노인에서 신체질환과 불면증 간의 전향적 연관성

김재민,김성완,양수진,김선영,배경열,조준영,윤탁,신일선,윤진상 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.5

Objectives : This study aimed to investigate the associations between physical disorders and prevalent/incident insomnia m a community dwelling older population. Methods : 1,204 people aged 65 or over evaluated at baseline. Insomnia was defined as difficulty in initiation or maintenance of sleep on at least three nights per week over the last month. Reported physical disorders covering 11 common and generally chronic health problems were ascertained. Covariates included were age, gender, education, housing, Past occupation, current employment, and depression. Of 879 without insomnia at baseline, 651 (74%) were followed 2 years later, and incident insomnia was evaluated. Results : Prevalent insomnia was significantly associated with 10 of 11 physical disorders. Incident insomnia was associated with 2 physical disorders : eyesight problems and hearing difficulty. Both prevalent and incident insomnia were significantly associated with increased number of physical disorders. Conclusion : Certain physical disorders were comorbid and precipitating factors of insomnia in elders.

장애인 고용경험이 장애인고용인식과 채용의사에 미치는 영향

김용탁,심진예 한국장애인고용촉진공단 고용개발원 2009 장애와 고용 Vol.19 No.3

본 연구는 고용주의 장애인고용경험이 장애인고용인식과 채용의사에 미치는 영향을 분석하고 장애인고용인식의 매개효과를 검증하는데 목적을 두었다. 분석대상은 한국장애인고용촉진공단이 2008년도에 실시한 사업체 장애인고용 실태조사의 심층조사에 참여한 사업체 2,510개소이다. 분석결과 고용경험은 고용주의 채용의사와 장애인고용인식에 유의미한 영향을 미치며 장애인고용인식은 고용경험과 채용의사 관계를 부분적으로 매개하는 것으로 나타났다. 연구결과는 장애인 고용경험 유무에 따른 정책대상별 차별화된 형태의 정책적 접근의 필요성과 장애인고용인식의 개선의 중요성을 시사하고 있다. This study aims to analyze the influence of experience regarding hiring of the disabled as it pertains to the intentions and perceptions of employing the disabled and verify mediating effect of perceptions of employing the disabled. 2,510 companies participated in the in-depth research which entailed a survey on the employment status of the disabled in business in 2008. According to the research, companies hiring workers with disabilities present a positive attitude toward employing the disabled. Moreover, experience of hiring the disabled acts as a meaningful variable which improves employers’ intentions and perceptions regarding employment of the disabled. The result of the study implies that it is necessary to use a political approach which considers various political objectives according to experience, regarding hiring of the disabled. For companies not having experience regarding hiring of the disabled, disability awareness training is needed. On the other hand, for experienced companies, a strong demand to raise employer satisfaction and draw a plan of support for more employment is apparent.

실시간 신경망 적응 노이즈 필터 개발을 위한 기초설계

김진선,장탁순,홍준희 충남대학교 공업교육연구소 2003 論文集 Vol.26 No.1

This Paper describes a nonlinear adaptive noise canceller using neural network for machine tools controller system. Back-Propagation Learning Algorithm based MLP(Multi Layer Perceptron) is used an adaptive filters. In this paper, it assume that the noise of primary input in the adaptive noise canceller is not the same characteristic as that of the reference input. Experimental results show that the neural network base noise canceller outperforms the linear noise canceller. Especially to make noise cancel close to realtime, Primary Input is divided by Unit and each divided part is processed for very short time than all the processed data are unified to whole data.

메시지 유형과 수용자 특성이 정치광고 효과에 미치는 영향에 관한 연구

탁진영,김상욱 계명대학교 사회과학연구소 2000 한국사회과학연구 Vol.19 No.2

신경병증성 통증 모델쥐 뒤뿌리신경절의 Nitric Oxide Synthase 아형 및 NADPH-diaphorase 발현에 관한 연구

정성균,김수일,양은진,류택근,권오유,박경란,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

Injury to peripheral nerve somtimes lead to neuropathic pain. Nitric oxide(NO) is increased in the dorsal root ganglia (DRG) of neuropathic pain models, and L-NAME, a nitric oxide synthase (NOS) inhibitor, reduces neuropathic pain. However, it is not known that underlying mechanism of NO involvement in development and maintanence of neuropathic pain. It was found that there were three NOS isoforms-nNOS, eNOS, and iNOS. It is also necessary to investigate NOS isoforms in neuropathic pain. The aim of this study is to investigate NOS isoforms and NADPH-diaphorase expressions and underlying mechanism of NO involvement in neuropathic pain. The 5^th lambar (L5) DRG were obtaind after tight ligation of L5 an L6 spinal nerves for 7 days. Toluidine blue stain, immunohistochemistry for nNOS, eNOS, and iNOS, and NADPH-diaphorase histochemistry were performed. All specimens were observed under light microscope. nNOS expression was increased significantly in the cytoplasm of the DRG of ligated side at 7 day post-ligation (7D PL). eNOS expression was also increased in the blood vessel, a few neurons or satellite cells, and cell membrane of Schwann cells in the DRG of ligated side at 7D PL. iNOS expression was increased in a few blood vessels and cytoplasm of small neurons in the DRG of ligated side at 7D PL. NADPH-diaphorase expression was increased significantly in the neurons of the DRG of ligate side at 7D PL, but NADPH-diaphorase expressions were weak or absent in the blood vessel and Schwann cell in the contralateral DRG and the DRG of ligated side at 7D PL. It is suggested that NOS isoforms may be closely related to development and mantanence of neuropathic pain in order of nNOS>eNOS>iNOS.

무리말뚝의 수평하중분담에 관한 실험적 연구

裵鍾淳,金成浩,崔震宇,姜秉卓 경상대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.16 No.-

Load distribution in group piles is an important matter of consequence for the safe design and the economical design. In the group piles, the model tests were to investigate the effects on spacing-to-diameter ratio of pile, number of piles and arrangement of the pile. The tops of pile were all set to rotate freely. This paper considered the load distribution by the location of the pile as compared the behavior of group piles with single pile. For a three row pile group at 3D spacing, the measured individual row distributions were 35~38%(lead), 32∼34%(middle) and 27∼30%(tail). This results were compared very favorably to those by McVay et al(1995). The shadowing effect for the parallel direction of lateral loading appears to be more significant than the one for the perpendicular direction of lateral loading.

An integrated analysis of elbasvir/grazoprevir in Korean patients with hepatitis C virus genotype 1b infection

Youn Jae Lee,Jeong Heo,Do Young Kim,Woo Jin Chung,Won Young Tak,Yoon Jun Kim4,백승운,Eungeol Sim,Susila Kulasingam,Rohit Talwani,Barbara Haber,Peggy Hwang 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.4

Background/Aims: In the Republic of Korea, an estimated 231,000 individuals have chronic hepatitis C virus (HCV) infection. The aim of the present analysis was to evaluate the safety and efficacy of elbasvir/grazoprevir (EBR/GZR) administered for 12 weeks in Korean patients who were enrolled in international clinical trial phase 3 studies. Methods: This was a retrospective, integrated analysis of data from patients with HCV genotype (GT) 1b infection enrolled at Korean study sites in four EBR/GZR phase 3 clinical trials. Patients were treatment-naive or had previously failed interferon-based HCV therapy, and included those with human immunodeficiency virus coinfection or Child- Pugh class A cirrhosis. All patients received EBR 50 mg/GZR 100 mg once daily for 12 weeks. The primary endpoint was sustained virologic response at 12 weeks after completion of therapy (SVR12, HCV RNA <15 IU/mL). Results: SVR12 was achieved by 73 of 74 (98.6%) patients. No patients had virologic failure and one discontinued from the study after withdrawing consent. SVR12 rates were uniformly high across all patient subgroups. A total of 16 patients had nonstructural protein 5A resistance-associated substitutions at baseline (16/73, 22%), all of whom achieved SVR12. Adverse events (AEs) reported in >5% of patients were fatigue (6.8%), upper respiratory tract infection (5.4%), headache (5.4%), and nausea (5.4%). Thirteen patients (17.6%) reported drug-related AEs, two serious AEs occurred, and two patients discontinued treatment owing to an AEs. Conclusions: In this retrospective analysis, EBR/GZR administered for 12 weeks was well-tolerated and highly effective in Korean patients with HCV GT1b infection.

LPCD법에 의한 Tin박막의 전계 에미터 어레이 제작

조경제,이상윤,류정탁,김연보,이진호 大邱大學校 科學技術硏究所 2001 科學技術硏究 Vol.8 No.2

Using low pressure chemical vapor deposition (LPCVD), TiN thin films as field emitter array were fabricated. In this Work, a method was transfered to a substrate and the wet-etching of the silicon substrate instead of fabricated method of mold shape was using in generally but we have fabricated gated field emitter tips as using mold shape of the new method that using a side wall space structure. Following sequences such as LPCVD method of a gate electrod and gate oxide on a silicon substrate and defesited BPSG thin film as a high temperature was flowed by the mold shape of a sharpen, the TiN as a materials of emitter tips was deposited after was bounded by anodic bonding and the wet-etching of the silicon substrate by using KOII solution, the last have fabricated a gated field emitter arrays of a sharpen. These emitters were estmated by scanning electron microscopy and X-ray diffraction.

사망진단서(사체검안서) 상의 선행사인으로부터 사망통계의 원사인이 선정되는 비율 : 3개 대학병원에서 교부된 사망진단서를 중심으로

박우성,박석건,정철원,김우철,탁우택,김부연,서순원,김광환,서진숙,부유경 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Background : To exatnine the problems intolved in writing practice of death certificates, we cotnpated the determination of underlying cause of death for wital statistics using recorded underlying cause of death in issued death statistics. Methods : We collected 688 rnortality certificates issue in year of 2,000 from 3 university hospitals. And we also collected vital statistics from ministry of statistics. The causes of death were coded by experienced medical record wpecialists. And causes of death determined at ministry of statistics for national vita statistics were mapped to causes of death recorded at each death certificates. The rate that underlying causes of death for vital statistics were derived from underlying causes of death recorded at issued death certificaties sere analysed. Results : 64.5% of underlying cause of death for could be derived from underlying cause of death recorded at issued death certificates, 8.6% derived from intermediate cause of death, and 3.9% derived from direct cause of death. In 23% of cases, underlying cause of death could not be derived using issued death certificates. The rate that underlying cause of death for vital statistics could be derived from underlying cause of death recorded at death certificates was different between 3 university hospitals. Ane the rate was also different between death certificates and postmortem certificates. We classified the causes of death using 21 major categories. The rate was different between diseases or conditions tha caused death too. Conclusion : When we examined the correctness of death certificate writing practice using abpve methods, cortectness of writing could not be told as satisfactory. There was difference in correctness of writing between hospotals, between death certificates and postmortem certificates, and between diseases and conditions that caused death. With this results, we suggested some strategy to improve the correctness of death certificate writing practice.

Enhanced Current Transport and Injection in Thin-Film Gallium-Nitride Light-Emitting Diodes by Laser-Based Doping

Kim, Su Jin,Kim, Kyeong Heon,Chung, Ho Young,Shin, Hee Woong,Lee, Byeong Ryong,Jeong, Tak,Park, Hyung Jo,Kim, Tae Geun American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.19

<P>This paper reports improvements in the electrical and optical properties of blue-emission gallium nitride (GaN)-based thin-film light-emitting diodes (TFLEDs) after laser-based Si doping (LBSD) of a nitrogen-face n-GaN (denoted as hereafter n-GaN) layer. Experimental results show that the light-output powers of the flat- and rough-surface TFLEDs after LBSD are 52.1 and 11.35% higher than those before LBSD, respectively, at a current of 350 mA, while the corresponding operating voltages are decreased by 0.22 and 0.28 V for the flat- and rough-surface TFLEDs after LBSD, respectively. The reduced operating voltage after LBSD of the top n-GaN layer may result from the remarkably decreased specific contact resistance at the metal/n-GaN interface and the low series resistance of the TFLED device. The LBSD of n-GaN increases the number of nitrogen vacancies, and Si substitutes for Ga (Si<SUB>Ga</SUB>) at the metal/n-GaN interface to produce highly Si-doped regions in n-GaN, leading to a decrease in the Schottky barrier height and width. As a result, the specific contact resistances are significantly decreased to 1.56 × 10<SUP>–5</SUP> and 2.86 × 10<SUP>–5</SUP> Ω cm<SUP>2</SUP> for the flat- and rough-surface samples after LBSD, respectively. On the other hand, the increased light-output power after LBSD can be explained by the uniform current spreading, efficient current injection, and enhanced light scattering resulting from the low contact resistivity, low lateral current resistance, and additional textured surface, respectively. Furthermore, LBSD did not degrade the electrical properties of the TFLEDs owing to low reverse leakage currents. The results indicate that our approach could potentially enable high-efficiency and high-power capabilities for optoelectronic devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-19/am5031165/production/images/medium/am-2014-031165_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am5031165'>ACS Electronic Supporting Info</A></P>