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      • Prognostic Value of MGMT Promoter Methylation and TP53 Mutation in Glioblastomas Depends on IDH1 Mutation

        Wang, Kai,Wang, Yin-Yan,Ma, Jun,Wang, Jiang-Fei,Li, Shao-Wu,Jiang, Tao,Dai, Jian-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

        Several molecular markers have been proposed as predictors of outcome in patients with glioblastomas. We investigated the prognostic significance of $O^6$-methylguanine-DNA methyltransferase (MGMT) promoter methylation and TP53 mutation status dependent on isocitrate dehydrogenase 1 (IDH1) mutation in glioblastoma patients. A cohort of 78 patients with histologically confirmed glioblastomas treated with radiation therapy and chemotherapy were reviewed retrospectively. We evaluated the prognostic value of MGMT promoter methylation and TP53 mutation status with regard to progression-free survival (PFS) and overall survival (OS). It was revealed that mutations in IDH1, promoter methylation of MGMT, TP53 mutation, age, Karnofsky performance status (KFS), and extension of resection were independent prognostic factors. In patients with an IDH1 mutation, those with an MGMT methylation were associated with longer PFS (p=0.016) and OS (p=0.013). Nevertheless, the presence of TP53 mutation could stratify the PFS and OS of patients with IDH1 wild type (p=0.003 and 0.029 respectively, log-rank). The MGMT promoter methylation and TP53 mutation were associated with a favorable outcome of patients with and without mutant IDH1, respectively. The results indicate that glioblastomas with MGMT methylation or TP53 mutations have improved survival that may be influenced by IDH1 mutation status.

      • Clinical Application of Transcatheter Arterial Chemoembolization Combined with Synchronous C-arm Cone-Beam CT Guided Radiofrequency Ablation in treatment of Large Hepatocellular Carcinoma

        Wang, Zhi-Jun,Wang, Mao-Qiang,Duan, Feng,Song, Peng,Liu, Feng-Yong,Wang, Yan,Yan, Jie-Yu,Li, Kai,Yuan, Kai Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

        Objective: This work aimed to evaluate the safety and clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with c-arm cone-beam CT guided synchronous radiofrequency ablation (RFA) in treatment of large hepatocellular carcinoma (HCC). Methods: 21 patients with large HCC were studied from January 2010 to March 2012. TACE combined with synchronous C-arm cone-beam CT guided RFA were performed on a total of 25 lesions. Conventional imaging examination (CEUS, enhanced CT or MRI) and AFP detection were regularly conducted to evaluate the technical success rate of combined treatment, complications, treatment response, time without disease recurrence and survival rate. Results: The technical success rate of combined treatment was 100%, without any significant complication. After 1 month, there were 19 cases with complete response and 2 cases with partial response, with an complete response rate of 90.4% (19/21) and a clinical effective rate of 100% (21/21). The complete response rates of single nodular lesions (100%, 17/17) was significantly higher than that of multiple nodular lesions (50%, 2/4) (P<0. 05). During 2 to 28 months of follow-up, in 19 cases with complete response, the average time without disease recurrence was $10.8{\pm}6$ months. The total survival rates of 6, 12 and 18 months in 21 patients were 100%, respectively. Conclusion: TACE combined with synchronous C-arm CT guided RFA is safe and effective for treatment of large HCC. The treatment efficacy for single nodular lesion is better than that for multiple nodular lesions.

      • KCI등재

        Sialoglycoprotein from Gadous morhua eggs improve high bone turnover activity via down-regulating BMP-2/Smads and Wnt/b-catenin signal pathways

        Kai Wang,Lihua Han,Na Wang,Yiming Wang,Jingfeng Wang 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.5

        The effect of sialoglycoprotein isolated from Gadous morhua eggs (Gm-SGP) on ovariectomized (OVX) induced osteoporosis, which is characterized by high bone turnover activity was investigated. Results revealed that Gm-SGP significantly increased bone mineral density, enhanced bone biomechanical properties and repaired the microstructure of the trabecular bone. Also, the treatment with Gm-SGP remarkably decreased biochemical marker contents or activities, such as serum BALP, PICP, BMP-2, TrACP, Cath-K, urine Ca and P, leading to the reduction in bone turnover. The elevation in the rate of bone formative process contributed in the increase of bone turnover. Both BMP-2/Smads and Wnt/b-catenin signaling pathways played an important role in osteogenesis. Gm-SGP suppressed the key factors expression in these two pathways such as BMP-2, Smad1, Smad4, Lrp-5b, Runx2, Osx, ALP, Col1, OCN and b-catenin. These findings might provide some theoretical basis for the application of Gm-SGP as a potential anti-osteoporotic drug or as functional food.

      • Geometric Optimization of a Mathematical Model of Radiofrequency Ablation in Hepatic Carcinoma

        Wang, Kai-Feng,Pan, Wei,Wang, Fei,Wang, Gao-Feng,Madhava, Pai,Pan, Hong-Ming,Kong, De-Xing,Liu, Xiang-Guan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

        Radio frequency ablation (RFA) is an effective means of achieving local control of liver cancer. It is a particularly suitable mode of therapy for small and favorably located tumors. However, local progression rates are substantially higher for large tumors (>3.0 cm). In the current study, we report on a mathematical model based on geometric optimization to treat large liver tumors. A database of mathematical models relevant to the configuration of liver cancer was also established. The specific placement of electrodes and the frequency of ablation were also optimized. In addition, three types of liver cancer lesion were simulated by computer guidance incorporating mathematical models. This approach can be expected to provide a more effective and rationale mechanism for employing RFA in the therapy of hepatic carcinoma.

      • KCI등재

        Surface nanocrystallization and its properties of a rare earth magnesium alloy induced by HVOF―SMB

        Kai-dong Xu,Ji-na Wang,Ai-hua Wang,Hua Yan,Xiang-lin Zhang,Zao-wen Huang 한국물리학회 2011 Current Applied Physics Vol.11 No.3

        The nanocrystalline microstructure in the surface of a rare earth magnesium alloy induced by a new process named HVOF―SMB (high velocity oxygen-fuel flame supersonic microparticles bombarding) has been characterized by means of X-ray diffractometry (XRD) and high-resolution transmission electron microscopy (HRTEM). The effects of HVOF―SMB on mechanical properties and corrosion resistance of the magnesium alloy have been investigated by microhardness distribution and polarization curves, and the cross-sectional observation of the treated Mg alloy sample has been characterized by optical microscopy (OM). Results showed that HVOF―SMB can induce surface nanocrystallization with a grain size level less than 20 nm at topmost surface layer, and the microhardness at the top surface layer increases up to about 170 HV_0.025 which is twice more than that of the substrate. The grain size increases as well as the microhardness decreases gradually with the depth varying from surface to substrate. The potentiodynamic polarization curves indicate that the HVOF―SMB treated surfaces show lower corrosion resistance in comparison with the untreated magnesium alloy in 3.5% NaCl solution. The underlying mechanism of the electrochemical properties on the nanocrystalline Mg-based alloy’s surface induced by severe plastic deformation in corrosion resistance is discussed.

      • KCI등재

        The visible and ultraviolet organic light-emitting diodes with germanium dioxide as facile solution-processed anode buffer layer

        Kai Xu,Zhenchang Tang,Yan Zhang,Wanshu Li,Haiou Li,Lihui Wang,Li-Ming Liu,Hong-Hang Wang,Feng Chi,Xiaowen Zhang 한국물리학회 2019 Current Applied Physics Vol.19 No.10

        Germanium dioxide (GeO2) aqueous solutions are facilely prepared and the corresponding anode buffer layers (ABLs) with solution process are demonstrated. Atomic force microscopy, X-ray photoelectron spectroscopy and ultraviolet photoelectron spectroscopy measurements show that solution-processed GeO2 behaves superior film morphology and enhanced work function. Using GeO2 as ABL of organic light-emitting diodes (OLEDs), the visible device with tris(8-hydroxy-quinolinato)aluminium as emitter gives maximum luminous efficiency of 6.5 cd/A and power efficiency of 3.5 lm/W, the ultraviolet device with 3-(4-biphenyl)-4-phenyl-5-tert-butylphenyl- 1,2,4-triazole as emitter exhibits short-wavelength emission with peak of 376 nm, full-width at halfmaximum of 42 nm, maximum radiance of 3.36 mW/cm2 and external quantum efficiency of 1.5%. The performances are almost comparable to the counterparts with poly (3,4-ethylenedioxythiophene):poly (styrenesulfonate) as ABL. The current, impedance, phase and capacitance as a function of voltage characteristics elucidate that the GeO2 ABL formed from appropriate concentration of GeO2 aqueous solution favors hole injection enhancement and accordingly promoting device performance.

      • SCOPUS

        Algorithms for Constructing Hesitant Neutrosophic Concept Lattices and Computing their Similarity Distances in Medical Decision-Making

        Kai Wang,Yue Cao 한국정보과학회 2019 Journal of Computing Science and Engineering Vol.13 No.4

        In medical decision-making, pros and cons of balancing treatment options are often required. However, clinical experts may well put forward their opinions on the basis of huge uncertain or incomplete information. To address this issue, the notion of hesitant neutrosophic concept lattice (HNCL) has been utilized to express the decision information based on hesitant neutrosophic sets (HNS) and formal concept analysis (FCA). Here, we present another improved hybrid model to measure the similarity distance among hesitant neutrosophic concepts (HNCon). An actual example was used to demonstrate the effectiveness and reliability of the proposed method.

      • Optimal design of porous baffle to improve the flow distribution in the tube-side inlet of a shell and tube heat exchanger

        Wang, Kai,Tu, Xin-Cheng,Bae, Chan-Hyo,Kim, Hyoung-Bum Elsevier 2015 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.80 No.-

        <P><B>Abstract</B></P> <P>An optimization study of a porous plate to improve the flow distribution in the tube side of a shell and tube heat exchanger was performed using numerical and experimental methods. The first assumption in the design stage of multichannel heat exchangers is that there is an even flow distribution along the multi channels. However, this assumption is generally not upheld in real situations. An experimental study was first performed to confirm the effectiveness of a porous baffle in improving the flow distribution in the tube side of a shell and tube heat exchanger. The results showed that the baffle can largely decrease maldistribution. We then performed numerical optimization of the porous baffle shape. The optimized curvature of a porous plate and the distribution of circular holes in the baffle were determined using the numerical method. The optimization results showed that the area-weighted averaged absolute error of the flow rate of the optimized baffle decreased to one-third that of the proto-type baffle model. For validation of the numerical optimization, the flow field with the optimized baffle was measured. Although there were some differences between the experimental and the numerical results, the results showed that the flow distribution using the optimized model was largely improved compared with that of the proto-type porous baffle.</P>

      • SCOPUSKCI등재

        Characteristics of the AlON-Al<sub>2</sub>O<sub>3</sub> Ceramic Coatings on the Al2021 Alloy by Electrolytic Plasma Processing

        Wang, Kai,Byeon, Sang-Sik,Kim, Geun-Woo,Park, Keun-Young,Ahmed, Faheem,Koo, Bon-Heun Materials Research Society of Korea 2012 한국재료학회지 Vol.22 No.3

        In this work, AlON-$Al_2O_3$ coatings were prepared on Al2021 alloy by the electrolytic plasma processing (EPP) method. The experimental electrolytes include: 2 g/l NaOH as the electrolytic conductive agent, 10 g/l $Na_2AlO_2$ as the alumina formative agent, and 0.5 g/l $NaNO_2$, $NaNO_3$, and $NH_4NO_3$ as the nitride inducing agents. The effects of different nitrogen inducing agents were studied by a combined compositional and structural analyses of the ceramic coatings carried out by Xray diffractometry (XRD) and scanning electron microscopy (SEM) for the specimens EPP-treated at room temperature for 15 min under a hybrid voltage of 260 DC along with an AC 50 Hz power supply (200 V). Microhardness tests and wear tests were carried out to correlate the evolution of the microstructure and the resulting mechanical properties. Potentiodynamic polarizations and immersion corrosion tests were carried out in 3.5wt% NaCl water solutions under static conditions in order to evaluate the corrosion behavior of the coated samples. The results demonstrate that $NaNO_2$ is proven to be a good nitrogen inducing agent to produce high quality AlON-$Al_2O_3$ ceramic coatings.

      • SCIESCOPUSKCI등재

        Multi-condition optimization and experimental verification of impeller for a marine centrifugal pump

        Wang, Kai,Luo, Guangzhao,Li, Yu,Xia, Ruichao,Liu, Houlin The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.1

        In order to improve the performance of marine centrifugal pump, a centrifugal pump whose specific speed is 66.7 was selected for the research. Outlet diameter D2, outlet width b2, blade outlet angle β2, blade wrap φ and blade number z of the impeller were chosen as the variables. The maximum weighted average efficiency and the minimum vibration intensity at the base were calculated as objectives. Based on the Latin Hypercube method, the impeller was numerically optimized. The numerical results show that after optimization, the amplitudes of pressure fluctuation on the main frequency at different monitoring points decrease in varying degrees. The radial force on impeller decreases obviously under off-design flow rates and is more symmetrical during the operation of the pump. The variation of the axial force is relatively small, which has no obvious relationship with the rotating angle of the impeller. The energy performance and vibration experiment was performed for verifying. The test results show that the weighted average efficiency under 0.8Qd, 1.0Qd and 1.2Qd increases by 4.3% after optimization. The maximal vibration intensity at M1-M4 on the pump base reduced from 0.36 mm/s to 0.25 mm/s, decreasing by 30.5%. In addition, the vibration velocities of bracket in pump side and outlet flange also have significant reductions.

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