Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

Kaba, Mehmet,Pirincci, Necip,Benli, Erdal,Gecit, Ilhan,Gunes, Mustafa,Yuksel, Mehmet Bilgehan,Tok, Adem,Kemik, Ahu Sarbay Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.

Pinch-Off Syndrome, a Rare Complication of Totally Implantable Venous Access Device Implantation: A Case Series and Literature Review

Burak Mehmet Ilhan,İsmail Cem Sormaz,Rüştü Türkay 대한흉부외과학회 2018 Journal of Chest Surgery (J Chest Surg) Vol.51 No.5

Background: Pinch-off syndrome (POS) is a rare complication after totally implantable venous access device (TIVAD) implantation. In cancer patients, it is important to prevent this rare complication and to recognize it early if it does occur. We present a case series of POS after TIVAD implantation and the results of a literature search about this complication. Methods: From July 2006 to December 2015, 924 permanent implantable central venous catheter implantation procedures were performed. The most common indication was vascular access for chemotherapy. Results: POS occurred in 5 patients in our clinic. Two patients experienced POS within 2 weeks, and the other 3 patients were admitted to department of surgery, Istanbul Faculty of Medicine at 6 to 14 months following implantation. The catheters were found to be occluded during medication administration, and all patients complained of serious pain. The transected fragments of the catheters had migrated to the heart. They were successfully removed under angiography with a single-loop snare. Conclusion: POS is a serious complication after TIVAD implantation. It is important to be aware of this possibility and to make an early diagnosis in order to prevent complications such as drug extravasation and occlusion events.

Serum Levels of Trace Elements in Patients with Prostate Cancer

Kaba, Mehmet,Pirincci, Necip,Yuksel, Mehmet Bilgehan,Gecit, Ilhan,Gunes, Mustafa,Ozveren, Huseyin,Eren, Huseyin,Demir, Halit Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Background: Trace elements are major components of biological structures; however, excessive levels of these elements can be toxic. Materials and Methods: In the present study, serum levels of trace elements were measured in 30 patients with newly diagnosed as prostate cancer and 32 healthy volunteer by using furnace atomic absorption spectrophotometry. Results: It was found that there was an increase in serum levels of Co, Cu, Mg and Pb (p<0.05), whereas a decrease in serum levels of Fe, Mn, and Zn levels in patients with prostate cancer (p<0.05). Conclusions: These changes may be important in the pathogenesis of prostate cancers; however, further prospective studies are needed to identify relationships between prostate cancer and trace elements.

Haptoglobin Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

Pirincci, Necip,Gecit, Ilhan,Gunes, Mustafa,Kemik, Ahu Sarbay,Yusel, Mehmet Bilgehan,Kaba, Mehmet,Ceylan, Kadir,Aslan, Mehmet Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Although alteration in the haptoglobin phenotype has been reported in patients with bladder cancer, serum haptoglobin levels have not been evaluated. We hypothesized that serum haptoglobin can be used as a biomarker. The aim of this study was to evaluate the expression of haptoglobin in bladder cancer and to determine the relationship with clinicopathological features. A total of 68 serum specimens obtained before surgery were used to investigate haptoglobin expression using the sandwich ELISA technique. Serum haptoglobin levels were higher in the patients with bladder cancer compared to healthy controls (p<0.0001). Additionally, the levels of haptoglobin protein increased with increasing tumor grades (p<0.001) and were significantly higher in patients with metastatic disease and the presence of lymphovascular involvement, lymph node metastases and increasing tumor burden (p<0.0001). This study suggests that elevated haptoglobin levels are associated with a higher stage, grade, and extent of distant metastasis and larger tumor size. Haptoglobin may therefore provide a useful diagnostic and treatment biomarker for patients with bladder cancer.

Intramural hematomas of the gastrointestinal system

Osman Kones,Ahmet Cem Dural,Murat Gonenc,Mehmet Karabulut,Cevher Akarsu,Ilhan Gok,M. Abdussamet Bozkurt,Mehmet Ilhan,Halil Alıs 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.85 No.2

Purpose: Although spontaneous intramural hematomas of the gastrointestinal tract are very rare, they may be observed with the use of oral anticoagulant, though less frequently in cases of hematological malignancy and other bleeding disorders. Cases diagnosed as spontaneous intramural hematoma have been assessed in our clinic. Methods: The cases, which were diagnosed as spontaneous intramural hematoma in the gastrointestinal tract (SIHGT) following anamnesis, physical examination, biochemical, radiological and endoscopic findings from July 2008 to July 2012, have been assessed retrospectively. Results: Seven out of 13 cases were women and the mean age was 65.1 years (34 to 82 years). The most frequent complaint on admission was abdominal pain. The most frequent location of SIHGT was the ileum (n = 8). Oral anticoagulant use was the most common cause of etiology (n = 12). In 10 cases, International normalized ratio values were higher than treatment range (2 to 3, where mechanical valve replacement was 2.5 to 3.5) and mean value was 7.6 (1.70 to 23.13). While 12 cases were discharged without problems with medical treatment, one case with acute myeloid leukemia died in the intensive care unit following cerebrovascular attack. Conclusion: Spontaneus bleeding and hematomas that may arise in connection with bleeding diathesis may be fatal in cases with long-term oral anticoagulant treatment and insufficient follow-up. In management of these cases, it may be necessary to arrange conservative follow up and/or initialize low molecular weight heparin, and administer vitamin K as well as replace blood products and coagulation factors when indicated.

Analysis of aerodynamic characteristics of 2 MW horizontal axis large wind turbine

Ilhan, Akin,Bilgili, Mehmet,Sahin, Besir Techno-Press 2018 Wind and Structures, An International Journal (WAS Vol.27 No.3

In this study, aerodynamic characteristics of a horizontal axis wind turbine (HAWT) were evaluated and discussed in terms of measured data in existing onshore wind farm. Five wind turbines (T1, T2, T3, T4 and T5) were selected, and hub-height wind speed, $U_D$, wind turbine power output, P and turbine rotational speed, ${\Omega}$ data measured from these turbines were used for evaluation. In order to obtain characteristics of axial flow induction factor, a, power coefficient, $C_p$, thrust force coefficient, $C_T$, thrust force, T and tangential flow induction factor, a', Blade Element Momentum (BEM) theory was used. According to the results obtained, during a year, probability density of turbines at a rotational speed of 16.1 rpm was determined as approximately 45%. Optimum tip speed ratio was calculated to be 7.12 for most efficient wind turbine. Maximum $C_p$ was found to be 30% corresponding to this tip speed ratio.

Analysis of aerodynamic characteristics of 2 MW horizontal axis large wind turbine

Akin Ilhan,Mehmet Bilgili,Besir Sahin 한국풍공학회 2018 Wind and Structures, An International Journal (WAS Vol.27 No.3

In this study, aerodynamic characteristics of a horizontal axis wind turbine (HAWT) were evaluated and discussed in terms of measured data in existing onshore wind farm. Five wind turbines (T1, T2, T3, T4 and T5) were selected, and hub-height wind speed, UD, wind turbine power output, P and turbine rotational speed, Ω data measured from these turbines were used for evaluation. In order to obtain characteristics of axial flow induction factor, a, power coefficient, Cp, thrust force coefficient, CT, thrust force, T and tangential flow induction factor, a', Blade Element Momentum (BEM) theory was used. According to the results obtained, during a year, probability density of turbines at a rotational speed of 16.1 rpm was determined as approximately 45%. Optimum tip speed ratio was calculated to be 7.12 for most efficient wind turbine. Maximum Cp was found to be 30% corresponding to this tip speed ratio.

Clinical Efficacy of Hormonal and Nonhormonal Agents in the Treatment of Vulvovaginal Atrophy

( Gokcen Ilhan ),( Mehmet Musa Aslan ),( Arif Serhan Cevrioglu ),( Muzaffer Yıldırım ),( Unal Erkorkmaz ) 대한폐경학회 2021 대한폐경학회지 Vol.27 No.1

Objectives: Symptomatic local treatment of vaginal atrophy (VA) in menopausal women includes hormonal and nonhormonal preparations. Some women may be reluctant to use vaginal estradiol preparations because of the concern for developing breast cancer and endometrial hyperplasia. Therefore, it is necessary to compare the therapeutic effectiveness of alternative vaginal drugs, such as promestriene, an estrogen agonist, and sodium hyaluronate (NaH), a nonhormonal, water-based agent. Methods: Ninety-one postmenopausal women diagnosed with symptomatic VA were divided into three groups and treated for 12 weeks; 30 women with vaginal estradiol (VE), 30 women with promestriene, and 31 women with NaH. Composite scoring, vaginal maturation index (VMI), pH, frequency of sexual activity, serum hormone levels, and endometrial thickness were evaluated VA before and after treatment. Results: In the comparison of VA examination findings composite scoring, VMI, and vaginal pH values, three different drugs were found to be effective in the treatment (P < 0.05). The VMI following VE treatment was significantly higher than that after NaH treatment (P = 0.031), whereas the promestriene group had a more positive change than the others in terms of increase in after treatment composite scoring and sexual activity frequency (P = 0.031, P = 0.020). There were no differences between the groups in terms of pre and after treatment serum E2 levels and endometrial thickness. Conclusions: Based on these findings, we can conclude that the use of promestriene or NaH can prove to be as effective and well tolerated as vaginal estradiol in the symptomatic treatment of vaginal atrophy.

Levels of Serum Trace Elements in Renal Cell Carcinoma Cases

Pirincci, Necip,Gecit, Ilhan,Gunes, Mustafa,Kaba, Mehmet,Tanik, Serhat,Yuksel, Mehmet Bilgehan,Arslan, Harun,Demir, Halit Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Trace elements which are essential components of biological structures may also be toxic when present at levels above the amounts required for biological function. In our study, trace element levels were measured with furnace atomic absorption spectrophotometry in 33 newly diagnosed renal cell carcinoma cases (preoperative) and 32 healthy controls. When compared with the control group, it was found that the levels of cadmium (Cd), lead (Pb) were higher and the levels of zinc (Zn), iron (Fe) and manganese (Mn) were lower in the patient group. These changes may be important in the formation of renal cell carcinoma, a question which should be explored with postoperative comparative studies.

Effect of Septoplasty on Voice Quality: A Prospective-Controlled Trial

Safak Gulec,Ismail Kulahli,Mehmet Ilhan Sahin,Kerem Kokoğlu,Murat Salih Gunes,Deniz Avci,Turan Arli 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.3

Objectives. The purpose is to investigate effect of septoplasty and widened nasal patency on voice quality. Methods. Fifty patients who undergone septoplasty were included in the study. Thirty-three people who had similar age and distribution were enrolled as control group. Before and 1 and 3 months after surgery, anterior rhinomanometry, voice analysis by Multi-Dimensional Voice Program, and spectrographic analysis were performed to patients. The recordings of /a/ vowel were used to evaluate average fundamental frequency (F0), jitter percent, and shimmer percent. In spectrographic analyses, F3–F4 values for the vowels /i, e, a, o, and u/, nasal formant frequencies of the consonants /m/ and /n/ in the word /mini/, and 4 formant frequencies (F1, F2, F3, and F4) for nasalized /i/ vowel following a nasal consonant /n/ in the word /mini/ were compared. The differences in nasal resonance were evaluated. All patients were asked whether change in their voices after the surgery. Preoperative and postoperative voice parameters and anterior rhinomanometry results were compared separately with the control group as well as in the patient group itself. Results. Preoperative total nasal resistance (TNR) values of patients were higher than the control group (P=0.001). TNR values of patients measured one day before surgery and after surgery in the 1st and 3rd months were different and these differences were significant statistically (P=0.001). There was no significant difference between the voice analysis parameters in preoperative, postoperative 1st, and 3rd months. As a result of their subjective reviews, 12 patients (36%) noted their voices were better than before surgery and 20 patients (61%) noted no change before and after surgery. Conclusion. Providing widened nasal cavity has no effect on voice quality.