Acidity in Precipitation and Solar North-South Asymmetry

Ga-Hee Moon,Kyoung-Yoon Ha,Seong-Hoon Kang,Byoung-Ho Lee,Ki-Beom Kim,Jung-Hee Kim,Heon-Young Chang 한국우주과학회 2014 Journal of Astronomy and Space Sciences Vol.31 No.4

We are motivated by both the accumulating evidence for the connection of solar variability to the chemistry of nitrogen oxide in the atmosphere and recent finding that the Galactic cosmic-ray (GCR) influx is associated with the solar northsouth asymmetry. We have analyzed the measured pH in precipitation over the 109 stations distributed in the United States. We have found that data of pH in precipitation as a whole appear to be marginally anti-correlated with the solar asymmetry. That is, rain seems to become less acidic when the southern hemisphere of the Sun is more active. The acidity of rain is also found to be correlated with the atmospheric temperature, while not to be correlated with solar activity itself. We have carried on the analysis with two subsamples in which stations located in the east and in the west. We find that the pH data derived from the eastern stations which are possibly polluted by sulfur oxides and nitrogen oxides are not correlated with the solar asymmetry, but with the temperature. On the contrary, the pH data obtained from the western stations are found to be marginally anti-correlated with the solar asymmetry. In addition, the pH data obtained from the western stations are found to be correlated with the solar UV radiation. We conclude by briefly pointing out that a role of the solar asymmetry in the process of acidification of rain is to be further examined particularly when the level of pollution by sulfur oxides and nitrogen oxides is low.

mRNA-centric semantic modeling for finding molecular signature of trace chemical in human blood

Ga-Hee Shin,Yeon-Kyung Kang,Seung-Hun Lee,Seung Jun Kim,황승용,남석우,류재천,Byeong-Chul Kang 대한독성 유전단백체 학회 2012 Molecular & cellular toxicology Vol.8 No.1

The vast quantities of information on toxicogenomics such as genome sequence, genotype, gene expression, phenotype, disease information, etc. are reflected in scientific literature. However, these various and heterogeneous data has to be reconstructed by proper data model to enhance our understanding. This study suggests a semantic modeling to organize heterogeneous data types and introduces techniques and concepts such as ontologies, semantic objects, typed relationships, contexts, graphs, and information layers. These concepts were used to represent complex biochemical networks relationship. The semantic modeling tool is used as an example to demonstrate how a domain such as risk assessment is represented and how this representation is utilized for research. In this work, we show focusing on mRNA centric semantic model as a representative. From experimental data, text-mining results and public databases we generate mRNA-centric semantic modeling and demonstrate its use by mining specific molecular networks together. Application of semantic modeling: 1. Common DEGs which are differentially expressed mRNA by VOCs are identified. 2. Diseases and biological processes associated with common DEGs are identified. 3. Finally subjects associated with common disease, biological process and DEGs are identified.

Reproduction and Cultivation of Sea Water Tilapia (Oreochromis mossambicus, Docheon strain)

Ga-Hyun Kang,Do-Hee Kim,Sun-Young Yu,Aswi A. Rofiqoh,Byeong-Dea Choi,Dong-Han Bae,Seok-Joong Kang 한국수산과학회 양식분과 2014 한국수산과학회 양식분과 학술대회 Vol.2014 No.10

Acidity in Precipitation and Solar North-South Asymmetry

Moon, Ga-Hee,Ha, Kyoung-Yoon,Kang, Seong-Hoon,Lee, Byoung-Ho,Kim, Ki-Beom,Kim, Jung-Hee,Chang, Heon-Young The Korean Space Science Society 2014 Journal of Astronomy and Space Sciences Vol.31 No.4

We are motivated by both the accumulating evidence for the connection of solar variability to the chemistry of nitrogen oxide in the atmosphere and recent finding that the Galactic cosmic-ray (GCR) influx is associated with the solar north-south asymmetry. We have analyzed the measured pH in precipitation over the 109 stations distributed in the United States. We have found that data of pH in precipitation as a whole appear to be marginally anti-correlated with the solar asymmetry. That is, rain seems to become less acidic when the southern hemisphere of the Sun is more active. The acidity of rain is also found to be correlated with the atmospheric temperature, while not to be correlated with solar activity itself. We have carried on the analysis with two subsamples in which stations located in the east and in the west. We find that the pH data derived from the eastern stations which are possibly polluted by sulfur oxides and nitrogen oxides are not correlated with the solar asymmetry, but with the temperature. On the contrary, the pH data obtained from the western stations are found to be marginally anti-correlated with the solar asymmetry. In addition, the pH data obtained from the western stations are found to be correlated with the solar UV radiation. We conclude by briefly pointing out that a role of the solar asymmetry in the process of acidification of rain is to be further examined particularly when the level of pollution by sulfur oxides and nitrogen oxides is low.

Metastatic colon cancer cell populations contain more cancer stem-like cells with a higher susceptibility to natural killer cell-mediated lysis compared with primary colon cancer cells

KIM, GA RIM,HA, GA-HEE,BAE, JAE-HO,OH, SAE-OCK,KIM, SUN-HEE,KANG, CHI-DUG D.A. Spandidos 2015 Oncology letters Vol.9 No.4

<P>In the present study, the soft agar clonogenicity and the susceptibility of clonogenic cancer cells to natural killer (NK) cells were compared between primary colon cancer cells (KM12C) and metastatic colon cancer cells (KM12L4a and KM12SM) to determine whether the metastatic cancer cells consisted of more cancer stem-like cells and were resistant to NK cell-mediated lysis. The majority of colon cancer cells were positive for putative cancer stem cell markers, including CD44, CD133 and EpCAM, with the exception of KM12C cells, of which only ~55% were positive for CD133. In addition, the expression levels of sex determining region Y-box 2, Nanog and octamer-binding transcription factor 4, which are essential for maintaining self-renewal, were higher in KM12L4a and KM12SM compared with that in KM12C cells. Consistently, an increased clonogenicity of KM12L4a and KM12SM compared with KM12C cells in soft agar was observed. The expression levels of NKG2D ligands, including major histocompatibility complex class I polypeptide-related sequence A/B and UL16 binding protein 2, and of death receptor 5 were significantly higher in KM12L4a and KM12SM than in KM12C cells. Furthermore, the results indicated an increased susceptibility of KM12L4a and KM12SM to NK cell-mediated cytotoxicity in comparison with KM12C cells. These results indicated that metastatic colon cancer cell populations may consist of more cancer stem-like cells, and have greater susceptibility to NK cell-mediated lysis compared with that of primary colon cancers.</P>

Immunohistochemical study of the distribution of sodium-dependent vitamin C transporters in adult rat brain

Mun, Ga Hee,Kim, Myeung Ju,Lee, Ju Hyun,Kim, Hyun Jun,Chung, Yoon Hee,Chung, Young Bae,Kang, Jae Seung,Hwang, Young Il,Oh, Seung Ha,Kim, Joong-Gon,Hwang, Douk Ho,Shin, Dong Hoon,Lee, Wang Jae Wiley Subscription Services, Inc., A Wiley Company 2006 Journal of neuroscience research Vol.83 No.5

<P>Sodium-dependent vitamin C transporters (SVCTs) is known to transport the reduced form of ascorbic acid into the cell, whereas the oxidized form of vitamin C (VC) is moved through a facilitative sugar transporter, such as glucose transporter (GLUT). With regard to the distribution of SVCT1 and -2 within the various organs, they were reported to be expressed in different types of cells. Especially in the central nervous system, only SVCT2 mRNA was expressed mainly in neurons and some types of neuroglial cells. However, data on the expression of SVCT proteins in the brain are scant. Therefore, we tried to develop comprehensive data on the distribution of SVCT proteins in adult rat brain by using immunohistochemical techniques for the first time. In our study, SVCT2 immunoreactivities (IRs) were intensely localized in the neurons of cerebral cortex, hippocampus, and Purkinje cells of cerebellum, and much weaker SVCT2 IRs were found in the other brain regions. Judging from double-immunohistochemical data, most of the cells expressing SVCT2 IRs were likely to be neurons or microglia, even though the cells in choroids plexus or ependymal cells around the ventricles also exhibited SVCT2 IRs. Complete mapping of the distribution of SVCT2 IRs was available by using a semiquantitative method. The subcellular localization of SVCT proteins is necessary for understanding the exact role of the protein, so the current overall mapping of SVCT IRs in the rat brain could be the basis for further studies on related subjects. © 2006 Wiley-Liss, Inc.</P>

비만 관련 SNP genotype-phenotype 정보기반의 맞춤 식단옴 추천

신가희(Ga-Hee Shin),이상민(Sang-Min Lee),강병철(Byeong-Chul Kang),장대자(Dai-Ja Jang),권대영(Dae Young Kwon),김민정(Min-Jung Kim),김리랑(Ri-Rang Kim),김진희(Jin-Hee Kim),양혜정(Hye Jeong Yang) 한국콘텐츠학회 2016 한국콘텐츠학회논문지 Vol.16 No.10

전 세계적으로 비만인구의 증가로 인해 경제적 부담이 확대되고 있으며, 그 원인으로 육체적 활동의 감소 및 식이관리의 실패가 손꼽히고 있다. 영양성분 및 칼로리를 기반으로 한 맞춤 식단정보 제공 시스템과는 차별적으로 본 연구는 개인 맞춤형 기능성 식품을 추천하기 위해 비만 관련 SNP (single nucleotide polymorphism) 정보를 활용하였다. 본 연구를 위해 GWAS (Genome-wide association study) 분석을 수행하여 한국인 특이적인 비만 관련 SNP을 발굴하고, 이를 활용하여 유전적 정보를 입력하여 SNP genoype-phenoype 정보에 따른 맞춤 식단옴을 추천하였다. 또한 USDA (The United States Department of Agriculture) 식품 정보를 활용할 수 있도록 식품 통합 Database를 구축하여 식단 추천에 적용하였다. 그 결과, 표현형 정보 BMI (Body Mass Index)는 정상 수치를 가지고 있으나, 비만 관련 SNP 정보를 가지고 있는 샘플은 유전적 비만 위험도를 나타내어 식이관리가 필요하다는 정보를 확인하였으며, 관련 식품 정보를 제공하였다. 따라서 표현형에 따른 비만에 관한 정보와 유전형 정보가 일치하는 것은 아니며, 이는 표현형적 정보만을 이용한 비만 관리 식이 추천에는 한계가 있음을 의미하며 이러한 결과는 비만외 다른 성인병들에도 적용이 필요하며 이를 위해서는 표현형-유전적 통합정보를 기반 한 맞춤식이 추천이 필요함을 나타내었다. Obesity extends the global economic burden and it causes that the failure of a reduction of physical activity, and diet management. In this work, nutritional information and personalized diet based on calorie supply system and is discriminatory utilized the obesity-related SNP information in order to recommend a personalized functional foods. This study performed a GWAS analysis for the excavation of a Korean-specific and obesity-related SNP, which utilizes genetic information were recommended by entering a personalized diet in accordance with the SNP genotype-phenotype information. In addition, we integrated Database with relation of nutrient for utilizing the USDA Food information and it was applied to recommend with Sickdanome. As a result, the obesity-related SNP information was confirmed in the sample which has the normal value BMI. In this study, we have recognized that the phenotype information related obesity, BMI is inconsistent with the SNP genotype information. This result is shown that it is necessary to provide the personalized dietary SickdanOme recommendation based on the both pheotype-genotype information.

Evaluation of Albumin Creatinine Ratio as an Early Urinary Biomarker for Chronic Kidney Disease in Dogs

Hyun-Min Kang,Heyong-Seok Kim,Min-Hee Kang,Jong-Won Kim,Dong-Jae Kang,Woong-Bin Ro,Doo-Won Song,Ga-Won Lee,Hee-Myung Park,Hwi-Yool Kim The Korean Society of Veterinary Clinics 2023 한국임상수의학회지 Vol.40 No.6

Chronic kidney disease (CKD) occurs in more than 15% of the dogs over 10 years of age and causes irreversible renal function deterioration. Therefore, it is important to diagnose CKD early and treat the disease properly. The purpose of this study aimed to to evaluate the clinical utility of urine albumin/creatinine ratio (ACR) using POC (point-of-care) device as an early detection urinary biomarker in CKD dogs and to confirm the correlation between ACR and other known CKD biomarkers. Urine and serum samples were obtained from 50 healthy dogs and 50 dogs with CKD. Serum blood urea nitrogen (BUN), creatinine, and symmetric dimethylarginine (SDMA) concentrations, and urine protein creatinine ratio (UPC) were measured. Urine specific gravity (USG) was evaluated using refractometer, and ACR was measured using an i-SENS A1Care analyzer. The ACR values of dogs with CKD were significantly different from those of healthy dogs (p < 0.001), as with other renal biomarkers. ACR showed significant differences between healthy dogs and dogs with CKD at every IRIS stage (p < 0.005), whereas no significant differences were observed between dogs with CKD IRIS stage I and healthy dogs with UPC. There are significant positive correlation between ACR and BUN (r = 0.611, p < 0.001), creatinine (r = 0.788, p < 0.001), SDMA (r = 0.747, p < 0.001), and UPC (r = 0.784, p < 0.001), and significant negative correlation between ACR and USG (r = -0.700, p < 0.001). In receiver operator characteristic curve analysis, the area under the curve (AUC) was 0.982 (95% CI 0.963-1.000, p < 0.001), with an optimal cut-off value of 64.20 mg/g (94% sensitivity and 94% specificity). Thus, ACR is a useful urinary biomarker for the early diagnosis of proteinuria in CKD and combined use of ACR and other renal biomarkers may be helpful for early diagnosis and prevention of CKD in dogs.

Identification of Genes Induced by Venturia nashicola in Indigenous Korean Pear ‘Hwangsilri’

Il Sheob Shin,Kyung Mi Bae,Ga Young Nam,Byoung-Cheorl Kang,Jaean Chun,Kang Hee Cho,Se Hee Kim,Hyung Seok Choi,Hyun Ran Kim,Hae Sung Hwang,Hee Jae Lee 한국원예학회 2012 한국원예학회 학술발표요지 Vol.2012 No.10

Role of serum bilirubin-to-albumin ratio as a prognostic index in critically ill children

Kang You Min,Kim Ga Eun,Park Mireu,Kim Jong Deok,Kim Minjung,Kim Yoon Hee,Kim Kyung Won,Son Myung Hyun,Kim Soo Yeon 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.2

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