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Kim, Joo Young,Kim, Min-Sun,Kim, Ki-Suk,Song, Ki-Byung,Lee, Seung Hun,Hwang, Dae Wook,Kim, Kyu-pyo,Kim, Hyoung Jung,Yu, Eunsil,Kim, Song Cheol,Jang, Hyeung-Jin,Hong, Seung-Mo Wolters Kluwer Health, Inc. All rights reserved. 2015 The American journal of surgical pathology Vol.39 No.5
Pancreatic neuroendocrine tumors (PanNETs) produce variable peptide hormones. The expression status of some hormones has been linked to the biological and clinical behaviors of PanNETs. A total of 226 surgically resected PanNETs were selected. Immunolabeling for peptide hormones was compared with various clinicopathologic factors, including patient survival. Expression of insulin, glucagon-like peptide 1, glucagon, gastrin, somatostatin, and serotonin were observed in 56 (24.8%), 41 (18.1%), 25 (11.1%), 5 (2.2%), 5 (2.2%), and 4 (1.8%) cases, respectively. Expression of 1, 2, and 3 hormones was noted in 70 (31.0%), 28 (12.4%), and 3 (1.3%) cases, respectively; 125 cases (55.3%) were negative for all hormones. PanNETs with insulin and glucagon-like peptide 1 expression were associated with a lower grade, smaller size, lower pT and pN classifications, absence of lymphovascular invasion, and lymph node metastasis and had better survival by univariate analysis, whereas PanNETs with gastrin expression were associated with a higher grade, larger size, higher pT and pN classifications, presence of lymphovascular invasion, and lymph node metastasis and had worse survival. Gastrin expression, increased age, and tumor grade were negative prognostic factors in multivariate analysis. As the number of hormones expressed increased, the survival rate of PanNET patients increased. In summary, PanNET patients showing insulin or glucagon-like peptide 1 expression and increased numbers of expressed hormones had a better survival outcome by univariate analysis, whereas gastrin expression was a negative prognostic indicator in surgically resected PanNET patients.
삼귀용탕(蔘歸茸湯)이 정상 흰쥐 및 Streptozotocin으로 유도된 당뇨병 흰쥐의 혈당에 대한 영향
김형철 ( Hyeung Cheol Kim ),한효상 ( Hyo Sang Han ),이영종 ( Young Jong Lee ) 대한본초학회 2009 大韓本草學會誌 Vol.24 No.4
Objectives: In order to evaluate the effect of Samguiyong-tang (SGYT) on diabetes, we prepared two types of Samguiyong-tang (Type-Ⅰ and -Ⅱ) which was composed of three kinds of oriental drug such as Ginseng, Angelica gigantis radix and Deer antler. Type Ⅰ was traditional hot-water extract prepared from three kinds of drug, and Type Ⅱ was the mixture of ethanol-extract of ginseng and hot-water extract prepared from the other two drugs. Methods: We tested the effects of SGYT on the blood glucose levels in normal rats by the method of glucose tolerance test. And also examined the effects of SGYT on the levels in normal rats or diabetic rats induced by Streptozotocin during 20 days. Results: 1. In the course of oral glucose tolerance test, the blood glucose level decreased by administration of SGYT Ⅰ or Ⅱ in normal rats. 2. In the course administration of SGYT during 20 days in normal rats, the blood glucose levels decreased until day 4 by Type Ⅰ or Type Ⅱ, but thereafter the level was recovered to the normal. 3. In the course administration of SGYT during 20 days in the diabetic rats induced by streptozotocin, Type Ⅰ (SGYT) had some effect on the blood glucose levels only at 12 day, and Type Ⅱ (SGYT) decreased the levels from 6th day and so on, significantly. Conclusions: The results suggested that SGYT Ⅱ had some decreasing effects on the blood glucose levels in diabetic rats induced by Streptozotocin.
안근성 중증근무력증이 동반된 갑상선 기능항진증의 임상상
유재명,박성우,유형준,임성희,김두만,최문기,김현규,최철수,서지영,김형철,송홍기,김덕환 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4
Myasthenia gravis is an autoimmune disease characterized by impaired neuromuscular transmission due to circulating antiacetylcholine receptor autoantibodies. The relation between myasthenia gravis and thyroid disease remains unclarified. The association is thought to be uncommon and approximately 0.2% of myasthenia gravis has been reported in patients with autoimmune thyroid disease. Clinical expression of myasthenia gravis varies, ranging from a mild localized disease such as ocular myasthenia gravis (OMG) to a severe generalized disease. A higher frequency of thyroid antibodies has been observed in OMG compared to generalized myasthenia gravis, but the exact mechanisms of this increased association between OMG and thyroid autoimmunity has not been confirmed. The $quot;see-saw$quot; relationship between hyperthyroidism and myasthenia gravis is presented by some authors, while others reported that the optimal maintenance of euthyroid status was essential in treatment. Today many authors agree to the latter and we think that the adequate control of hyperthyroidism is more important. We have experienced six cases of hyperthyroidism combined with OMG and it was somewhat difficult to diagnose myasthenia gravis when the patient have Graves ophthalmopathy (J Kor Soc Endocrinol 15:606-613, 2000).
Effects of Magnetic Infrared Laser on Dinitrofluorobenzene-induced Contact Dermatitis in Mice
Kim, Cheol-Young,Back, Young-Doo,Chang, Jeong Hyun,Lee, Hyeung-Sik,Park, Kyung-Won,Choi, Seong-Hun,Chung, In-Kwon,Cheon, Woo-Hyun,Ku, Sae-Kwang The Society of Physical Therapy Science 2011 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.23 No.3
<P>[Purpose] The purpose of the present study was to investigate the effect of a magnetic infrared laser (MIL) on the 2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis, type I allergic mouse model. [Subjects] Male ICR mice. [Methods] Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. MIL radiation doses of 1.33, 2.66 and 6.65 J/cm<SUP>2</SUP> were given, once a day for 7 continuous days, to DNP-OVA sensitized mice and compared with 15 mg/kg dexamethasone (intraperitoneal treatment). The edematous changes and scratching behavior were measured together with ear histopathological observations. [Results] Immediately after DNFB challenge to the ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected as well as anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these DNFB-induced increases of edematous changes and scratching behavior were significantly and dose-dependently decreased by MIL irradiation. [Conclusion] The results obtained in this study suggest that MIL radiation has relatively favorable effects on allergic dermatitis, and MIL therapy may represent an alternative approach for the treatment of allergic cutaneous diseases.</P>
Kim, Yumi,Kim, Kang-Hoon,Lee, In-Seung,Park, Ji Young,Na, Yun-Cheol,Chung, Won-Seok,Jang, Hyeung-Jin Elsevier 2019 Phytomedicine Vol.56 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Timosaponin A3 (TA3), one of the active components of spirostanol saponin isolated from <I>A. asphodeloides</I>, is widely used as an anticancer agent in a variety of cancer cell lines. However, the research on the anticancer efficacy is very limited in human pancreatic cancer models.</P> <P><B>Purpose</B></P> <P>In this study, we investigated the molecular targets in the active component<ce:cross-out>s</ce:cross-out> of <I>A. asphodeloides</I>, which showed anti-cancer effects in human pancreatic cancer cells, and confirmed the pathways involved.</P> <P><B>Study design</B></P> <P>The apoptotic effects of five solvent extracts of <I>A. asphodeloides</I> in human pancreatic cancer cells (AsPC-1) was studied, and the phytochemical leading to their effects identified. Next, we determined whether the phytochemical inhibit STAT3 and ERK1/2, and investigated the pathways involved.</P> <P><B>Methods</B></P> <P>Five solvent extracts of <I>A. asphodeloides</I> (100 µg/ml, 24 h) was investigated for their cytotoxicity against AsPC-1 cells. The active ingredient of the extract exhibiting the highest toxicity were analyzed by liquid chromatography-mass spectrometry. Next, we studied the mechanism of action of the phytochemical in pancreatic cancer. Cell cycle and annexin V/FITC assays were performed to assess cell growth and apoptosis capacity. The effects on apoptosis and proliferation-related pathways, STAT3, and MAPKs were confirmed at the protein level using immunoblotting. The factors regulated in the pathways were investigated using reverse transcription polymerase chain reaction.</P> <P><B>Results</B></P> <P>The results showed that the ethyl acetate extract of <I>A. asphodeloides</I> (EAA) induced apoptotic and anti-proliferative activities through the STAT3 and MAPKs pathways. We found that TA3, an active component of EAA, inhibits constitutive STAT3 and ERK1/2 proteins. EAA and TA3 decreased the viability of AsPC-1 cells, leading to cell cycle arrest at the sub-G1 and G2/M phases. Moreover, TA3 inhibited the expression of various genes encoding anti-apoptotic (Bcl-2, Bcl-xl), proliferative (Cyclin D1), metastatic (MMP-9), and angiogenic (VEGF-1) proteins.</P> <P><B>Conclusion</B></P> <P>The results indicated that TA3, an active phytochemical from <I>A. asphodeloides</I>, could induce apoptosis and suppress cell proliferation by inhibiting the STAT3 and ERK1/2 pathways. Thus, TA3 is a candidate cancer chemotherapeutic agent instead to treat human pancreatic cancer.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Effects of the Inhaled Treatment of Liriope Radix on an Asthmatic Mouse Model
Kim, Ki-Suk,Cho, Dong-Hyuk,Yang, Hea Jung,Choi, Eun-Kyeong,Shin, Min Hee,Kim, Kang-Hoon,Ahn, Kwang Seok,Ha, In Jin,Na, Yun-Cheol,Um, Jae Young,Chung, Won Seok,Jung, Hee-Jae,Jung, Sung-Ki,Jang, Hyeung- World Scientific 2015 The American journal of Chinese medicine Vol.43 No.3
<P>As a treatment for allergic asthma, inhaled treatments such as bronchodilators that contain β2-agonists have an immediate effect, which attenuates airway obstructions and decreases airway hypersensitivity. However, bronchodilators only perform on a one off basis, but not consistently. Asthma is defined as a chronic inflammatory disease of the airways accompanying the overproduction of mucus, airway wall remodeling, bronchial hyperreactivity and airway obstruction. Liriope platyphylla radix extract (LPP), a traditional Korean medicine, has been thoroughly studied and found to be an effective anti-inflammatory medicine. Here, we demonstrate that an inhaled treatment of LPP can attenuate airway hyperresponsiveness (AHR) in an ovalbumin-induced asthmatic mouse model, compared to the saline-treated group (p < 0.01). Moreover, LPP decreases inflammatory cytokine levels, such as eotaxin (p < 0.05), IL-5 (p < 0.05), IL-13 (p < 0.001), RANTES (p < 0.01), and TNF-α (p < 0.05) in the bronchoalveolar lavage (BAL) fluid of asthmatic mice. A histopathological study was carried out to determine the effects of LPP inhalation on mice lung tissue. We performed UPLC/ESI-QTOF-MS, LC/MS, and GC/MS analyses to analyze the chemical constituents of LPP, finding that these are ophiopogonin D, spicatoside A, spicatoside B, benzyl alcohol, and 5-hydroxymethylfurfural. This study demonstrates the effect of an inhaled LPP treatment both on airway AHR and on the inflammatory response in an asthmatic mouse model. Hence, LPP holds significant promise as a nasal inhalant for the treatment of asthmatic airway disease.</P>