Study of upfront surgery versus neoadjuvant chemotherapy followed by interval debulking surgery for patients with stage IIIC and IV ovarian cancer, SGOG SUNNY (SOC-2) trial concept

Rong Jiang,Jianqing Zhu,김재원,Jihong Liu,Kazuyoshi Kato,김희승,Yuqin Zhang,Ping Zhang,Tao Zhu,Daisuke Aoki,Aijun Yu,Xiaojun Chen,Xipeng Wang,Ding Zhu,Wei Zhang,Huixun Jia,Ting-Yan Shi,Wen Gao,Sheng Yin,Yan 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.5

Background: Two randomized phase III trials (EORTC55971 and CHORUS) showed similarprogression-free and overall survival in primary or interval debulking surgery in ovariancancer, however both studies had limitations with lower rate of complete resection and lack ofsurgical qualifications for participating centers. There is no consensus on whether neoadjuvantchemotherapy followed by interval debulking surgery (NACT-IDS) could be a preferred approachin the management of advanced epithelial ovarian cancer (EOC) in the clinical practice. Methods: The Asian SUNNY study is an open-label, multicenter, randomized controlled,phase III trial to compare the effect of primary debulking surgery (PDS) to NACT-IDS instages IIIC and IV EOC, fallopian tube cancer (FTC) or primary peritoneal carcinoma (PPC). The hypothesis is that PDS enhances the survivorship when compared with NACT-IDS inadvanced ovarian cancer. The primary objective is to clarify the role of PDS and NACT-IDS inthe treatment of advanced ovarian cancer. Surgical quality assures include at least 50% of nogross residual (NGR) in PDS group in all centers and participating centers should be nationalcancer centers or designed ovarian cancer section or those with the experience participatingsurgical trials of ovarian cancer. Any participating center should be monitored evaluatingthe proportions of NGR by a training set. The aim of the surgery in both arms is maximalcytoreduction. Tumor burden of the disease is evaluated by diagnostic laparoscopy orpositron emission tomography/computed tomography scan. Patients assigned to PDS groupwill undergo upfront maximal cytoreductive surgery within 3 weeks after biopsy, followed by6 cycles of standard adjuvant chemotherapy. Patients assigned to NACT group will undergo 3cycles of NACT-IDS, and subsequently 3 cycles of adjuvant chemotherapy. The maximal timeinterval between IDS and the initiation of adjuvant chemotherapy is 8 weeks. Major inclusioncriteria are pathologic confirmed stage IIIC and IV EOC, FTC or PPC; ECOG performancestatus of 0 to 2; ASA score of 1 to 2. Major exclusion criteria are non-epithelial tumors as wellas borderline tumors; low-grade carcinoma; mucinous ovarian cancer. The sample size is 456subjects. Primary endpoint is overall survival. Trial Registration: ClinicalTrials.gov Identifier: NCT02859038

Soluble Expression of Recombinant Human Smp30 for Detecting Serum Smp30 Antibody Levels in Hepatocellular Carcinoma Patients

Zhang, Sheng-Chang,Huang, Peng,Zhao, Yong-Xiang,Liu, Shu-Yan,He, Shu-Jia,Xie, Xiao-Xun,Luo, Gou-Rong,Zhou, Su-Fang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Senescence marker protein 30 (SMP30), a hepatocellular carcinoma (HCC) associated antigen, was earlier shown by our research group to be highly expressed in HCC paracancerous tissues, but have low levels in HCC tissues. In order to detect anti-SMP30 antibody in serum of HCC patients, we established pET30a-SMP30 and pColdIII-SMP30 expression systems in Escherichia coli. However, the expression product was mainly in the form of inclusion bodies. In this research, we used several combinations of chaperones, four molecular chaperone plasmids with pET30a-SMP30 and five molecular chaperone plasmids with pColdIII-SMP30 to increase the amount of soluble protein. Results showed that co-expression of HIS-SMP30 with pTf16, combined with the addition of osmosis-regulator, and a two-step expression resulted in the highest enhancement of solubility. A total of 175 cases of HCC serum were studied by ELISA to detect anti-SMP30 antibody with recombinant SMP30 protein. Some 22 were positive and x2 two-sided tests all showed P>0.05, although it remained unclear whether there was a relationship between positive cases and clinical diagnostic data.

Analysis and Design of a New Topology of Soft-Switching Inverters

Rong Chen,Jia-Sheng Zhang 전력전자학회 2013 JOURNAL OF POWER ELECTRONICS Vol.13 No.1

This paper proposes the power conversion mechanism of a bailer-charge-transfer zero-current-switching (CT-ZCS) circuit. The operation modes are analyzed and researched using state trajectory equations. The topology of CT-ZCS based on soft-switching inverters offers some merits such as: tracking the input reference signal dynamically, bearing load shock and short circuit, multiplying inverter N+1 redundancy parallel, coordinating power balance for easy control, and soft-switching commutation for high efficiency and large capacity. These advantages are distinctive from conventional inverter topologies and are especially demanded in AC drives: new energy generation and grid, distributed generation systems, switching power amplifier, active power filter, and reactive power compensation and so on. Prototype is manufactured and experiment results show the feasibility and dynamic voltage-tracking characteristics of the topology.

Modified Dual-Buck Inverter Based on Resonant Link

Rong Chen,Jia-Sheng Zhang,Wei Liu 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.6

The efficiency and reliability of the dual-buck inverter (DBI) were greatly improved by eliminating the shoot-through problem and optimally designing the freewheeling diode. The traditional DBI suffers from large harmonic components with low output voltage and large capacity output filter inductor. To overcome the aforementioned disadvantages, a modified DBI (MBDI) was proposed by adopting a quasi-resonant link and pulse density modulation (PDM). This paper first introduces the working principle of the MBDI and PDM, and then the selection principle of system parameters is presented. Finally, a mathematical model of the MBDIis built, and an experiment prototype is set up. Simulation and experimental results verify the correctness of the theoretical analysis and the feasibility of the scheme.

The evaluation of online course of Traditional Chinese Medicine for Medical Bachelor, Bachelor of Surgery international students during the COVID-19 epidemic period

Zhang Qing,He Yi-Jing,Zhu Yu-Hang,Dai Min-Chen,Pan Man-Man,Wu Jia-Qi,Zhang Xian,Gu Ying-Er,Wang Fang-Fang,Xu Xiang-Rong,Qu Fan 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background: During the COVID-19 epidemic period, Traditional Chinese Medicine (TCM) course for international students of Medical Bachelor, Bachelor of Surgery (MBBS) program in Zhejiang University has shifted from traditional classroom to online environment. This study aimed to investigate MBBS international students’ perception on online TCM course, and to assess the online learning efficacy. Methods: A total of 84 MBBS international students attending course of “Basic Traditional Chinese Medicine” during 2020 academic years at Zhejiang University were enrolled in this study. A quantitative questionnaire was respectively completed before and after the TCM course using a pretest–post-test design. By means of two online learning platforms, Learning in ZJU and DingTalk, TCM course was broadcast in both live and archived format to students. Results: A total of 48 participants completed both baseline and follow-up questionnaires. The majority of participants preferred face-to-face classroom learning (26, 54.17% of total) when compared with online learning. Students felt that the course had brought in much benefits (mean 3.88, SD 0.87), and they were satisfied with the course content (mean 3.83, SD 0.95). Students’ TCM related knowledge and their behaviors of discussion and consulting were significantly improved by online TCM course (all P < 0.001). Students’ awareness of the necessity of TCM education and their feeling of difficulty in learning TCM were significantly strengthened (P = 0.042, 0.025, respectively). Conclusion: Online learning is a good alternative for TCM course of MBBS international students when classroom learning is suspended, whereas it cannot replace the need for onsite and face-to-face learning.

Half Load-Cycle Worked Dual Input Single Output DC/AC Inverter

Rong Chen,Jia-Sheng Zhang 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.6

A novel half load-cycle worked dual input single output (DISO) DC/AC inverter is presented. The basic circuit consists of a dual buck regulator, which works in continuous current mode. The working principle of DISO DC/AC inverter has been used. The control method applied for half load-cycle worked DISO DC/AC inverter has been studied. The control effects of the open-loop proportional control and closed-loop proportional-integral control are compared by using PSIM software. The parameters are adopted in the realistic simulation and experiment test. Moreover, the waveforms, such as voltage of modulation reference signal and output voltage, were given. The simulation and experiment results proved that the half load-cycle worked DISO DC/AC inverter could achieve good performance, gain a line frequency of 50 Hz, and verify the correctness of theoretical analysis.

Effects of duck activities on a weed community under a transplanted rice-duck farming system in southern China

Jia En Zhang,Rong Bao Xu,Xin Chen,Guo Ming Quan 한국잡초학회 2009 Weed Biology and Management Vol.9 No.3

Suppressive Effect of Sinomenine Combined with 5-Fluorouracil on Colon Carcinoma Cell Growth

Zhang, Ji-Xiang,Yang, Zi-Rong,Wu, Dan-Dan,Song, Jia,Guo, Xu-Feng,Wang, Jing,Dong, Wei-Guo Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

It is reported that sinomenine (SIN) and 5-fluorouracil (5-FU) both are effective for colon cancer, but their cooperative suppressive effects and toxicity remain to be clarified in detail. This study aimed to determine suppressive effects and toxicity of sinomenine (SIN) plus 5-fluorouracil (5-FU) on LoVo colon carcinoma cells in vitro and in vivo. CCK-8, Hoechst 33258 staining and an annexin V-FITC/PI apoptosis kit were used to detect suppressive effects. Western blotting was applied to investigate the essential mechanism underlying SIN and 5-FU-induced apoptosis. SIN or 5-FU or both were injected into nude mice, and then suppressive effects and side effects were observed. SIN plus 5-FU apparently inhibited the proliferation of LoVo cells and induced apoptosis. Moreover the united effects were stronger than individually (p<0.05). The results of annexin V-FITC/PI staining and Hoechst 33258 staining showed that the percentage of apoptotic cells induced by SIN and 5-FU combined or alone was significantly higher than the control group (p<0.05). Expression of Bax and Bcl-2 was up-regulated and down-regulated respectively. SIN or 5-FU significantly inhibited effects on the volume of tumour xenografts and their combined suppressive effects were stronger (p<0.05). No obvious side effects were observed. It was apparent that the united effects of SIN and 5-FU on the growth of colorectal carcinoma LoVo cells in vitro and in vivo were superior to those using them individually, and it did not markedly increase the side effects of chemotherapy.

Half Load-Cycle Worked Dual SEPIC Single-Stage Inverter

Rong Chen,Jia-Sheng Zhang,Wei Liu,Chang-Ming Zheng 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.1

The two-stage converter is widely used in traditional DC/AC inverter. It has several disadvantages such as complex topology, large volume and high loss. In order to overcome these shortcomings, a novel half load-cycle worked dual SEPIC single-stage inverter, which is based on the analysis of the relationship between input and output voltages of SEPIC converters operating in the discontinuous conduction mode (DCM), is presented in this paper. The traditional single-stage inverter has remarkable advantages in small and medium power applications, but it can’t realize boost DC/AC output directly. Besides one pre-boost DC/DC converter is needed between the DC source and the traditional single-stage inverter. A novel DC/AC inverter without pre-boost DC/DC converter, which is comprised of two SEPIC converters, is studied. The output of dual SEPIC converters is connected with anti-parallel and half load-cycle control is used to realize boost and buck DC/AC output directly and work properly, whatever the DC input voltage is higher or lower than the AC output voltage. The working principle, parameter selection and the control strategy of the inverters are analyzed in this paper. Simulation and experiment results verify the feasibility of the new inverter.

Modified Dual-Buck Inverter Based on Resonant Link

Chen, Rong,Zhang, Jia-Sheng,Liu, Wei The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.6

The efficiency and reliability of the dual-buck inverter (DBI) were greatly improved by eliminating the shoot-through problem and optimally designing the freewheeling diode. The traditional DBI suffers from large harmonic components with low output voltage and large capacity output filter inductor. To overcome the aforementioned disadvantages, a modified DBI (MBDI) was proposed by adopting a quasi-resonant link and pulse density modulation (PDM). This paper first introduces the working principle of the MBDI and PDM, and then the selection principle of system parameters is presented. Finally, a mathematical model of the MBDIis built, and an experiment prototype is set up. Simulation and experimental results verify the correctness of the theoretical analysis and the feasibility of the scheme.