안면 비대칭의 평가를 위한 기준에 관한 정보 두부 방사선 계측학적 연구

백선호,안병근,김선해,손홍범,한호진,강수만 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.1

This study was undertaken to investigate the middle having the least difference between the right and left structures among the lines that had been used in the study of the craniomaxillofacial asymmetry. The sample of this study consisted of twenty six Korean girls(average 18.9 years old) having normal facial appearance and occlusion. On the frontal cephalometric films of the sample, we divided the whole craniomaxillifacial area into four portions, i.e., cranial, upper facial, lower facial, and dental portion. So, we have found the midlines having the least difference in the whole craniomaxillofacial area itself, and in the each divided four portions, furtherly in the other portions from aimed portion. The findings were as follow : 1. In the whole craniomaxillofacial area, the connecting line between crista galli and anterior nasal spine and the perpendicular bisecting line between right and left foramen rotundrums were suitable for the midline. 2. In the cranial portion, established all six lines were suitable for midlines. In the other portions, the perpendicular bisection line between both condylion, the line passing the contact point between right and left mandibular central insisiors among the perpendicular lines between right and left mandibular central incisial tips were suitable midlines for evaluating the asymmetry of cranial portion. 3. In the upper facial portion, the perpendicular bisecting line between right and left zygions was the most suitable midline. In the other portions, the line between the crista galli and the most superior point of the odontoid process, the perpendicular bisecting line between right and left gonions, the perpendicular bisecting line between right and left condylions, and perpendicular bisecting line between right and left foramens rotundum were suitable midlines for evaluating the asymmetry of the upper facial portion. 4. In the dental portion, the perpendicular bisecting lines between right and left buccal cusps of both maxillary first molars and between right and left mandibular first molars were suitable midlines. In the other portions, the perpendicular bisecting line between right and left landmarks crossing the lesser wing of the connecting line between crista galli and prosthion were suitable midlines for evaluating the asymmetry of dental portion. 5. In the lower facial portion, the perpendicular bisecting lines between right and left condylions and between right and left gonions were suitable midlines. In the other portions, the line between the crista galli and anterior nasal spine, the perpendicular bisecting line between right and left foramen rotundums, and the perpendicular bisecting lines between right and left buccal cusps of both mandibular first molars and between right and left maxillary first molars were suitable midlines for evaluating the asymmetry of the lower facial portion.

우울증 증세를 동반한 뇌종양 3례

김정진,도규영,한진희,김광수,백인호 한국의학사 1993 診斷과治療 Vol.13 No.2

뇌동맥류파열에 의한 뇌지주막하출혈 환자의 수술시기에 따른 예후 분석

손진열,박인성,황수현,백선하,김은상,정진명,김재형,한종우 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.3

원예치료가 만성정신분열증 환자의 자아존중감 및 사회성 향상에 미치는 영향

손기철,엄수진,김수연,송종은,백기엽 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-

만성정신분열증 환자들은 장기간의 치료를 필요로 하고, 지금까지는 대부분의 환자들이 약물치료나 전통적인 정신치료에만 의존해왔다. 최근에는 정신분열증 환자치료에 있어서 여러 가지 사회 재활 프로그램이 도입되고 있는 실정이나 원예치료프로그램의 적용사례는 미비한 실정이다. 이에 본 연구는 원예치료가 만성정신분열증 환자의 자아존중감 및 사회성 향상에 미치는 효과를 알아보기 위하여 음성 꽃동네 정신분열증 환자 남녀 대조군 20명, 치료군 남녀 25명을 선정하여 실험을 실시하였다. 대조군 20명에게는 원예치료를 실시하지 않았으나, 치료군 25명에게는 주 2회씩 2000년 4월 13일부터 9월 7일까지 원예치료를 실시하였다. 치료효과 검증을 위해 원예활동 평가표(evaluation of horticultural activity), 사회행동척도(social behavior scale), 자아존중감척도(self-esteem Scale), 인간관계측정지, 간이정신건강진단지(SCL-90-R) 등을 치료 전후로 시행하여 비교하였다. 자아존중감과 인간관계측정지에서는 대조군에서는 유의한 결과가 보이지 않은 반면, 치료군에서는 향상된 결과를 볼 수 있었다. 사회행동척도에서는 언어적인면보다 비언어적인면, 대화의 내용에서 치료군만 유의하게 향상된 결과를 보였다. 간이정신건강진단지 평가는 불안, 우울, 대인예민성 부분에서 역시 치료군만 유의하게 호전된 효과를 볼 수 있었다. 또한 신체화, 강박증, 적대감, 공포불안, 편집증 등이 호전된 것으로 보여졌으나 통계적으로 유의한 차이는 나타나지 않았다. 원예활동평가에서는 참여성과 자아개념 및 주체성에서 유의한 차이를 볼 수 있었다. 따라서 원예치료프로그램은 우울ㆍ폐쇄적인 대인관계를 보이는 정신분열증 환자들에게 심리ㆍ정서면과 사회성 향상에 효과적이라 판단된다. 또한 원예치료프로그램을 치료적인 목적뿐만 아니라 직업재활의 한 방면으로 이용가능 할 것이라 판단된다.

비선형 웹 이송 시스템의 장력제어

윤석찬,백승훈,정진태,한창수 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.5

This paper presents the study of the tension control in a web transfer system. In this study the sliding mode controller is applied to a time-varying nonlinear mathematical model. The model was derived to consider the effects of changing the roll rad;us in tension variation during winding and unwinding. The uncertainty in modeling may be due to unmodelled dynamics, on variations in system model. Designed sliding mode controller made the system error always staying in the suggested surface from the beginning. Through this, system is maintained to be robust against a disturbance and uncertainty. To verify the designed controller has a good performance, various inputs such as desired velocity, step input, and trapezoidal input are applied. When the sliding mode controller was used, the system(the tension control) performance was improved comparing to the PID controller. The robustness of the controller with respect to an estimation error was verified through simulations.

Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-κB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells

Choi, Soo-Jin,Paek, Hee-Jeong,Yu, Jin Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-

<P>Anionic nanoclays are layered double hydroxide nanoparticles (LDH-NPs) that have been shown to exhibit toxicity by inducing reactive oxidative species and a proinflammatory mediator in human lung epithelial A549 cells. However, the molecular mechanism responsible for this LDH-NP-induced toxicity and the relationship between oxidative stress and inflammatory events remains unclear. In this study, we focused on intracellular signaling pathways and transcription factors induced in response to oxidative stress caused by exposure to LDH-NPs in A549 cells. Mitogen-activated protein kinase (MAPK) cascades, such as extracellular signal-regulated kinase, c-Jun-N-terminal kinase (JNK), and p38, were investigated as potential signaling mechanisms responsible for regulation of oxidative stress and cytokine release. Src family kinases (SFKs), which are known to mediate activation of MAPK, together with redox-sensitive transcription factors, including nuclear factor kappa B and nuclear factor-erythroid 2-related factor-2, were also investigated as downstream events of MAPK signaling. The results obtained suggest that LDH-NP exposure causes oxidative stress, leading to expression of antioxidant enzymes, such as catalase, glucose reductase, superoxide dismutase, and heme oxygenase-1, via a SFK-JNK and p38-nuclear factor kappa B signaling pathway. Further, activation of this signaling was also found to regulate release of inflammatory cytokines, including interleukin-6 and interleukin-8, demonstrating the inflammatory potential of LDH-NP.</P>

독사교상후 발생한 급성신부전에 대한 임상적 고찰

백진기(Jin Ki Paek),유병우(Byung Woo Yu),안영수(Young Soo An),김종봉(Jong Bong Kim),김태준(Tae Jun Kim),김홍수(Hong Soo Kim),최태명(Tae Jun Kim),양동호(Dong Ho Yang),홍세용(Sae Yong Hong),양승하(Seung Ha Yang),이현순(Hyun Soon Lee) 대한내과학회 1994 대한내과학회지 Vol.46 No.4

N/A Objectives: The pathogenesis of acute renal failure developed after snake bite has been variously attributed to the direct renal damage by the venoms, and the secondary effects of disseminated intravascular coagulation, shock, intravascular hemolysis, the defibrination syndrome, and myoglobinuria. We analysed the thirteen cases of renal involvement after snake bite to elucidate possible causes and clinical characteristics of acute renal failure. Method: We reviewed the clinical symptoms, physical examination, laboratory data, and renal biopsies (two cases) in the 13 cases of acute renal failure developed after snake bite among 195 cases during the recent 10 years, Results: 1) The sex ratio of the patients with acute renal failure after snake bite (man: woman) was 1:5.5, presenting female predominance. Most of the cases were over 50 years of age covering more than 90% of the total snake bite cases 2) As respects to the time elapse from the snake bite to the hospital care, four cases were within 1 hour, two cases were within 1~2 hours, two cases were within 3~12 hours, and the rest of them (ten cases) were within 24 hours. 3) The systemic symptoms and signs of snake bite are as follows: nausea, vomiting, dyspnea, macroscopic hematuria, dizziness, headache, altered consciousness, and visual disturbance. Most of the patients complained of localized edema and pain around the wound of snake bite. Oliguria was noted in four patients, and it lasted for 13 days in average. 4) On admission, urinalysis of the patients with acute renal failure showed proteinuria (ten cases) and hematuria (six cases). Most of the patients with renal failure had hyperkalemia, hypocalcemia, elevated SGOT and LDH. The serum BUN and creatinine levels were elevated (more than 2.0 mg/dl and 4.2 mg/dl, respectively) above the normal range. 5) Renal biopsy performed in two cases of convalescent stage showed the findings of acute tubular necrosis with intact glomeruli. 6) Hemodialysis was performed in six patients out of thirteen cases of acute renal failure. 7) Of the thirteen patients with renal failure after snake bite, eight patients improved. But five patients were discharged against our will. All but one (self discharged) of the six patients with hemodialysis were discharged with clinical improvement. Conclusions: Acute renal failure caused by snake bite is not uncommon in Korea. We analysed the thirteen cases of snake bite with acute renal failure that revealed direct renal tubular necrosis on biopsy. And we speculate that the renal damage may be caused by the nephrotoxin of the venom. It is suggested that immediate intervention and preventive measures for renal failure after snake bite are needed.

Characterization of Bacteriocin Produced by Lactobacillus bulgaricus

( Hyun Jin Kim ),( Ji Hyun Kim ),( Jeong Hwa Son ),( Hyo Jin Seo ),( So Jin Park ),( Nam Soo Paek ),( Sung Koo Kim ) 한국미생물생명공학회 2004 Journal of microbiology and biotechnology Vol.14 No.3

Effect of α-Glycosidase Inhibitor in Multidrug Resistant Cell Lines

Paek, Nam Soo,Namgung, Jun,Lee, Jung Joon,Choi, Yong Jin,Kim, Tae Han,Kim, Kee Won The Korea Science and Technology Center 1998 BMB Reports Vol.31 No.3

The objective of this study was sto evaluate the reversal of multidrug resistance of human cell lines by specific inhibitors of α-glucosidases and mannosidases that had been reported to be involved in N-linked oligosaccharide processing of glycoproteins. N-methyldeoxynojirimycin, 1-deoxynojirimycin, and castanospermine, which were known to be potent inhibitors of both α-glcosidase I and II, showed no activity against the multidrug resistant phenotype of the cell lines of SNU1DOX, KB-V1, and MCF-7/ADR. In contrast, 1-deoxymannojirimycin, and inhibitor of mannosidase I, resulted in a slight reversal for the vinblastine resistance of the KB-V1 cell line, but did not show any activity toward the other cell lines. Parallel experiments with tunicamycin, an inhibitor of N-linked glycosylation, also resulted in no significant changes in multidrug resistant (MDR) phenotype of the cell lines tested in this work. These observations suggest that the unglycosylation of P-glycoprotein associated with the inhibitor treatments might not be correlated with the reversal of multidrug resistance of the cell lines tested in this study.

Effect of ${\alpha}$-Glycosidase Inhibitor in Multidrug Resistant Cell Lines

Paek, Nam-Soo,Namgung, Jun,Lee, Jung-Joon,Choi, Yong-Jin,Kim, Tae-Han,Kim, Kee-Won Korean Society for Biochemistry and Molecular Biol 1998 Journal of biochemistry and molecular biology Vol.31 No.3

The objective of this study was to evaluate the reversal of multi drug resistance of human cell lines by specific inhibitors of ${\alpha}-glycosidase$ and mannosidases that had been reported to be involved in N-linked oligosaccharide processing of glycoproteins. N-methyldeoxynojirimycin, I-deoxynojirimycin, and castanospermine, which were known to be potent inhibitors of both ${\alpha}-glycosidase$ I and II, showed no activity against the multidrug resistant phenotype of the cell lines of SNU1DOX, KB-V1, and MCF-7/ADR. In contrast, I-deoxymannojirimycin, an inhibitor of mannosidase I, resulted in a slight reversal for the vinblastine resistance of the KB-V1 cell line, but did not show any activity toward the other cell lines. Parallel experiments with tunicamycin, an inhibitor of N-linked glycosylation, also resulted in no significant changes in multidrug resistant (MDR) phenotype of the cell lines tested in this work. These observations suggest that the unglycosylation of P-glycoprotein associated with the inhibitor treatments might not be correlated with the reversal of multidrug resistance of the cell lines tested in this study.