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P247 : A study on use of complementary and alternative medicine for acne
( Sook Kyung Lee ),( Taek Geun Lee ),( Hyun Hwang Bo ),( Tae Gwang Kwon ),( Se Won Jung ),( Young Seok Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Complementary and alternative medicine (CAM) is any practice that has healing effects, but is not based on evidence demonstrated by scientific method. Recently, CAM has been used in various diseases including acne. However, there have been no studies on CAM for acne in Korea. Objectives: The purpose of this study was to analyze the use of CAM in acne patients. Methods: A total of 159 patients with acne were enrolled on the study, and filled out a questionnaire about use of CAM. Results: Overall 87.4% (139/159) of the patients reported the previous or current use of at least one more type of CAM. Cosmetics for acne (100, 22.9%) was most frequently used, followed by diet therapy (81, 18.5%), spa and bath therapies (77, 17.6%), health food supplement (67, 15.3%), skin care shop (64, 14.6%), oriental medicine (38, 8.7%), and aromatherapy (9, 2.1%). The most common reason for using CAM was ``wish to try everything`` (28.6%), and the most common source of information was internet (40.5%). The therapeutic effect of CAM was best with diet therapy (32.1%). The most common side effect of CAM was aggravation of symptoms. The most common monthly cost for CAM was between 50,000 and 100,000 won/person. Conclusion: As our results, we can predict that the use of various types of CAM for acne will become more common. Therefore, dermatologists need to study about benefits and adverse effects of CAM for acne.
김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.1
Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
Won, Hyejung,Lee, Hye-Ryeon,Gee, Heon Yung,Mah, Won,Kim, Jae-Ick,Lee, Jiseok,Ha, Seungmin,Chung, Changuk,Jung, Eun Suk,Cho, Yi Sul,Park, Sae-Geun,Lee, Jung-Soo,Lee, Kyungmin,Kim, Daesoo,Bae, Yong Chul Nature Publishing Group, a division of Macmillan P 2012 Nature Vol.486 No.7402
Autism spectrum disorder (ASD) is a group of conditions characterized by impaired social interaction and communication, and restricted and repetitive behaviours. ASD is a highly heritable disorder involving various genetic determinants. Shank2 (also known as ProSAP1) is a multi-domain scaffolding protein and signalling adaptor enriched at excitatory neuronal synapses, and mutations in the human SHANK2 gene have recently been associated with ASD and intellectual disablility. Although ASD-associated genes are being increasingly identified and studied using various approaches, including mouse genetics, further efforts are required to delineate important causal mechanisms with the potential for therapeutic application. Here we show that Shank2-mutant (Shank2<SUP>??/??</SUP>) mice carrying a mutation identical to the ASD-associated microdeletion in the human SHANK2 gene exhibit ASD-like behaviours including reduced social interaction, reduced social communication by ultrasonic vocalizations, and repetitive jumping. These mice show a marked decrease in NMDA (N-methyl-d-aspartate) glutamate receptor (NMDAR) function. Direct stimulation of NMDARs with d-cycloserine, a partial agonist of NMDARs, normalizes NMDAR function and improves social interaction in Shank2<SUP>??/??</SUP> mice. Furthermore, treatment of Shank2<SUP>??/??</SUP> mice with a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), which enhances NMDAR function via mGluR5 activation, also normalizes NMDAR function and markedly enhances social interaction. These results suggest that reduced NMDAR function may contribute to the development of ASD-like phenotypes in Shank2<SUP>??/??</SUP> mice, and mGluR modulation of NMDARs offers a potential strategy to treat ASD.
Geun Young Lee,Sung Yu,Hyun Gu Kang,Jin Seon Kim,Kyoo Won Lee,Jung-Ho Lee 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.2
Purpose: To assess choroidal thickness (CT) variation according to refractive errors using enhanced-depth imaging optical coherence tomography. Methods: Eighty-nine eyes (in 89 children) <±6 diopter were categorized into three groups: hyperopia, emmetropia, and myopia, according to refractive error, and underwent choroidal scans using enhanced-depth imaging-optical coherence tomography. CT was measured at the fovea and at 1 mm and 3 mm nasal (N1 and N3), temporal (T1 and T3), superior (S1 and S3), and inferior (I1 and I3) from the fovea. Results: Mean foveal CTs were 346.86 μm, 301.97 μm, and 267.46 μm in the hyperopia, emmetropia, and myopia groups, respectively (p < 0.05). CTs at N3 and T3 were 214.59 μm and 318.68 μm, 163.92 μm and 320.79 μm, and 153.93 μm and 295.61 μm in the hyperopia, emmetropia, and myopia groups, respectively (p < 0.05). All CTs in the hyperopia group were thicker than those of other groups (p < 0.05). Fovea was thickest and was significantly thicker than at N3 and I3 in hyperopia (p < 0.05). T3 thickness in the emmetropia and myopia groups was greater than thickness at other areas, particularly the nasal and inferior choroids (p < 0.05). CT was positively correlated with spherical equivalent (p = 0.029). Conclusions: In Korean children, CTs were greater in the hyperopia group than in the emmetropia and myopia groups. The temporal choroid was thicker than the nasal choroid, regardless of the refractive error. The thickest location in the hyperopia group was the fovea; however, the temporal choroid was thickest in the emmetropia and myopia groups.
Construction of a Verification System for Paper Result
Geun-Chul Park,Sung-Jin Jhun,Ki-Seok Choi,Tae-Sang Huh,Won-Kyun Joo,Jung-Hoon Park,Man-Hee Park,Hong-Ro Lee 한국콘텐츠학회 2009 ICCC International Digital Design Invitation Exhib Vol.2009 No.12
The result of various R&D activities such as paper, patent and program are used to evaluate the performance of the research. The authenticity of the result has to be guaranteed in order to use it as an evaluation factor and in the case of a paper, whether it has actually been published or not is an important factor. A system for checking the authenticity of a paper is designed in this paper. The major components of the paper are automatically check and manual confirmation is processed through the search for the document similarity. The system aims to increase the effectiveness of verifying a paper.