상피세포 종양에서 bcl-2 표출에 관한 연구

김의한,정현,이종석,이성열,조명구 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Background : The bc1-2 protein, contrast to p53, has been shown to be suppress the apoptosis, and overexpression of the bc1-2 protein has been reported in several malignant tumors. Although how the bc1-2 protein takes part in tumorgenesis has not been proved, the bc1-2 positive tumors appeared to have good prognosis in some malignant tumors. The expression pattern of the bc1-2 in keratinocyte originated skin tumors have not been well known. The authors analyzed immunohistochemically expression of the bc1-2 protein to invastigate the role of the bc1-2 protein in developing skin tumors. Method : 21 squamous cell carcinoma, 19 basal cell carcinoma, 9 keratoacanthoma 11 seborrehic keratosis and 9 Bowen's disease were immunostained with anti-bc1-2 monoclonal antibody. Results : 1. The bc1-2 negative reactions were seen in all cases of sqaumous cell carcinoma, keratoacanthoma and Bowen's disease. The basal layer in keratoacanthoma and Bowen's disease shown to be intense positive reaction in bc1-2, whch suggested of the protected barrier function from tumor cell invasion into the dermis. 2. The bc1-2 were positive in all basal cell carcinoma. 3. In seborreheic keratosis, 9 cases were negative and 2 cases were positive. The positive cases appeared to be resulted from invagination of the basal cells in the epidermis. Conclusion : The bc1-2 protein did not appear to express in full matures cell, but positive reaction are seen in proliferating activity cells. The bc1-2 positive cells are rahter not abnormal cells than have function of protection of tumor cell proliferation by the prolongation of survival time normal cell.

大學院生의 體型과 最大筋力間의 關係

金承烈,全鍾貴 忠南大學校體育科學硏究所 1985 體育科學硏究誌 Vol.3 No.1

After the authors tried to find their interrelations between somatotype and maximum muscular strength in eight male graduate students of D. University, the main results obtained were as follows; 1. The correlation coefficient between endomorphic component and maximum muscular strength was revealed as the certainly correlation. r=0.40, Y=1.494x+30.98, Sy.x=4.80. 2. The correlation coefficient between mesomorphic component and maximum muscular strength turned out a significantly high correlation at the level of 5 percent, r=0.70(p<0.05), Y=2.218x+27.08, Sy.x=3.74. 3. The correlation coefficient between ectomorphic component and maximum muscular strength was revealed as a high neqative correlation at the level of five percent, r=0.75(p<0.05), Sy.x=3.58. 4. As their mean somatotype, the graduate students group was revealed as Mesomorph-Endomorph. (S=4.81-5.00-1.75).

정신분열증 환자의 자살

김종우,한진희,유태열 한국의학사 1989 診斷과治療 Vol.9 No.12

粉末洗濟에 대한 生分解度와 重金屬에 대한 硏究

김영철,김종섭,유찬주,주충열 漢陽大學校 環境工學硏究所 1997 環境科學論文集 Vol.18 No.-

현재 국내에서 시판중인 의류용 세탁 분말세제 6종을 대상으로 미생물에 의해 분해될 수 있는 정도를 파악하기 위한 생분해도(Biodegradability)를 측정하고 동시에 인체에도 직접적인 영향을 미치는 중금속(Pb,Cd,As 및 Hg)를 분석하였다. 분석결과 전제품이 KS 기준에 모두 적합하였으나 석유계 계면활성제인 AOS 또는 LAS가 다량 포함 되어있는 제품에서는 상대적으로 생분해도가 낮다는 것을 알 수 있으며 중금속 함유량은 제품 6종 모두 화장품 원료기준에 훨씬 못미치는 우수한 제품인 것을 알 수 있었다. As the subject of study of six kinds of laundry powder detergents for clothing that come into the domestic market at present, the biodegradabilities to understand the extent of microorganisms decomposition were measured and the heavy metals(Pb, Cd, As and Hg) to have a direct effect on human body were analyzed. Analysis results show that though they all suit KS(Korean Industrial Standards) well, powder detergents containing plenty of petroleum surface active agents have the lower biodegradability than the others and Heavy metal contents are that all of them are very good at the cosmetic material standards.

IDI형 정적연소기에서의 연락공각도가 연소특성, 및 열유속에 미치는 영향

김시범,윤수한,이상석,하종률,전대수 東亞大學校 大學院 1998 大學院論文集 Vol.23 No.-

We use the IDI type constant volume which is applied Indirect Injection strafied charge method to solve the problems of lean-burn such as misfire and cycle-variation. There are many factors to effect on the combustion charateristics in indirect injection strafied engine. The passagehole angle is the most important factor in that determine the direction of inflowed fuel and flame to the main chamber. In this study, we measured combustion pressure and wall temperature to examine the combustion characteristics and heat flux with the passagehole angle in the main chamber.

배관내에서 자유수면 와동에 관한 연구

김상녕,이종원,오율권,장완호 慶熙大學校 1991 論文集 Vol.20 No.-

During mid­loop operation of nuclear power to prevent the residual heat removal system from failure due to air entrainment of free surface vortex in the piping system a set of simulating experiments was performed. Through these experiments, a relation between the non­dimensionalized numbers, such as submergence H/d. Froude number, Reynolds number, was found. However, the effect of the Reynolds number is not so dominant as that of the Froude number. It was also found that the boundary conditions of the free surface, that is, the perturbation of the free surface due to opening of closing pump and valves have significant effects on the free surface vortex. Futhermore a modified inlet device which reducer type with vortex breaker has strongly been recommended for the prevention of air entrainment.

인체 흑색종 세포군에서의 Vascular Endothelial Growth Factor(VEGF) 분비

김현조,황규왕,조문균,박영립,이종성,이성열 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Backgroung : Vascular endothelial growth factor(VEGF) is an angiogenic cytokine expressed by many human and animal tumors. Ultraviolet radiation(UVR) has been causally linked to melanoma initiation and progression. UVR is a known melanocyte mutagen and induces specific mutations in cellular oncogenes such as p53 and ras. Activated H-ras activates tumor angiogenesis in other cell types, and angiogenic switching is accompanied by up-regulation of VEGF. Objective : The purpose of this study was to determine whether VEGF release from human melanoma cell lines was altered by activating ras mutations or by inactivation of p53 induction and whether VEGF release of these transfected melanoma cell lines was changed after UVR radiation. Results : 1. Release of VEGF from menolayer culture of melanoma cells was significantly higher in cells with activating ras mutations and lower in cells with expression of dominant negative p53. 2. In spheroid culture, dominant negative p53 decreases VEGF release in WM35 cells, but activating ras did not affect VEGF release significantly. 3. The control cell line(WM35Neo) had higher VEGF release in the spheroid culture than in the monolayer culture, and dominant negative p53 or activating ras did not affect VEGF release significantly between these two culture systems. 4. Higher cell density increases VEGF release in all tested melanoma cell lines was shown in both spheroid and monolayer culture. This cell density effect was strongest in cells with activated ras in monolayer culture. 5. UVR inhibits VEGF release in all tested melanoma cell lines, and this effect was stronger in monolayer culture than in spheroid culture. The effect of UVR on VEGF release was significantly lower in the DNp53 transfectants. 6. UVR decreased the cell viability in a dose dependent manner regardless of the cell density or cell culture system. Conclusion : VEGF release in human melanoma was inhibited by ultraviolet radiation at cytotoxic doses, and this effect is stronger in monolayer culture than in spheroid culture. VEGF release from melanoma cell lines was also influenced by p53, ras and cell growth conditions in a complex manner.

대칭형 보에 의해 보강된 등방성 평판의 음향방사에 관한 연구

김택현,오택열,김종태 한국공작기계학회 1998 한국생산제조학회지 Vol.7 No.1

The determination of sound pressure radiated from peoriodic plate structures is fundamental in the estimation of noise levels in aircraft fuselages and ship hull structures. As a robust approach to this problem, here a very general and comprehensive analytical model for predicting the sound radiated by a vibrating plate stiffened by periodically spaced orthogonal symmetric beams subjected to a sinusoidally time varying point load is developed. The plate is assumed to be infinite in extent, and the beams are considered to exert both line force and moment reactions on it. Structural damping is included in both plate and beam materials. A space harmonic series representation of the spatial variables is used in conjunction with the Fourier transform to find the sound pressure in terms of harmonic coefficients. From this theoretical model, The sound pressure levels on axis in a semi-infinite fluid (water) bounded by the plate with the variation in the loactions of an external time harmonic point force on the plate can be calculated efficiently using three numerical tools such as the Gauss-Jordan method, the LU decomposition method and the IMSL numerical package.

설하선에서 기인한 경부하마종 치험 2례

김일규,김영렬,김종철,유선열,문승옥 대한악안면성형외과학회 1986 대한악안면성형외과학회지 Vol.8 No.1

모바일 데이터 리플리케이션 아키텍쳐 설계

김종완,박용팔,류성열 崇實大學校 生産技術硏究所 2001 論文集 Vol.31 No.-

The database to save and manage for data, in distributed system, very difficult to maintain consistency by lack of stability, access of multi-user. The distributed database has used in client/server system by connected with wired LAN. But we will be used distributed database in Mobile System, like PDA(Personal Digidal Assistant). Specially, The Mobile System has some limitations to connect and link of databases or networks. Then any method will be required for database management different from wired LAN's to maintain. This thesis will consider already LAN based distributed data replication and suggests a extended Data Replication Method for mobile system and Architecture. The case study shows that positive results we developed data replication for Mobile MIS(Medical Information System) with Company A.