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김찬식,강순선,오명협,현해남 濟州大學校亞熱帶農業硏究所 1996 亞熱帶農業硏究 Vol.13 No.-
SummaryDistributions of actinomycetes, bacteria, and fungi were examined in citrus house and field soils sampled from volcanic ash soil area. pH, electrical conductivity, and exchangeable K, Ca, and Mg content in citrus house soil were higher than them in citrus field soil, however, total nitrogen content in citrus house soil is lower than that in citrus field soil.Number of total microorganisms in citrus house soil was about 3.1×105, which was 10 times lower than that in citrus field soil, and also that was remarkably lower than similar group of volcanic ash soil in cultivating and upland soil. Number of actinomycetes and bacteria in citrus house soil were similar to citrus field soil, however, that of fungi in citrus house soil was lower than that in citrus field soil.Electical conductivity and Bray No. 1 P in citrus field soil and pH and exchangeable Mg content in citrus house soil were positively correlated with distribution of actinomycetes in soils and Bray No. 1 P in citrus field soil and exchangeable Mg content in citrus house soil were negatively correlated with distribution of fungi in soils Keywords : volcanic ash citrus orchard soil, soil chemical property, actinomycetes, bacteria, fungi in soils
Kim, Seung Up,Seo, Yeon Seok,Lee, Han Ah,Kim, Mi Na,Lee, Yu Rim,Lee, Hye Won,Park, Jun Yong,Kim, Do Young,Ahn, Sang Hoon,Han, Kwang-Hyub,Hwang, Seong Gyu,Rim, Kyu Sung,Um, Soon Ho,Tak, Won Young,Kweon Elsevier 2019 Journal of hepatology Vol.71 No.3
<P><B>Background & Aims</B></P> <P>It is currently unclear which antiviral agent, entecavir (ETV) or tenofovir disoproxil fumarate (TDF), is superior for improving prognosis in patients with chronic hepatitis B (CHB). Here, we assessed the ability of these 2 antivirals to prevent liver-disease progression in treatment-naïve patients with CHB.</P> <P><B>Methods</B></P> <P>From 2012 to 2014, treatment-naïve patients with CHB who received ETV or TDF as a first-line antiviral agent were recruited from 4 academic teaching hospitals. Patients with decompensated cirrhosis or hepatocellular carcinoma (HCC) at enrollment were excluded. Cumulative probabilities of HCC and death or orthotopic liver transplant (OLT) were assessed.</P> <P><B>Results</B></P> <P>In total, 2,897 patients (1,484 and 1,413 in the ETV and TDF groups, respectively) were recruited. The annual HCC incidence was not statistically different between the ETV and TDF groups (1.92 <I>vs</I>. 1.69 per 100 person-years [PY], respectively; adjusted hazard ratio [HR] 0.975 [<I>p</I> = 0.852] by multivariate analysis). Propensity score (PS)-matched and inverse probability of treatment weighting (ITPW) analyses yielded similar patterns of results (HR 1.021 [<I>p</I> = 0.884] and 0.998 [<I>p</I> = 0.988], respectively). The annual incidence of death or OLT was not statistically different between the ETV and TDF groups (0.52 <I>vs</I>. 0.53 per 100 PY, respectively; adjusted HR 1.202 [<I>p</I> = 0.451]). PS-matched and ITPW analyses yielded similar patterns of results (HR 1.248 [<I>p</I> = 0.385] and 1.239 [<I>p</I> = 0.360], respectively). These findings were consistently reproduced in patients with compensated cirrhosis (all <I>p</I> >0.05).</P> <P><B>Conclusions</B></P> <P>The overall prognosis in terms of HCC and death or OLT was not statistically different between the ETV and TDF groups. Further studies are needed to validate our results.</P> <P><B>Lay summary</B></P> <P>It is currently unclear which antiviral agent, entecavir or tenofovir disoproxil fumarate, is superior for improving prognosis in patients with chronic hepatitis B virus infection. In this analysis we found that there was no difference in terms of overall prognosis, including risk of hepatocellular carcinoma, death, or the need for a liver transplant, in patients receiving either antiviral.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The hepatocellular carcinoma risk was not statistically different between the ETV and TDF groups. </LI> <LI> The death or liver transplant risk was not statistically different between the 2 groups. </LI> <LI> These results were consistently reproduced after adjusting for confounding variables. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Tae Jung,Park, Han Gyeol,Lee, Sang Hyub,Hwang, Soo Min,Hwang, Soon Yong,Kim, Jun Young,Choi, Junho,Kang, Yu Ri,Kim, Young Dong,Joo, Jinho American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.11
<P>The dielectric functions of amorphous GdAlO(x) (GAO) films grown by the sol-gel process were investigated from 1.12 to 8.5 eV as a function of annealing temperature using spectroscopic ellipsometry (SE). A GAO precursor sol with a molar ratio of Gd:Al = 1:1 was prepared. Thin layers were formed by spin-coating on p-type Si substrates. The layers were sintered at 400 degrees C for 2 h in an ambient atmosphere, then rapid-thermal-annealed (RTA) at 700 or 800 degrees C for 1 min in an N2 ambient. The optical properties were measured via variable angle SE, at room temperature. The angle of incidence was varied from 50 to 70 degrees in 10 degrees steps. The dielectric functions of the resulting GAO films were obtained from the measured pseudodielectric functions by multilayer-structure calculations using the Tauc-Lorentz (TL) dispersion relation. The real and imaginary parts of the dielectric functions were found to increase with increasing RTA temperature. The film thicknesses and TL parameters (threshold energy E(g) and broadening C) decrease with increasing RTA temperature.</P>
( Hyung Soon Lee ),( Gi Hong Choi ),( Jin Sub Choi ),( Kwang-hyub Han ),( Sang Hoon Ahn ),( Do Young Kim ),( Jun Yong Park ),( Seung Up Kim ),( Sung Hoon Kim ),( Yoon Dong Sup ),( Jae Keun Kim ),( Jon 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Purpose: The long-term outcome in patients with spontaneous ruptured hepatocellular carcinoma (HCC) who received staged partial hepatectomy or transarterial chemoembolization (TACE) remains unclear. We compare the efficacy of staged partial hepatectomy or TACE for the treatment of spontaneous ruptured HCC. Methods: This study is a retrospective analysis of a multicenter collected database of patients with newly diagnosed ruptured HCC. The survival curves for staged hepatectomy group and TACE-alone group were compared to evaluate the impact of treatment on patient prognosis. To identify prognostic factors for patient with spontaneous ruptured HCC, clinical characteristics at diagnosis of tumor rupture were investigated using univariate and multivariate Cox-regression analysis. Results: Between January 2000 and December 2014, a total of 172 consecutive patients with newly diagnosed ruptured HCC were treated in six Korean centers. Among these 172 newly diagnosed ruptured HCC patients, 117 patients with Child-Pugh class A were identified: 112 patients initially treated with transcatheter arterial embolization (TAE) for hemostasis, 5 underwent emergency surgery for bleeder ligation. Among the 112 patients treated with TAE, 44 underwent staged partial heatectomy, 61 received TACE-alone, and 7 received conservative treatment after TAE. The staged partial hepatectomy group showed significantly higher overall survival than the TACE-alone group (P<0.001). Multivariate analysis showed that patients receiving TACE-alone, presence of portal vein thrombosis and pre-treatment transfusion above 1200 ml were associated with poor overall survival of patients with spontaneous ruptured HCC. Conclusion: Our study indicates that staged partial hepatectomy may offer better long-term survival than TACE for resectable HCC with recent tumor rupture. And TACE remains a local therapy option for patients who do not eligible for surgery.
( Hyung Soon Lee ),( Gi Hong Choi ),( Jin Sub Choi ),( Kyung Sik Kim ),( Kwang Hyub Han ),( Jinsil Seong ),( Sang Hoon Ahn ),( Do Young Kim ),( Jun Yong Park ),( Seung Up Kim ),( Beom Kyung Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: The aim of this study was to evaluate the outcome of salvage resection after concurrent chemoradiation therapy (CCRT) followed by hepatic arterial infusion chemotherapy (HAIC) in locally advanced hepatocellular carcinoma (HCC) and to identify the prognostic factors for tumor recurrence and survival rate after salvage resection. Methods: From 2005 to 2011, 254 patients received CCRT followed by HAIC with 5-FU and cisplatin for locally advanced HCC with Child-A liver cirrhosis at our institution. Fourty-one (16.8%) patients underwent salvage resection after CCRT. Prognostic factors for salvage resection group were investigated through the clinicopathologic variables. We measured increasing rate of functional residual liver volume (% FRLV) after CCRT in patients with major liver resection by using CT volumetry. Responder was defined as down-staging of tumor and/or above partial response after CCRT. We used one-to-one propensity score matching to select control for responder (n=33) among the patients who underwent hepatic resection with no pre-operative treatment (n=136). Survival analysis were undertaken to compare these propensity score-matched groups. Results: In multivariate analysis, poor prognostic factors for disease-free survival in salvage resection group were nonresponder (HR=3.455, p=0.010) and presence of satellite nodule (HR=7.424, p=0.003). Non-responder was the only independent poor prognostic factor for overall survival in salvage resection group (HR=3.542, p=0.024). And % FRLV was significantly increased from 49% to 72% after CCRT in patients with major liver resection (p=0.000). In survival analysis between responder and propensity matched group, there were no significant differences of disease-free survival rates (p=0.427) and overall survival rates (p=0.306). Conclusions: Salvage resection after CCRT followed by HAIC shows improved overall survival rates in selected patients with locally advanced HCC. The responder of CCRT followed by HAIC may be the best candidate for salvage resection.
( Hyung Soon Lee ),( Gi Hong Choi ),( Jin Sub Choi ),( Kyung Sik Kim ),( Kwang Hyub Han ),( Jin Sil Seong ),( Sang Hoon Ahn ),( Do Young Kim ),( Jun Yong Park ),( Seung Up Kim ),( Beom Kyung Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: The aim of this study was to evaluate the outcome of salvage resection after concurrent chemoradiation therapy (CCRT) followed by hepatic arterial infusion chemotherapy (HAIC) in locally advanced hepatocellular carcinoma (HCC) and to identify the prognostic factors for tumor recurrence and survival rate after salvage resection. Methods: From 2005 to 2011, 254 patients received CCRT followed by HAIC with 5-FU and cisplatin for locally advanced HCC with Child-A liver cirrhosis at our institution. Fourty-one (16.8%) patients underwent salvage resection after CCRT. Prognostic factors for salvage resection group were investigated through the clinicopathologic variables. We measured increasing rate of functional residual liver volume (% FRLV) after CCRT in patients with major liver resection by using CT volumetry. Responder was defined as down-staging of tumor and/or above partial response after CCRT. We used one-to-one propensity score matching to select control for responder (n=33) among the patients who underwent hepatic resection with no pre-operative treatment (n=136). Survival analysis were undertaken to compare these propensity score-matched groups. Results: In multivariate analysis, poor prognostic factors for disease-free survival in salvage resection group were nonresponder (HR=3.455, p=0.010) and presence of satellite nodule (HR=7.424, p=0.003). Non-responder was the only independent poor prognostic factor for overall survival in salvage resection group (HR=3.542, p=0.024). And % FRLV was significantly increased from 49% to 72% after CCRT in patients with major liver resection (p=0.000). In survival analysis between responder and propensity matched group, there were no significant differences of disease-free survival rates (p=0.427) and overall survival rates (p=0.306). Conclusions: Salvage resection after CCRT followed by HAIC shows improved overall survival rates in selected patients with locally advanced HCC. The responder of CCRT followed by HAIC may be the best candidate for salvage resection.