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Lee, Geum Seon,Yim, Dongsool,Cheong, Jae Hoon,Kang, Tae Jin Informa Healthcare 2012 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Vol.34 No.6
<P>Our previous report showed that Hydnocarpi Semen (HS) extract has wound repair activity at ulcer lesion in diabetic mice. In this study, fractions of <I>n</I>-Hexane, ethylacetate (EtOAc), and butanol (BuOH) from HS crude extract were evaluated for their wound healing activity by using <I>in vivo</I> diabetic ulcer models and <I>in vitro</I> acute inflammation model. Although <I>n</I>-Hexane and EtOAc fractions promote wound healing in mice with ulcer, the BuOH fraction exhibited the most potent wound healing activity and the wound area score significantly decreased after treatment of BuOH fraction even at dose of 2 mg/kg. BuOH fraction stimulated macrophages to increase the production of nitric oxide (NO) and TNF-α. The BuOH fraction also enhanced the production of TGF-β and VEGF, which were involved in fibroblast activation and angiogenesis. The mRNA expression and activation of MMP-9 were increased by three fractions and the activity was higher in BuOH fraction-treated group compared to the other groups. The mechanism that the HS helps to promote healing of diabetic ulcer is possibly associated with the production of TNF-α, a proinflammatory cytokine, as well as the secretion of VEGF, TGF-β, and MMP-9, which were involved in proliferation of capillaries and fibroblasts. These results suggest that HS can be a new candidate material for the treatment of wound in skin ulcer.</P>
Stress related activities of Sun-ginseng in SD Rats and ICR Mice
( Geum Seon Lee ),( Blendyl Saguan Tan Lee ),( Mi Kang Kim ),( Kyung Uoo Dong ),( Joo Yun Kim ),( Gu Young Yu ),( Jeong Sup Han ),( Hong Sook Ko ),( Il Ho Park ),( Jae Hoon Cheong ) 한국응용약물학회 2004 Biomolecules & Therapeutics(구 응용약물학회지) Vol.12 No.4
The Role of the Ethylacetate Fraction from Hydnocarpi Semen in Acute Inflammation In Vitro Model
Lee, Geum Seon,Shim, Hong,Lee, Ki-Man,Kim, Seung Hyun,Yim, Dongsool,Cheong, Jae Hoon,Kang, Tae Jin The Korean Association of Immunobiologists 2012 Immune Network Vol.12 No.6
We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated for their wound healing activity by using in vitro acute inflammation model. GC and GC/MS analysis shows that the main constituents in EtOAc fraction are chaulmoogric acid, hydnocarpic acid, and gorlic acid. EtOAc fraction activated macrophages to increase the production of TNF-${\alpha}$. The fraction also increased the production of TGF-${\beta}$ and VEGF, which induced fibroblast activation and angiogenesis. These results suggest that the mechanism that the fraction helps to enhance healing of skin wound is possibly associated with the production of TNF-${\alpha}$, as well as secretion of VEGF, TGF-${\beta}$ and HS may have a new bioactive material for the treatment of skin wound.
Geum Seon Lee,Tae Jin Kang 대한약학회 2021 약학회지 Vol.65 No.1
Our previous study reported that cuttlebone (CB) extract shows wound healing activity and enhances cell migration. In the present study, we examined the anti-inflammatory effect of CB in RAW 264.7 cells activated with lipopolysaccharide (LPS) for induction of inflammation. The expression of inflammatory mediators, including proinflammatory cytokines, was measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) tests. The results showed that CB suppressed nitric oxide (NO) production in macrophages stimulated with LPS. Production of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNFα), interleukin (IL)-1β, and IL-6, decreased in LPS-induced RAW 264.7 cells after treatment with CB in a dose-dependent manner. Additionally, gene expression was inhibited by CB in a dose-dependent manner in LPS-stimulated macrophages. Furthermore, CB inhibited nuclear factor kappa B (NF-KB) p65 activation in macrophages activated with LPS. Therefore, these results suggest that CB exerts its anti-inflammatory effects via regulation of the NF-KB signaling pathway.
Success and Failure of Surgical Endodontic Treatment in Molar Teeth
Geum, Yun-Seon,Lee, Jang-Ryeol,Kim, Hyeon-Cheol,Lee, Sang-Cheol,Kim, Yeong-Uk Korean Academy of Dental Science 2010 Journal of korean dental science Vol.3 No.2
Despite the latest advancement made in its techniques and devices/apparatuses and the resulting rising expectation in the field of dental surgery, apicoectomy performed in the molar teeth remains a technical challenge and lacks evidence substantiated by long-term follow-up studies. This study sought to investigate the treatment outcomes and post-operative success rate in the root-end resected molar teeth accompanied by a high level of surgical risks due to their close proximity to the mandibular canal and maxillary sinus. A total of 68 patients who received treatment at Livingwell Dental Hospital between 2004 and 2010 and underwent apical surgery in the maxillary or mandibular molar area were enrolled in this study. A total of 160 roots collected from 75 molar teeth were subjected to surgical endodontic treatment and subsequently evaluated clinically as well as radiographically. Based on the results of the study, the clinical success rate was found to be 78.8% in cases involving radiological healing. Likewise, 90.7% of the roots recorded a robust clinical survival rate, but with incomplete healing as shown by radiography. The results indicate that the apical procedure involving molar teeth is a prognosis-friendly method that promises positive outcomes and higher success rate based on long-term follow-up observations.