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( Hyun Jik Lee ),( Chang Min Cho ),( Jun Heo ),( Min Kyu Jung ),( Tae Nyeun Kim ),( Kook Hyun Kim ),( Hyunsoo Kim ),( Kwang Bum Cho ),( Ho Gak Kim ),( Jimin Han ),( Dong Wook Lee ),( Yoon Suk Lee ) 대한간학회 2020 Gut and Liver Vol.14 No.2
Background/Aims: Few studies have addressed the relationship between the occurrence of adverse events (AEs) in endoscopic retrograde cholangiopancreatography (ERCP) and hospital case volume or endoscopist’s experience with inconsistent results. The aim of our study was to investigate the impact of hospital case volume and endoscopist’s experience on the AEs associated with ERCP and to analyze patient- and procedure-related risk factors for post-ERCP AEs. Methods: From January 2015 to December 2015, we prospectively enrolled patients with naïve papilla who underwent ERCP at six centers. Patient- and procedure-related variables were recorded on data collection sheets at the time of and after ERCP. Results: A total of 1,191 patients (median age, 71 years) were consecutively enrolled. The overall success rate of biliary cannulation was 96.6%. Overall, 244 patients (20.5%) experienced post-ERCP AEs, including pancreatitis (9.0%), bleeding (11.8%), perforation (0.4%), cholangitis (1.2%), and others (0.9%). While post-ERCP pancreatitis (PEP) was more common when the procedure was performed by less experienced endoscopists, bleeding was more common in high-volume centers and by less experienced endoscopists. Multivariate analysis showed that a less experience in ERCP was significantly associated with PEP (odds ratio [OR], 1.630; 95% confidence interval [CI], 1.050 to 2.531; p=0.030) and post-ERCP bleeding (OR, 1.439; 95% CI, 1.003 to 2.062; p=0.048). Conclusions: Our study demonstrated that overall AEs following ERCP were associated with the experience of the endoscopist. To minimize post-ERCP AEs, rigorous training with a sufficient case volume is required, and treatment strategies should be modified according to the endoscopist’s expertise.
1차원 충돌 동역학 모델을 이용한 한국형 고속전철의 충돌안전도 평가
조현직(Cho Hyun-Jik),구정서(Koo Jeong Seo),윤영한(Youn Young Han) 한국철도학회 2002 한국철도학회 학술발표대회논문집 Vol.- No.-
In this study, the crashworthiness of KHST is evaluated by analysing a nonlinear spring/bar-damper-mass model using 1 dimensional collision dynamics. The numerical results show that KHST can easily absorb kinetic energy at lower impact force and acceleration in heavy collisions, when compared with KTX. Also, in a light collision like a traint-to-train accident at speed under 8 kph, the carbody and components of KHST can be protected without any damage except a energy absorbing tube to be replaced easily. However, KTX may be much damaged in the light collision because there is no energy absorbing tube. In conclusion, the crashworthy performance of KHST has been much improved than that of KTX, although there remains something to be improved for a better performance.
국내 철도차량안전법 요구 압괴 성능의 대형장애물 수치모델 개발
조현직(Cho Hyun-Jik),구정서(Koo Jeong-Seo),이장욱(Lee Jang-Wook),박경창(Park Kyoung-Chang),박근수(Park Geun-Soo) 한국철도학회 2009 한국철도학회 세미나자료 Vol.2009 No.5
This study aims to develope a numerical model of the huge obstacle defined in the Korean Rollingstock Safety Regulations. The shape and mechanical properties to be satisfied in the numerical model were based on the Regulations. Through a troublesome trial and error simulations, we developed the numerical model of the huge obstacle to satisfy physical properties of the specified guideline in the regulations. By applying the developed numerical obstacle, we carried out a crash simulation to evaluate vehicle crashworthiness.
충돌동역학 모델링 기법에 따른 충돌가속도 응답특성 분석
조현직(Cho Hyun-Jik),김운곤(Kim Woon-Gon),구정서(Koo Jeong-Seo) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-
In the Rail Safety Regulations article 16, deceleration rate in the survival spaces should be limited as far as is practicable to 5g, and shall not be more than 7.5g. As it is impractical to evaluate complete train behaviour by testing, the achievement of the objectives shall be validated by dynamic simulations corresponding to the reference collisions scenarios. But initial design and evaluation procedure, impact dynamics model which classified 1D and 2D is more useful than full scale model. This paper presents acceleration response characteristics between 1D and 2D dynamics model under head-on collision in standard collision scenarios.
철도안전법 시행지침 16조의 충격가속도 평가를 위한 객차의 데이터 필터링 연구
조현직(Cho Hyun-Jik),김운곤(Kim Woon-Gon),구정서(Koo Jeong-Seo),송달호(Song Dhal-Ho) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-
In the article 16 of the domestic rolling stock crashworthiness regulations, the collision acceleration level during collision accidents should remain under the maximum 7.5g and the average 5g. By the way, the accelerations obtained in crash simulations and tests contain many kinds of high frequency components due to numerical oscillations or noisy signals. So, this paper aims to develop reliable post-processing methods to filter high frequency oscillations and extract the rigid body motions of passenger rail cars. For this study we used the 1-dimensional dynamic model of KHST (Korean high-speed train), and evaluated acceleration data at the driver"s area in the first power car and the passenger area in the following trailer.
Lee, Hyun-Jik,Bae, Sun-Hyun,Cho, Kwang Hwan,Jeong, Jae-Hong,Kwon, Su-Il,Lee, Kil-Dong Korean Society of Medical Physics 2017 의학물리 Vol.28 No.4
Effects on skin caused by the dose from linear accelerator (LINAC) opposing portal irradiation and TomoDirect 3-D modeling treatment according to the radiation devices and treatment methods were measured, and a comparative analysis was performed. Two groups of 10 patients each were created and measurements were carried out using an optically stimulated luminescence dosimeter. These patients were already receiving radiation treatment in the hospital. Using the SPSS statistical program, the minimum and maximum average standard deviations of the measured skin dose data were obtained. Two types of treatment method were selected as independent variables; the measured points and total average were the dependent variables. An independent sample T-test was used, and it was checked whether there was a significance probability between the two groups. The average of the measured results for the LINAC opposing portal radiation was 117.7 cGy and PDD 65.39% for the inner breast, 144.7 cGy and PDD 80.39% for the outer breast, 143.2 cGy and PDD 79.56% for the upper breast, 151.4 cGy and PDD 84.11% for the lower breast, 149.6 cGy and PDD 83.11% for the axilla, and 141.32 cGy and PDD 78.51% for the total average. In contrast, for TomoDirect 3-D conformal radiotherapy, the corresponding measurement values were 137.6 cGy and PDD 76.44%, 152.3 cGy and PDD 84.61%, 148.6 cGy and PDD 82.56%, 159.7 cGy and PDD 88.72%, and 148.6 cGy PDD 82.56%, respectively, and the total average was 149.36 cGy and PDD 82.98%. To determine if the difference between the total averages was statistically significant, the independent sample T-test of the SPSS statistical program was used, which indicated that the P-value was P=0.024, which was 0.05 lower than the significance level. Thus, it can be understood that the null hypothesis can be dismissed, and that there was a difference in the averages. In conclusion, even though the treatment dose was similar, there could be a difference in the dose entering the body surface from the radiation treatment plan; however, depending on the properties of the treatment devices, there is a difference in the dose affecting the body surface. Thus, the absorbed dose entering the body surface can be high. During breast cancer radiotherapy, radiation dermatitis occurs in almost all patients. Most patients have a difficult time while undergoing treatment, and therefore, when choosing a radiotherapy treatment method, minimizing radiation dermatitis is an important consideration.
Kim, Bong Jik,Cho, Sung Woo,Jeon, Yung Jin,An, Sujin,Jo, Ara,Lim, Jae Hyun,Kim, Dong-Young,Won, Tae-Bin,Han, Doo Hee,Rhee, Chae-Seo,Kim, Hyun Jik Springer-Verlag 2018 Applied Microbiology and Biotechnology Vol.102 No.1
<P>We studied the contribution of Duox2 in mucosal host defense against influenza A virus (IAV) infection in in vivo lung. We found that Duox2 was required for the induction of type I and III interferon (IFN)s and transient Duox2 overexpression using cationic polymer polyethyleneimine (PEI) leads to suppression of IAV infection in in vivo lung. Twenty mice (C57BL/6J) were anesthetized and challenged by intranasal administration of 213 pfu/30 mu l of IAV (WS/33/H1N1), and IAV-infected mice were euthanized at 1, 3, 5, 7, 10, 14 days post infection (dpi). Duox2 small hairpin RNA (shRNA) and pCMV-Duox2 formulated with PEI were inoculated to mice to assess the regulatory mechanism between Duox2 and IFN secretion. Following intranasal IAV inoculation, viral infection was significantly aggravated from 3 dpi in in vivo lung and viral titer was highest at 7 dpi. Consistent with this, Duox2 messenger RNA (mRNA) and protein expressions were significantly induced from 3 dpi in the lung tissue of IAV-infected mice. Viral titer was much higher in IAV-infected mice that were inoculated with Duox2 shRNA accompanied with lower survival rate and extensive lung pathologies. Interestingly, severe lung pathologies in IAV-infected mice were not observed and viral titer was significantly reduced in mice with pulmonary administration of pCMV-Duox2 formulated with PEI before IAV inoculation. Both mRNA and secreted protein levels of IFN-beta and IFN-lambda(2/3) were highly elevated in IAV-infected mice with pCMV-Duox2 formulated with PEI. Duox2 is necessary for the regulation of IFN secretion in in vivo lung, and pulmonary administration of Duox2 DNA using cationic polymer triggers the induction of type I and III IFNs resulting in more complete suppression of IAV infection.</P>
도로대장(道路臺帳) 전산화 데이타베이스를 활용한 상수도 시설관리시스템의 개발에 관한 연구
조기성,조재호,이재기,이현직 충북대학교 건설기술연구소 1993 建設技術論文集 Vol.12 No.2
Recently, the construction of Urban information system is going ahead with a plan to solve the urban problems in each urban. Utilizing a mad register to be sonstructed, this study aims at developing Water Facility Management System for efficient management of water facility which reach to management margin because of urban extension. As a result of this study, we recognized that the road register to be constructed could be used for development of Water Facility Management System. It was proved that pilot system to be developed with the road register was rome effective to the Water Facility Management Work.