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( Paulo Gustavo Kotze ),( Antonino Spinelli ),( Rodolff Nunes Da Silva ),( Ivan Folchini De Barcelos ),( Fabio Vieira Teixeira ),( Rogerio Saad Hossne ),( Idblan Carvalho De Albuquerque ),( Marcia Ola 대한장연구학회 2015 Intestinal Research Vol.13 No.3
Background/Aims: Postoperative endoscopic recurrence (PER) occurs in nearly 80% of patients 1 year after ileocecal resection in patients with Crohn`s disease (CD). Biological agents were more effective in reducing the rates of PER in comparison with conventional therapy, in prospective trials. The aim of this study was to compare the PER rates of biological versus conventional therapy after ileocecal resections in patients with CD in real-world practice. Methods: The MULTIPER (Multicenter International Postoperative Endoscopic Recurrence) database is a retrospective analysis of PER rates in CD patients after ileocecalresection, from 7 referral centers in 3 different countries. All consecutive patients who underwent ileocecal resections between 2008 and 2012 and in whom colonoscopies had been performed up to 12 months after surgery, were included. Recurrence was defined as Rutgeerts` score ≥i2. The patients were allocated to either biological or conventional therapy after surgery,and PER rates were compared between the groups. Results: Initially, 231patients were evaluated, and 63 were excluded. Of the 168 patients in the database, 96 received anti-tumor necrosis factor agents and 72 were treated with conventional therapy after resection. The groups were comparable regarding age, gender, and perianal disease. There was longer disease duration, more previous resections, and more open surgical procedures in patients on biologicals postoperatively. PER was identified in 25/96 (26%) patients on biological therapy and in 24/72 (33.3%) patients on conventional therapy (P =0.310). Conclusions: Inthis retrospective observational analysis from an international database, no difference was observed between biological and conventional therapy in preventing PER after ileocecal resections in CD patients. (Intest Res 2015;13:259-265)
Preoperative use of anti-tumor necrosis factor therapy in Crohn`s disease: promises and pitfalls
( Paulo Gustavo Kotze ),( Subrata Ghosh ),( Willem A. Bemelman ),( Remo Panaccione ) 대한장연구학회 2017 Intestinal Research Vol.15 No.2
Recent advances in medical and surgical therapy were achieved during the last two decades in the management of Crohn`s disease (CD). Anti-tumor necrosis factor (anti-TNF) agents are widely used worldwide. However, a significant proportion of patients still need surgical resections. The impact of previous exposure to these agents on the perioperative and postoperative outcomes is still controversial. In this critical review, we aimed to position the strategy of intentional preoperative use of anti- TNF agents in the management of CD. The indications and contraindications for this strategy are detailed, and despite scarce evidence, the possible advantages and disadvantages of the intentional use of anti-TNF agents before abdominal surgery in CD are discussed. (Intest Res 2017;15:160-165)
( Paulo Gustavo Kotze ),( Rogerio Saad Hossne ) 대한장연구학회 2013 Intestinal Research Vol.11 No.4
In most patients, postoperative endoscopic recurrence (PER) occurs 1 year after abdominal resection for Crohn`s disease (CD). Preventing PER is essential for disease control, as most patients develop further clinical and surgical recurrences. Conventional therapy with nitroimidazoles, aminosalicylates, and immunomodulators have limited efficacy for preventing PER. Initial trials with biological therapy (infliximab and adalimumab) showed promising results in preventing PER, and the efficacy of these drugs seems higher than that with conventional therapy. The aim of this review is to outline the results of studies that used infliximab or adalimumab for preventing and treating PER in CD patients. Data with both agents are available, and a few, small prospective trials have shown the efficacy of these drugs in patients with a high risk for recurrence. We believe that, in 2013, biological agents will be better accepted for the prevention PER in CD patients, in addition to the already existing data. Larger trials are still underway, and their results will certainly determine the role of these agents in PER, which develops after bowel resection for CD. (Intest Res 2013;11:256-260)
Paulo Gustavo Kotze,Daniela Oliveira Magro,Barbara Saab,Mansur Paulo Saab,Lilian Vital Pinheiro,Marcia Olandoski,Maria de Lourdes Setsuko Ayrizono,Carlos Augusto Real Martinez,Claudio Saddy Rodrigues 대한장연구학회 2018 Intestinal Research Vol.16 No.1
Background/Aims: The use of anti-tumor necrosis factor (anti-TNF) agents seems to reduce surgical rates and delay surgicalprocedures in prospective trials and population-based studies in the management of Crohn’s disease (CD). This study aimedto identify whether preoperative anti-TNF agents influence the time from diagnosis to surgery. Methods: An observationalretrospective cohort study was conducted on patients with CD submitted to intestinal resections due to complications ormedical therapy failure in a period of 7 years. The patients were allocated into 2 groups according to their previous exposure toanti-TNF agents in the preoperative period. Epidemiological aspects regarding age at diagnosis, smoking, perianal disease, andpreoperative conventional therapy were considered. A Kaplan-Meier survival analysis was used to outline possible differencesbetween the groups regarding the time to surgery. Results: A total of 123 patients were included (71 and 52 with and withoutprevious exposure to biologics, respectively). The overall time to surgery was 108±6.9 months (maximum, 276 months). The survival estimation revealed no difference in the mean time to intestinal resection between the groups (99.78±10.62 months inthe patients without and 114.01±9.07 months in those with previous anti-TNF use) (log-rank P =0.35). There was no significantdifference in the time to surgery regarding perianal CD (P =0.49), smoking (P =0.63), preoperative azathioprine (P =0.073) andsteroid use (P =0.58). Conclusions: The time from diagnosis to surgery was not influenced by the preoperative use of anti-TNFtherapy in this cohort of patients.
Kim, Min-Kyong,Kotz, David Korean Institute of Information Scientists and Eng 2011 Journal of Computing Science and Engineering Vol.5 No.1
Pervasive applications such as digital memories or patient monitors collect a vast amount of data. One key challenge in these systems is how to extract interesting or unusual information. Because users cannot anticipate their future interests in the data when the data is stored, it is hard to provide appropriate indexes. As location-tracking technologies, such as global positioning system, have become ubiquitous, digital cameras or other pervasive systems record location information along with the data. In this paper, we present an automatic approach to identify unusual data using location information. Given the location information, our system identifies unusual days, that is, days with unusual mobility patterns. We evaluated our detection system using a real wireless trace, collected at wireless access points, and demonstrated its capabilities. Using our system, we were able to identify days when mobility patterns changed and differentiate days when a user followed a regular pattern from the rest. We also discovered general mobility characteristics. For example, most users had one or more repeating mobility patterns, and repeating mobility patterns did not depend on certain days of the week, except that weekends were different from weekdays.
Minkyong Kim,David Kotz 한국정보과학회 2011 Journal of Computing Science and Engineering Vol.5 No.1
Pervasive applications such as digital memories or patient monitors collect a vast amount of data. One key challenge in these systems is how to extract interesting or unusual information. Because users cannot anticipate their future interests in the data when the data is stored, it is hard to provide appropriate indexes. As location-tracking technologies, such as global positioning system, have become ubiquitous, digital cameras or other pervasive systems record location information along with the data. In this paper, we present an automatic approach to identify unusual data using location information. Given the location information, our system identifies unusual days, that is, days with unusual mobility patterns. We evaluated our detection system using a real wireless trace, collected at wireless access points, and demonstrated its capabilities. Using our system, we were able to identify days when mobility patterns changed and differentiate days when a user followed a regular pattern from the rest. We also discovered general mobility characteristics. For example, most users had one or more repeating mobility patterns, and repeating mobility patterns did not depend on certain days of the week, except that weekends were different from weekdays.
Strength Modeling using Weibull Distributions
Dr. Nadarajah Saralees,Dr. Kotz Samuel 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.7
The two-parameter Weibull distribution is the most popular model for material strength. However, it may not be a good model for all materials over a wide range of sizes. In this note, a comprehensive review of the known variations help providing better modeling. Over 20 variations are re-viewed. The appropriateness of the variations is discussed as models for brittle versus ductile strength. A comparison study of a selection of the variations is also provided. It is hoped that this review will also serve as an important refer-ence and encourage developments of further variations of the two-parameter Weibull distribution.