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Hyunah Kim,Hyun Kyung Kim,Hyun-Na Koo,Gil-Hah Kim 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.10
The two spotted mite, Tetranychus urticae Koch, is a global pest, and has developed severe resistance to several types of acaricides. Acequinocyl-resistant strain and bifenazate-resistant strain of T. urticae showed higher relative activity level of glutathion-S-transferases (GSTs) than susceptible strain. Studies of resistance in T. urticae have focused on classical detoxifying enzyme system, such as GSTs. We examined the expression of six GSTs genes in T. urticae belong to five different cytosolic classes, including two in delta, one in omega, one in mu, one in zeta, and one mitochondrial GSTs class, kappa. RT-qPCR results showed that, among these six GSTs genes, the relative expression level of delta 1 was significantly higher in bifenazate-resistant strain than in other strains (susceptible, abamectin, acequinocyl, etoxazole and pyridaben strain). Expression level of the delta 2 was also higher in acequinocyl-resistant strain than in other strains. The elevated GSTs gene transcripts following exposure to acequinocyl, bifenazate might be one of the mechanisms involved in detoxification of these acaricide. These results may be caused by different mechanisms in the resistance development of T. urticae to these two different types of acaricides.
Future Prospects of Health Management Systems Using Cellular Phones
Kim, Hun-Sung,Hwang, Yunji,Lee, Jae-Ho,Oh, Hye Young,Kim, Yi-Jun,Kwon, Hyeon Yoon,Kang, Hyoseung,Kim, Hyunah,Park, Rae Woong,Kim, Ju Han Mary Ann Liebert 2014 TELEMEDICINE JOURNAL AND E HEALTH Vol.20 No.6
<P>Cellular phones enable communication between healthcare providers and patients for prevention, diagnosis, and treatment of diseases. However, few studies have examined the user-friendliness or effectiveness of cellular phone-based medical informatics (CPBMI) for healthcare.</P>
Sung Il Kim,Won Jin Kang,Yeseul Choi,Hyunah Kim,Bueyong Park,Hyun Kyung Kim,Hyun-Ha Koo,Gil-Hah Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04
The two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), is one of the most important pest species devastating many horticultural and ornamental crops and fruit trees. In the present study, a field strain was collected in January 2001 and has been selected for sixteen years with acequinocyl. The resistance ratio calculated from the LC50 of eggs and adults was 191- and 4,237-fold, respectively. The laboratory-selected acequinocyl resistance (LSAR16) strain was screened with 11 acaricides for cross-resistance. The detoxifying enzyme activities and quantitative real-time PCR analysis were performed in the LSAR16 strain. Crossing experiments revealed that LSAR16 strain was inherited maternally, incompletely dominant and monogenic. Most importantly, we identified two new point-mutations at mitochondrial cytb from acequinocyl resistant T. urticae.
Sung-chan Yang,Byung-Eon Noh,Eun Jung Lee,Bong Gu song,Hyunwoo Kim,Tea-Kyu Kim,Seong Yoon Kim,Won Il Park,Hyung-Woo Lim,Hak Seon Lee,Gi-Hun Kim,Chang won Jang,Jin Hwan Jeon,Se Jin Jeong,Hyunah Kim,Kyu 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.04
We performed a survey for flavivirus infection and distribution of Aedes albopictus that known as Zika and Dengue virus vector using black–light trap and BG-sentinel trap around urban area in Korea. Mosquitoes were collected in 27 cities during March to November (twice a month) year 2016. Total numbers of mosquitoes collected 102,102 including 19 species 8 genera during collecting period. Total 21,467 Ae. albopictus was collected that 20,961(24.3%) by BG-sentinel trap and 506 (3.2%) by Black-light trap in urban area. Trap index(trap/night) of Ae. albopictus was showed highest in Hamyang (TI:992.3) and lowest in Taebaek (TI:0.3) there was only collected by Black-light trap. A total of 894 pools from all collecting Ae. albopictus were performed a Flavivirus detection. Flavivirus was not detected during study period. This study may provide basic information for surveillance of imported diseases (include Zika virus) and vectors in Korea.
Novel JAK1-selective benzimidazole inhibitors with enhanced membrane permeability
Kim, Hyungmi,Kim, Mi Kyoung,Choo, Hyunah,Chong, Youhoon Elsevier 2016 Bioorganic & medicinal chemistry letters Vol.26 No.14
<P><B>Abstract</B></P> <P>The previously identified Janus kinase 1 (JAK1)-selective inhibitor, 1-(2-aminoethyl)-2-(piperidin-4-yl)-1<I>H</I>-benzo[<I>d</I>]imidazole-5-carboxamide (<B>2</B>), suffered from low cell permeability, which resulted in poor pharmacokinetic properties. In this study, by introducing less polar hydrogen bond donors at <I>N</I> <SUP>1</SUP> (a hydroxyalkyl or a methylaminoalkyl group) and C2 (a cyclohexanol group) positions, a series of novel benzimidazole derivatives were prepared, which exhibited selective JAK1 inhibitory activity (IC<SUB>50</SUB> against JAK1=0.08–0.15μM; JAK1-selectivity=26–40 fold vs JAK2, 12–23 fold vs JAK3, and 38–54 fold vs Tyk2) along with significantly increased lipophilicity (3.3–15.8 times) as well as membrane permeability (6.3–12 times).</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Jongsoon,Lee, Byungju,Kim, Hyungsub,Kim, Hyunah,Kang, Kisuk American Chemical Society 2016 Chemistry of materials Vol.28 No.19
<P>Defects in crystals such as antisites generally lead-to the deterioration of the ionic conductivity of solid-state ionic conductors. Herein, using first principles calculations, we demonstrate that the Li diffusion in Li2MP2O7 (M = Fe or Mn), a promising battery material, is sensitively affected by the presence of Li/M antisites; however, unexpectedly, the antisites significantly promote Li diffusion. The calculations reveal that the presence of antisites reduces the barrier of Li hopping and opens new paths for Li diffusion in the Li2MP2O7 crystal. In our experimental verification, we succeeded in synthesizing crystalline Li2MnP2O7 with varying Li/Mn antisite contents and demonstrated that the inclusion of antisites results in improved power capability with faster Li diffusion for Li-ion battery electrodes. We believe that this unexpected finding of increasing the ionic conductivity by introducing antisite defects broadens our understanding of solid-state ionic conductors and provides a new strategy for improving Li diffusion in conventional electrode materials for Li rechargeable batteries.</P>