Energy storage capabilities of nitrogen-enriched pyropolymer nanoparticles fabricated through rapid pyrolysis

Yun, Young Soo,Kim, Yu Hyun,Song, Min Yeong,Kim, Na Rae,Ku, Kyojin,An, Ji Su,Kang, Kisuk,Choi, Hyoung Jin,Jin, Hyoung-Joon Elsevier 2016 Journal of Power Sources Vol.331 No.-

<P><B>Abstract</B></P> <P>Nanostructured pyropolymers contain significant amounts of redox-active heteroatoms, have high specific surface areas, and a defective carbon microstructure, indicating good potential for pseudocapacitive charge storage. In this study, nitrogen-enriched pyropolymer nanoparticles (N-PNs-50) are fabricated from polyaniline nanotubes through rapid pyrolysis at 50 °C min<SUP>−1</SUP>. N-PNs-50 exhibit a nitrogen content of 9.8 wt%, a high specific surface area of 875.8 m<SUP>2</SUP> g<SUP>−1</SUP>, and an amorphous carbon structure with an I<SUB> <I>D</I> </SUB>/I<SUB> <I>G</I> </SUB> intensity ratio of 0.95. These unique characteristics lead to good electrochemical performances, in which reversible capacities of 660 and 255 mAh g<SUP>−1</SUP> are achieved for Li-ion and Na-ion storage, respectively, with favorable voltage characteristics (<1.5 V for Li-ions and <1.2 V for Na-ions). This study provides a more feasible production method for nitrogen-doped pyropolymers and their practicable electrochemical performances for use as an anode in energy storage devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nanostructured pyropolymers (N-PNs-50) were fabricated by rapid pyrolysis. </LI> <LI> N-PNs-50 exhibited a nitrogen content of 9.8 wt% and amorphous carbon structure. </LI> <LI> N-PNs-50 exhibited a high specific surface area of 875.8 m<SUP>2</SUP> g<SUP>−1</SUP>. </LI> <LI> 660 and 255 mAh g<SUP>−1</SUP> were achieved for Li-ion and Na-ion storage, respectively. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Nitrogen-enriched pyropolymer nanoparticles (N-PNs-50) were fabricated from polyaniline nanotubes through rapid pyrolysis at 50 °C min<SUP>−1</SUP>, showing superior electrochemical performances.</P> <P>[DISPLAY OMISSION]</P>

Hierarchically nanoporous pyropolymer nanofibers for surface-induced sodium-ion storage

Yoon, Hyeon Ji,Lee, Min Eui,Kim, Na Rae,Yang, Seung Jae,Jin, Hyoung-Joon,Yun, Young Soo Pergamon Press 2017 Electrochimica Acta Vol. No.

<P><B>Abstract</B></P> <P>Surface-driven charge storage materials based on both electrochemical double layer (EDL) formation and pseudocapacitive behavior can deliver high energy and power capabilities with long-lasting cycling performance. On the other hand, the electrochemical performance is strongly dependent on the material properties, requiring sophisticated electrode design with a high active surface area and a large number of redox-active sites. In this study, hierarchically nanoporous pyropolymer nanofibers (HN-PNFs) were fabricated from electrospun polyacrylonitrile nanofibers by simple heating with KOH. The HN-PNFs have a hierarchically nanoporous structure and an exceptionally high specific surface area of 3,950.7m<SUP>2</SUP> g<SUP>−1</SUP> as well as numerous redox-active heteroatoms (C/O and C/N ratio of 10.6 and 16.8, respectively). These unique material properties of HN-PNFs resulted in high reversible Na-ion capacity of ∼292mAhg<SUP>−1</SUP> as well as rapid kinetics and stable cycling performance in the cathodic potential range (1-4.5V vs. Na<SUP>+</SUP>/Na). Furthermore, energy storage devices based on HN-PNFs showed a remarkably high specific energy of ∼258 Wh kg<SUP>−1</SUP> at ∼245Wkg<SUP>−1</SUP> as well as a high specific power of ∼21,500Wkg<SUP>−1</SUP> at ∼78 Wh kg<SUP>−1</SUP>, with long and stable cycling behaviors over 2,000 cycles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hierarchically nanoporous pyropolymer nanofibers (HN-PNFs) were fabricated. </LI> <LI> HN-PNFs have a high specific surface area of ∼3,950m<SUP>2</SUP> g<SUP>−1</SUP> and numerous heteroatoms. </LI> <LI> HN-PNFs exhibit high capacities of ∼292mAhg<SUP>−1</SUP> and great rate/cycling performances. </LI> <LI> High energy (258Whkg<SUP>−1</SUP>) and high power (21,500Wkg<SUP>−1</SUP>) are achieved. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Hierarchically nanoporous pyropolymer nanofibers (HN-PNFs) fabricated from electrospun polyacrylonitrile nanofibers by simple heating with KOH exhibited high electrochemical performance for Na-ion storage.</P> <P>[DISPLAY OMISSION]</P>

난치성 간질로 절제한 대뇌피질의 병리소견에 대한 소아군과 성인군의 비교:164예의 분석

김나래,서연림 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.12

전격성 제1형 당뇨병 1예

노동현,김도형,김나래,박종선,이창헌,김미경,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

전격성 제1형 당뇨병은 특발성 당뇨병환자에서 임상 경과가 짧고 진단 당시 심각한 대사 합병증을 동반하면서 췌장 효소 수치가 높고 췌도 특이 자가항체가 음성인 새로운 아형으로 알려져 있으며, 일본과 일본 외에서의 유병률에는 차이가 있는 것으로 보인다. 아직 전격성 제1형 당뇨병의 발생 기전은 명확하지 않으며 유전적 감수성이 있는 개체에서 바이러스 감염 등의 환경적인 인자와의 연관성이 가능한 병태생리로 제시되고 있으며 이에 대한 추가적인 연구가 요구된다. 저자들은 케톤산증으로 내원하여 전격성 제1형 당뇨병을 진단받은 증례를 경험하였기에 문헌고찰과 함께 보고 하는 바이다. Some patients with idiopathic type 1 diabetes have a fulminant disorder characterized by the absence of insulitis and of diabetes-related antibodies, a remarkably abrupt onset and high serum pancreatic enzyme concentrations. This is referred to as fulminant type 1 diabetes. A 29-year-old man suffering from abdominal pain, nausea and vomiting consulted to our hospital. Laboratory findings revealed high blood glucose level and the evidence of diabetic ketoacidosis, but the serum HbA1c was normal nevertheless. The low level of plasma C-peptide indicated the loss of endogenous insulin secretion. The patient satisfied the criteria for the diagnosis of fulminant type 1 diabetes. After the patient has been treated with insulin, his symptoms were improved and abnormal laboratory data were normalized. We report this case with a review of the literature

팽대부주위 암종에서 Cytokeratin 7과 20의 발현

최종순,감나래,안긍환,박철근 대한병리학회 2000 Journal of Pathology and Translational Medicine Vol.34 No.1

Preclinical Evaluation of <i> In Vitro</i> and <i> In Vivo</i> Antiviral Activities of KCT-01, a New Herbal Formula against Hepatitis B Virus

Kim, Hong,Jang, Eungyeong,Kim, So-Young,Choi, Ji-Yoon,Lee, Na-Rae,Kim, Dae-Sung,Lee, Kyung-Tae,Inn, Kyung-Soo,Kim, Bum-Joon,Lee, Jang-Hoon Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-

<P>Hepatitis B virus (HBV) infectious diseases currently remain incurable due to limitations of conventional antivirals such as incapability of eradicating HBV DNA, prolonged use, drug resistance, and virological relapse. KCT-01, a 30% ethanol extract consisting of<I> Artemisia capillaris</I>,<I> Sanguisorba officinalis</I>, and<I> Curcuma longa</I>, was newly developed. The objective of this study was to investigate pharmacological activities of KCT-01 against HBV using HepG2.2.15 cells and a hydrodynamic injection model. KCT-01 significantly lowered antigen secretion, virion production, and pgRNA synthesis in HepG2.2.15 cells without affecting cell viability. KCT-01 administration also resulted in significant decrease of serum virion production, liver covalently closed circular (ccc) DNA levels, and mRNA synthesis of cytokines in the liver of mice injected with HBV DNA hydrodynamically. Interestingly, coadministration of KCT-01 with entecavir enhanced its<I> in vitro</I> and<I> in vivo</I> antiviral activities. Moreover, safety of KCT-01 was assured up to 5000 mg/kg in rats in both single and repeated-dose preclinical studies. Taken together, our findings demonstrate that KCT-01 is capable of suppressing HBV replication and inflammatory cytokine production in<I> in vitro</I> and<I> in vivo</I> models without showing toxicity, suggesting the potential of using KCT-01 alone or in combination with entecavir as antiviral agent.</P>

Vitamin C down‐regulates VEGF production in B16F10 murine melanoma cells via the suppression of p42/44 MAPK activation

Kim, Ha Na,Kim, Hyemin,Kong, Joo Myung,Bae, Seyeon,Kim, Yong Sung,Lee, Naeun,Cho, Byung Joo,Lee, Seung Koo,Kim, Hang‐,Rae,Hwang, Young‐,il,Kang, Jae Seung,Lee, Wang Jae Wiley Subscription Services, Inc., A Wiley Company 2011 Journal of cellular biochemistry Vol.112 No.3

<P><B>Abstract</B></P><P>It is known that vitamin C induces apoptosis in several kinds of tumor cells, but its effect on the regulation of the angiogenic process of tumors is not completely studied. Vascular endothelial growth factor (VEGF) is the most well‐known angiogenic factor, and it has a potent function as a stimulator of endothelial survival, migration, as well as vascular permeability. Therefore, we have investigated whether vitamin C can regulate the angiogenic process through the modulation of VEGF production from B16F10 melanoma cells. VEGF mRNA expression and VEGF production at protein levels were suppressed by vitamin C. In addition, we found that vitamin C suppressed the expression of cyclooxygenase (COX)‐2 and that decreased VEGF production by vitamin C was also restored by the administration of prostaglandin E2 which is a product of COX‐2. These results suggest that vitamin C suppresses VEGF expression via the regulation of COX‐2 expression. Mitogen‐activated protein kinases are generally known as key mediators in the signaling pathway for VEGF production. In the presence of vitamin C, the activation of p42/44 MAPK was completely inhibited. Taken together, our data suggest that vitamin C can down‐regulate VEGF production via the modulation of COX‐2 expression and that p42/44 MAPK acts as an important signaling mediator in this process. J. Cell. Biochem. 112: 894–901, 2011. © 2010 Wiley‐Liss, Inc.</P>

Effect of fermented porcine placenta on physical fatigue in mice

Kim, Hee-Yun,Han, Na-Ra,Kim, Na-Rae,Lee, Mikyung,Kim, Jongbae,Kim, Chang-Ju,Jeong, Hyun-Ja,Kim, Hyung-Min SAGE Publications 2016 Experimental biology and medicine Vol.241 No.17

<P>The fatigue spreads among the people who live under stressful life and brings about a negative impact on physical function. Here we evaluated the anti-fatigue effects of fermented porcine placenta (FPP) and main constituents, lysine (Lys) and leucine (Leu) with treadmill stress test and forced swimming test (FST) in animal models. The mice were administrated with FPP, Lys, and Leu for 21 days. After treadmill exercise, FPP, Lys, and Leu significantly reduced fatigue-related biochemical parameters, including lactate, lactate dehydrogenase, glucose, creatine kinase, urea nitrogen, cortisol, and pro-inflammatory cytokines, whereas superoxide dismutase activity and glycogen levels were significantly increased by FPP, Lys, and Leu. In the FST, FPP, Lys, and Leu significantly decreased immobility times and up-regulated brain-derived neurotrophic factor expression in brain. Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-kappa B, interleukin (IL)-6, IL-1, and IL-4 through blockade of caspase-1/nuclear factor-B pathway in stimulated splenocytes. In addition, FPP, Lys, and Leu significantly promoted proliferation of splenocytes. In conclusion, these findings suggest the potential of FPP as a novel functional food for the regulation of fatigue.</P>

Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity

Kim, Na-Rae,Nam, Sun-Young,Ryu, Ka-Jung,Kim, Hyung-Min,Jeong, Hyun-Ja SPANDIDOS PUBLICATIONS 2016 MOLECULAR MEDICINE REPORTS Vol.14 No.2

Reverse Transcription Recombinase Polymerase Amplification Assay for Rapid and Sensitive Detection of Barley Yellow Dwarf Virus in Oat

Na-Kyeong Kim,Sang-Min Kim,Rae-Dong Jeong 한국식물병리학회 2020 Plant Pathology Journal Vol.36 No.5

Barley yellow dwarf virus (BYDV) is an economically important plant pathogen that causes stunted growth, delayed heading, leaf yellowing, and purple leaf tip, thereby reducing the yields of cereal crops worldwide. In the present study, a reverse transcription recombinase polymerase amplification (RT-RPA) assay was developed for the detection of BYDV in oat leaf samples. The RT-RPA assay involved incubation at an isothermal temperature (42°C) and could be performed rapidly in 5 min. In addition, no cross-reactivity was observed to occur with other cereal-infecting viruses, and the method was 100 times more sensitive than conventional reverse transcription polymerase chain reaction. Furthermore, the assay was validated for the detection of BYDV in both field-collected oat leaves and viruliferous aphids. Thus, the RT-RPA assay developed in the present study represents a simple, rapid, sensitive, and reliable method for detecting BYDV in oats.