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양상국,신현준,김홍섭,정상원,노용수,김상윤 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-
Testicular microlithiasis is a rare disease characterized by calcifications within the seminiferous tubules. Testicular microlithiasis has been found with a wide variety of testicular pathology, but to our knowledge its association with torsion of appendix testis has been reported only one case. Therefore, we report on an 13-year-old boy with torsion of testis appendix and bilaterally diffusely echogenic testes on sonography.
김진우,고영옥,신동국,이 협,전현식,이종옥 진주산업대학교 산업과학기술연구소 2005 산업과학기술연구소보 Vol.- No.12
This experiment was carried out to measure the elimination effect of nitrate nitrogen from green tea extracts through the column system filled with charcoal activated and bamboo charcoal powder compare to that of an nitrate nitrogen standard solution prepared with KNO3 chemicals. The change patterns of pH, and the amount of removed nitrate nitrogen from green tea and nitrate nitrogen standard solution were analyzed according to time course and the amount of charcoal treatments. The results were summarized as follow: 1. pH The pH of Green tea extractions treated with charcoal was high up to 8.17(after 30min treated with 0.4% charcoal) and 8.36(after 60min with 0.4% charcoal) which pH of non-treated green tea (control) was 5.8 The results indicated that the pH values were variable to the treated amount of charcoal and the teated time course. 2. Nitrate nitrogen From the nitrate nitrogen standard solution, the least rate 69.1% and the highest rate 74.5% of nitrate nitrogen were observed to be absorbed through the column treatment (60 min), which with green tea extract solution 21.3% (the least) and 43.8% (the highest) were detected to be absorbed through column treatment (after 60min with 0.4% charcoal). In the case of bamboo treatments with nitrate nitrogen solution samples were showed the least rate 62.8% (30min with 0.1% bamboo) and the highest rate 68.9% (60min with 0.4% bamboo), and with green tea extract solution were observed the least 13.6 (30min with 0.1% bamboo) the highest rate 29.4% (60min with 0.4% bamboo). In general, the elimination activity of nitrate nitrogen was higher by the charcoal activated powder treatment than bamboo charcoal.
신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예
이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4
저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.
Hyun Kuk Kim,Udaya S. Tantry,Hyun Woong Park,Eun-Seok Shin,Tobias Geisler,Diana A. Gorog,Paul A. Gurbel,Young-Hoon Jeong 대한심장학회 2021 Korean Circulation Journal Vol.51 No.3
Arterial and venous atherothrombotic events are finely regulated processes involving a complex interplay between vulnerable blood, vulnerable vessel, and blood stasis. Vulnerable blood (‘thrombogenicity’) comprises complex interactions between cellular components and plasma factors (inflammatory, procoagulant, anticoagulant, and fibrinolytic factors). The extent of thrombogenicity may determine the progression of atheroma and the clinical manifestation of atherothrombotic events, with the highest thrombogenicity in African Americans and lowest in East Asians. Inherent thrombogenicity may influence clinical efficacy and safety of specific antithrombotic treatments in high-risk patients, which may in part explain the observation that East Asian patients have reduced anti-ischemic benefits and elevated bleeding risk with antithrombotic therapy compared to Caucasian patients. In this review, we discuss available evidence regarding the racial differences in thrombogenicity and its impact on clinical outcomes among patients with atherosclerotic cardiovascular disease.
Effect of Naturally Occurring Coumarins on Drug Metabolism
Shin, Kuk Hyun,Woo, Won Sick,Lee, Chung Kyu 생화학분자생물학회 1987 BMB Reports Vol.14 No.4
In the course of continued search for medicinal plants affecting drug metabolizing function in the liver, it has been found that Angelica plants exhibited the most potent activity. Systematic fractionation of these plants monitoring animal experiments led to principles which were identified as coumarins. This finding provoked us to investigate the effect of various natural coumarins on the activity of drug metabolizing emzymes. The potency of the natural coumarins such as furano, pyrano and simple coumarins on drug metabolism was tested and compared by evaluating hexobarbital induced hypnosis, strychnine mortality, serum level of hexobarbital as well as barbiturate metabolism in vitro. Among coumarins tested, only furanocoumarins such as imperatorin, isoimperatorin, bergapten, oxypeucedanin and isooxypeucedanin were found to be active but, other coumarins with acyclic substituents pyranocoumarins and dihydrofuranocoumarins were inactive at the dosage used. The mode of action of furanocoumarins were very similar to those of SKF-525A, indicating that these compounds may belong to an enzyme inhibitor rather than an enzyme inducer. A double bond in furan ring seems to be essential for the manifestation of the activity, as the activity could not be observed in nodakenin and nodakenetin in which the furan ring is saturated.
Biological Evaluation of Mace for Drug Metabolism Modifying Activity
Kuk Hyun Shin,Won Sick Woo 한국생약학회 1986 생약학회지 Vol.17 No.3
The single acute treatment of mice with the steam distillate, non-volatile ether extract and methanol extract from mace, arils of Myristica fragrans(Myristicaceae) caused a significant prolongation of hexobarbital-induced narcosis, an increase in strychnine toxicity as well as a significant decrease in hepatic microsomal drug metabolizing enzyme activities. On seven daily consecutive administrations, however, the duration of narcosis was markedly shortened and significant increases in the hepatic enzyme activities were shown. From the non-volatile ether fraction, macelignan, a new lignan, mp 70∼72° was isolated as an active principle.
Shin, Kuk-Hyun,Chung, Myung-Sook,Cho, Tae-Soon The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
The ether extract from the roots of angelica clahurica was found to inhibit bovine lens aldose reductase (BLAR0 activity in vitro by 100% at 100.mu.g/ml. Systematic fractionation of the ether soluble fraction and subsequent active frctions monitorede by bioassy led to isolation of four furanocoumarins, isoimperatorin (I0, imperatorin (II), ter-O-methyl byakangelicin (III) and byakangelicin (IV), among which compound III and IV were identified as potential AR inhibitors, their $IC_{50}$ values being $2.8{\mu}M{\;}and{\;}6.2{\mu}M$, respectively. Galactosemic cataract formation tors, in rats treated with 40 g/kg/day of galactose was blocked almost completely throughout the exeprimental periods up to 44 days by i.p. administrations of byakangelicin (IV) at 50 mg/kg/day. In coincidence with the inhibitory action on cataract formation, the galactitol accumulation in rats treated with byakangelicin (IV) was found to be markedly prevented by approximately 80.5% compared to those of the contro. These results indicate that byakangelicin (IV), as a main principle of this plant, possesses high potential for a clinically useful drug of the future which prevents and/or improves sugar cataract as well as diabetic complications.
Islation of Aldose Reductase Inhibitors from the Flowers of Chrysanthemum boreale
Shin, Kuk-Hyun,Kang, Sam-Sik,Seo, Eun-Ah,Shin, Seung-Won The Pharmaceutical Society of Korea 1995 Archives of Pharmacal Research Vol.18 No.2
The methanol extract from the whole parts of the flowers of Chrysanthemum boreals was found to exhibit a significant inhibition of a rat lens aldose reductase (RLAR) activity in vitro. Bioassay guided systematic fractionation of the methanol extract led to the isolation of four flavonoids which were identified as acacetin (1), apigenin (II), luteolin (III) and linarin (IV). Compounds I-III were demonstrated to exhibit a significant inhibition of RLAR. Luteolin (II) was found to be the most potent AR inhibitor with $IC_{50}$ value of $5{\times}10^{-7}M$.