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김효겸,문정대,문성배 부산대학교 사범대학 과학교육연구소 1997 科學敎育硏究報 Vol.24 No.-
The content of oxidation-reduction in the chemistry textbooks from middle school to college was analyzed to see the effective connection of curricular articulation. For this purpose, oxidation-reduction content between the school unit were selected in chemistry textbooks and formed five types of classification from groups of "first concept", "same concept", "overlap", "development" and "gap". The result indicated that there was a deep big gap from middle school to senior high school and the effectiveness from senior high school to college was looked acceptable. Finally, the new concept maps between the school unit were suggested.
Hyo-Jung Park,Jun-Kyum Kim,Hye-Min Jeon,Se-Yeong Oh,Sung-Hak Kim,Do-Hyun Nam,Hyunggee Kim 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.2
This paper was initially submitted to Journal ‘Molecules and Cells’ without approval from two coauthors. According to the decision of editorial committee, I, as a corresponding author for this paper, withdraw authorship of two coauthors who did not agree to use of XO1, XO2, and XO3 cells shown in Fig. 1B. Thus, we change data shown in Fig. 1B by removing expression of TLX in these cells. We deeply regret this circumstance and apologize to the community.
Development of In-Core Fuel Management Scoping Tools for PWR
Kim, Chang-Hyo,Kim, Teak-Kyum Korean Nuclear Society 1993 Nuclear Engineering and Technology Vol.25 No.1
This paper concerns with developing a simplified in-core fuel management scoping tool for PWR. For this purpose the point reactivity model is put into a fuel cycling decision code, FCYPRM. Modified Borresen's coarse-mesh diffusion theory and nodal expansion method are utilized to form a spatial neutron analysis code, CMSNAP. Numerical experiments are per- formed to determine a set of empirical shuffling rules for working out an automated fuel loading pattern search code, ALPS. The numerical examples are presented for verifying effectiveness and applicability of individual codes. By structuring and applying three codes for reload core design problem of a PWR, it is demonstrated that these codes provide an effective in-core fuel management scoping tool for PWR.
Kim, Hyo Seon,Kim, Sang Kyum,Kang, Keon Wook MDPI 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.12
<P>Epoxyeicosatrienoic acid (EET) is a cardioprotective metabolite of arachidonic acid. It is known that soluble epoxide hydrolase (sEH) is involved in the metabolic degradation of EET. The abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) play important roles in the pathogenesis of atherosclerosis and restenosis. Thus, the present study investigated the effects of the sEH inhibitor 12-(((tricyclo(3.3.1.13,7)dec-1-ylamino)carbonyl)amino)-dodecanoic acid (AUDA) on platelet-derived growth factor (PDGF)-induced proliferation and migration in rat VSMCs. AUDA significantly inhibited PDGF-induced rat VSMC proliferation, which coincided with Pin1 suppression and heme oxygenase-1 (HO-1) upregulation. However, exogenous 8,9-EET, 11,12-EET, and 14,15-EET treatments did not alter Pin1 or HO-1 levels and had little effect on the proliferation of rat VSMCs. On the other hand, AUDA enhanced the PDGF-stimulated cell migration of rat VSMCs. Furthermore, AUDA-induced activation of cyclooxygenase-2 (COX-2) and subsequent thromboxane A2 (TXA<SUB>2</SUB>) production were required for the enhanced migration. Additionally, EETs increased COX-2 expression but inhibited the migration of rat VSMCs. In conclusion, the present study showed that AUDA exerted differential effects on the proliferation and migration of PDGF-stimulated rat VSMCs and that these results may not depend on EET stabilization.</P>
Park, Hyo-Jung,Kim, Jun-Kyum,Jeon, Hye-Min,Oh, Se-Yeong,Kim, Sung-Hak,Park, Myung-Jin,Soeda, Akio,Nam, Do-Hyun,Kim, Hyung-Gee Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.5
A growing body of evidence indicates that deregulation of stem cell fate determinants is a hallmark of many types of malignancies. The neural stem cell fate determinant TLX plays a pivotal role in neurogenesis in the adult brain by maintaining neural stem cells. Here, we report a tumorigenic role of TLX in brain tumor initiation and progression. Increased TLX expression was observed in a number of glioma cells and glioma stem cells, and correlated with poor survival of patients with gliomas. Ectopic expression of TLX in the U87MG glioma cell line and Ink4a/Arf-deficient mouse astrocytes (Ink4a/$Arf^{-/-}$ astrocytes) induced cell proliferation with a concomitant increase in cyclin D expression, and accelerated foci formation in soft agar and tumor formation in in vivo transplantation assays. Furthermore, overexpression of TLX in Ink4a/$Arf^{-/-}$ astrocytes inhibited cell migration and invasion and promoted neurosphere formation and Nestin expression, which are hallmark characteristics of glioma stem cells, under stem cell culture conditions. Our results indicate that TLX is involved in glioma stem cell genesis and represents a potential therapeutic target for this type of malignancy.
요추 추간판 탈출증 환자의 보존적 치료결과와 흡연의 상관성에 대한 임상적 고찰
반효정(Hyo-Jung Bahn),김석(Seok Kim),윤현석(Hyun-Seok Yoon),김한겸(Han-Kyum Kim),김선민(Sun-Min Kim),김지용(Jee-Yong Kim),김태헌(Tae-Hun Kim),박병윤(Byoung-Yoon Park) 척추신경추나의학회 2010 척추신경추나의학회지 Vol.5 No.2
Objectives : To investigate the association between cigarette smoking and clinical outcomes of conservative treatment for lumbar herniated disc. Methods : We reviewed 74 male patients with lumbar herniated disc who were hospitalized at the Jaseng Oriental Medicine Hospital. 74 patients were divided into 2 groups(smokers, non-smokers) and we measured age, ODI score, SF-36 score, VAS. Results : Between smokers and non-smokers, statically significant differences were found in clinical symptoms on the time of 6 months later, effective scores of treatments, value of ODI and value of VAS on the time of 6 months later. And in these values of measurements, non-smokers were higher than those of smokers. Conclusion : These results suggest that possibility of the association between cigarette smoking and clinical outcomes of conservative treatment for lumbar herniated disc.