin, and derivatives of chitosan have been shown to inhibit platelet aggregation and adhesion. We hypothesized that fermented preparations of these products may possess stronger antiplatelet effects than the non-fermented forms owing to the increased bioavailability of the bioactive compounds produced during fermentation. Therefore, we compared these compounds via in vitro and ex vivo platelet aggregation assays by using standard light transmission aggregometry and ex vivo granule secretions from rat platelets. We found that fermented preparations exerted more potent and significant inhibition of platelet aggregation both in vitro and ex vivo. Likewise, ATP release from dense granules of platelets was also significantly inhibited in fermented preparation-treated rat platelets compared to that in non-fermented preparation-treated ones. We concluded that fermented preparations exerted more potent effects on platelet function both in vitro and ex vivo, possibly as a result of the increased bioavailability of active compounds produced during fermentation. We therefore suggest that fermented products may be potent therapeutics against platelet-related CVDs and can be used as antiplatelet and antithrombotic agents.
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Development of EMS mutant populations in Capsicum annuum and identification of non-pungent mutants
Muhammad Irfan Siddique,Koeun Han,Doyeon Hwang,Hee-Jin Jeong,Arti Rai,Byoung-Cheorl Kang 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
Plant breeding requires genetic diversity of useful traits for crop improvement. EMS-induced mutation is practiced to generate mutations at loci regulating economically important traits and/or to knock out the genes to elucidate their functions. The present study was aimed to induce mutations in a Korean local land race Capsicum annuum ‘Yuwol-cho’. This accession is pungent and also has advantage to mature early. A total of about 1,500 M2 families were screened and three non-pungent mutants were identified and crossed with wild type ‘Yuwol-cho’. After phenotyping of F2 population for pungency, MutMap approach will be used to identify the genes controlling the pungency in mutants. In addition to this, another C. annuum accession “Micro-Pep” was used to develop a mutant population. Micro-Pep is a small, pungent pepper generally used as ornamental purpose. Having compact growth habit, and small size, it has advantage to handle and utilize easily in mutation study and molecular research. On the basis of preliminary experiment 1.3% of mutagen was used for treatment of pepper seeds and 30% less germination percentage was observed in EMS treated seeds in comparison to control seeds. A total of 4,674 M1 plants are grown under greenhouse condition and M2 population will be studied for characterization of phenotypic variation including fruit color and pungency. Newly constructed mutant populations will be valuable assets for identification of functional genes and molecular breeding of pepper.
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Muhammad Irfan,Hira Munir,Hammad Ismail 한국생체재료학회 2021 생체재료학회지 Vol.25 No.2
Background: Herein, we first time used the gum Moringa oleifera as reducing and capping agent for successful synthesis of silver nitrate and zinc oxide nanoparticles(NPs) through green synthesis approach. This study was aimed to check antibacterial activities of synthesized NPs against multidrug resistant bacteria methicillin-resistant Staphylococcus aureus (MRSA). Methods: Aqueous solutions of AgNO3 and purified gum powder were mixed with 1:1 ratio, autoclaved at 120oC for 2 min. NPs pellet collected after centrifugation at 10,000 g for 20 min. ZnO NPs were prepared by mixing purified gum powder and metal salt with1:1 ratio, heated (70oC) and stirred at 100 rpm for 4 h followed by centrifugation at 10,000 g for 20 min. Pellet was washed and calcinated at 400oC for 4 h. Antibacterial potential against E. coli, S. aureus and methicillin-resistant Staphylococcus aureus (MRSA) was assessed by widely used Kirby- Bauer antibiotic susceptibility test. Results: Optical observation of colour change from transparent to dark and UV-Visible analysis confirmed the synthesis of NPs. Fourier transform infrared spectroscopy (FTIR) of prepared nonmaterial revealed the characteristic AgNPs and ZnO stretch vibrations at wave number of 523 cm− 1 and 471 cm− 1resectively. Crystalline nature of AgNPs and ZnO NPs was confirmed by x-ray diffraction pattern with clear sharp Peaks. Scanning electron microscopy (SEM) revealed good surface morphology of AgNPs and ZnO NPs with 50nm and 60nm size respectively. AgNPs and ZnO NPs exhibited excellent antibacterial activity against E. coli (with zone of inhibition of 21 ± 02mm and 22 ± 03mm) and S.aureus ( with zone of inhibition of 20 ± 03mm and 21 ± 02mm) while good activity was observed against “super bug” methicillin-resistant Staphylococcus aureus (MRSA) with 16 ± 03mm ad 17 ± 02mm zone if inhibitions respectively. Conclusions: This novel addition of Moringa Gum based nanoparticles will open new dimensions in the field of nanomedicine and pharmaceutics especially against MDR bacterial strains.
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