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정확한 Closed-Form 그린함수를 이용한 코플래너 도파로 불연속 해석
강연덕,송성찬,이택경 한국항행학회 2003 韓國航行學會論文誌 Vol.7 No.2
실수축 상의 적분 방법에 의한 정확한 closed-form 그린함수를 이용하여 코플래너 도파로의 불연속에 대한 공간영역 full-wave 해석을 하였다. MPIE(Mixed Potential Integral Eqution)를 풀기 위한 수치계산 방법으로는 삼각형 요소를 이용한 갤러킨 방법을 사용하였다. 경계면에서 삼각형 요소상의 기저함수로는 선형함수를 사용하였으며, 관측점과 전원점이 일치하는 특이점 근방의 적분 계산을 위해 면적분을 선적분 형태로 바꾸어 피적분 함수의 특이점이 사라지도록 하는 해석적인 방법을 사용하였다. 실수축 적분방법에 의한 그린함수를 이용함으로써 불연속에 대한 정확한 특성을 구하였다. By using accurate closed-form Green's functions obtained from real-axis integration method, the full-wave analysis of CPW discontinuities are performed in space domain. In solving MPIE(Mixed Potetial Integral Equation), Galerkin's scheme is employed with the linear basis functions on the truangular elements in air-dielectric boundary. In the singular integral arising when the observation point and source point coincides, the surface integral is transformed into the line integral and the integral is evaluated by regular integration. By using the green's function from the real-axis integration method, the discontinuities are characterized accurately.
測定用 寫眞과 非測定用 寫眞의 組合에 依한 圓筒形 構造物의 全面解析
姜準默,裵淵晟,李鎭德 忠南大學校 産業技術硏究所 1991 산업기술연구논문집 Vol.6 No.2
본 연구는 C.R.P.에서 측정용과 비측정용 사진을 조합하여 원통형 구조물의 전면해석을 시도하고 그의 정확도를 실험적으로 구명한 것이다. 대상물 주위에 원형의 노출 network을 구성하고 측정용과 비측정용 카메라를 이용하여 multi-station photography를 실시하였다. strip과 block을 bundle조정에 의하여 촬영 거리별로 측정용 사진과 비측정용 사진으로 각각 해석하고, 정확도를 비교함으로써 비측정용 카메라의 적용가능성을 입증하였다. 또한 원통형 구조물의 全面을 단시간에 해석하기 위하여 측정용 사진과 비측정용 사진의 조합해석을 시도하고 이의 효용성을 제시하였다. The objective of this study is to suggest the ways of analyzing the entrire-area of cylindrical structure with combination of metric and non-metric photos in C.R.P. and also investigate characteristics of accuracies. For it, circular exposure network was disigned and multi-station photography was executed with metric and non-metric camera respectively. Bundle adjustment was performed to compute three dimensional coordinates of unknown points. By comparing accuracies of results analyzed with metric photos and non-metric photos, we proved applicability of non-metric camera to purpose of measurement. Also, by positioning through combining metric and non-metric pothos, we proved the effectiveness of it and found out characteristics of accuracy of it.
Kang, Nae-Won,Kim, Min-Hwan,Sohn, Seo-Yeon,Kim, Ki-Taek,Park, Ju-Hwan,Lee, Sun-Young,Lee, Jae-Young,Kim, Dae-Duk Elsevier 2018 Biomaterials Vol.182 No.-
<P><B>Abstract</B></P> <P>Cellulose nanofiber (CNF) is an attractive biomaterial given its film-forming properties, excellent mechanical properties and biocompatibility. Herein, CNF film was prepared as a topical drug delivery system by hybridizing curcumin (Cur)-loaded nanostructured lipid carriers (NLCs). NLCs with a mean diameter of ≈500 nm were fabricated by using a solvent diffusion method. The lipid composition of the NLCs was optimized based on the efficiency of Cur delivery to the artificial skin and mechanical strength of the developed films, where a composition containing shea butter and Capmul MCM EP exhibited the highest values of 233.2 ± 96.6 μg/cm<SUP>2</SUP>/mg and 4.86 ± 0.14 MPa, respectively. The Cur-loaded lipid-hybridized CNF (lipid@CNF) films with a smooth rather than particle-embedded surface were obtained by vacuum filtration of the NLCs and CNF mixture, which were confirmed by TEM, SEM, AFM, XPS, and FTIR analyses. The Cur-loaded lipid@CNF films exhibited more than 2.0-fold increases in Cur deposition to the epidermis of imiquimod (IMQ)-induced psoriatic mouse compared with the films without lipids, which potentially resulted from the amorphous state of Cur observed in the DSC and PXRD analyses and the permeation-enhancing effect of lipids. The <I>in vivo</I> anti-psoriatic efficacy test revealed that the Cur-loaded lipid@CNF films ameliorated the psoriatic skin symptoms in IMQ-induced mice, reducing the pro-inflammatory cytokine levels in the skin almost comparable to a commercially available topical corticosteroid cream. These results could be attributed to the enhanced Cur deposition along with the skin hydration effect of the films. These findings suggest that the developed CNF films can be used as a promising topical drug delivery system for psoriasis therapy.</P>
Yeon Hee Yu,Seong-Wook Kim,Juhyeon Kang,Yejin Song,Hyuna Im,Seo Jeong Kim,Dae Young Yoo,Man-Ryul Lee,Dae-Kyoon Park,Jae Sang Oh,Duk-Soo Kim 대한신경외과학회 2022 Journal of Korean neurosurgical society Vol.65 No.5
Objective : Patients with mild ischemic stroke experience various sequela and residual symptoms, such as anxious behavior and deficits in movement. Few approaches have been proved to be effective and safe therapeutic approaches for patients with mild ischemic stroke by acute stroke. Sildenafil (SIL), a phosphodiesterase-5 inhibitor (PDE5i), is a known remedy for neurodegenerative disorders and vascular dementia through its angiogenesis and neurogenesis effects. In this study, we investigated the efficacy of PDE5i in the emotional and behavioral abnormalities in rats with mild ischemic stroke. Methods : We divided the rats into four groups as follows (n=20, respectively) : group 1, naïve; group 2, middle cerebral artery occlusion (MCAo30); group 3, MCAo30+SIL-pre; and group 4, MCAo30+SIL-post. In the case of drug administration groups, single dose of PDE5i (sildenafil citrate, 20 mg/kg) was given at 30-minute before and after reperfusion of MCAo in rats. After surgery, we investigated and confirmed the therapeutic effect of sildenafil on histology, immunofluorescence, behavioral assays and neural oscillations. Results : Sildenafil alleviated a neuronal loss and reduced the infarction volume. And results of behavior task and immunofluorescence shown possibility that anti-inflammation process and improve motor deficits sildenafil treatment after mild ischemic stroke. Furthermore, sildenafil treatment attenuated the alteration of theta-frequency rhythm in the CA1 region of the hippocampus, a known neural oscillatory marker for anxiety disorder in rodents, induced by mild ischemic stroke. Conclusion : PDE5i as effective therapeutic agents for anxiety and movement disorders and provide robust preclinical evidence to support the development and use of PDE5i for the treatment of mild ischemic stroke residual disorders.