달 탐사선의 발사 요구조건 및 임무궤도 사례연구

석병석(Suk, Byong-suk),민승용(Min, Seung-yong),권재욱(Kwon, Jae-wook),김창균(Kim, Chang-kyoon),문상만(Moon, Sang-man),최수진(Choi, Su-jin),구철회(Koo, Cheol-hea),김인규(Kim, In-kyu),류동영(Ryu, Dong-young) 한국항공우주연구원 2015 항공우주산업기술동향 Vol.13 No.2

시험용 달 궤도선의 발사 요구조건 사전 분석 단계로 최근 외국에서 발사한 달 탐사선의 발사 요구조건을 분석하였다. 일반적으로 달 탐사선의 발사 요구조건은 달 임무 궤도를 결정하는 중요한 요소이며, 또한 지구, 달, 태양의 상대적인 운동으로 인해 임무궤도 요구조건을 만족하는 발사 가능 시간이 주기적으로 반복되는 경향이 있다. 분석 결과 설정된 발사 요구조건들로부터 달 궤도선의 주 임무가 달의 남/북극 지역의 광학 관측 임을 간접적으로 알 수 있었다. 향후 우리나라 달 궤도선 발사 요구 조건 설정에 본 논문이 도움이 되길 기대한다. In the preliminary study on launch window requirement for Korea Path-finder Lunar Orbiter(KPLO), the recent foreign lunar orbiter’s lauch window requirement was analyzed. Normally, the launch requirements depends on the mission orbit. Based on the relationship between Moon, Earth, and Sun, the launch time will be available periodically to meet requirements. In this paper, it is understood that the launch window requirements come from payload mission requirements to take picture each poles of Moon. This paper might be a practical example to derive KPLO launch requirements in the future.

Malignant proliferating trichilemmal tumor: A rare case showing metastasis to multiple organ

( Sang Jin Cheon ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Hoon Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Malignant proliferating trichilemmal tumor (MPTT) is a rare neoplasm derived from the outer sheet of hair follicle. These tumors are almost benign, and are often cystic, characterized by trichilemmal keratinization. However, at times, the tumor has an aggressive clinical course. 4 years ago, a 73-year-old man admitted to our department after wide excision surgery. 7 years ago, well-defined subcutaneous nodule appeared on left buttock. So he had undergone a wide excision surgery at local clinic. On histopathologic exam, MPTT was diagnosed and then transferred to our department. In abdomen CT showed ipsilateral inguinal lymph node enlargement and confirmed metastasis of MPTT in left inguinal lymph node by biopsy. So left lymph node dissection was done. After 1 month, subcutaneous nodule appeared post operative site so reoperated by Mohs micrographic surgery to clarify clear surgical margin. After surgery, the patient followed up for 3 months apart. But 3 months ago, erythematous plaque was appeared on left cheek, left palm and 4th fingertip respectively. All of them revealed meatastasis of MPTT by histopathologic exam. Eventually, He transferred hematooncology department, being treated with cisplatin and 5-fluorouracil combination chemotherapy. Our case showed prior incomplete surgical excision of MPTT could induce aggressive clinical course and reinforce importance of complete surgical excision to prevent recurrence and metastasis.

Five-Year Clinical Outcomes of Copeptin in patient with ST elevation Acute Myocardial I nfarction

( Moon Ki Jung ),( Jee Eun Kwon ),( Seong Hyeop Hyeon ),( Young Kim ),( Hoyoun Won ),( Seung Yong Shin ),( Wang Soo Lee ),( Kwang Je Lee ),( Sang Wook Kim ),( Tae Ho Kim ),( Chee Jeong Kim ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

We collected 111 coronary arterial blood samples at the coronary artery ostium during primary percutaneous coronary intervention(PCI) in STEMI and assessed the clinical outcomes depending on Copeptin. We evaluated cardiac biomarkers[CK, CK-MB, troponin-I, CRP] and additionally measured the recently introduced biomarkers [Copeptin(C-terminal Provasopressin), N-terminal pro-B-type natriuretic peptide(NT-proBNP)]. Intravascular ultrasound (IVUS) imaging was performed before and after stent implantation during primary PCI. Results: Pt age was 59±12 yrs and 86% were male. STEMI pts had a higher copeptin level than normal pts(243.31±169.68 pmol/L in vs 18.14±6.17 pmol/L, p=0.010). NT-proBNP was not correlated with copeptin (r=0.183, p=0.085). IVUS analysis of the culprit lesion showed the ruptured plaque in 47%(40/86 pts). VH-TCFA was identified in 36 patients, however, the mean copeptin level was similar compared to non-VH-TCFA pts(292.62±199.77 pmol/L vs 240.78±189.46 pmol/L, p=0.328). In hospital death occurred in 7 pts who showed higher Copeptin level than survivors. All were due to cardiogenic shock after primary PCI. The level of Copeptin was higher in-hospital death group than survivor(382.7±263 pmol/L vs. 211.3±127 pmol/L, p=0.0001). The clinical outcomes was worse in pts with Copeptin ≥300 pmol/L during five years follow up (p=0.046). Conclusions: Stress stimulated Copeptin might be one of the prognostic marker in long-term outcomes of STEMI. Thepotential role of Copeptin deserves to confirm with a further study.

Lentigo maligna melanoma: single centre experience focusing on the differentiation from other clinically similar pigmented disorders

( Sang Jin Cheon ),( Jeong Min Kim ),( Gun Wook Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Lentigo maligna melanoma (LMM) is a raresubtype of melanoma in Korea and usually found on elderly face. In early stage, it is difficult to differentiate from other facial pigmented lesions including senile lentigo, lichen planus-like keratosis, and pigmented actinic keratosis. But till now, report on the characteristic of LMM is not sufficient. Objectives: To find the characteristics of clinical and dermoscopic features LMM in Korea. Methods: Twelve patients with histopathology-proven LMMs were analyzed retrospectively based on their clinical and dermoscopic photos, medical records, and pathologic findings. As controls, senile lentigo (n=12), lichen planus-like keratosis (n=12), and pigmented actinic keratosis (n=12) were also analyzed.Results: Of 12 LMM, 9 were women and 3 were men. The mean age was 68 years (range 36-88) . The lesion was predominantly on the cheek (50%), followed by periorbital (33%) and temporal area (16%). Most (66 %) of lesions showed smooth surface. According to Stolz``s criteria of LMM, asymmetric hyperpigmented follicular opening (66%) was the most common followed by annular-granular pattern (55%), and rhomboidal structure (55%). Also, 55% of lesions presented an increased density of vascular structure Conclusion: The results of this study could be helpful clue to differentiate LMM in Korea from other clinically similar and common skin disorders including senile lentigo, lichen planus-like keratosis, and pigmented actinic keratosis.

Clinical characteristics of psoriatic arthritis among patients with psoriasis visiting PNUH

( Sung Min Park ),( Jeong Min Kim ),( Gun Wook Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Byung Soo Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: The prevalence and clinical characteristics of psoriatic arthritis (PsA) in patients with psoriasis were known to have ethnic variation. However limited data exist on psoriatic arthritis in Korean psoriasis patients. Objectives: To investigate the clinical characteristics of PsA in Korean patients with psoriasis Methods: Patients diagnosed with psoriatic arthritis between 2011 and 2015 at Pusan National University Hospital were included. Clinical characteristics of psoriasis/PsA, comorbidities, and treatment patterns were assessed via physical examination and medical records. Results: Of 29 psoriasis patients diagnosed as PsA, 20were male, 9 female (ratio 2.2:1), and mean age was 46.5 years. Diabetes, hypertension, hyperlipidemia were more common in PsA patients compared with general population. Asymmetric oligoarthritis pattern was the most common manifestation of PsA. Nail change, scalp and intergluteal involvement were found in 72.4%, 86.2% and 53.8% respectively. Methotrexate was the most common treatment modality to treat psoriasis and PsA, followed by non-steroidal anti-inflammatory drugs, biologics, and sulfasalazine. Conclusion: Our study presents the detailed clinical characteristics of PsA in Korean psoriasis patients. These results were similar with previous report in the Korea, but asymmetric oligoarthritis pattern was more common in present study.

Two cases of pigmented neurofibroma with hypertrichosis

( Sang Jin Cheon ),( Hyun Ju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Hoon Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Pigmented neurofibroma (PNF) is a rare variant of tumor consisting neurofibroma with melanin-laden pigmented cells. Rarely, there has been reported PNF with hypertrichosis. In that case, differential diagnoses of smooth muscle harmatoma and combined with Becker’s nevus are required. Case 1, a 29-year-old man presented with localized brownish plaque with hypertrichosis on the left side of forehead. In physical examination, 15x15cm size, well-defined brownish plaque with excessive terminal hair on the left side of forehead. On histopathologic finding, the hair follicles were abundant in the dermis and the spindle cell proliferation with wavy nuclei were detected within deep reticular dermis. Spindle cells were positive for S-100 and also showing positive to melan-A melanin-laden cells were scattered. Case 2, 7-year-girl presented with solitary palpable mass in subcutis and brownish patch with hypertrichosis on the left shin. Also on histologic exam, revealed prominent hair follicle, spindle cell proliferation and scattered melanin-laden cells were observed. Both patients, the diagnosis of PNF with hypertrichosis was made by distinctive histopathologic findings. Herein, we experience two cases of PNF with hypertrichosis. This will be helpful understanding distinctive histopathologic finding of PNF with hypertrichosis.

Epidermal nevus with Meyerson phenomenon

( Sang Jin Cheon ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Since Meyerson first described a peculiar eczematous halo surrounding acquired melanocytic nevi in 1971, Meyerson phenomenon was reported in numerous cutaneous diseases such as benign melanocytic nevi, seborrheic keratosis, molluscum contagiosum, dermatofibroma, keloid, insect bites, capillary malformation and basal cell carcinoma. Currently, the mechanism of pathogenesis in Meyerson phenomenon is still not elucidated. An 8-month-old male infant presented yellowish to brownish verrucous plaque on left upper back with surrounding woozy erythematous patch.There was a complaint of mild itching over the lesion occasionally. Histopathological finding from verrucous plaque in center of the lesion showed hyperkeratosis, papillomatosis, and acanthosis. Simultaneously, spongiosis of epidermis and superficial perivascular lymphocytic infiltration in upper dermis was shown from erythematous patch of peripheral lesion. Based on the clinicopathologic finding, diagnosis of epidermal nevus with Meyerson phenomenon was made.After 1 month, surrounded eczema resolved spontaneously and epidermal nevus was completely excised. To our best knowledge, it has not been reported an epidermal nevus as preexisting lesion on the Meyerson phenomenon in dermatologic literature. Herein, we report a unique case of Meyerson phenomenon surrounding epidermal nevus.

Protective Effect of Irradiated Renal Carcinoma Expressing Hepatitis B Surface Antigen Against Renal-Cell Carcinoma-Mediated Tumors

Moon, Yuseok,Cho, Seok Goo,Lee, Jong Wook,Min, Woo Sung,Kim, Chun Choo,Lee, Hae-Kyung,Kim, Yong-Goo,Chang, Hong Seok,Chae, Hyun Seok,Kim, Ho-Youn,Tani, Kenzaburo Mary Ann Liebert 2006 Cancer biotherapy & radiopharmaceuticals Vol.21 No.3

<P>Radiation therapy and chemotherapy have little effect on renal-cell carcinomas (RENCAs). We investigated the effect of the tumor vaccination strategy on preventing tumor formation after a challenge with RENCA. The hepatitis surface antigen (HBsAg) was used to enhance the antitumor immunity and tumor vaccination efficiency. RENCA cells expressing HBsAg (RENCA/HBS) were completely susceptible to HBsAg vaccination, which implies that HBsAg vaccination induces specific antitumor immunity against HBsAg- expressing cancer cells. As with HBsAg vaccination, vaccination with irradiated RENCA/HBS retarded tumor formation following a RENCA/HBS challenge. After HBsAg vaccination, the irradiated RENCA/HBS tumor vaccine completely prevented the tumor formation by RENCA/HBS. Tumor vaccination with irradiated RENCA/HBS (5 x 10(4) cells), but not with RENCA, reduced the tumor rate after a challenge with 5 x 10(6) RENCA cells, whereas a lower tumor load was overcome by the RENCA vaccination alone. These results confirm the postulate that RENCA/HBS vaccination elicits an antitumor immune response to some putative antigens or enhances the general immune competence in immunosuppressed renal tumor patients.</P>

Clinical Comparison for Colon Polyps between Right and Left Colon in Koreans

( Wook Hyun Um ),( Hyun Gun Kim ),( Seong Ran Jeon ),( Tae Hee Lee ),( Wan Jung Kim ),( Bong Min Ko ),( Jin Oh Kim ),( Joo Young Cho ),( Joon Seong Lee ),( Moon Sung Lee ) 대한장연구학회 2012 Intestinal Research Vol.10 No.4

Background/Aims: Comparative studies of colon polyps between right and left colon in Korean population are limited. We investigated the clinical characteristics of the patients according to polyp location and compared the results of the morphological and histological analysis of right and left colon polyps. Methods: The study was performed prospectively for the patients who underwent colon polypectomy for health check-ups in a single tertiary center. The patients were classified into three groups by the location of the polyps: right group (from the cecum to the splenic flexure), left group (from the descending colon to the anus), and total group. The size, the morphology, the location and the pathology of the polyps were evaluated. Results: From June 2010 to June 2011, Overall 2596 polyps from 950 patients (male=646) were analyzed. Colon polyps were right side-shift with increased patients age (P<0.001). The incidence of polyps was most common in sigmoid colon (26.5%). Polyps less than 5 mm size were more common in left colon (P<0.001) and flat polyps larger than 1 cm in right colon (P=0.006), respectively. In histopathological findings, the distribution of advanced adenoma was not different according to the location, however tubular adenomas and serrated adenomas (P<0.001) were more common in right colon. Female was more distributed in right group, respectively (P<0.001). Conclusions: In a single center study, colon polyps were more distributed in right colon with age and in females. Also flat polyps larger than 1cm, tubular adenoma and serrated adenoma were found in larger proportion in right colon. (Intest Res 2012;10:372-378)

Wideband and wide-view circular polarizer for a transflective vertical alignment liquid crystal display.

Moon, Je-Wook,Kang, Wan-Seok,Han, Hag yong,Kim, Sung Min,Lee, Seung Hee,Jang, Yong gyu,Lee, Chul Heon,Lee, Gi-Dong Optical Society of America 2010 Applied optics Vol.49 No.20

<P>We propose an optical configuration for a transflective mode with a circular polarizer for the vertical alignment liquid crystal cell, which can show the wideband property of high contrast in oblique incidence. The proposed configuration consists of a biaxial film and two uniaxial films for satisfying both the transmissive and the reflective modes. Optimization of the optical configuration of the circular polarizer has been performed on the Poincaré sphere in the entire visible wavelength range using the Stokes vector and the Mueller matrix method. We also verify the excellent optical characteristics of the proposed configuration by comparing the viewing angle and contrast ratio in the oblique direction with a conventional optical configuration in calculation.</P>