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성음(聲音)과 언어(言語)에 관(關)한 문헌적(文獻的) 고찰(考察)
정희재,오태환,정승기,이형구,Jeong, Hee-Jae,Oh, Tae-Hwan,Jung, Sung-Gi,Rhee, Hyung-Koo 대한한방내과학회 1991 大韓韓方內科學會誌 Vol.12 No.1
The results of the investigation of literature were summerized as follows ; 1. Information of voice, the pharynx, the larynx, the epiglottis, the uvula and the hyoid bone were concerned. 2. In disorders of voice and speech, Lung channel, Stomach channel, Spleen channel, Heart channel, Liver channel, Kidney channel, Im channel (任脈), and Chung channel (衝脈) were concerned. 3. The disorders of voice and speech were showed as follows ; aphonia, ashasia, seong-shi (?嘶), seom-eo(?語) kwang-eo (狂語), jeong-seong (鄭?), dok-eo (獨語) and chak-eo (錯語). 4. The cause of Aphonia and Aphasia were freauently as follows ; abnormal rising of Liver energy (肝邪暴逆), excessive heart fire (心火太過), deficiency of heart-blood (心血太虛), apoplexy of heart spleen (心脾俱中風), consumption of lung fluid caused by heat evil (肺津被灼), deficiency of lung energy (肺氣虛寒) and dificiency of kidney energy (腎虛). 5. The cause of seom-eo, kwang-eo, Jeong-seong were as follows ; the heart of stomach (胃中熱), the heat evil attach the blood chamber (血人血室) and the consumption of healthy energy (精氣奪). 6. In disorders of voice and speech, flaceid tong with aphasia (舌?) and aphasia due to throat disease (喉?) were divided.
Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
A Korean case of neurofibromatosis type 1 with an exonic splicing enhancer site mutation
Sang wook Park,Young Bae Sohn,In Soon Chung,Ji Hee Hong,Eun Jung Jung,Seon Yong Jeong,Hyun Seok Jin 대한의학유전학회 2014 대한의학유전학회지 Vol.11 No.1
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease characterized by neurological, cutaneous, and ophthalmological manifestations. A 33-year-old woman with typical symptoms of NF1 visited Ajou University Hospital. Screening of the whole-messenger RNA region of NF1 at the complementary DNA level by polymerase chain reaction-direct sequencing confirmed the presence of an NF1 mutation at the genomic level. The mutation analysis revealed an in-frame skipping of exon 46 (c.6757_6858del) caused by a point mutation (c. 6792C>A) in exon 46. In this report, we have described the first Korean case of a proband with NF1 that carries an allele with an exon 46 deletion caused by an exonic splicing enhancer site mutation, leading to the skipping of the whole of exon 46 (c.6757_6858del).
Right iliac arterial aneurysm in a 4-year-old girl who does not have a right external iliac artery
Jeong-Hwan Lee,Chaeyoun Oh,Joong Kee Youn,Ji-Won Han,Hyun-Young Kim,Sung-Eun Jung 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.91 No.5
Pediatric arterial aneurysm is rare disease. Among them, idiopathic-congenital arterial aneurysm is extremely rare. This is a case report of right common iliac artery idiopathic aneurysm with absence of right external iliac artery. A 4-year-old girl who had been complaining of intermittent abdominal pain since 2 years prior presented with a right lower abdominal mass that had been palpable since 6 months prior. Abdominal CT revealed a 5.2 cm × 4.5 cm × 5.1 cm, right-sided, partially thrombosed, saccular, iliac artery aneurysm. She underwent to operation, aneurismal resection. A pathological examination confirmed that it was a true aneurysm, considering that all layers of the vascular wall were stretched with no deficit. The patient was discharged 3 days after the surgery without any complication. Five months passed since the surgery, and the patient is doing well without any abdominal or leg pain.
Epidemiologic and clinical study of cholinergic urticaria for the recent 10 years
( Jung Eun Kim ),( Hyun Ju Yu ),( Do Hyun Lee ),( Young Sun Eun ),( Young Min Park ),( Hyun Jeong Park ),( Dong Su Yu ),( Hoon Kang ),( Sang Hyun Cho ),( Chul Jong Park ),( Si Yong Kim ),( Jun Young L 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.3
Jeong, Chan Jin,Roy, Arup Kumer,Kim, Sung Han,Lee, Jung-Eun,Jeong, Ji Hoon,In, Insik,Park, Sung Young RSC Pub 2014 Nanoscale Vol.6 No.24
<P>Water soluble fluorescent carbon nanoparticles (FCP) obtained from a single natural source, mango fruit, were developed as unique materials for non-toxic bio-imaging with different colors and particle sizes. The prepared FCPs showed blue (FCP-B), green (FCP-G) and yellow (FCP-Y) fluorescence, derived by the controlled carbonization method. The FCPs demonstrated hydrodynamic diameters of 5-15 nm, holding great promise for clinical applications. The biocompatible FCPs demonstrated great potential in biological fields through the results of in vitro imaging and in vivo biodistribution. Using intravenously administered FCPs with different colored particles, we precisely defined the clearance and biodistribution, showing rapid and efficient urinary excretion for safe elimination from the body. These findings therefore suggest the promising possibility of using natural sources for producing fluorescent materials.</P>
Jung Seung Eun,Kim Sang Woo,Jeong Seongtae,Moon Hanbyeol,Choi Won Seok,Lim Soyeon,Lee Seahyoung,Hwang Ki-Chul,Choi Jung-Won 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Myocardial infarction (MI) damage induces various types of cell death, and persistent ischemia causes cardiac contractile decline. An effective therapeutic strategy is needed to reduce myocardial cell death and induce cardiac recovery. Therefore, studies on molecular and genetic biomarkers of MI, such as microRNAs (miRs), have recently been increasing and attracting attention due to the ideal characteristics of miRs. The aim of the present study was to discover novel causative factors of MI using multiomics-based functional experiments. Through proteomic, MALDI-TOF-MS, RNA sequencing, and network analyses of myocardial infarcted rat hearts and in vitro functional analyses of myocardial cells, we found that cytochrome c oxidase subunit 5a (Cox5a) expression is noticeably decreased in myocardial infarcted rat hearts and myocardial cells under hypoxic conditions, regulates other identified proteins and is closely related to hypoxia-induced cell death. Moreover, using in silico and in vitro analyses, we found that miR-26a-5p and miR-26b-5p (miR-26a/b-5p) may directly modulate Cox5a, which regulates hypoxia-related cell death. The results of this study elucidate the direct molecular mechanisms linking miR-26a/b-5p and Cox5a in cell death induced by oxygen tension, which may contribute to the identification of new therapeutic targets to modulate cardiac function under physiological and pathological conditions.
( Sang Heon Suh ),( Yu Na Jeong ),( Mi Ok Jang ),( Seung Ji Kang ),( Hee Chang Jang ),( Sook In Jung ),( Kyung Hwa Park ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
71-year old female patient was referred from an outside hospital to our facility for evaluation of persistent fever with rash in spite of in-hospital care for more than 20 days. Considering her medication history that she had been suffered from intermittent febrile sense and dry cough for about 5 months, for which other medications were prescribed from several general physicians` clinics, and lack of evidence for infection, she was tentatively diagnosed with drug hypersensitivity syndrome (DHS). While starting the treatment with intravenous methylprednisolon 62.5 mg per day, we reviewed the medical history more specifically to find out the culprit that might trigger DHS, although her medication history failed to nominate the culprit drug, because any drugs were not taken long enough to evoke DHS. Seeking for alternative diagnoses, lymphoproliferative diseases were suspected, since marked lymphadenpathies were observed in chest and abdomen computed tomography. After initial stabilization with steroid treatment, excisional biopsy from right axillary lymph nodes was done on hospital day 3. Confirmatory reading available on hospital day 8 demonstrated angioimmunoblastic lymphoma (AITL), although patient expired on hospital day 5 due to refractory hypomia by ventilator-associted pneumonia. Serologic and molecular evaluation indicated the patient`s Ebstein-barr virus (EBV) infection (Table 1). Here, we report a case of EBV-associated AITL with an unusual cutaneous manifestation mimicking DHL.
Sang-Ho Jeong,Kyungsoo Bae,Chang-Youn Ha,Young-Joon Lee,Ok-Jae Lee,Woon-Tae Jung,Sang-Kyung Choi,Soon-Chan Hong,Eun-Jung Jung,Young-Tae Ju,Chi-Young Jeong,Woo-Song Ha 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.84 No.2
Purpose: Before laparoscopic gastrectomy for gastric cancer can be planned, it is very important to know the precise location of the tumor. The aim of this study was to evaluate 3 methods of predicting the exact location of the tumor: preoperative gastrofibroscopy (GFS), preoperative computed tomography gastroscopy (CT), and intraoperative gastroscopy-guided laparoscopy (Lap). Methods: In this study, 15 patients were prospectively identified, and endoscopic clips were preoperatively placed on the proximal 1 cm of the tumor, at the angle on the greater curvature and opposite the angle on the greater curvature. The distances between the pylorus and the proximal tumor clip (PT), the angle clip (PA), the greater curvature clip (PG), and the gastroesophageal junction were measured by preoperative GFS, preoperative CT, intraoperative Lap, and visual inspection (Vis). Results: PT, PA, and PG values measured by preoperative GFS differed significantly from the Vis values (P 〈 0.01). However, preoperative CT measurements of PT, PA, and PG did not differ from the Vis values (P = 0.78, P = 0.48, and P = 0.53, respectively). Intraoperative Lap and Vis PT values differed by only 1.1 cm on an average (P = 0.10), but PA and PG values varied by 1.9 and 3.4 cm, respectively (P = 0.01 for both). Conclusion: Endoscopic clipping combined with preoperative CT gastroscopy is more useful than preoperative GFS for preoperatively predicting the location of early gastric cancers and will be helpful for planning laparoscopic gastrectomy.