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( Ki Chul Yoon ),( Eun Jung Cho ),( In Hye Cha ),( Ha Na Yang ),( Hae Won Kim ),( Myung Gyu Kim ),( Sang Kyung Jo ),( Won Yong Cho ),( Hyoung Kyu Kim ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.1
Autoimmune pancreatitis is a recently established clinicopathologic entity often associated with various types of other autoimmune diseases. We report a case of postrenal acute kidney injury (AKI) due to retroperitoneal fibrosis associated with autoimmune pancreatitis. The seventy one year old male patient was admitted because of oliguria and lower extremity edema. He had been diagnosed to have autoimmune pancreatitis and retroperitoneal fibrosis by increased serum IgG and IgG4 level with the presence of rim like attenuation around pancreas and the retroperitoneal fibrosing mass in abdominal CT scan 1 year ago but was lost to follow up. Magnetic resonance cholangiopancretogram and follow up abdominal CT scan showed progressed retroperitoneal fibrosis with newly developed bilateral hydronephrosis and atrophied left kidney despite partial improvement in pancreatitis. Because of progressively rising serum creatinine and oliguria, percutaneous nephrostomy in right kidney was performed. Steroid treatment was initiated with insertion of double J catheter at right ureter and renal function gradually returned. We report here a rare case of postrenal AKI developed in unilateral functioning kidney complicated by combined retroperitoneal fibrosis and autoimmune pancreatitis.
( Ki Cheon Kim ),( Mei Jing Piao ),( Jian Zheng ),( Cheng Wen Yao ),( Ji Won Cha ),( Madduma Hewage Susara Ruwan Kumara ),( Xia Han ),( Hee Kyoung Kang ),( Nam Ho Lee ),( Jin Won Hyun ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.4
Fucodiphlorethol G (6`-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2`,4,4`,6-pentol) is a compound purifi ed from Ecklonia cava, a brown alga that is widely distributed offshore of Jeju Island. This study investigated the protective effects of fucodiphlorethol G against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) irradiation. Fucodiphlorethol G attenuated the generation of 2, 2-diphenyl-1-picrylhydrazyl radicals and intracellular reactive oxygen species in response to UVB irradiation. Fucodiphlorethol G suppressed the inhibition of human keratinocyte growth by UVB irradiation. Additionally, the wavelength of light absorbed by fucodiphlorethol G was close to the UVB spectrum. Fucodiphlorethol G reduced UVB radiation-induced 8-isoprostane generation and DNA fragmentation in human keratinocytes. Moreover, fucodiphlorethol G reduced UVB radiationinduced loss of mitochondrial membrane potential, generation of apoptotic cells, and active caspase-9 expression. Taken together, fucodiphlorethol G protected human keratinocytes against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging reactive oxygen species.
Patterns of care and treatment outcomes for primary thyroid lymphoma: a single institution study
Cha, Hyejung,Kim, Jun Won,Suh, Chang-Ok,Kim, Jin Seok,Cheong, June-Won,Lee, Jeongshim,Keum, Ki Chang,Lee, Chang Geol,Cho, Jaeho The Korean Society for Radiation Oncology 2013 Radiation Oncology Journal Vol.31 No.4
Purpose: The aim of this study was to analyze the patterns of care and treatment outcomes in patients with primary thyroid lymphoma (PTL) in a single institution. Materials and Methods: Medical records of 29 patients with PTL treated between April 1994 and February 2012 were retrospectively reviewed. Diagnosis was confirmed by biopsy (n = 17) or thyroidectomy (n = 12). Treatment modality and outcome were analyzed according to lymphoma grade. Results: The median follow-up was 43.2 months (range, 3.8 to 220.8 months). The median age at diagnosis was 57 years (range, 21 to 83 years) and 24 (82.8%) patients were female. Twenty-five (86.2%) patients had PTL with stage IEA and IIEA. There were 8 (27.6%) patients with mucosa-associated lymphoid tissue (MALT) lymphoma and the remaining patients had high-grade lymphoma. Patients were treated with surgery (n = 2), chemotherapy (n = 7), radiotherapy (n = 3) alone, or a combination of these methods (n = 17). Treatment modalities evolved over time and a combination of modalities was preferred, especially for the treatment of high-grade lymphoma in recent years. There was no death or relapse among MALT lymphoma patients. Among high-grade lymphoma patients, 5-year overall survival (OS) and 5-year progression-free survival (PFS) were 75.6% and 73.9%, respectively. Complete remission after initial treatment was the only significant prognostic factor for OS (p = 0.037) and PFS (p = 0.003). Conclusion: Patients with PTL showed a favorable outcome, especially with MALT lymphoma. Radiotherapy alone for MALT lymphoma and chemotherapy followed by radiotherapy for high-grade lymphoma can be effective treatment options for PTL.
Methods of measuring the vibrations of a gun tube under impulse loads
Won-yeong Choi,유승열,노명규,Ki-up Cha,Chang-ki Cho,Sung-soo Kim 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.12
In many respects, accelerometers are convenient for measuring the lateral vibrations of a gun tube under impulse loads. Reliable measurements by accelerometers must overcome two issues: exceedingly large acceleration at high frequencies due to stress waves, and the elimination of drifts accumulating through the integration of acceleration signals. In this paper, we use a mechanical filter that reduces the effect of stress waves. Also, we propose a new double integration algorithm based on multi-resolution wavelet decomposition. Using a test-rig, we measure the vibration characteristics of commercially-available damping materials. Based on the test results, we design a mechanical filter and experimentally verify the performance of the filter. The proposed double integration algorithm is shown to be as effective as other existing algorithms without arbitrary selection of parameters.