P168 : Split-face comparison study of new hyaluronic acid filler for efficacy and safety of HA-IDF versus Restylane® for correction of nasolabial folds

( Jie Hyun Jeon ),( Joo Ha Kim ),( Jung Woo Lee ),( Kui Young Park ),( Seong Jun Seo ),( Hae Jun Song ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: After successive trials and failures of various injectable materials such as bovine collagen, polyacryamide, calcium hydroxylapatite, etc., hyaluronic acid (HA) has become the most popular filling material. Many new HA fillers are being produced for the purpose of correcting wrinkles and augmentation of soft tissue. Objectives: This study aimed to test the efficacy, tolerability, and safety of a new HA filler, HA-IDF (Yvoire Classic s touch-up, LG Life Sciences, Inc., Seoul, South Korea) and compare HA-IDF with Restylane (Q-Med, Uppsala, Sweden). Methods: Fifty-eight subjects with visible nasolabial folds (NLFs) were enrolled in a randomized, multi-center, single-blind, active-controlled, matched-pair clinical study. Each subject was injected with HA-IDF in one NLF and Restylane in the other. All participants were assessed for cosmetic change at 2, 10, 18, and 26 weeks. Results: At screening, the average Wrinkle Severity Rating Scale (WSRS) for both right and left NLFs was 3.24±0.43. After 26 weeks, the results were 2.56±0.09 for both groups. There was no significant difference in WSRS scores for wrinkle improvement and in incidence of adverse events for both HA filler treatments. Conclusion: The new HA filler HA-IDF is effective and safe for correcting NLFs.

Effect of Non-animal-Derived Nitrogen Sources on the Production of Hyaluronic Acid by Streptococcus sp. KL0188

Lee, Gil-Yong,Ha, Suk-Jin,Jung, Jong-Hyun,Seo, Dong-Ho,Park, Jong-Yul,Kim, Su-Rin,Park, Nam-Woo,Kweon, Dong-Keon,Park, Sang-Hoo,Park, Cheon-Seok The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.3

Hyaluronic acid (HA) is a linear high-molecular-weight polysaccharide with useful biomedical applications. Streptococcus zooepidemicus, a typical HA-producing bacterium, requires an animal-derived nitrogen source such as tryptone, peptone or sheep blood as a nutrient. Sixteen non-animal-derived (NAD) nitrogen sources were tested as a replacement for the expensive animal-derived nitrogen sources, which may have safety issues. Among the sixteen tested NAD nitrogen sources, a yeast-derived nitrogen source (YE 0251) showed the highest HA productivity, which was equivalent to the control HA production medium containing tryptone in a 5-L jar and in 3,000-L industrial fermentations. In the 3,000-L fermentation, YE 0251 increased cell mass (dry cell weight) and HA production by 11% and 8%, respectively, compared with the control HA production medium. The fmal specific volumetric productivity (0.41 g/L h) was improved by about 70% after reducing the fermentation time from 20 h to 12 h, compared to the conventional production medium.

Survey of Cultivation and Status of Gerbera Smart Farms

Oh Keun Kwon,Jae Ah Jung,Myung Suk Ahn,Hyun Young Song,Manjulatha Mekapogu,Dan Hye Kim,Doo Jong Ha 한국화훼학회 2021 화훼연구 Vol.29 No.4

본 연구는 거베라 주산지인 경북과 경남 지역의 농가 재배 및 스마트팜 현황을 조사하고 분석하고자 수행하였다. 조사방법은 2020년 81 농가를 대상으로 대면 설문조사를 실시하였다. 거베라 경영주 연령은 50∼60대가 71.6%로 가장 많았고, 30∼ 40대가 16%, 70세 이상이 9.9%, 30세 이하는 2.5% 순이었다. 거베라 재배 경력은 5년 이하가 37%였으며, 6∼10년 25.9%, 11∼20년 29.6%, 21년 이상 농가가 7.4%였다. 재배 면적은 0.3 ∼0.6ha가 61.7%로 가장 많았고, 0.3ha 미만이 30.9%, 0.6ha 이상이 7.4%였으며, 전체 평균재배 면적은 0.37ha였다. 거베라 재배 농가당 평균 인력은 자가 노동력 2.1명, 고용 노동력 0.8명 이었다. 재배 방식에서 토경 88.9%, 양액재배 농가는 11.1%였다. 국산품종을 전체 또는 일부라도 재배하고 있는 농가는 61.7%였고 외국산 거베라 품종만 재배하고 있는 농가는 38.3% 였다. 거베라 병해충 발생조사에서 병 발생이 많았다고 응답한 농가는 91.4%였으며, 충 발생이 많았다고 응답한 농가는 98.8% 였다. 스마트팜 시스템을 설치한 농가는 12.3%였으며, 설치하지 않은 농가에서 향후 설치할 의향이 있다고 응답한 농가는 76.9% 였다. 향후 경영계획을 묻는 질문에서 현상유지 80.2%, 축소 8.6%, 경영확대 11.1%였으며, 경영 확대를 대답한 농가는 경북 지역이 8농가로 경남지역 1농가 보다 많았다. This study was conducted to investigate and analyze gerbera cultivation and the status of smart farms in Korea. The survey was conducted in person for 81 farms, in 2020. About 71.6% managers of the gerbera farms were in their 50s and 60s, 16% in their 30s and 40s, 9.9% were over 70, and 2.5% under 30. About 37% of the farmers have cultivation experience of less than five years; 25.9%, 6–10 years; 29.6%, 11–20 years; and 7.4%, over 21 years. Around 61.7% of the area under gerbera cultivation was 0.3–0.6 ha, 30.9% was less than 0.3 ha, and 7.4% was over 0.6 ha; and the average area under cultivation was 0.37 ha. The average family labor of the gerbera farms was 2.1 people and the employed labor was 0.8 people. The cultivation methods included about 88.9% soil and 11.1% nutrient cultivation farms. However, 61.7% of the farmers cultivated all or part of the domestic gerbera varieties, whereas 38.3% only cultivated foreign varieties. In the pest survey, around 91.4% of the farm managers responded to have observed different diseases, and around 98.8% farms exhibited various pests. The smart farm system has been installed by 12.3% of the farming households. However, 76.9% of farming households with no prior smart farms are planning to install them in the future. Future plans include the status quo of 80.2%, reduction in total area by 8.6% and expansion in total area by 11.1%, and around eight farms in Gyeongbuk and one farm in Gyeongnam area are planning to expand their management.

Bloodstream Infections and Clinical Significance of Healthcare-associated Bacteremia: A Multicenter Surveillance Study in Korean Hospitals

Son, Jun Seong,Song, Jae-Hoon,Ko, Kwan Soo,Yeom, Joon Sup,Ki, Hyun Kyun,Kim, Shin-Woo,Chang, Hyun-Ha,Ryu, Seong Yeol,Kim, Yeon-Sook,Jung, Sook-In,Shin, Sang Yop,Oh, Hee Bok,Lee, Yeong Seon,Chung, Doo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.7

<P>Recent changes in healthcare systems have changed the epidemiologic paradigms in many infectious fields including bloodstream infection (BSI). We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood isolates were collected from 2006 to 2007, and 1,144 isolates were considered true pathogens. HA-BSI accounted for 48.8%, CA-BSI for 33.2%, and HCA-BSI for 18.0%. HA-BSI and HCA-BSI were more likely to have severe comorbidities. <I>Escherichia coli</I> was the most common isolate in CA-BSI (47.1%) and HCA-BSI (27.2%). In contrast, <I>Staphylococcus aureus</I> (15.2%), coagulase-negative <I>Staphylococcus</I> (15.1%) were the common isolates in HA-BSI. The rate of appropriate empiric antimicrobial therapy was the highest in CA-BSI (89.0%) followed by HCA-BSI (76.4%), and HA-BSI (75.0%). The 30-day mortality rate was the highest in HA-BSI (23.0%) followed by HCA-BSI (18.4%), and CA-BSI (10.2%). High Pitt score and inappropriate empirical antibiotic therapy were the independent risk factors for mortality by multivariate analysis. In conclusion, the present data suggest that clinical features, outcome, and microbiologic features of causative pathogens vary by origin of BSI. Especially, HCA-BSI shows unique clinical characteristics, which should be considered a distinct category for more appropriate antibiotic treatment.</P>

발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

꽃게 껍질을 이용한 키토산의 제조 및 Escherichia coli의 생육 억제효과

하정욱,이광현,황용일 慶南大學校 附設 工業技術硏究所 1996 硏究論文集 Vol.14 No.1

고분자당류인 키토산은 가식성 포장제, 항암제, 생물응집제, 항균물질등으로 폭넓은 이용성을 갖는다. 다량으로 폐기되고 있는 갑각류의 껍질을 효율적으로 이용하기 위하여 꽃게 껍질에서 키틴을 분리정제한 후 탈아세틸화하여 키토산을 제조하였다. 제조된 키토산은 탈아세틸과정 중 NaOH의 농도와 처리시간에 비례하여 탈아세틸화도가 증가하며, 저분자화되는 경향을 보였다. 대장균, Escherichia coli O157:NM을 공시균으로 하여 생육억제효과를 시험한 결과 고분자량의 키토산보다 저분자량의 키토산이 억제효과가 높았다. 이는 제조된 키토산의 항균효과가 탈아세틸화도와 분자량과 상관관계가 있음을 시사하였다. Chitosan was well known as an available material preparing for edible film, antiturmor agent, biocoagulant, and antimicrobiotics etc. For the effective use of Crustacean shell, chitin was prepared from the shell of Blue crab, and chitosan was made through the deacetylation of above chitin. Chitosan prepared from Blue crab, and showed higher degree of deacetylation and lower molecular weight according to the higher concentration and longer treatment time of NaOH in the deacetylation process. The antimicrobial effect of chitosan prepared on Escherichia coli revealed that the chitosan of lower molecular weight had of antimicrobial effect than of that higher molecular weight. The antimicrobial effect of chitosan depends on the degree of deacetylation and its molecular weight.

실시간 렌더링을 위한 다각형 감소 기법 연구

하정호,윤경현 중앙대학교 기술과학연구소 1997 기술과학연구소 논문집 Vol.27 No.-

현재 컴퓨터 그래픽스 기술을 이용하여 물체를 표현하기 위한 작업들은 물체의 복잡도에 따라 많은 시간을 요구한다. 따라서, 실시간 렌더링을 요구하는 응용분야에서는 다른 기술을 요구한다. 이러한 요구에 따라 본 연구에서는 실시간 렌더링을 지원하기 위해서 물체의 원형을 유지하면서 단순화시키는 다각형 감소 기술을 다루고 있다. 다각형 감소를 위해서 물체의 지형정보 분석, 면합성, 재삼각형화 같은 기술들이 필요하다. 본 연구를 통하여 기대되는 효과는 현재 많이 연구되고 있는 가상현실 공간에서나 지형저보시스템등에서 더욱 빠른 시간내에 현실감있는 영상을 만들 수 있을 것으로 기대된다. In present, the jobs which express objects with computer graphics need execution time as much as object complexity. So, real-time application needs other techniques. In this research, we studied the polygon reduction technique which maintain the object frame and reduce the object. This technique require the geometric analysis of object, face merge and re-triangulation. In this research, the applied region which we hope are VR(Virtual Reality) and GIS(Geographical Information System).

다기능 5축 복합가공기 구조 최적설계 및 동강성 평가

정용민,장성현,황현영,최영휴,하종식 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

This paper describes a structural design. optimization for light weight and minimum compliance using G.A. and a study on dynamic stiffness evaluation of a 5-axes multi-tasking machine tool. Dynamic stiffness is one of important factors regarding to machine tool accuracy. In design optimization, we optimized the thickness of structural member which minimize the compliance and weight of the machine structure under several constraints. Furthermore, dynamic stiffness, in this study, were obtained by using both FEM analysis and an experimental dynamic stiffness test, that is a random excitation test by using a hydraulic exciter. Both the theoretical and experiment analysis results showed good agreement with each other. Finally, some discussion and review from the view point absolute dynamic stiffness were made based on the analysis results.

비스판 변이주인 Bacillus polyfermenticus KD21의 주요 생균제 특성

정민용,정황영,하정욱,백현동 慶南大學校 附設 基礎科學硏究所 2002 硏究論文集 Vol.16 No.-

Bacillus polyfermenticus SCD which is commonly called as Bispan strain are being used for functional foods using the treatment of long-term intestinal disorders, since the live strains in the form of active endospores can successfully reach the target intestine in both humans and animals. B. polyfermenticus KD21 was obtained for higher sporulation through the NTG mutagenesis. The cells of B. polyfermenticus KD21 was treated for 24 h in artificial bile after incubation for 2 h in artificial gastric juice and final number of the strain was reached to around 10^8 CFU/㎖. In test of API ZYM kit, β-glucuronidase or β-glucosidase were not produced by B. polyfermenticus KD21. B. polyfermenticus KD21 was resistant to antibiotics such as nisin, tetracyclin, streptomycin, and rifamycin. B. polyfermenticus KD21 was shown to inhibit the growth of Listeria monocytogenes ATCC 19111 completely within 24 h of incubation, which indicates its bactericidal nature.

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.