http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
적응 요인에 따른 보조부화술 (Assited Hatching, AH)의 효과
김지수,강승호,권윤정,손인표,최규완,김수경,전한식,이제규,이승재,박종민,Kim, J.S.,Kang, S.H.,Kwon, Y.J.,Son, I.P.,Choi, K.W.,Kim, S.K.,Chun, H.S.,Lee, J.G.,Lee, S.J.,Park, J.M. 대한생식의학회 1998 Clinical and Experimental Reproductive Medicine Vol.25 No.2
Implantation rates remain low following human in vitro fertilization (IVF). Suboptimal culture conditions may limit the ability of embryos to hatch as blastocysts, and artificial opening of the zona pellucida has been proposed as a means to promote subsequent hatching (assisted hatching). In this study, assisted hatching (AH) by zona drilling using acidic Tyrode's solution was performed in 320 patients, due to their age of more than 38 years (group A), the thick zona pellucida (group Z; $ZP\geq0.18{\mu}m$), and failures in implantation more than 3 times in previous IVF-ET trial (group P). This study was designed firstly, to study the effects of AH on the outcomes of IVF-ET according to the indications and secondly, to verify the appropriate application of AH. The results were as follows; 1. There was no difference in pregnancy rate between AH group (26.6%) and non-AH group (26.5%). 2. Assisted hatching (AH) showed significantly higher pregnancy rate of the patients with thick zona pellucid a than those of the patients with age factor and with the history of repeated implantation failure. But in the patients with age factor only, AH resulted in higher pregnancy rate. 3. Interestingly, the patients with complex factors including zona factor (Z: 33.9%; ZA: 30.4%; ZP: 31.6%; ZAP: 21.4%) showed higher pregnancy rates than other complex factors excluding zona factor (A: 24.4%, P: 0%; AP: 10.8%). From these results, AH is more helpful to the patients with thick zona pellucida rather than patients with older age and/or previous repeated implantation failure.
J. S. Kong(공정식),K. Min(민경현),J. Kim(김종민),J. Kim(김지수),G. Gao(가오그),H. Park(박효신),H. H. Han(한현호),D.-W. Cho(조동우) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월
To treat peripheral nerve deficits, a variety of synthetic and decellularized materials with anisotropic architectures are developed due to the advantages proposed by aligned structures with respect to cell activity, migration, and directionality. Additionally, narrowing microscale topological cue has advantages on alignment and migration of cells. However, up to date, fabricating 3D hydrogel constructs composed of thin microfibers under 50 μm using mechanically weak hydrogel like low concentrated dECM bioink is challenge, unlike synthetic polymer-based fabrication. In this study, we created a microgel printing bath solution to three-dimensionally print a dECM bioink, derived from porcine nerve, as a thin microfiber. A 30 μm filament resolution of low viscosity dECM hydrogel with a neutral pH was achieved using an alginate microgel supplemented printing bath. To treat the sciatic nerve defect model of rats, 3D printed cylindrical constructs retaining bundle of dECM microfibers were used as a filler of the polycaprolacton (PCL) conduit. The total number of regenerated axons and relative gastrocnemius muscle weight ratio were comparable to those of the autologous nerve graft group. Meanwhile, the results were superior to those of the porcine decellularized nerve tissue group or the 3D printed filler only group.