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Estrogen과 Androgen이 웅성 백서의 신장에 미치는 영향에 대한 병리학적 연구
윤율로,이충식,강대영 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2
A pathologic study was performed to study the effects of estrogen and androgen on kidney, which was thought to induce benign prostatic hyperplasia in the human and the dog. Forty male Sprague Dawley rats were castrated via a scrotal incision. The remaining 10 rats served as normal controls. A two week period was allowed for the sex accessory tissues of castrated rats to involute after which the rats received 25 daily intramuscular injections of 2mg testosterone only, 0.02mg of estradiol only, or a combination of both steroids, each dissolved in 0.2m1 of propylene glycol. Normal and castrate control groups were injected with 0.2m1 of propylene glycol only. Twenty four hours after the last injection, rats were killed and weighed, and then both kidneys were removed and weighed. Light microscopic and electron microscopic studies of the kidneys were performed. The results were as follows: 1. There was a significant increase in the average weight of the kindeys of the groups treated with testosterone plus estradiol when compared to control group (p<0.01). 2. The average weight of the groups treated with testosterone plus estradiol showed a significant decrease compared to those of castrated controls (p<0.05). 3. In the castrate controls, the kidneys were microscopically unremarkable, but the kidneys of the groups treated with testosterone only and estradiol only showed mild vesicle formation in the cytoplasm. The groups treated with testosterone plus estradiol showed enlargement of convoluted tubules and severe vesicle formation. 4. Electron microscopically, the kidneys of the groups treated with testosterone only and estradiol only showed mild edematous change in the cytoplasm, but the groups treated with testosterone plus estradiol showed severe edematous change in mitochondrias and increase of polyribosomes. The above results suggest that the increased weight of the kidney and tubular er largement of The groups treated with testosterone plus estradiol is caused by water accumulationin the cytoplasm.
최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2
Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.
金瑩洙,河泰原,朴滿洙,姜瞬求,李重禾,尹栗老,薛鍾求 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2
Rhabdomyosarcoma, which is a very rare and highly malignant disease in urologic field, has three categories-pleomorphic, alveolar, embryonal, and may arise from any part of the body that contains embryonal mesenchyme, whether striated muscle tissue is present or not. The common site in the genitourinary tract are prostate, bladder, and vagina. Herein we experienced a rhabdomyosarcoma of the pelvic cavity and reviewed literature briefly.
하지 동맥경화증의 수술 전 진단에서 고식적 혈관조영술과 다중검출 나선식 컴퓨터 혈관조영술의 비교
이강율(Kang Yool Lee),김일명(Il Myung Kim),유병욱(Byung Ook You),윤진(Jin Yoon),박상수(Sang Su Park),신동규(Dong Gue Shin),강성구(Sung Gu Kang),황호경(Ho Kyung Hwang),이성아(Sung A Lee) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.4
Purpose: We performed this study to assess the suitability of conventional angiography (CA) vs. multi-detector row helical CT angiogram (MD-CTA) as a method of preoperative diagnostic imaging for low extremity arterial surgery. Methods: From February 2004 to September 2006, 23 patients (4 claudicants, 19 limb-threatening ischemia) were studied with CA and MD-CTA preoperatively. The site and degree of stenotic or occlusive lesions in arterial segments from the renal artery to the dorsalis pedis artery were compared with both methods. We also compared the surgical inflow and outflow site changes in preoperative planning based on CA and MD-CTA and the final outcome. Additional diagnostic value and test-related complications were also analyzed. Results: The median age of patients was 68 years old (range: 43∼89 years), with a male to female ratio of 1.3:1. Twenty-three patients had CA after an MD-CTA scan. One hundred fifty lesions were detected in these patients. The total ratio of consistency for occlusion in CA vs. MD-CTA was 69.6%. Three patients received amputation treatment and eleven patients received a bypass operation. The agree ment between the preoperative plan based on MD-CTA and the final operation was 100%, even in critical limb ischemia. There were no serious complications related to the tests. Conclusion: These findings suggest that MD-CTA is an adequate preoperative imaging study of infrainguinal arterial surgery and may be substituted for conventional angiography without any serious complications.
Hyun-Min Kang,Heyong-Seok Kim,Min-Hee Kang,Jong-Won Kim,Dong-Jae Kang,Woong-Bin Ro,Doo-Won Song,Ga-Won Lee,Hee-Myung Park,Hwi-Yool Kim The Korean Society of Veterinary Clinics 2023 한국임상수의학회지 Vol.40 No.6
Chronic kidney disease (CKD) occurs in more than 15% of the dogs over 10 years of age and causes irreversible renal function deterioration. Therefore, it is important to diagnose CKD early and treat the disease properly. The purpose of this study aimed to to evaluate the clinical utility of urine albumin/creatinine ratio (ACR) using POC (point-of-care) device as an early detection urinary biomarker in CKD dogs and to confirm the correlation between ACR and other known CKD biomarkers. Urine and serum samples were obtained from 50 healthy dogs and 50 dogs with CKD. Serum blood urea nitrogen (BUN), creatinine, and symmetric dimethylarginine (SDMA) concentrations, and urine protein creatinine ratio (UPC) were measured. Urine specific gravity (USG) was evaluated using refractometer, and ACR was measured using an i-SENS A1Care analyzer. The ACR values of dogs with CKD were significantly different from those of healthy dogs (p < 0.001), as with other renal biomarkers. ACR showed significant differences between healthy dogs and dogs with CKD at every IRIS stage (p < 0.005), whereas no significant differences were observed between dogs with CKD IRIS stage I and healthy dogs with UPC. There are significant positive correlation between ACR and BUN (r = 0.611, p < 0.001), creatinine (r = 0.788, p < 0.001), SDMA (r = 0.747, p < 0.001), and UPC (r = 0.784, p < 0.001), and significant negative correlation between ACR and USG (r = -0.700, p < 0.001). In receiver operator characteristic curve analysis, the area under the curve (AUC) was 0.982 (95% CI 0.963-1.000, p < 0.001), with an optimal cut-off value of 64.20 mg/g (94% sensitivity and 94% specificity). Thus, ACR is a useful urinary biomarker for the early diagnosis of proteinuria in CKD and combined use of ACR and other renal biomarkers may be helpful for early diagnosis and prevention of CKD in dogs.
음차표기된 외래어의 발음특성을 이용한 자동 영어단어 복원
이상율(Sang-Yool Lee),강인수(In-Su Kang),나승훈(Seung-Hoon Na),이종혁(Jong-Hyeok Lee) 한국정보과학회 2003 한국정보과학회 학술발표논문집 Vol.30 No.1B
음차 표기된 외래어의 원어 복원 문제에 있어서 확률모델을 이용한 방법들이 기존에 많이 사용되었다. 이는 ‘발음단위’개념(이재성 1998)을 이용하여 서로 대응될 수 있는 한글발음단위와 영어발음단위의 쌍들을 대역어 집합으로부터 추출하고 이를 확률모델에 적용하는 방법이다. 하지만 영어 철자를 영어 발음단위로 변환하는 과정에서 그 단어의 어원에 따라 서로 다른 발음상의 특징을 보이게 되는데, 이것이 기존의 연구에서 성능을 떨어뜨리는 원인이 되었다. 따라서 본 논문에서는 학습 데이터(대역어 집합)들을 발음 특성에 따라 분류하고, 분류된 각 데이터 집합을 학습과정에서 따로 적용함으로써 서로 다른 특성을 가지는 여러 개의 복원 모델을 얻을 수 있고, 이를 이용하여 원어 복원에 대한 성능을 높일 수 있음을 보여준다.
Chung, Dai-Jung,Choi, Chi-Bong,Lee, Sung-Ho,Kang, Eun-Hee,Lee, Jae-Hoon,Hwang, Soo-Han,Han, Hoon,Lee, Jong-Hwan,Choe, Bo-Young,Lee, Soo-Yeol,Kim, Hwi-Yool Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of neuroscience research Vol.87 No.16
<P>The present study examined the effects of human umbilical cord blood-derived mesenchymal stem cells (HUCB-derived MSCs) delivered through the basilar artery in a canine thromboembolic brain ischemia model. Cerebral ischemia was induced through occlusion of the middle cerebral artery by injecting thrombus emboli into 10 beagles. In the HUCBC group (n = 5), 1 × 10<SUP>6</SUP> HUCB-derived MSCs were transplanted through the basilar artery 1 day after ischemic induction using an endovascular interventional approach. In the control group (n = 5), phosphate-buffered saline (PBS) was injected in the same manner in as the HUCBC group. Upon neurobehavioral examination, earlier recovery was observed in the HUCBC group. The HUCBC group showed a decrease in the infarction volume at 1 week after cerebral ischemic induction, whereas the control group showed an increase in the infarction volume at 1 week, by magnetic resonance image analysis. Transplanted cells had differentiated into neurons and astrocytes and were observed in and around endothelial cells that were positive for von Willebrand factor (vWF). HUCB-derived MSCs expressed neuroprotective factors, such as brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), at 4 weeks after the transplantation. The transplanted cells demonstrated their efficacy by reducing the infarction lesion volume and through earlier recovery from the neurological deficit. These results suggest that intraarterial transplantation of HUCB-derived MSCs could be useful in clinical treatment of cerebral ischemia. © 2009 Wiley-Liss, Inc.</P>