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Kim, Kyuseok,Ha, Injin,Kim, Eunok,Kim, Kyunglee Williams & Wilkins Co 2017 Medicine Vol.96 No.45
<P><B>Abstract</B></P><P>Acne is a multifactorial dermatosis, which is influenced not only by hormones but also by the biochemical relationship between them and the pilosebaceous unit. Inflammatory cytokines, chemokines, active oxygen, and zinc are known to be associated with the development of acne. Further, steroid metabolism is known as one of the important factors related to sebum secretion and comedone formation in acne. However, there is a lack of studies comparing these human biomarkers between healthy individuals and patients with acne. In particular, no study has investigated the relationship between human biomarkers and patterns of acne yet.</P><P>The purpose of this study is to investigate diagnostic human biomarkers in acne by comparing the biological and metabolic biomarkers between healthy individuals and patients with acne and identify the relationship between human biomarkers and patterns of acne.</P><P>This study is a protocol for a cross-sectional study. Forty healthy participants and 60 patients with acne will be recruited at 1 center. We will collect their blood samples and analyze the molecular biological and metabolic biomarkers (cytokines, chemokines, reactive oxygen species, corticotropin-releasing hormone, zinc, amino acid, 1-carbon metabolite, lipid metabolite, etc.). Further, we will administer questionnaires regarding their diet, sleep, stress, and other factors relating to acne and measure their skin elasticity.</P><P>The study protocol was approved by the Institutional Review Board of Oriental Medical Hospital at Kyung Hee Medical Center (KOMCIRB-161118-HR-062). Written informed consent will be obtained from all the participants. The trial was registered in the Clinical Research Information Service, Republic of Korea: KCT0002212.</P><P>This trial will provide evidence regarding diagnostic human biomarkers in acne and the relationship between the human biomarkers and patterns of acne.</P>
In Silico Evaluation of Glucose Control Protocols for Critically Ill Patients
Lee, Jung Chan,Kim, Myeungseon,Choi, Ka Ram,Oh, Tae Jung,Kim, Min Young,Cho, Young Min,Kim, Kyuseok,Kim, Hee Chan,Kim, Sungwan IEEE 2012 IEEE Transactions on Biomedical Engineering Vol.59 No.1
<P>This letter presents an in silico evaluation method of glucose control protocols for critically ill patients with hyperglycemia. Although various glucose control protocols were introduced and investigated in clinical trials, development and validation of a novel glucose control protocol for critically ill patients require too much time and resources in clinical evaluation. We employed a virtual patient model of the critically ill patient with hyperglycemia and evaluated the clinically investigated glucose control protocols in a computational environment. The three-day simulation results presented the time profiles of glucose and insulin concentrations, the amount of enteral feed and intravenous bolus of glucose, and the intravenous insulin infusion rate. The hyperglycemia and hypoglycemia index, blood glucose concentrations, insulin doses, intravenous glucose infusion rates, and glucose feed rates were compared between different protocols. It is shown that a similar hypoglycemia incidence exists in simulation and clinical results. We concluded that this in silico simulation method using a virtual patient model could be useful for predicting hypoglycemic incidence of novel glucose control protocols for critically ill patients, prior to clinical trials.</P>
Joo, Seung-Moon,Lee, Kyoung Ho,Kim, Young Hoon,Kim, So Yeon,Kim, Kyuseok,Kim, Kil Joong,Kim, Bohyoung Radiological Society of North America 2009 Radiology Vol.251 No.3
<P>PURPOSE: To determine the frequency of normal appendix visualization at low-dose (LD) unenhanced computed tomography (CT) performed with a 16- or 64-detector row scanner when images are reviewed by using the sliding slab averaging technique. MATERIALS AND METHODS: The institutional review board approved the study and waived the informed consent requirement. A total of 259 patients, 37 (14.3%) of whom had previously undergone appendectomy, underwent LD unenhanced CT (mean effective dose, 1.7 mSv) performed with a 16- or 64-detector row scanner to assess urinary colic. Three readers used the sliding slab averaging technique to retrospectively review the thin-section (0.67- or 2.00-mm section thickness) images and grade the appendix as absent, unsurely or partly visualized, or clearly and entirely visualized. Interobserver agreement was measured with weighted kappa statistics. McNemar tests were used to compare sensitivity between the readers. Logistic regression analysis was performed to assess the effects of body mass index, patient sex, and type of CT scanner on appendiceal visualization. RESULTS: The kappa statistics for each reader pair were as follows: 0.97 for agreement between readers 1 and 2, 0.93 for agreement between readers 2 and 3, and 0.92 for agreement between readers 1 and 3. Each reader clearly identified the entire appendix in 213 (96.0%), 209 (94.1%), and 205 (92.3%) of the 222 patients without a history of appendectomy. When unsurely or partly visualized appendices were included, the frequencies increased to 99.1% (n = 220), 98.7% (n = 219), and 97.3% (n = 216), respectively, for readers 1, 2, and 3. These frequencies rarely differed between the readers. (P values ranged from .021 to greater than .99.) The three readers consistently reported that the appendix was not visualized in the 37 patients who had undergone appendectomy. None of the tested variables significantly affected appendix visualization. CONCLUSION: Most normal appendices are visualized on thin-section LD unenhanced CT images reviewed with the sliding slab averaging technique.</P>
Defect Dynamics at a Single Pt Nanoparticle during Catalytic Oxidation
Kim, Dongjin,Chung, Myungwoo,Kim, Sungwon,Yun, Kyuseok,Cha, Wonsuk,Harder, Ross,Kim, Hyunjung American Chemical Society 2019 NANO LETTERS Vol.19 No.8
<P>Defects can affect all aspects of a material by altering its electronic properties and controlling its chemical reactivity. At defect sites, preferential adsorption of reactants and/or formation of chemical species at active sites are observed in heterogeneous catalysis. Understanding the structural response at defect sites during catalytic reactions provides a unique opportunity to exploit defect control of nanoparticle-based catalysts. However, it remains difficult to characterize the strain and defect evolution for a single nanocrystal catalyst in situ. Here, we report Bragg coherent X-ray diffraction imaging of defect dynamics in an individual Pt nanoparticle during catalytic methane oxidation. We observed that the initially tensile strained regions of the crystal became seed points for the development of further strain and subsequent disappearance of diffraction density during oxidation reactions. Our detailed understanding of the catalytically induced deformation at the defect sites and observed reversibility during the relevant steps of the catalytic oxidation process provide important insights of defect control and engineering of heterogeneous catalysts.</P> [FIG OMISSION]</BR>
Kim, Kyuseok,Lee, Min-Hee,Lee, Youngjin Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.11
A gamma camera system using radionuclide has a functional imaging technique and is frequently used in the field of nuclear medicine. In the gamma camera, it is extremely important to improve the image quality to ensure accurate detection of diseases. In this study, we designed a blind-deconvolution framework after a noise-reduction algorithm based on a non-local mean, which has been shown to outperform conventional methodologies with regard to the gamma camera system. For this purpose, we performed a simulation using the Monte Carlo method and conducted an experiment. The image performance was evaluated by visual assessment and according to the intensity profile, and a quantitative evaluation using a normalized noise-power spectrum was performed on the acquired image and the blind-deconvolution image after noise reduction. The result indicates an improvement in image performance for gamma camera images when our proposed algorithm is used.
A Study on Usage Frequency of Translated English Phrase Using Google Crawling
( Kyuseok Kim ),( Hyunno Lee ),( Jisoo Lim ),( Sungmin Lee ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2
People have studied English using online English dictionaries when they looked for the meaning of English words or the example sentences. These days, as the AI technologies such as machine learning have been developing, documents can be translated in real time with Kakao, Papago, Google translators and so on. But, there has still been some problems with the accuracy of translation. The AI secretaries can be used for real-time interpreting, so this kind of systems are being used to translate such the web pages, papers into Korean. In this paper, we researched on the usage frequency of the combined English phrases from dictionaries by analyzing the number of the searched results on Google. With the result of this paper, we expect to help the people to use more English fluently.
Kim, Jin-Sun,Choi, Kyuseok,Kim, Ju-Jin,Noh, Dong-Youn,Park, Sang-Kyu,Lee, Ha-Jin,Lee, Haeseong American Scientific Publishers 2007 Journal of Nanoscience and Nanotechnology Vol.7 No.11
<P>We observed that single-walled carbon nanotube (SWNT) was aligned in the presence of TTF. This alignment was induced by a specific interaction between SWNT and tetrathiafulvalene (TTF), a well-known organic donor. The interaction between the two molecules can be explained by a charge-transfer, which was confirmed by X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The binding energies of S (2P1/2) and S (2P3/2) were shifted from 163.0 eV and 164.1 eV to 163.9 eV and 165.1 eV, respectively. In Raman spectra of the SWNT-TTF, three peaks of SWNT in radial breathing mode were also upshifted by 4-5 cm<SUP>−1</SUP>. The charge-transfer interaction also contributed in modifying the electronic structure of SWNT and furthermore enhanced the electrical conductivity of SWNT. A more conductive thin film was fabricated using the SWNT-TTF. Four-probe measurement revealed that the surface resistance of the SWNT-TTF film was reduced to 4.359 Ω at room temperature while that of SWNT film was 6.894 Ω. These results enable carbon nanotubes to be utilized more for practically for industrial applications in fabricating peculiar nano-sized building blocks.</P>