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Video Quality Adaptation for Extended Playback Time on Mobile Devices With Limited Energy
Jo, Sung-Woong,Yoo, Wonsuk,Chung, Jong-Moon IEEE 2018 IEEE communications letters Vol.22 No.6
<P>In this letter, a HTTP-based adaptive rate control streaming (HARCS) scheme that selects the video quality level of each chunk for extending playback time is proposed. For this purpose, the expected energy consumption for downloading remaining chunks to be received is stochastically modeled by considering the time-varying wireless network conditions and video characteristics. Then, based on the derived energy model as well as the mobile device’s remaining battery energy, the proposed HARCS scheme adaptively selects the video quality level of each chunk. Measurement results show that HARCS can extend the video playback time up to 57.64% when compared with the conventional adaptation scheme that only considers the wireless network status.</P>
Fabrication and Characterization of Finite-Size DNA 2D Ring and 3D Buckyball Structures
Jo, Soojin,Kim, Seungjae,Lee, Byung Ho,Tandon, Anshula,Kim, Byunghoon,Park, Sung Ha,Kim, Moon Ki MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.7
<P>In order to incorporate functionalization into synthesized DNA nanostructures, enhance their production yield, and utilize them in various applications, it is necessary to study their physical stabilities and dynamic characteristics. Although simulation-based analysis used for DNA nanostructures provides important clues to explain their self-assembly mechanism, structural function, and intrinsic dynamic characteristics, few studies have focused on the simulation of DNA supramolecular structures due to the structural complexity and high computational cost. Here, we demonstrated the feasibility of using normal mode analysis for relatively complex DNA structures with larger molecular weights, i.e., finite-size DNA 2D rings and 3D buckyball structures. The normal mode analysis was carried out using the mass-weighted chemical elastic network model (MWCENM) and the symmetry-constrained elastic network model (SCENM), both of which are precise and efficient modeling methodologies. MWCENM considers both the weight of the nucleotides and the chemical bonds between atoms, and SCENM can obtain mode shapes of a whole structure by using only a repeated unit and its connectivity with neighboring units. Our results show the intrinsic vibrational features of DNA ring structures, which experience inner/outer circle and bridge motions, as well as DNA buckyball structures having overall breathing and local breathing motions. These could be used as the fundamental basis for designing and constructing more complicated DNA nanostructures.</P>
Microbiological survey of Korean animal facilities from 2014 to 2019
Sang woon Kim,Hi jo SHIN,Se hee PARK,Teak chang LEE,Hae jin LEE,Ok sung MOON,Ki hoan NAM,Won kee YOON,Hyoung chin KIM,Hyo jung KWON,Young Suk WON 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
To survey the mouse microbiological contamination rate in Korean animal facilities, we tested for common contaminants in these facilities using serological, culture, and parasitological methods. A total of 21,292 experimentally housed mice from 206 animal facilities, including hospitals, universities, companies and research institutes, were tested over a 6-year period from 2014 to 2019. The most commonly found contaminants were various species of non-pathogenic protozoa (47.2%). The most common pathogenic bacteria were Staphylococcus aureus (21.2%), Pasteurella pneumotropica (12.5%) and Pseudomonas aeruginosa (5.8%). Mouse hepatitis virus (6.1%) was detected, but no other viral or bacterial pathogens were found. These results establish that the main pathogens that currently contaminate animal facilities in Korea are opportunistic pathogens, whereas important such as those in categories B or C, were decreased.
Moon, Sung-Ung,Choi, Soo Kyoung,Kim, Han Jo,Kumar Bokara, Kiran,Park, Kyung Ah,Lee, Won Taek,Lee, Jong-Eun D. A. Spandidos 2011 MOLECULAR MEDICINE REPORTS Vol.4 No.6
<P>p53 is a widely known tumor-suppressor gene product that plays a key role in apoptotic cell death induced by DNA-damaging chemotherapeutic agents. Human glioma cells with functional p53 are known to be more resistant to 관-radiation. The aim of this study was to investigate whether the mutant glioblastoma cells (U87MG) transfected with human papilloma virus-type 16 E7 (HPV16 E7) genes were capable of increasing sensitivity towards irradiation and hypoxia-induced cell death. The pLXSN retroviral vector expressed HPV-16E7 genes and was infected into the p53 mutated U87MG cell line. A specific amplification band of HPV16 E7 genes was detected in E7 genes and transfected in the U87MG cell line using a reverse transcriptase polymerase chain reaction. The experimental groups included the mutant glioblastoma cell line (U87MG), empty vector (pLXSN) transfected to mutant glioblastoma cell line (U87MG-LXSN), and retrovirus carrying HPV16 E7 genes transfected to the mutant glioblastoma cell line (U87MG-E7). Hypoxic conditions were optimized using LDH assay and the subjects were exposed to hypoxia (16 and 20 h) and irradiation (9 h). Hoechst-propidium iodide (PI) staining results showed that hypoxia and irradiation increased the number of dead cells in the U87MG-E7 cells compared to U87MG and U87MG-LXSN cells. Results of the FACS analysis showed a similar pattern and recorded 80.44 and 58.94% of apoptotic cells in U87MG-E7 and U87MG cells, respectively. Cell cycle analysis by FACS revealed that, following irradiation and hypoxia, cells showed G2-M arrest. Additionally, the Western blot analysis results showed altered expression of E2F-1, Rb and p53 in the irradiation- and hypoxia-induced U87MG-E7 cells compared to U87MG and U87MG LXSN cells. In conclusion, the over-expression of HPV16 E7 genes in U87MG cell lines increasd cell apoptosis and E2F1 expression compared to the HPV non-infected U87MG cells following irradiation and hypoxia. These results indicate that tumor-specific therapies that increase sensitivity towards radiation and hypoxic conditions may be beneficial for suppression of cancers.</P>