Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-kB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1

( Jae Ho Choi ),( Sun Woo Jin ),( Eun Hee Han ),( Bong Hwan Park ),( Hyung Gyun Kim ),( Tilak Khanal ),( Yong Pil Hwang ),( Minh Truong Do ),( Hyun Sun Lee ),( Young Chul Chung ),( Hee Suk Kim ),( Tae 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

Purpose: The consequences of precipitously rising allergic skin inflammation rates worldwide have accelerated the risk of atopic dermatitis (AD). Natural product-based agents with good efficacy and low risk of side effects offer promising prevention and treatment strategies for inflammation-related diseases. We have already reported that Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) have many pharmacological effects, including anti-inflammatory and anti-allergic effects, but its influence on AD remains unclear. Therefore, we evaluated the inhibitory effect of CKS, mainly platycodin D, on AD-like skin symptoms in mice and the possible mechanisms in cells. Methods: Mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB). Four weeks after challenge, mice were treated with oral administration of CKS for 4 weeks. In addition, cells were used to evaluate the effect of CKS, mainly platycodin D, on the TARC expression regulated mechanism. Results: CKS attenuated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells and mast cells in the ears. Moreover, CKS and platycodin D inhibited TNF-α/IFN-γ-induced TARC expression through the suppression of NF-κB and STAT1 and induction of Nrf2/ARE-mediated hemeoxygenase-1 (HO-1) expression in cells. Conclusion: We suggest that CKS and platycodin D inhibited the development of AD-like skin symptoms by regulating cytokine mediators and may be an effective alternative therapy for AD-like skin symptoms.ⓒ2014 Elsevler Gmbh. All rights reserved.

요추부 척추협착증 수술환자에서 극돌기간 연성고정물 사용군과 비사용군의 치료결과 비교

김재도,장재호 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Background : To compare of the clinical and radiologic results between microscopic decompression(MD) and MD with Device for Intervertebral Assisted Motion(DIAM) in lumbar canal stenosis. Materials and Methods : The retrospective evaluation was performed after surgery of stenosis. MD with DIAM was performed in 17 cases(Group A) and MD in 20 cases(Group B). In radiologic evaluation, checked the preoperative and postoperative disc height, intervertebral foraminal dimension, lumbar lordotic angle and instability by Panjabi. In clinical evaluation, preoperative and postoperative pain was checked by VAS. Disability was checked by RMQ(Roland Morris Questionnaire) and sf-36(PF). Results : In radiologic results, disc height changed from 11mm to 13mm in Group A(11mm to 11.8mm in Group B)(p=0.669). Intervertebral foraminal dimension was changed from 20.6mm to 22.3mm in Group A(19.5mm to 20.5mm in Group B)(p=0.536). Lumbar lordotic angle was changed from 15.40 to 14.20 in Group A(14.80 to 19.50 in Group B)(p=0.033). Instability score was improved from 0.9 to 0.2 in Group A(1 to 0.2 in Group B)(p=0.642). VAS score improved in group A from 10 to 2(9 to 2 in Group B)(p=0.612). On sf-36(PF), the values changed from 34/100 to 58/100 in Group A(30/100 to 58/100 in Group B)(p=0.535). Conclusion : Using dynamic interspinous stabilizer(DIAM) appears to be a useful and effective methods in surgery of lumbar canal stenosis with better radiologic results than MD only, but lumbar lordotic angle was decreased, slightly

糖, 아미노酸 및 無機窒素化合物이 人蔘褐變促進에 미치는 影響

都在浩,金相達,吳勳一,洪淳根 한국응용생명화학회 1982 Applied Biological Chemistry (Appl Biol Chem) Vol.25 No.3

紅蔘褐變의 適合한 促進方法을 究明하기 위하여 人蔘에 糖, amino酸 및 無機窒素化合物을 處理한 結果 糖類中에서는 maltose와 glucose가 가장 强한 褐變促進作用을 나타내었다. amino酸은 basic amino acid인 lysine, histidine, arginine이 가장 크게 促進했으며 糖과 amino酸 混合處理에서는 glucose와 glutamic acid 退合處理區가 가장 크게 促進되었다. Glucose 濃度別 處理時의 褐變促進效果는 glucose濃度가 增加함에 따라 褐變이 促進되었으며 無機窒素化合物中에서는 urea>(NH₄)₂)HCO₃>COONH₄등의 順으로 褐變이 促進되었다. In order to find out pertinent methods for the acceleration of browing during ginseng processing, various treatments were made or fresh ginseng (Panax Ginseng C.A. Meyer) with sugars, amino acids and inorganic nitrogenous compounds and the extent of browning was measured. Among sugars tested, maltose resulted in the greatest acceleration of browning followed in decreasing order by glucose and lactose, whereas pentoses, fructose, sucrose and raffinose had negligible effect. A marked browning occurred in ginseng treated with basic amino acids, while the extent of browning was not greatly increased when ginseng was treated with aliphatic amino acids, hydroxy amino acids, or acidic amino acids used in the experiment. Among treatments with sugar-amino acid mixture, a mixture of glucose with glutamic acid gave the greatest acceleration. The brown color intensity gradually increased with an increase in glucose concentration for up to 0.5M. inorganic nitrogenous compounds enhanced the browning in general, and the effect varied greatly with the different compounds.

만성두통환자에게 적용한 비약물적 치료가 통증행동에 미치는 영향

최도영,임사비나,차남현,김건식,이재동,김수영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : This study is a random-controlled post-design for confirmation of headache degree, quality of life, and satisfaction to therapeutical effect on chronic headache adults after management of non-medicinal treatment (acupuncture therapy and stellate ganglion block therapy). Methods : 51 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as chronic headache patients. The qualified patients were classified in to two groups, acupuncture group (AT group, n=28) and stellate ganglion block group (SGB group, n=23). Treatment was applied 2 times a weeks for 4 weeks. The effects of both groups were analyzed using VAS scores, BPI (Brief Pain Inventory) and the satisfaction degree to the therapy. Results : 1. The recognized score of the headache of AT group and SGB group was reduced indicating the degree of the headache was released. 2. The recognition at damage to the quality of life was reduced post therapy of AT group and SGB group, in which general activity, mood, enjoyment of life, personal relationship, and sleeping showed significant improvement of life quality. 3. The satisfaction degree to the therapy showed lower score than expectation to it in AT group and SGB group, however, it was not significant. Conclusions : The results showed that the four-week non-medicinal treatment (AT and SGB) in chronic headache patients was effective for reducing headache and releasing its damage in daily life, however, no difference in superiority was found. Therefore, non-medicinal treatment (AT therapy and SGB) could be utilized in chronic headache patients.

다발성 골수종으로 이행한 단일형질세포종 1예

정재용,모성환,기장도,문철호,김창욱,전용준,박유환,정춘해,오윤경 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

전자상거래에서의 번들링 상품으로서의 택배서비스에 관한 분석

송재도,천세학,주지호,김재철 한국경영과학회 2004 經營 科學 Vol.21 No.3

We discuss that the proliferation of new types of retailers such as Internet shopping mails, home shopping systems, which use telecommunication media as means of providing information of products, makes delivery service generally available. Then, we show that the delivery service can be used strategically for profit maximization by intentionally homogenizing consumers and, furthermore, social welfare generally increases by this delivery service unless the cost of delivery service is higher than that of ail consumer groups.

림프관 확장증형 모기질종 1예

김도현,김재욱,이지범,김성진,원영호,이승철 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.2

Pilomatricoma is a benign adnexal tumor differentiating toward elements of the hair matrix and shaft. It typically presents as a solitary, deep, dermal nodule, but other variants, such as anetodermic form and pseudo-bullous form have rarely been reported. A 22-year-old man presented with erythematous 4×5㎝ sized bulla-like nodule of about 1 month history on the upper back. Histopathologic examination of the lesion showed a well-circumscribed dermal nodule composed of basophilic cells, shadow cells, and transitional cells. There were also marked lymphangiectatic dilatations above the tumor in the upper dermis. We diagnosed this case as a lymphangiectatic pilomatricoma with pseudo-bullous appearance. (Korean J Dermatol 2003;41(2) : 258∼260)

발달장애아동의 감각운동에 대한 문화기술적 분석

김도호,박재성 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

This study attempts to investgate th aspects on the sensory exercise class of children with developmental disabilities. This study is to analyze by ethnographic research method. The subjects in this study were 11 selected children who were attending, The Data were collected through 35 participation observations, 3 teacher Interviews during a period from March, 2004 to July, 2004. The class of sensory exercise were tape-recoarded, videotaped, and field jotting and field records were made, In addition with the teacher were also duplicated and materialized, Collected data were encoded, categorized and analyzed by each case, The findings of this study were as below: First, the sensory exercise class was effective for the enhancement of the motor abilities of the children with developmental disabilities. As a result of checking out balance, mobility and coordination, the subfactors of major muscular movement. Second, the sensory exercise class was effective for the enhancement of the social skills of the children with developmental disabilities. As a result of checking out spontaneousness, concentration, imitation and cohesive force, the subfactors of interpersonal relationship and social adjustment behaviors.

정신지체아동의 감각운동에 대한 문헌적 연구

김도호,황영성,박재성,한성유,허정석,이수판 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose or this study is to consider the effect of the sensory exercise which has been judged as improving mentally retarded children's motor ability, social maturity, recognition ability, emotional behavior through stimulation of sensory organs. Result are as follows: 1. (First) Sensory exercise was promoting motor ability of the mentally retarded children. 2. (Second) Sensory exercise was promoting social maturity of the mentally retarded children. 3. (Third) Sensory exercise was promoting recognition ability of the mentally retarded children. 4. (Finally) Sensory exercise was promoting emotional behavior or the mentally retarded children.

시나리오 역할 게임을 통한 신속 시스템 설계/검증 방법 : 패키지 응용 시스템을 대상으로 for Package Based System Implementation

예도경,이용재,강두호,최열현 한국경영과학회 1998 한국경영과학회 학술대회논문집 Vol.- No.1

Recently, many enterprises wish to preoccupy competitive positions in the market by motivating themselves towards CALS(Commerce At Light Speed), and try hard to achieve system implementation with the use of new concept-based backbone systems such as ERP(Enterprise Resource Planning) or ERP(Enterprise Resource Planning). However, unfortunately there is an inevitable discrepancy during implementation period between package vendors and customers due to lack of clear methodology and misunderstanding about system. In some cases, consensus on partially verified system design invokes customers’ continuous change demands and often it tends to result in unnecessary project delays. PDM application system implementation project of the company L has been studied here to solve these sorts of problems. The major yields of this work are achievement of a willing approval from customers and rapid system design under a time-limited and conceptually defined project scope, and finally, through fully verified system design, we were able to reach successful system implementation.