중장염전증의 임상적 고찰

김관우(Kwan-Woo Kim),김연철(Yeon-Chol Kim),김대연(Dae-Yeon Kim),김성철(Seong-Chul Kim),윤종현(Chong-Hyun Yoon),김인구(In-Koo Kim) 대한외과학회 2002 Annals of Surgical Treatment and Research(ASRT) Vol.63 No.4

각종 간질환에서 Tc - 99m pertechnetate 경직장 문맥신티그라피를 이용한 문맥 순환의 평가

김관우 ( Kwan Woo Kim ),김종순 ( Chong Soon Kim ),김학산 ( Hak San Kim ),박원 ( Won Park ),이범우 ( Bum Woo Lee ),서관식 ( Kwan Sik Suh ),이봉휘 ( Bong Hwi Lee ),김광일 ( Kang Il Kim ) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4

N/A Portal circultion in patients with various liver diseases was evaluated by Tc-99m pertechnetate per-rectal scintigraphy. 10mCi of pertechnetate was instilled into the upper rectum, and serial scintigrams were taken. Time-activity curves for the liver and heart were recorded sequentially. Through analysis of these curves, the per-rectal portal shunt indices were calculated for 15 norrnal controls, 12 with acute hepatitis (AH), 28 with chronic hepatitis, 51 with liver cirrhosis, 1 with falminant hepatic failure (FHF ). 5 with hepatic congestion (I-IC) due to congestive heart failure (CHF). The results obtained were as follows: 1) 15 normal controls and the patients with acute and chronic hepatitis all had 'Pattern II' scintigrams, and the patients with liver cirrhosis (LC) and hepatic congestion had 'Pattern II' scintigrams. One patient with FHF showed 'Pattern II' scintigram. 2) The shunt index (SI) in the normal controls was l.32±1.30%, in AH 10.9±5.7%, in CPH 5.4±2.3%, in CAH 11.8±4.2%, in LC 72.4±21.6%, in HC 39.9±27.2%, and in one FHF 75.4%. 3) Patients with various liver diseases had the significantly higher SI than the normal controls (p < 0.001). Also, the SI in pts. with liver cirrhosis was significantly higher than that of all the other groups (p < 0.001). 4) The mean SI was significantly higher for chronic liver diseases, that were more severe, increasing in the order of CPH, CAH and liver cirrhosis (p<0.001). Also, pts. With AH and CAH showed the significantly higher SI than pts. With CPH (p<0.001), and there was no significant difference in the SI between pts. With AH and CAH (p>0.05). 5) The mean SI was significantly higher in the cirrhotic pts. With varices, encephalopathy, splenomegaly or ascites than in such patient without them (p<0.005). 6) The mean SI in the cirrhotic pts, was calculated according to the modified Child's classification, of which results were that the SI was increased significantly in the order of Grade A, B and C (p< 0.001). 7) In one patient with LC, SI was much decreased from 39.5% before surgery to 7.1% after surgery. The above results suggest that per-rectal portal scintigraphy can be used to evaluate the portal circulation non-invasively and diagnose the portal hypertension in various liver diseases. Also, it can be used to express the degree of any portal hypertension not only by images but also quantitatively, using shunt index, and it is considered useful for the observation of the course of liver diseases and eva]uation of effectiveness of therapy.

스포츠교육모형의 적용이 핸드볼 수업에 미치는 효과

김관우(Kim Kwan Woo),김승재(Kim Seung Jae) 한국스포츠교육학회 2003 한국스포츠교육학회지 Vol.10 No.2

본 연구의 목적은 스포츠교육모형을 적용한 핸드볼 수업 후에 중학생들의 정의적 영역에 어떠한 변화가 있는지를 알아보고 체육 수업의 새로운 방향을 제시하는데 목적을 두고 시도하였다. 연구의 목적을 달성하기 위하여 연구자가 담당하고 있는 중학교 1학년생 106명을 대상으로 하였으며, 실험집단은 스포츠교육 모형을 비교집단은 전통적 수업모형을 적용하였다. 정의적 영역에 대한 검사는 설문지를 통하여 자료을 수집하였다. 연구절차는 실험처치 전 사전검사를 실시하였으며 4주(12시간)간 수업을 실시한 후 사후검사를 실시하였다. 사전·사후검사를 통해 나타난 결론은 다음과 같다. 첫째, 정의적 영역의 수업에 대한 기본적인 태도의 사후검사에서 스포츠교육모형 집단이 전통적 수업모형 집단에 비하여 높은 점수를 얻었으며, 이러한 결과는 스포츠교육모형의 적용이 학습자의 수업에 임하는 태도에 긍정적인 영향을 미친다는 것을 알 수 있다. 둘째, 정의적 영역의 심리적 측면에 대한 사후검사에서 스포츠교육모형 집단이 전통적 수업모형 집단에 비하여 높은 점수를 얻어 유의한 차이가 있는 것으로 나타났으며, 이러한 결과는 스포츠 교육모형의 적용이 학습자의 심리적 측면에 긍정적인 영향을 미친다는 것을 알 수 있다. 셋째, 정의적 영역의 사회적 측면에 대한 사후검사에서 스포츠교육모형 집단이 전통적 수업모형 집단에 비하여 높은 점수를 얻어 유의한 차이를 보였으며, 이러한 결과는 스포츠교육모형이 사회적 측면의 발달에 효과적임을 알 수 있다. The purpose of this study were to clarify what kind of changes were in the affective domain of the middle school students, to suggest the new direction of the physical education class by using the footage of the real-life games in teaching. To achieve these purposes, this study selected 106 students from the first grade of Ⅰ middle school in I county and divided them into two groups, which were the experimental group and comparison one. The former was subjected to the sports-education model and the latter the general teaching model. The conclusions which have been gained through the comparing and analyzing the result of the both tests are as followings. First, as for the post-test about the basic attitude toward the affective domain class, the sports education model group got higher mark in all items than the traditional teaching model and from this result we can see the application of the sports-education model have a positive effect on the attitude of the learners` preparing for the class. Second, as for the post-test about the psychological aspect of the affective domain, the sports education model group got higher mark in all items than the traditional teaching model, which proved to be a meaningful difference. This result represents the application of the sports education model have a positive effect on the psychological aspect. Third, as for the post-test about the social aspect of the affective domain, compared with the traditional teaching model, the sports education model group got high score in all, which proved to be a meaningful difference. This result means the sports education model is effective in developing the social aspect.

Utilization of Probiotics for Enhancing the Biological Functions of Medicinal Crops

Kwan Woo Kim(김관우),Young Seob Lee(이영섭),Gi Hwan Lee(이기환),Chang Yeol Yang(양창열),Dae Young Lee(이대영),Da Hye Yoon(윤다혜),Geum Soog Kim(김금숙) 한국약용작물학회 2022 한국약용작물학회 학술대회논문집 Vol.2022 No.1

원형 커버의 펄스 레이저 용접 후 부품 잔류변형 개선에 관한 유한요소해석

김관우(Kwan-Woo Kim),조해용(Hae-Yong Cho) 대한용접·접합학회 2015 대한용접·접합학회지 Vol.33 No.6

Molten zone shape of pulse laser welding is affected by welding conditions such as beam power, beam speed, irradiation time, pulse frequency, etc. and is divided into conduction type and keyhole type. It is necessary to design heat source model for irradiation of laser beam in the pulse laser welding. Shape variables and the maximum energy density value of the heat source model are different depending on the molten zone shape. In this paper, pulse laser welding simulation for joining of cylindrical part and circular cover was carried out. The heat source model for pulse laser beam with circular path was applied to the heat input boundary condition, radiative and conductive heat transfer were considered for the thermal boundary condition. For each phase, thermal and mechanical properties according to temperature were also applied to analysis. Analytical results were in good agreement with the molten zone size of specimen under the same welding conditions. So, the reliability of the welding simulation was verified. Finally, the improvements for reducing residual deformation after cover welding could be reviewed analytically.

재래흑염소와 교잡종 염소의 Monomorphic SNP 분석을 통한 유전적 다양성과 집단구조의 비교 및 검증

김관우(Kwan-Woo Kim),이진욱(Jinwook Lee),이은도(Eun-Do Lee),이성수(Sung-Soo Lee),최유림(You-Lim Choi),임현태(Hyun-Tae Lim),김유삼(Yousam Kim),이상훈(Sang-Hoon Lee) 한국생명과학회 2020 생명과학회지 Vol.30 No.11

본 연구는 우리나라 고유의 재래흑염소 집단인 당진, 장수, 통영 및 경상대 계통과 교잡종 염소 계통 또는 해외품종의 개체 식별을 위한 유전적 다양성과 관계 조사 및 검증을 위해 수행하였다. 각 염소 집단에 존재하는 Monomorphic SNP를 수집한 이후 공통적으로 존재하는 SNP 133개를 선발하여 분석에 이용하였다. Monomorphic SNP 133개를 통한 재래흑염소와 교잡종 염소의 유전적 구조 차이를 나타냈으며, 주성분 분석 결과 재래흑염소와 교잡종 염소가 명확히 구분되는 것으로 나타났다. 또한, 참조집단 이외의 70두(Native Korean goat = 24, Cross breed = 46)로 구성된 검증집단을 분석한 결과 국내 재래흑염소 계통의 참조집단과 동일한 유전적 구조를 나타냈으며, 교잡종 염소의 경우 참조집단의 일부 유전적 구성을 공유하는 것으로 나타났다. 국내 재래흑염소의 경우는 하나의 군집을 형성한 반면 해외 품종 및 교잡종 계통의 경우 재래흑염소 계통에 비해 넓게 퍼져 군집을 형성하는 것으로 나타났다. 따라서, 본 연구 결과는 국내 재래흑염소 유전자원 집단을 보존을 위한 기초자료로 활용하고 추후 유전적 다양성을 고려한 염소의 개량을 위한 기초자료로 유용하게 활용 할 수 있을 것으로 판단된다. This study was conducted to analyze the genetic diversity and relationships that discriminate between Korean native black goat populations (Dangjin, Jangsu, Tongyoung, and Gyeongsang National University strains) and crossbred goats. Monomorphic single nucleotide polymorphisms (SNPs) in each strain were collected, and 133 common SNPs were selected for analysis. These 133 monomorphic SNPs showed differences in the genetic structure of the Korean native black goat and crossbred goats, and results from the principal component analysis (PCA) showed that the two can be clearly separated. Furthermore, analysis of the validation population comprising 70 individuals (Korean native black goats, n = 24; crossbred goats, n = 46) with the reference population showed that Korean native black goat strains and the reference population have the same genetic structure, and the crossbred goats shared only part of the genetic structure with the reference population. The result of the PCA analysis showed that the Korean native black goat strains form one population, whereas the foreign strains form another population which is more widely dispersed than the Korean native black goat strains. Thus, the results from this study can be used as baseline data for the conservation of genetic resources of Korean native black goat communities through utilization of monomorphic SNPs and for the introduction of exotic species for further improvement in genetic diversity. This study can also help reduce unnecessary inbreeding and gene flow between native strains.

Anti-neuroinflammatory Effect of the Ethanolic Extract of Peucedanum japonicum

Kwan Woo Kim(김관우),Gi Hwan Lee(이기환),Chang Yeol Yang(양창열),Dae Young Lee(이대영),Da Hye Yoon(윤다혜),Yoon Ji Lee(이윤지),Je Seung Jeon(전제승),Je Hun Choi(최재훈),Geum Soog Kim(김금숙),Young Seob Lee(이영섭) 한국약용작물학회 2023 한국약용작물학회 학술대회논문집 Vol.2023 No.1

분리형 섕크를 갖는 SPR의 형상 설계를 위한 유한요소해석

김관우(Kwan-Woo Kim),김동범(Dongbum Kim),조해용(Hae-Yong Cho) 대한용접·접합학회 2016 대한용접·접합학회지 Vol.34 No.2

SPR(Self-Piercing rivet) is mechanical element of joining sheet metal components without the need for pre-punched or pre-drilled holes. Newly designed SPR is developed for high joining strength and shearing strength than semi-tubular rivet. In this study, divided shank of self-piercing rivet were designed for joining DP440 and SILAFONT. Newly designed SPR was simulated by using FEM code DEFORM-3D. In simulations of SPR process, various shape of self-piercing rivet were considered for semi-tubular and newly designed SPR. In other to examine the joinability, joining load and lap-shear load of newly designed SPR were compared with semi-tubular by simulated results and experimental ones.

Hormone Analysis during Artificial Estrus Induction in Korean Black Goats

Kwan-Woo Kim(김관우),Dayeon Jeon(전다연),Jinwook Lee(이진욱),Seungchang Kim(김승창),Sang-Hoon Lee(이상훈) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.8

본 연구의 목적은 한국 재래흑염소 번식생리의 이해를 돕고자 서로 다른 발정동기화법을 적용하였을 때 혈액내 프로게스테론과 에스트로겐의 농도변화를 알아본 것이다. 발정동기화법은 소의 방법을 기본으로 하여 품종의 크기에 따라 호르몬의 용량을 조절하는 것을 가장 많이 사용되고 있으나, 흑염소에 적용하였을 때 발정동기화 후 인공수정 적기의 판단이 정확하지 않아 효율이 매우 낮게 조사된다. 연구에 조사된 발정동기화 방법으로는 소에서 많이 이용되어왔던 CIDR + PGF2ɑ, PGF2ɑ + GnRH + PGF2ɑ, 그리고 CIDR + PGF2ɑ + PMSG 세가지를 적용하였다. 혈액내 프로게스테론과 에스트로겐은 발정동기화 각 처치 후와 최종 처치 후 수일간의 변화를 조사하였다. 혈액내 프로게스테론과 에스트로겐 농도를 조사한 결과, 세가지 발정동기화 방법 마지막 처치 전까지는 모두 다른 변화를 보였으나, 그 후로는 서로 유사한 패턴으로 호르몬이 변화하는 것을 관찰할 수 있었다. 결론적으로 발정동기화를 위한 호르몬 주사가 개체에 서로 다르게 작용하여 발정을 유도하고 최종 처치 후로는 유사한 발정이 유도되어 유사한 호르몬 상태를 보인 것으로 생각된다. 본 연구의 결과를 한국 재래흑염소 번식에서 인공수정이나 수정란 이식과 같은 기술에 접목한다면 효율적인 개량유도에 기여할 것으로 판단된다. The purpose of the study is to investigate the change in the blood progesterone (P4) and estrogen (E2) levels when applying different estrus induction protocols to Korean black goats, and this was done to gain understanding about their reproduction physiology. For the experiment, we performed three estrus induction protocols that are commonly used in bovine: controlled internal drug release (CIDR) + prostaglandin F2ɑ (PGF2ɑ), PGF2ɑ + gonadotropin-releasing hormone (GnRH) + PGF2ɑ, and CIDR + PGF2ɑ + PMSG. The P4 and E2 concentrations showed different patterns until the last treatment of the three protocols. However, similar concentration patterns were shown after the last treatment in all the protocols. In conclusion, we monitored the blood P4 and E2 levels in Korean black goats following three different estrus induction protocols. Our findings may be used in other breeding programs of Korean black goats, such as artificial insemination and embryo transfer.

한국 재래흑염소의 계통별 인공수정과 임신진단 키트의 활용

김관우(Kwan-Woo Kim),이진욱(Jinwook Lee),전다연(Dayeon Jeon),이성수(Sung-Soo Lee),김승창(Seungchang Kim),이상훈(Sang-Hoon Lee) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.10

본 연구의 목적은 인공수정 기법을 이용한 한국 재래흑염소 계통별 인공수정 수태율을 알아보고자 정액의 성상, 수태율 및 분만율을 조사하고, 임신진단을 위한 소의 임신진단 키트의 활용 가능성을 알아보는 것이다. 재래흑염소에서 전기자극을 통해 정액을 채취하여 3계통(당진, 장수, 통영)별 정액분석과 발정동기화 된 암컷에 인공수정을 실시하여 계통별 번식능력을 조사하였다. 인공수정된 암컷에서는 소의 임신진단 키트(IDEXX Rapid Visual Pregnancy Test kit)와 초음파진단으로 임신을 확인하였다. 그 결과 개통별 정액채취량은 1∼1.5 ml 내외였으며, 정액농도는 18∼25 x 10<SUP>8</SUP>/ml, 정액 채취 직후 정자활력은 97% 이상 높게 나타났다. 그리고 임신진단의 결과에서 소의 임신진단 키트와 초음파진단 모두 동일한 결과를 보였으며, 계통별 인공수정 수태율의 효율은 20∼44%로, 통영계통이 44%로 가장 높게 나타났고 장수계통이 20%로 인공수정 수태율이 낮게 나타났다. 본 연구 결과를 통해 한국 재래흑염소의 계통별 인공수정 효율을 알 수 있었고, 조기 임신진단을 위한 소 임신진단 키트의 활용가능성을 확인할 수 있었다. 본 연구 결과는 재래흑염소 증식과 개량에 기여할 수 있을 것으로 사료된다. This study investigated the application of artificial insemination and pregnancy diagnosis kit for Korean native black goats. Semen was collected by electrical ejaculation, followed by semen analysis and artificial insemination in three goat strains (Dangjin, Jangsu and Tongyoung). Pregnancy was confirmed using a cow pregnancy test kit (IDEXX Rapid Visual Pregnancy Test kit) and ultrasound diagnosis. Analysis revealed that semen collected from male Korean native black goats by electrical ejaculation was about 1~1.5 ml in volume, 18~25 x 108/ml concentration, and having > 97% motility. Furthermore, confirmation of pregnancy by pregnancy test kit and ultrasound diagnosis after artificial insemination were similar. In addition, the efficiency of pregnancy was 20~40% for all three strains: Tongyoung was the highest with 44%, followed by Dangjin (%), and Jangsu (20%). This study determines the artificial fertilization efficiency and the feasibility of using a cow pregnancy test kit for early pregnancy diagnosis in Korean native black goats. Although further research is required for validation, the results of the current study contribute to the breeding and improvement of Korean native black goat in research institutions as well as in general farms.