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홍수민;박경식;박일권;손형래;구호석;고행일 인제대학교 2011 仁濟醫學 Vol.32 No.-
Hepatitis A is a mild, self-limiting disease of the liver, critical complications of which, such as acute kidney injury, are rare. Two cases of patients with acute hepatitis A who had an acute renal failure complication are reported herein. The first case is that of a 30-year-old man who showed up at the author’s hospital complaining of fever and myalgia. His laboratory tests upon his admission showed 9,520 lU/L of aspartate transaminase, 5,600 lU/L of alanine transaminase, 31.9 mg/dL of blood urea nitrogen, and 5.5 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. Upon his admission, supportive treatment was started, which included fluid therapy. The laboratory tests on the next day showed 53 mg/dL of blood urea nitrogen, 9.9 mg/dL of creatinine, and lower urine output per day. Renal replacement therapy was performed only once. A renal biopsy was performed and the result was Acute Tubular Necrosis (ATN). The patient recovered from acute renal failure without sequela. In the second case, a 35-year-old man complained of fever and abdominal pain. His laboratory tests upon his admission showed 8,570 lU/L of aspartate transaminase, 4,510 lU/L of alanine transaminase, 16 mg/dL of blood urea nitrogen, and 1.19 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. He experienced acute renal failure and recovered after two-time renal replacement therapy. The result of the renal biopsy was Acute Tubular Necrosis and C1q nephropathy.
법랑아세포종에서의 p53 및 MIB-1 발현 : 임상 및 병리학적 요인들간의 연관성 Correlation Between Clincopathologic Parameters
이수운,한지용,권창석,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4
Thirty five patinets' paraffin embedded biops block , which was previously diagnosed ameloblastoma and obtained from oral and maxillofacial surgery dept. of pusan paik hospital and OMS dept of collage dentistry, pusan national university hospital, from January 1994 to march 1999, were performed immunohistochemistry with p-53 and MIB-1. On investigating the expression, correlation between clinical and histologic factor and correlation between prognosis and moleculopathologic property were examined. And we obtained the following results; 1. Age over forty, recurrence rate was 58.5%. 91.4% of the tumor was developed on mandibule, recurrence rate of maxilla area tumor was 66.7% On radiologic and histologic feature, multilocular and follicular type has high recurrence rate but no significance statistical difference was found 2. Expression of p-53 was 25.7%, When underage of forty. location on mandibule, multilocular and plexiform type, the expression of p-53 was somewhat higher and recurred cases of tumor, expression rate was 12.5%. 3. MIB-1 expression rate was 77.1%. When location on mandibule, unilocular, plexiform type tumor and previously recurred case, MIB-1 expression was 87.5% which was somewhat higher than no recurrence case of 74.1%. 4. 33.3.% of positive on MIB-1 have expression of p-53 and all p-53 positive case express MIB-1 positive. All p-53 positive case have high cell proliferation rate. From this result, age and location have closely related with the prognosis of tumor, histologic feature and MIB-1 expression has related with the prognosis of tumor. But p-53 has highly expressed on cell proliferation area, not closely related with the prognosis of tumor.
육안적 혈뇨로 내원한 환자에서 발견된 방광 유전분증 : 증례보고
김은진;성 현;홍수민;정성연;박경식;손형래;박일권;구호석;고행일 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-
Amyloidosis is a disease resulting in deposition of amyloid in the body. The disease can be either primary or secondary. The amyloidosis of urinary bladder is more usually affected by primary amyloidosis and also very rare. The patient with primary amyloidosis of the bladder usually presents with gross hematuria. The amyloidosis resembles bladder cancer in cystoscopy. It can be confirmed by biopsy. The treatment consists of medication (e.g., steroid, antitumor agent, cholchicine, DMSO) and/or transurethral resection. The standard treatment is mephalan and prednisolone. A 49-year-old man complained of recently developed gross hematuria without abdominal pain. We examined urinary bladder cystoscope for gross hematuria. It revealed small bulging mass on trigone are a of bladder. Therefore we did bladder biopsy. Finally, it revealed bladder amyloidosis. The patient was improved by medication (mephalan 2mg and prednisolone 1 mg/kg po daily). We report an unusual case of amyloidosis involving bladder.
Rhodiosin, an Antioxidant Flavonol Glycoside from Rhodiola rosea
Kwon, Hyung-Jun,Ryu, Young-Bae,Jeong, Hyung-Jae,Kim, Jang-Hoon,Park, Su-Jin,Chang, Jong-Sun,Kim, Min-Soo,Rho, Mun-Chual,Lee, Woo-Song The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.5
The EtOAc fraction of Rhodiola rosea ethanolic extracts showed a strong antioxidant activity. Through activity-guided fractionation and purification, we isolated two flavonol glycosides, which were identified as the well known flavonoids, rhodionin (1) and rhodiosin (2). To compare their antioxidant activities, we used an authentic aglycone compound, herbacetin (3). Among the compounds tested, rhodiosin (2) exhibited strong antioxidant activity, with $IC_{50}$ values of 0.21 and 0.15 ${\mu}M$ against ${\cdot}OH$ and ${\cdot}O^-{_2}$, respectively. Rhodiosin (2) (100 mg/kg) reduced MDA content in the liver induced by irradiation when given prior to exposure of ${\gamma}$-radiation.
중학교 체육교사와 스포츠강사의 조직동일시, 직무몰입, 그리고 이직의도의 관계
권형일 ( Hyung Il Kwon ),김은혜 ( Eun Hye Kim ),이지원 ( Ji Won Lee ),강인석 ( In Suk Kang ),고수진 ( Su Jin Ko ),김아형 ( A Hyung Kim ),송주은 ( Ju Eun Song ),유효석 ( Hyo Suk You ) 중앙대학교 학교체육연구소 2013 Asian Journal of Physical Education of Sport Scien Vol.1 No.-
본 연구는 정규직인 체육교사들과 비정규직인 스포츠강사의 직무몰입과 이에 관련된 변인들의 집단차이에 대한 경험적인 규명을 하는데 목적이 있다. 이를 위해 비확률표집(non probability sampling)을 사용하여 총 129명의 체육교사와 스포츠강사가 설문에 참가하였다. 응답자 중 남자는 101명 여자는 28명이었다. 가설 검증을 위해 변인들의 집단 차를 보는 가설 1, 2, 3은 one-way MANOVA를 통해 검증하였고, 조직몰입의 매개효과를 검증하는 가설 4는 다중회귀분석이 사용되었다. 가설 검증 결과, 직무몰입은 체육교사들이 스포츠강사들보다 높은 평균값을 나타냈으며, 이직의도는 스포츠강사들이 체육교사들보다 높은 평균값을 나타내었다. 그러나, 체육교사들과 스포츠강사들의 조직동일시의 차이는 나타나지 않아 가설 1은 지지되지 않았다. The purpose of the study is two-fold. First, this study attempted to examine possible group differences between PE teachers and sport instructors in terms of organizational identification, job commitment, and turnover intention. Second, this study examined mediating effect of job commitment in the relationship between organizational identification and turnover intention using Baron and Kenny’s (1986) method. The data were collected from 129 (men = 101; women = 28) PE teachers and instructors. The sample of the study was drawn by convenience sampling. Using convenience sampling, 74 PE teachers and 55 instructors were secured. The data were collected using a questionnaire that included three scales that measured organizational identification, job commitment, turnover intention. In addition, several demographic questions were included. The six items of organizational identification were adapted from Mael and Ashforth (1992). The Cronbach’s alpha of the scale was .90, which indicated a good internal consistency. The job commitment was measured with Meyer, Allen, and Smith’s (1993) six items (Cronbach’s alpha = .86). The turnover intention was measured with three items of Yoo (2011). The internal consistency of the items was .90. The research hypotheses (H1, H2, and H3) were tested using one-way MANOVA. To test mediating effect of organizational commitment, multiple regression analyses were utilized. Normality of the data was examined using skewness (-.59 and -1.79) and kurtosis (-.59 and -2.34). In addition, the assumption of using MANOVA was examined using Box’s M test (p = .11). The results of MANOVA indicated that there was statistically significant group difference (Wilk’s Lamda = .82, p < .001. ηp2=.18, power=.99). Follow up univariate analyses indicated that PE teachers scored higher on job commitment(p<.001) and instructors group scored higher on turn over intention(p<.001). The groups were in variant in terms of organizational identification(p=.08). There search hypothesis 4 was tested using Baron and Kenny’s(1986) method. The direct relationship between organizational identification and turn over intention was insignificant(β = .07, p < .44). However, the path between organizational identification and job commitment (β = .42, p < .001) and the path between job commitment and turnover intention (β = =-.47, p < .001) were statistically significant. The denoted that job commitment mediated the relationship between organizational identification and turnover intention. The Sobel test statistic was -.268 (p = .004).
( Byung Su Kwon ),( Hyun Joo Lee ),( Juseok Yang ),( Yong Jung Song ),( Dong Soo Suh ),( Dong Hyung Lee ),( Ki Hyung Kim ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.6
Objective To investigate the prognostic significance of preoperative lymphocyte-monocyte ratio (LMR) in elderly patients with advanced epithelial ovarian cancer (EOC) receiving primary cytoreductive surgery and adjuvant platinum-based chemotherapy. Methods A total of 42 elderly patients (≥65 years) diagnosed with EOC who are receiving primary cytoreductive surgery and adjuvant platinum-based chemotherapy from 2009 to 2012 was included. LMR was calculated from complete blood cell count sampled before operation. Receiver operating characteristic (ROC) curves were used to calculate optimal cut-off values for LMR. Prognostic significance with respect to overall survival (OS) and progression-free survival (PFS) were determined using log-rank test and Cox regression analysis. Results The optimized LMR cut-off value determined by ROC curve analysis was 3.63 for PFS and OS. The high LMR group (LMR ≥3.63) was found to be significantly more associated with optimal debulking (P=0.045) and platinum response (P=0.018) than the low LMR group. In addition, Kaplan-Meier analysis revealed the LMR-high group was significantly more associated with high PFS and OS rates (P=0.023 and P=0.033, respectively), and univariate analysis revealed that a high LMR, histology type, and optimal debulking and platinum responses were significantly associated with prolonged PFS and OS. However, subsequent Cox multivariate analysis showed only optimal debulking and platinum response were independent prognostic factors of PFS or OS. Conclusion This study suggests that LMR might be associated with treatment and survival outcomes in elderly patients with EOC receiving standard oncology treatment.