Adiponectin is a negative regulator of NK cell cytotoxicity.

Kim, Kun-Yong,Kim, Jae Kwang,Han, Seung Hyun,Lim, Jong-Seok,Kim, Keun Il,Cho, Dae Ho,Lee, Myeong-Sok,Lee, Jeong-Hyung,Yoon, Do-Young,Yoon, Suk Ran,Chung, Jin Woong,Choi, Inpyo,Kim, Eunjoon,Yang, Young American Association of Immunologists 2006 Journal of Immunology Vol.176 No.10

<P>NK cells are a key component of innate immune systems, and their activity is regulated by cytokines and hormones. Adiponectin, which is secreted from white adipose tissues, plays important roles in various diseases, including hypertension, cardiovascular diseases, inflammatory disorders, and cancer. In this study the effect of adiponectin on NK cell activity was investigated. Adiponectin was found to suppress the IL-2-enhanced cytotoxic activity of NK cells without affecting basal NK cell cytotoxicity and to inhibit IL-2-induced NF-kappaB activation via activation of the AMP-activated protein kinase, indicating that it suppresses IL-2-enhanced NK cell cytotoxicity through the AMP-activated protein kinase-mediated inhibition of NF-kappaB activation. IFN-gamma enhances NK cell cytotoxicity by causing an increase in the levels of expression of TRAIL and Fas ligand. The production of IFN-gamma, one of the NF-kappaB target genes in NK cells, was also found to be suppressed by adiponectin, accompanied by the subsequent down-regulation of IFN-gamma-inducible TRAIL and Fas ligand expression. These results clearly demonstrate that adiponectin is a potent negative regulator of IL-2-induced NK cell activation and thus may act as an in vivo regulator of anti-inflammatory functions.</P>

Bisphosphonates의 이독성에 관한 연구

박일석,김형종,임현준 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.3

족삼리 침자극의 복통 억제기전 연구

임사비나,임형택,박히준,장지련,최일환,이석찬,김대수,신희섭 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : Acupuncture has been used for treatment of numerous disorders, especially for pain control in Oriental Medicine. However, the mechanism of pain control by acupuncture was not clear until now. This study was performed to prove analgesic mechanism of acupuncture treatment at acupoint ST_(36) by observing the changes of abdominal pain and c-Fos expression in the thalamus. Methods : Abdominal pain was induced by acetic acid, and the changes of writhing reflex after acupuncture treatment an ST_(36) and non-acupoints were measured. c-Fos immunohistochemistry was also performed to study the changes of the neuronal activity in the thalamus. Results : The writhing reflex decrease significantly after acupuncturing at ST_(36) compared with control group(p<0.05). The changes of the writhing reflex by non-acupoint acupuncture treatment also showed significant decrease compared with control group(p<0.05). c-Fos expression in the thalamus, especially periventricular part was significantly decreased after acupuncturing at ST_(36) compared with control groups(p<0.05). Conclusion : This study shows that the acupuncture has the analgesic effect in the abdominal pain induced by acetic acid and the thalamus might be a important area for this mechanism.

榮山江 淡水魚中의 有害性 重金屬 含量에 관한 硏究

崔炯一,林官圭 조선대학교 환경연구소 1988 環境公害硏究 Vol.5 No.-

This study was carried out to investigate the heavy metal content of freshwater fishes which were collected at 7 areas located on Youngsan river from march to april in 1988. The results obtained were as follows : 1. Generally mean value of heavy metal contents of fishes collected on lower and upper parts of Youngsan river were higher than those of middle parts. 2. The highest percent of water in edible portion of samples was 81.5% in cyprinus carpio, the lowest was 74.7% in Pseudogobio esocinus, and. the other samples were 75.3% to 78.0. 3. In the cadmiuum contents, the highest value was 14.67 ppb in Carassius auratus and the value at Dongmal ferry area was higher than those at other parts on Youngsan river. 4. In the lead contents, the highest was 0.236 ppm in carassius auratus and that in Zacco platypus was the lowest 0.112 ppm, 5. In the copper contents, the highest value was 2.007ppm in Carassius auratus and the contents of fishes of fishes of dongmal ferry was higher than those of any other area. 6. In the chromium contents, the highest was 1.102ppm in carassius auratus and that in zacco playpus was the lowest 0.887 ppm. The contents of samples of Dongmal ferry area was also higher than those of other area. 7. Accumulation of heavy metals in freshwater fishes intended to increase with growth.

위암수술 환자에서의 cp 개발과 cp적용에 따른 질 향상 활동에 관한 연구

임은주,황순휘,박도중,하광일,배현주,김형호 한국의료QA학회 2006 한국의료질향상학회지 Vol.13 No.2

Background : In an era of increasing medical costs, safe reduction in postoperative stay has become a major focus to optimize utilization of healthcare resources. The authors aimed to evaluate the clinical significance of the critical pathway(CP) for gastrectomy patients by implementing standardized postoperative management and electronic medical records. Method : From August 2006 to April 2007, critical pathways were introduced to inpatients and outpatients with gastric cancer. 60 consecutive patients undergoing distal gastrectomy were randomly divided into two groups; 30 CP group(A) and 30 non-CP group(B). Simultaneously, we also retrospectively reviewed the records of 438 patients(C:control group) who were able to be enrolled in CP program. We compared group(A) with (B), (C) in terms of hospital stay, complication rate, use of antibiotics and hospital costs. Patient satisfaction was surveyed by questionnaires. Result : There was no significant demographic difference between group(A) and (B). Of 30 patients in group(A), 5 drop-outs and 14 variances occurred. The mean postoperative hospital stays(Laparoscopy-assisted distal gastrectomy: LADG/Open distal gastrectomy: ODG) were 7.6/10.5 days for the group(A), 8.9/12.7 days for the group(B) and 12.6/14.5 days for the group(C) (p=0.02 in LADG). The total hospital cost of group(A) had a tendency to be less than that of group(B) and the amount of hospital cost per day in group(A) was significantly higher than that in group(B). The usage rates of the first generation antibiotics were 73.33%, 63.33%, and 59.2% in group(A), (B), and (C), respectively. Patients’ satisfaction had a tendency to be higher in the CP group than non-CP group. Conclusion : The mean hospital stay in LADG patients was shortened meaningfully and hospital cost per day was enlarged after introduction of clinical pathway. It is necessary to apply a number of patients to the critical pathway and to make an effort to reduce the variation and drop-out rates.

전류제어에 의한 단상유도전동기의 기동특성 개선

박수강,최낙일,백형래,임양수,이기용,신사현 조선대학교 에너지.자원신기술연구소 1998 에너지·자원신기술연구소 논문지 Vol.20 No.1

A single phase induction motor(SPIM) with two windings, main and auxiliary, is probably the most widely used motor in the world due to their ruggedness, low maintenance and simplicity of construction There are several ways of starting single phase motors The most popular arrangements is centrifugal switch An auxiliary winding connected in series with a capacitor, is brought into the circuit during starting The closing and opening of the switch must be speed dependant The switch meets the speed requirements, but it also has many drawback random switching, arcing, many models necessary for different speeds and shaft diameters, space required inside the motors and limited lifetime to name some of them. In this paper, the starting current of single phase induction motor was detected by a small detector and determined TRIAC gate signal. The strategy of current control is based on limited main and auxiliary current angle during starting period in the closed-loop control. The experimental result show the motor's starting characteristics of the proposal starting system and are compared with centrifugal switch starting motor.

CA 약침액의 항산화,항염증 효능 및 염증성 사이토카인 억제 효과

김학주 ( Hak Ju Kim ),최일환 ( Il Hwan Choi ),정철 ( Chul Jung ),임형호 ( Hyung Ho Lim ),송윤경 ( Yun Kyung Song ) 대한면역약침학회 2012 대한면역약침학회지 Vol.1 No.1

Objectives: This purpose of this study was to analyzed the Biological Activities of CA Yakchim Fluid. Methods: The protein content, glucose content, crude fat content, crude ash content in CA Yachim fluid were analyzed, and DPPH radical scavenging, inhibition of COX-2 activities were investigated. Also TNF-α, IL-6, GAPDH as inflammatory cytokines were measured. Results: The protein, 1.46%, glucose, 0.13%, crude fat 96.18%, crude ash 0.51% in CA Yachim fluid were confirmed. The electron donation ability of CA Yakchim on DPPH WAS 21%. The inhibition of COX-2 activity of CA Yakchim fluid was 68%. The TNF-α, IL-6 were increased in RAW 264.7 treated with LPS, and were decreased in RAW 264.7 pre-treated with CA Yakchim fluid. Conclusions: We conclude that the CA Yakchim fluid has anti-oxidant, anti-inflammatory activities and inhibition effect of the inflammatory cytokines.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue

Kim, Kun-yong,Kim, Hwa Young,Kim, Jae Hyeong,Lee, Chul-Ho,Kim, Do-Hyung,Lee, Young Ho,Han, Seung Hyun,Lim, Jong-Seok,Cho, Dae Ho,Lee, Myeong-Sok,Yoon, Sukjoon,Kim, Keun Il,Yoon, Do-Young,Yang, Young Elsevier 2006 FEBS letters Vol.580 No.16

<P><B>Abstract</B></P><P>CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-α and IL-1β. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (<I>fa/fa</I>) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.</P>

An Algorithm on Optimal Placement Decision of Automatic Switches for 6 Sections/3 Links Configuration in DAS

Il-Hyung Lim,Wen-Hao Zhang,HamsyahTrirohadi,Myeon-Song Choi,Seung Jae Lee,Bok-Nam Ha 대한전기학회 2011 Journal of Electrical Engineering & Technology Vol.6 No.3

A Distribution Automation System (DAS) is operated by monitoring and control of the field statesusing Feeder Remote Terminal Units (FRTUs) installed together withautomatic switches. An optimal placement of automatic switchescan enhance efficiencyof the operation and restoration, and improve the power supply reliability ofa DAS.This paper proposes an algorithm to decide the optimalplacement of automatic switches ina DAS.The proposed algorithm was developed ona DAS witha six sections and three links configuration. The proposed algorithm was provided inaneight-feeder power distribution system.